应征

yingzheng.jpg

 应 征

Zheng Ying, Ph.D.

zheng.ying@suda.edu.cn

 

RESEARCH INTERESTS

Increasing evidence indicates that further exploration of protein quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease. The goal of our studies is to describe how protein quality control systems, including autophagy-lysosome pathway and ubiquitin-proteasome system, fail to protect neurons at disease stages. To this end, we will use cell biology, molecular biology, biochemical approaches and genetic manipulation of animal models to investigate the relationship between protein quality control system and neurodegeneration.

 

EDUCATION

2004-2009  University of Science and Technology of China

                   Ph.D in Neurobiology, November 2009

2000-2004  University of Science and Technology of China

                   B.S. in Bioscience, July 2004

 

RESEARCH EXPERIENCE

2016-present  Professor

Department of Pharmacology, Soochow University College of Pharmaceutical Sciences

2012-2016    Associate Professor

Department of Pharmacology, Soochow University College of Pharmaceutical Sciences

2010-2012    Postdoctoral Research Associate with Dr. Arthur Horwich

Yale University School of Medicine / Howard Hughes Medical Institute (HHMI)

2004-2009    Ph.D Student with Dr. Guanghui Wang

Laboratory of Molecular Neuropathology, Department of Neurobiology, School of Life Sciences, University of Science and Technology of China

 

SCIENTIFIC TITLE AND AWARD

2015-present Associate Editor of the Journal of Alzheimer's Disease (JAD)

2010 Qiu Shi Graduate Student Scholarship by Hong Kong Qiu Shi Science & Technologies Foundation

 

SELECTED PUBLICATIONS  (*Corresponding author)

2016-present

1.        Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z* and Wang G* (2016). TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J. 35(2):121-42. Notes: Cover story and highlighted in News & Views in this issue.

2.        Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H* and Wang G* (2016) TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners. Autophagy 12(4):707–8.

3.        Xia Q, Wang G*, Wang H, Hu Q, Ying Z* (2016). Folliculin, a tumor suppressor associated with Birt-Hogg-Dube´ (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation. Hum Mol Genet. 25(1):83-96.

 

2015

4.        Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, Chen D, Fu C, Zheng L, Ying Z*, Wang G* (2015). Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia. Cell Death Dis. 6:e1702.

5.        Xia Q, Wang H, Zhang Y, Ying Z* and Wang G* (2015). Loss of TDP-43 Inhibits ALS-linked Mutant SOD1 Aggresome Formation in an HDAC6-dependent Manner. J Alzheimers Dis. 45(2):373-86.

6.        Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*, Ying Z* (2015). Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum Mol Genet. 24(9):2426-41.

7.        Zhou L, Wang H, Ren H, Hu Q, Ying Z* and Wang G* (2015). Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease. Mol Neurobiol. 52(3):1180-9.

8.        Hou X, Si J, Ren H, Chen D, Wang H, Ying Z, Hu Q, Gao F, Wang G (2015). Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells. Acta Pharmacol Sin. 36(11):1300-7.

9.        Guo D, Ying Z, Wang H, Chen D, Gao F, Ren H, Wang G (2015). Regulation of autophagic flux by CHIP. Neurosci Bull. 31(4):469-79.

 

2014

10.    Zhou L, Wang H, Chen D, Gao F, Ying Z* and Wang G* (2014). p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine. Int J Mol Sci. 15(9):14997-15010.

 

2013

11.    Zhou L, Wang H, Wang P, Ren H, Chen D, Ying Z* and Wang G* (2013). Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between bcl-xl and bax. Neuroscience. 243:14-21.

12.    Zhou L, Wang H, Ren H, Chen D, Gao F, Hu Q, Fu C, Xu R, Ying Z* and Wang G* (2013). Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacol Sin. 34(5):651-6.

13.    Ying Z1, Wang H1, Wang G (2013). The ubiquitin proteasome system as a potential target for the treatment of neurodegenerative diseases. Curr Pharm Des. 19(18):3305-14. (1Co-first author)

 

Before 2013

14.    Wang H1, Ying Z1, Wang G (2012). Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains. J Biol Chem. 287(34):28576-85. (1Co-first author)

15.    Farr GW, Ying Z, Fenton WA, Horwich AL (2011). Hydrogen-deuterium exchange in vivo to measure turnover of an ALS-associated mutant SOD1 protein in spinal cord of mice. Protein Sci. 20(10):1692-6.

16.    Ying Z, Wang H, Fan H, Wang G (2011). The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin. J Biol Chem. 286(23):20835-44.

17.    Li H, Tong S, Li X, Shi H, Ying Z, Gao Y, Ge H, Niu L, Teng M (2011). Structural basis of pre-mRNA recognition by the human cleavage factor I(m) complex. Cell Res. 21(7):1039-51.

18.    Wang X, Fan H, Ying Z, Li B, Wang H, Wang G (2010). Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system. Neurosci Lett. 469(1):112-116.

19.    Ying Z, Wang H, Fan H, Zhu X, Zhou J, Fei E, Wang G (2009). Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.Hum Mol Genet. 18(22):4268-81.

20.    Fan J, Ren H, Fei E, Jia N, Ying Z, Jiang P, Wu M, Wang G (2008). Sumoylation is critical for DJ-1 to repress p53 transcriptional activity.FEBS Lett. 582(7):1151-6.

21.    Jia NL, Fei EK, Ying Z, Wang HF, Wang GH (2008). PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner. Neurosci Bull. 24(4):201-8.

22.    Tao RS, Fei EK, Ying Z, Wang HF, Wang GH (2008). Casein kinase 2 interacts with and phosphorylates ataxin-3. Neurosci Bull. 24(5):271-7.

23.    Fei E, Jia N, Yan M, Ying Z, Sun Q, Wang H, Zhang T, Ma X, Ding H, Yao X, Shi Y, Wang G (2006). SUMO-1 modification increases human SOD1 stability and aggregation. Biochem Biophys Res Commun. 347(2):406-12.