崔京浩

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姓  名:崔京浩

职称职务:教授,药剂学教研室主任

联系电话:0512-65882077

电子邮箱:jhcui@suda.edu.cn

办公地址:云轩楼1326

 

 

个人简介:

一、学习工作经历

1、学历背景:

1985.91989.7 延边大学药学院本科

1989.91992.6 延边大学药学院药剂学硕士生

1992.71996.7 延边大学药学院药剂学教研室,助教、讲师

1996.81999.8 韩国江原大学药学院药剂学,药学博士

1999.92003.4 延边大学药学院药剂学教研室,副教授

2006.3-至今    苏州大学药学院药剂学教研室,副教授、教授

2、国外学习研究经历:

2000.122001.5 日本城西大学药学部,访问教授

2003.042004.5 日本京都药科大学药物动力学研究室,博士后

2004.052004.2 日本天藤制药株式会社创药中心,主席研究员

3、工作经历:

1992.71996.7 延边大学药学院药剂学教研室,助教、讲师

1999.92003.4 延边大学药学院药剂学教研室,副教授

2006.3-至今    苏州大学药学院药剂学教研室,副教授、教授

二、研究方向

1)生物大分子药物的靶向给药系统研究

2)粘膜及经皮给药系统的研究与开发

3)口服结肠定位释药制剂

三、主要研究成果

发表学术论文44篇,其中SCI收录论文15篇。主持和参与国家自然科学基金各1项,参与获得科技部国际科技合作项目和国家新药重大专项各1项。

() 论文*表示为通讯作者

1.  Yanhang Ma, Lin Zhou, Haoquan Zheng, Lei Xing, Chenguang Li, Jinghao Cui* and Shunai Che*pH-responsive mitoxantrone (MX) delivery using mesoporous silica nanoparticles (MSN)Journal of Materials Chemistry2011, 21, 9483-9486. 1区杂志,IF2008: 4.65

2.  Qing-Ri Cao, Jing-Hao Cui, Jun Bom Park, Hyo-Kyung Han, Jaehwi Lee, Kyung Taek Oh, In choon Park, Beom-Jin Lee, Effect of food components and dosing times on the oral pharmacokinetics of nifedipine in rats, Int. J. Pharm., 2010, 396 (1-2): 39-44. (IF2008: 3.061)

3.  Yu-Ling Li, Li Zhu, Zhaozhong Liu, Ru Cheng, Fenghua Meng, Jing-Hao Cui, Shun-Jun Ji, and Zhiyuan ZhongReversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer CellsAngew. Chem. Int. Ed.2009, 48, 99149918.(IF2008: 10.879 )

4.  Jing-Hao Cui, Qing-Ri Cao, Beom-Jin Lee, Enhanced delivery of bifidobacteria and fecal changes following the oral administration of gastric acid resistant bifidobacteria-loaded alginate poly-l-lysine microparticles in human volunteers, Drug Delivery, 200714: 265271. (IF2008: 1.55)

5.  Jing-Hao Cui, Qing-Ri Cao, Yun-Jae Choi and Beom-Jin LeeEffect of Additives on the Viability of Bifidobacteria Loaded in Alginate Poly-l-lysine Microparticles During the Freeze-drying ProcessArchives of Pharmacal Research 29 (8), 707-711, 2006. (IF2008: 1.074)

6.  Qing-Ri Cao, Yun-Woong Choi, Jing-Hao Cui and Beom-Jin Lee, Formulation, release characteristics and bioavailability of novel monolithic hydroxypropyl -methylcellulose matrix tablet containing acetaminophen, Journal of Controlled Release, 2005, 108 (2-3): 351-361. (IF2008: 5.69)

7.  Qing-Ri Cao, Yun-Woong ChoiJing-Hao Cui and Beom-Jin Lee, Effect of Solvents on Physical Properties and Release Characteristics of Monolithic Hydroxypropylmethylcellulose Matrix Granules and Tablets. Archives of Pharmacal Research, 2005 28:493-501. (IF2008: 1.074)

8.  Jing-Hao Cui, Juhn-Su Goh, Seung-Yong Park, Pyeung-Hyeun Kim, and Beom-Jin Lee, Preparation and physical characterization of alginate poly-l-lysine microparticles using air-atomization technique, Drug Dev. Ind. Pharm. 27(4), 307-317, 2001(IF2008: 1.104)

9.  Jing-Hao Cui, Juhn-Su Goh, Pyeung-Hyeun Kim, Suk-Ho Choi, Beom-Jin Lee Survival and stability of bifidobacteria loaded in alginate poly-l-lysine microparticles, Int. J. Pharm., 210 (2000) 51-59. (IF2008: 3.061)

10. Beom-Jin Lee, Jing-Hao Cui, Ok-Sun Park, Juhn Soo Goh, Tae Seok Ahn and Seung Yong Park, Stability and gastric acid resistance of Lactobacilli and Bifidobacteria in Commercial Yoghurts, Korean J. Microbiol., 35 (1), 89-93 (1999).

