王光辉

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姓  名:王光辉

职称职务:教授、博导

联系电话:65884845

电子邮箱:wanggh@suda.edu.cn

办公地址:云轩楼2405

 

个人简介:

一、学习工作经历

1、学历背景:

1981.9-1987.7   上海医科大学本科

1987.9-1990.7   上海医科大学组织胚胎学硕士生

1997.4-2001.3   日本东京大学医学部神经内科 Ph.D

2001.4-2001.10  新加坡国立大学博士后

2001.11-2003.8  美国依阿华大学医学院博士后

2、国外学习研究经历:

1995.10-1997.3  日本东京大学附属医院访问学者

3、工作经历:

1990.8-1995.9   上海医科大学组织胚胎学 助教、讲师

2003.10-2011.5  中国科学技术大学 教授、博导

2011.5-至今     苏州大学药学院 教授、博导

 

二、研究方向

1)帕金森病中的线粒体损伤和清除的机制

2)帕金森病中神经元与胶质细胞相互作用在疾病发生中的作用

3)神经退行性疾病相关蛋白的功能和机制研究

 

三、近年来主要研究成果

近年来,在EMBO JMol PsychiatryCell Death DifferBrainHum Mol GenetOncogeneCell Death DisScience SignalingJBC等期刊发表通讯作者论文60余篇,其中,2010年发表在Cell Death Differ上关于帕金森病的线粒体蛋白Omi与自噬的论文被Nature网站列为神经科学特色论文;2011年发表在Mol Psychiatry上有关精神分裂症dysbindin在神经发育中的机制研究被选为封面论文;2012年发表的帕金森病蛋白Omi调控小胶质细胞激活的研究以封面论文发表在Science子刊Science Signaling上,并受到该杂志电话采访,也被Nature Immunology编辑Laurie Dempsey作为研究亮点在Nature Immunology评述。2016年发表在EMBO J上的有关TDP-43与自噬的研究被列为封面论文,并被该期刊专题评述。

 

一)近年来代表性通讯作者论文

1.         Mao J, Xia Q, Liu C, Ying Z, Wang H, Wang G. A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation. Hum Mol Genet. 2017; 26: 1877-1889.

2.         Gu C, Zhang Y, Hu Q, Wu J, Ren H, Liu CF, et al. P7C3 inhibits GSK3beta activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo. Cell Death Dis. 2017; 8: e2858.

3.         Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z*, Wang G*. TDP-43 loss of fuction increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J. 2016; 35:121-142. (封面论文)

4.         Xia Q, , Wang H, Hu Q, Ying Z*,Wang G*. Folliculin, a tumor suppressor associated with Birt-Hogg-Dube (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation. Hum Mol Genet. 2016; 25: 83-96.

5.         Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H, Wang G*. TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners. Autophagy .2016,4,707-708.

6.         Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*, Ying Z*. Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum Mol Genet, 2015, 24: 2426-41.

7.         Gao F, Chen D, Si J, Hu Q, Fang M and Wang G*. Impairment of Nix-mediated mitophagy is linked to the pathogenesis of Parkinson's disease. Hum Mol Genet, 2015, 24: 2528-38.

8.         Zhou L, Wang H, Ren H, Hu Q, Ying Z*Wang G.* Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease. Mol Neurobiol. 2015, 52:1180-9.

9.         Xu R, Hu Q, Ma Q, Liu C, Wang G*.The protease Omi regulates mitochondrial biogenesis through the GSK3b/PGC-1a pathway. Cell Death and Dis. 2014, 5:e1373.

10.      Ren H, Fu K, Mu C, Zhen X, Wang G*. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener. 2012, 7:40.

11.      Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G*  The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation. Science Signal. 2012, 5:ra61.(封面论文,并被该杂志电话采访)

12.      Wang H, Ying Z, Wang G* Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains. J Biol Chem. 2012, 287:28576-28585.

13.      Ren H, Fu K, Wang D, Mu C, Wang G*  Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. J Biol Chem. 2011, .

14.      Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G*  DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene. 2011, 31:1311-1322.

15.      Ma X, Fei E, Fu C, Ren H, Wang G*  Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry. 2011, 16:1105-1116. (封面论文)

16.      Ying Z, Wang H*, Fan H, Wang G*  The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin. J Biol Chem. 2011, 286: 20835-20844.

17.      Fei E, Ma X, Zhu C, Xue T, Yan J, Xu Y, Zhou J, Wang G*  Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia related protein, regulates synapsin I expression. J Biol Chem. 2010 28538630-38640.

18.      Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G*  Parkin mono-ubiquitinates BCL-2 and regulates autophagy. J Biol Chem. 2010, 28538214-38223.

19.      Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei N, Wang G* Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death & Differ 2010, 17:1751-1759.

20.      Ren H, Fu K, Mu C, Li B, Wang D, Wang G* DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells. Cancer Lett 2010, 297:101-108.

21.      Zhou T, Wang S, Ren H, Qi X, Luchetti S, Kamphuis W, Zhou J, Wang G* and Swaab D* Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain 2010, 133: 3069-3079.

22.      Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M, Wang G* DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity. J Biol Chem 2008, 283:4022-4030.

23.      Liu C, Fei E, Jia N, Wang H, Tao R, Iwata A, Nukina N, Zhou J, and Wang G*Assembly of lysine 63 linked ubiquitin-conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis. J Biol Chem 2007, 282:14558-14566

 

二)近年来主持的课题

1) 项目来源:国家自然基金国际合作项目(81761148024)        

课题名称:具有抗帕金森病的小分子化合物的筛选和鉴定

起止时间:2017/01-2019/12

资助经费: 200万元

 

2) 项目来源:国家自然科学基金重点项目(31330030          

课题名称:帕金森病遗传与环境因素对小胶质细胞的激活及机制

起止时间:2014/01-2018/12 

资助经费: 307万元

 

3) 项目来源:国家重点研发计划(2016YFC1306000)子课题          

课题名称:遗传、环境、老化因素及其之间的交互作用在帕金森病发生发展机制中的作用

起止时间:2016/01-2020/12 

资助经费: 35 万元

 

  

三)专利

1)发明专利:OMI蛋白及其编码基因的一种新用途 ZL 2008  0239317.5 (授权日2011.7.27)

 

四)主要荣誉

2004年入选中国科学院“百人计划”

2011年入选江苏省“双创计划”

2014年入选江苏省双创计划团队核心成员