乔春华

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乔春华                                                     

博士,教授

联系方式:(051265882092

Emailqiaochunhua@suda.edu.cn

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教育背景

1989.9-1993.7  东北师范大学化学系,学士学位

1993.8-1996.7  北京师范大学化学系,硕士学位

1999.9-2004.8  美国凯斯西部保留地大学(Case Western Reserve University  化学系, 博士学位

工作经历:

1996.8-1999.7  中国科学院北京化学研究所,研究助理

2004.9-2005.4  美国密执根大学(University of Michigan)化学系,博士后

2005.5-2007,12  美国明尼苏达大学(University of Minnesota)药物设计中心,博士后

2008,2-        江苏省苏州大学药学院,特聘教授,博士生导师, 合成药物化学教研室主任

获奖及荣誉:

1998   中科院北京化学所优秀青年科技工作者

2004            2004 PPG Merit Award, Outstanding Graduate Performance

2008   苏州市引进紧缺高层次人才

2009            苏州大学2009陈金荣生命科学英才奖科研成果二等奖

2011   江苏省第四期“333高层次人才培养工程”第三层次人才资助

研究基金和项目:

2009-2010   Rhodanine(罗丹宁)衍生物作为新型抗肿瘤药物的研究 

创新药物重大专项侯选药物资助

2011-2013:泛酸合成酶抑制剂作为抗结核药物的研究

2011-1012:水产用环丙沙星免疫试剂盒的研制

2011-2013Rhodanine 衍生物作为新型抗癌药物的研究

教学:

本科生课程: «药物化学»

硕士研究生:药学研究进展

博士研究生:SCI论文解析与写作

研究方向:(1)抗肿瘤小分子药物的设计与合成:a:STAT3靶点;b:HDAC靶点。(2)抗寄生虫药物的设计与合成

发表论文

1        Zhixiang Xu, Wei Yin, Leonardo K. Martinelli, Joanna Evans, Jinglei Chen, Yang Yu   Daniel J. Wilson, Valerie Mizrahi, Chunhua Qiao*, Courtney C. Aldrich*  Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase Bioorganic & Medicinal Chemistry, 2014, 22, 1726–1735.

2        Shu-hua Xiao, Chunhua Qiao, Jian Xuea, Lili Wang Mefloquine in combination with hemin causes severe damage toadult Schistosoma japonicum in vitro. Acta Tropica 2014,131, 71– 78

3        Lili Wang, Cong Li, Yingying Zhang, Chunhua Qiao, Yonghao Ye, Synthesis and biological evaluation of benzofuroxan derivatives as fungicides against phytopathogenic fungi, J. Agric. Food Chem. 2013, 61(36), 8632-8640.

4        Zhi-xia Wang, Jing-lei, Chen, Chunhua Qiao*, Praziquantel derivatives with antischistosomal activity: aromatic ring modification. Chemical Biology & Drug Design, 2013, 82, 2, 216-225.

5        Jinglei Chen, Weizhen Sun, Jingjing Yang, Huan Sun, Zhixia Wang, Lanlan Dong, Chunhua Qiao,* Chao-ming Xia,*  Development of a novel class of pyrrolo-[1,2,5]benzothiadiazepine derivatives as potential anti-schistosomal agents Bioorg. Med. Chem. Lett. 2013,23,3785–3787

6        Xing Yan, Chunhua Qiao*, Zhong-Wu Guo Tin (IV) chloride promoted reaction of oxiranes with hydrogen peroxide SYNLETT. 2013, 24, 0502-0506.  

7        Jian-zhong Wu, Zhixia Wang, Chunhua Qiao* Synthesis of Stagonolide C from Mulzer Epoxide Tetrahed Lett. 2012,53,1153-1155.

8        Wenwen, D.; Sijie, Q.; Yue, Z.; Chunhua, Qiao;* Chaoming, Xia*.; “Praziquantel Derivatives Exhibit Activity against both Juvenile and Adult Schistosoma japonicum” Bioorg.Med.Chem.Lett. 2012,22,1587-1590

9        Zhaoli Zhang, Jinglei Chen, Qiongming XuChunhua Qiao* Efficient Synthesis of Hydroxytyrosol from 3,4-Dihydroxybenzaldehyde. Synth. Commun. 2012, 42, 6, 794-798

10    Huan-qiu, Li, Jing Yang, Shuhua Ma, Chunhua Qiao*, Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein Bioorg. Med. Chem. 2012, 20, 4194–4200

11    XingYan, Jinglei Chen, Chunhua Qiao* Phosphomolybdic Acid Catalyzed  Synthesis of 1,2,4,5-Tetraoxanes, SYNLETT. 2011, 19, 2827-2830.