11. Beom-Jin Lee, Geun-Hong Min and Jing-Hao Cui, Correlation of drug solubility with trapping efficiency and release characteristics of alginate beads, Pharm. Pharmacol. Commun. 5: 85-89 (1999).

12. Beom-Jin Lee, Seung-Goo Ryu and Jing-Hao Cui, Formulation and release characteristics of hydroxypropyl methylcellulose matrix tablet Containing Melatonin, Drug Dev. Ind. Pharm., 25(4), 493-501 (1999).

13. Beom-Jin Lee, Seung-goo Ryu and Jing-Hao Cui, Controlled release of dual drug-loaded delivery hydroxypropyl-methylcellulose matrix tablet using aqueous-based polymeric coatings, Int. J. Pharm., 18871-801999.

14. Beom-Jin Lee, Jing-Hao Cui, Keith A. Parrott, James W. Ayres and Robert L. Sack, Percutaneous absorption and model membrane variation of melatonin in aqueous-based propylene glycol and 2-hydroxypropyl-β-cyclodextrin vehicles, Arch. Pharm. Res. 21 (5), 503-507 (1998).

15. Beom-Jin Lee, Jing-Hao Cui, Tae-Wan Kim, Min-Young Heo, and Chong-Kook Kim, Biphasic release characteristics of dual drug-loaded alginate beads, Arch. Pharm. Res. 21 (6), 645-650 (1998).

(二)课题

1. 国家自然科学基金面上项目(编号:81173005),受体介导的温敏性纳米载体对siRNA体内外传递及药效的影响和机制研究,资助金额60万,2012-2015,主持。

2. 国家自然科学基金面上项目(编号:81173004),肿瘤细胞核靶向p53基因聚酰胺-胺聚合物递送系统的研究,资助金额50万,2012-2015,参与。

3. 国家“重大新药创制”科技重大专项(编号:2009ZX09502-009),中药制剂物理改性技术研究,资助金额:36万,2009-2011,苏大主持。

4. 科技部国际合作项目(编号:2009DFA31330),艾迪冻干粉针的制剂技术及药代动力学,资助金额:90万,2009-2011,苏大主持。

5. 江苏省高校自然科学基础研究面上项目(编号:08KJB350003), DEC-205介导树突状细胞靶向温度敏感性纳米载体的研究,资助金额:3万,2008-2010,主持。

()、专利

1.申请人:崔京浩、陈莉,专利名称:一种抗原递呈细胞靶向纳米粒子及其制备方法,专利申请号:200910201415.4

2.申请人:崔京浩、崔启华,专利名称:一种含丹皮酚活性物质的结肠靶向给药制剂及其制备方法,专利申请号:200910201417.3

3. 申请人:崔京浩、缪文俊、崔载胜,专利名称:一种卡巴拉汀缓释微球及其制备方法,专利申请号:200910201416.9

4. 申请人:崔京浩、缪文俊、崔载胜,专利名称:一种司来吉兰缓释微球及其制备方法,专利申请号:200910201414. X

5. 申请人:崔京浩、钱颖,专利名称:一种溃疡性结肠炎靶向姜黄素纳米粒的制备方法,专利申请号:200910201403.1

6. 申请人:曹青日、崔京浩,专利名称:一种缬沙坦生物粘附性包衣微丸制剂及其制备方法,专利申请号:201010590790.5

7. 申请人:曹青日、崔京浩,专利名称:扎那米韦固体脂质纳米粒的口服制剂及其制备方法,专利申请号:201010590798.1

8. 申请人:崔京浩、敖桂珍、韩莎、曹青日,专利名称:布洛芬丹皮酚酯药用化合物及其亚微乳剂和制备方法,专利申请号:201010590939.X

9. 申请人:敖桂珍、崔京浩,专利名称:一种新型非甾体抗炎药制备方法及其抗炎镇痛作用,专利申请号:201010590911.6

10. 申请人:崔京浩、吴丹、曹青日,专利名称:一种镇静安神的缬草制剂及其制备方法,专利申请号:201010590797.7

11. 申请人:崔京浩、朱云峰、曹青日、刘江云,专利名称:治疗呼吸道感染与炎症的金莲花提取物干粉吸入剂及其制备方法,专利申请号:201110051770.5

四、社会兼职

西南民族药新型制剂国家地方联合工程研究中心,主任;世中联中药药剂委员会,常务理事、副秘书长;ISRN Pharmaceutics,编委;Journal of controlled release, International Journal of Pharmaceutics, Nanomedicine: Nanotechnology, Biology, and MedicineJ Drug Delivery等国际刊物的特约审稿人。