杨增杰

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姓   名:杨增杰
职   称:特聘教授
电子邮箱:yangzj@suda.edu.cn
办公地点:云轩楼2107

 
个人简介
一、学习经历及背景

2009.5 美国外国医学毕业生教育委员会,医学学位认证
2001.7-2005.5  英国诺丁汉大学, 医学遗传学, 博士
1997.7-2000.7  复旦大学医学院,医学遗传学,  硕士
1992.7-1997.7  华北理工大学,   临床医学,学士

二、研究工作经历
2015.3-至今    苏州大学药学院,特聘教授
2010.5-2015.2  美国福克斯蔡司癌症研究中心(Fox Chase Cancer Center),
               肿瘤学系,助理教授
2005.5-2010.5  杜克大学 (Duke University), 药学和肿瘤学院,博士后
2000.5-2001.7  国家基因组南方研究中心,助理研究员

三、主要学术兼职
2001年至今   英国发育生物协会会员(British Society of Developmental Biology)
2008年至今   美国神经肿瘤学会会员(Society for Neuro-Oncology)
2008年至今  美国肿瘤协会会员(American Association for Cancer Research)

四、担任杂志论文评审(2009至今)
受邀为下列期刊定期审稿:PNAS, J. Neurobiology, J. Neuroscience, European Journal of Neuroscience, Oncogene, J. Neuro-oncology, Oncogene, Cancer Letter, Cell Research, J. Neurochemistry, Apoptosis, Clinical Cancer Research.

五、奖励及荣誉
2012年获WW Smith Charitable Trust基金会颁发杰出研究学者奖 (Research Award)。
2008年获 American Brain Tumor Association美国脑肿瘤协会颁发基础研究奖。
2006年获美国神经肿瘤协会 (American  Society for Neuro-Oncology) 颁发杰出研究奖 (Award for Excellence in Brain Research)
2001-2005年获诺丁汉儿童肿瘤基金会 (Nottingham Children Brain Tumor Foundation) 颁发留学研究奖学金
2001-2005年获英国国家教育委员会 (Committee of Vice-Chancellors and Principals) 颁发海外杰出研究奖学金 (Oversea Research Scholarship, ORS)

六、国内主持的主要科研项目
国家自然科学基金面上项目: 髓母细胞瘤中胆固醇的细胞来源及作用, 2016.1-2019.12,项目负责人。

七、和课题相关的主要论著
1.Li, P., Lee, E.H., Muradimova, R.E., Zhang, H., Peng, G., Du, F., Ng, J.M.Y., Curran, T., Yang, Z.J.Nestinmediates hedgehog pathway tumorigenesis. Under 2nd review by Nature.
2. Du, F., Lee, E.H., Yuelling, L.W., Muradimova, R.E., Peng, G., Cai, K.Q., Ng, J.M.Y., Curran, T.,Yang, Z.J. Astrocytes drive Nestin expression to promote medulloblastomatumorigenesis. Under 2nd review by Nature.
3. Xu, G., Wang, R., Wang, Z., Lei, Q., Yu, Z., Liu, C., Li, P., Yang, Z.J., Cheng, X., Li, G., Wu, M., NGL-2 is a new partner of PAR complex in axon differentiation. Journal of Neuroscience 35 (18):7153-64, 2015.
4. Chow, H., Dong, B., Duron, S.G., Campbell, D.A., Ong, C.C., Hoeflich, K.P., Chang, L., Welling, D.B., Yang, Z.J.,Chernoff, J., Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget,6(4):1981-94, 2015.
5. Yuelling, L.W., Du, F., Li, P., Muradimova, R., Yang, Z.J. Isolation of distinct cell populations from thedeveloping cerebellum by microdissection. Journal of visualized experiments:JoVE, doi:10.3791/51323, 2014.
6. Li, P., Du, F., Yuelling, L., Lin, T., Muradimova, R., Enikolopov, G., Wechsler-Reya, R., Yang, Z.J. A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity. Nature Neuroscience 16 (12):1737-1744, 2013. Highlighted by “New progenitors NESTIN(g) in the EGL”. Nature Neuroscience 16 (12):1710-2, 2013.
7. Gibson, P., Tong, Y., …Yang, Z.J.,Brun, S., Lee, Y., Zindy, F., Lindsey, J.C., Taketo, M.M., Boop, F.A., Sanford, R.A., Gajjar, A., Clifford, S.C., Roussel, M.F., McKinnon, P.J., Gutmann, D.H., Ellison, D.W., Wechsler-Reya, R., Gilbertson, R.J. Subtypes of medulloblastoma have distinct developmental origins. Nature 468 (7327): 1095-1099, 2010. Highlighted by “Medulloblastoma:origins”. Nature Review Cancer, 11(2):79, 2010.
8. Kessler, J.D., Hasegawa, H., Brun, S.N., Emmenegger, B.A., Yang, Z.J., Dutton, J.W., Wechsler-Reya, R.J. N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes and Development 23:157-170, 2009.
9. Yang, Z.J., Ellis, T., Markant, S.L., Read, T.A., Kessler, J.D., Bourboulas, M., Schüller, U., Machold, R., Fishell, G., Rowitch, D.H., Wainwright, B.J., Wechsler- Reya, R.J. Medulloblastoma can be initiated by deletion of Patched in lineage- restricted progenitors or stem cells. Cancer Cell 14:135-145, 2008. Highlighted by “Even cancers want commitment: lineage identity and medulloblastoma formation”. 14(2):105-7, 2008.
10. Yang, Z.J., Wechsler-Reya, R.J. Hit ‘em where they live: Targeting the cancer stem cell niche. Cancer Cell 11:3-5, 2007.