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欧阳艺兰

发布者:金雪明发布时间:2019-07-13浏览次数:10




姓    名:欧阳艺兰
职称职务:讲师
电子邮箱:y_ouyang@suda.edu.cn


一、学习工作经历


1
、学历背景:


2009.9-2013.7 黑龙江大学,本科,制药工程(化学)

2013.9-2016.7 苏州大学,硕士,药物分析学

2016.9-2019.7 苏州大学,博士,药物分析学

2018.10-2019.10 美国伦斯勒理工博士联合培养

二、研究方向


1.
糖胺聚糖等硫酸多糖寡糖的糖组学

2. 肝素及类肝素糖类药物的分析、鉴定

3. 糖类药物的研究与开发


三、主要研究成果


近年来发表SCI论文十余篇。


1
、论文

1. Ouyang, Y.; Han, X.; Xia, Q.; Chen, J.; Velagapudi, S.; Xia, K.; Zhang, Z.*; Linhardt, R. J.* Negative-Ion Mode Capillary Isoelectric Focusing Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides. Anal. Chem.2019, 91 (1), 846–853.

2. Ouyang, Y.Zeng, Y.; Rong, Y.; Song, Y.; Shi, L.; Chen, B.; Yang, X.; Xu, N.; Linhardt, R. J.; Zhang, Z. * Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two-dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry. Anal. Chem.2015, 87(17): 897-8963.


3. Ouyang, Y.; Yu, Y.; Zhang, F.; Chen, J.; Han, X.; Xia, K.; Yao, Y.; Zhang, Z.*; Linhardt, R. J.* Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications. J. Med. Chem.2019, 62, 1067-1072.

4. Ouyang, Y.; Zeng, Y.; Yi, L.; Tang, H.; Li, D.; Linhardt, R. J.; Zhang, Z.* Qualitative and Quantitative Analysis of Heparin and Low Molecular Weight Heparins Using Size Exclusion Chromatography with Multiple Angle Laser Scattering/Refractive Index and Inductively Coupled Plasma/Mass Spectrometry Detectors. J. Chromatogr. A2017, 1522, 56–61.

5. Ouyang, Y.; Zhu, M.; Wang, X.; Yi, L.; Fareed, J.; Linhardt, R.J.; Zhang, Z.* Systematic Analysis of Enoxaparins from Different Sources with Online One- and Two-dimensional Chromatography. Analyst. 2019, 144, 3746-3755.

6. Ouyang, Y.; Han, X.; Yu, Y.; Chen, J.; Fu, L.; Zhang, F.; Linhardt, R. J.; Fareed, J.; Hoppensteadt, D.; Jeske, W.; Kouta, A.; Zhang, Z.*; Xia, K.* Chemometric Analysis of Porcine, Bovine and Ovine Heparins. J. Pharm. Biomed. Anal.2019, 164, 345-352.

7. Ouyang, Y.;Wu, C.; Sun, X.; Liu, J.; Linhardt, R. J.; Zhang Z.* Development of Hydrophilic-Interaction-Chromatography with Quadruple-Time-of-Flight Mass Spectrometry for Heparin and Low-Molecular-Weight-Heparin Disaccharide Analysis, Rapid Commun. Mass Spectrom., 2016, 30: 277-284.


8. Yi, L.; Ouyang, Y.;Sun, X.; Xu, N.; Linhardt, R. J.; Zhang, Z.* Qualitative and Quantitative Analysis of Branches in Dextran using High-Performance Anion Exchange Chromatography coupled to Quadrupole Time-of-Flight Mass Spectrometry, J. Chromatogr. A2015, 1423, 79-85.


9. Yi, L.; Sun, X.; Du, K.; Ouyang, Y.; Wu, C.; Xu, N.; Linhardt, R. J.; Zhang, Z. * UP-HILIC-MS/MS to Determine the Action Pattern of Penicillium sp. Dextranase, J. Am. Soc. Mass Spectr. 2015, 26, 1174-1185.

10. Yi, L.; Xu, N.; Sun, X.; Li, D.; Tao, L.; Ouyang, Y.; Linhardt, R. J.; Zhang, Z.* N -Glycans Released from Glycoproteins Using a Commercial Kit and Comprehensively Analyzed with a Hypothetical Database. J. Pharm. Anal.2017, 7 (2), 87–94.

11. Sarnaika, A.; Abernathy, M. H.; Han, X.; Ouyang, Y.; Xia, K.; Chen, Y.; Cress, B.; Zhang, F.; Lali, A.; Pandit, R.; Linhardt, R. J.; Tang, Y. J.; Koffas, M. A. G.* Metabolic Engineering of Cyanobacteria for Photoautotrophic Production of Heparosan, a Pharmaceutical Precursor of Heparin. Algal Res.2018, 37 (June 2018), 57–63.

12. Khan, S.; Liu, J.; Szabo, Z.; Kunnummal, B.; Han, X.; Ouyang, Y.; Linhardt, R. J.; Xia, Q.* On-Line Capillary Electrophoresis/Laser-Induced Fluorescence/Mass Spectrometry Analysis of Glycans Labeled with TealTM Fluorescent Dye Using an Electrokinetic Sheath Liquid Pump-Based Nanospray Ion Source. Rapid Commun. Mass Spectrom.2018, 32 (11), 882–888.

13. Mikael, P. E.; Willard, C.; Koyee, A.; Barlao, C.-G.; Liu, X;Han, X.; Ouyang, Y.; Xia, K.; Linhardt, R. J.; Dordick, J. S.* Remodeling of Glycosaminoglycans During Differentiation of Adult Human Bone Mesenchymal Stromal Cells Toward Hepatocytes. Stem Cells Dev.2018, 28 (4), 278–289.

14. Haeger, S. M.; Liu, X.; Han, X.; Brennan McNeil, J.; Oshima, K.; McMurtry, S. A.; Yang, Y.; Ouyang, Y.; Zhang, F.; Nozik-Grayck, E.; Zemans, R. L.; Tuder, R. M.; Bastarache, J. A.; Linhardt, R. J.; Schmidt, E. P.* Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am. J. Respir. Cell Mol. Biol.2018, 59 (3), 363–374.



2、课题

1、肝素类药物糖组学研究(81673388),国家自然科学基金项目(面上),51万,2017.01-2020.12,重要参与者。

2、复杂蛋白聚糖的序列分析(81473179),国家自然科学基金项目(面上),80万,2015.01-2018.12,重要参与者。