Mechanism of Drug Action, Proteomics and Protein Modification
Liang Zhou
Assistant Professor
B.S. Inner Mongolia University, 2008
Ph.D. University of Science and Technology of China, 2013
Postdoctoral Fellow, National Institutes of Health (NIH), 2013-2016

1. The molecular and cellular mechanisms of mental retardation
2. The ubiquitin modification, and the biological functions in disease development

1. Gu X※, Mao X※, Lussier MP※, Hutchison MA※, Zhou L, Hamra FK, Roche KW, Lu W. GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nature Communications 7,10873 (2016).
2. Gu X, Zhou L, Lu W. An NMDA receptor-dependent mechanism underlies inhibitory synapse development. Cell Reports 14, 471-478 (2016).
3. Zhou L※, Wang H※, Ren H, Hu Q, Ying Z, Wang G. Bcl-2 decreases the affinity of SQSTM1/p62 to Poly-Ubiquitin chains and suppresses the aggregation of misfolded protein in Neurodegenerative disease. Molecular Neurobiology  52, 1180-1189 (2015).
4. Zhou L, Wang H, Chen D, Gao F, Ying Z, Wang G. p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine. International Journal of Molecular Sciences 15, 14997-15010 (2014).
5. Zhou L, Wang H, Wang P, Ren H, Chen D, Ying Z, Wang G. Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax. Neuroscience 243, 14-21 (2013).
6. Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH. Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacologica Sinica  34, 651-656 (2013).
7. Wang P, Li B, Zhou L, Fei E, Wang G. The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins. Neuroscience 190, 43-55 (2011).

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