12    Wei Yin, Chunhua Qiao* Synthesis of Epigoitrin from (R)-(+)-4-Hydroxy-γ-butyrolactoneJ. Heterocycl. Chem  In press.

13    Huan-Qiu Li*, Yin LuoChunhua Qiao* The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone Mini-Review  Med. Chem.  2012124350-362

14      Chunhua Qiao, Amol Gulpte, Helena Boshoff, Daniel J. Wilson, Eric  Bennett,Clifton E. Barry III, and Courtney C. Aldrich, “5’-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins. J. Med.Chem. 2007, 50, 6080-6094.  

15      Chunhua Qiao, Daniel J. Wilson, Eric Bennett, and Courtney C. Aldrich, “A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity Probe” J. Am. Chem. Soc. 2007, 129, 6350-6351

16      Chunhua Qiao, Ke-Qing Ling, Eric M. Shepard, David M. Dooley, and Lawrence M. Sayre,   “Mechanism-Based Cofactor Derivatization of a Copper Amine Oxidase by a Branched Primary Amine Recruits the Oxidase Activity of the Enzyme to Turn Inactivator into Substrate” J. Am. Chem. Soc.  2006, 128, 6206-6219

17      Ravindranadh Somu, Helena Boshoff, Chunhua Qiao, Eric Bennett, Clifton E. Barry III, and Courtney C. Aldrich, “Rationally Designed Nucleoside Antibiotics that Inhibit Siderophore Biosynthesis of Mycobacterium tuberculosisJ. Med. Chem. 2006, 49, 31-34.

18      Miri Yoon, Anjali Patwardhan, Chunhua Qiao, Steven O. Mansoorabadi, Ann L. Menefee, George H. Reed, and E. Neil G. Marsh, “Reaction of Adenosylcobalamin-Dependent Glutamate Mutase with 2-Thiolglutarate” Biochemistry, 2006, 45, 11650-11657

19      Chunhua Qiao, and E. Neil G. Marsh, “Mechanism of Benzylsuccinate Synthase: Stereochemistry of Toluene Addition to Fumarate and Maleate” J. Am. Chem. Soc. 2005, 127, 8608-8609

20      Chunhua Qiao, Heung-Bae Jeon, and Lawrence M. Sayre, “Selective Inhibition of Plasma Amine Oxidase by Homopropargylamine, a New Inactivator Motif” J. Am. Chem. Soc. 2004, 126, 8038-8045

21      Zbynek Lamplot, Marek Sebela, Michal Malon, Rene Lenobel, Karel Lemr, Jan Havlis, Pavel Pec, Chunhua Qiao, Lawrence M. Sayre,   1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases”    Eur. J. Biochem., 2004, 271(23/24) ,  4696-4708

22      Heung-Bae Jeon, Younghee Lee, Chunhua Qiao, He Huang, and Lawrence M. Sayre, “Inhibition of Bovine Plasma Amine Oxidase by 1,4-diamino-2-butenes and -2-butynes” Bioorg. Med. Chem., 2003, 11, 4631-4641

申请专利

1.乔春华,王良友。 一种绕丹宁衍生物、其制备方法及其应用,专利申请号:2008101562585。授权号: 2011090100515060

2.乔春华。 罗丹宁衍生物作为抗肿瘤药物的应用,专利申请号:  20110003962.9。授权号:2012071000613650.

3.  乔春华,张兆利等。一种羟基酪醇的制备方法。专利申请号:201010233438.6。授权号:2013022700250610

4乔春华,夏朝明等。10-羟基吡喹酮的制备及其作为抗血吸虫药物的应用。专利申请号:201110142534.4。授权号:2012052800771510.

5. 夏朝明,乔春华等。 一种吡喹酮衍生物及其制备和应用。专利申请号:201110142538.2

6. 乔春华,叶永浩,王利利 苯并氧化呋咱衍生物在抗植物病原真菌中的应用.专利申请号:201310003647.5