秦正红

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姓  名:秦正红

职称职务:教授、博士生导师

联系电话:65882071

电子邮箱:qinzhenhong@suda.edu.cn

办公地址:云轩楼2409

 

 

 

职称:苏州大学医学部药学院药理系特聘教授, 博士生导师。

职务:苏州市“衰老与神经疾病重点实验室”

联系地址:苏州大学药学院药理系,苏州市文景路云轩楼2409,邮编215123。电话:0512-65882071 (办公室)13913161918(手机)。

EmaiL: qinzhenhong@suda.edu.cn

学历:

哲学博士 (1994)       美国Drexal大学医学院(原宾州医学院)药理系

医学硕士 (1985)      原苏州医学院药理教研室

医疗专业 (1980)       原苏州医学院医疗系     

主要工作经历:

2003-至今:        苏州大学药学院药理系系,教授, 博导。

1999-2003:      哈佛大学医学院附属麻省总医院,讲师,研究员。

1994-1999:   美国国家卫生研究院,博士后。

1988-1994:      美国Drexal大学(原宾州医学院)医学院药理系,攻读博士学位。

1988-1988:   原苏州医学院药理教研室,讲师。

学术社团:

中国老年学学会衰老与抗衰老学术委员会副主任。

中国药理学会理事。

生化与分子药理专业委员会委员。

神经与精神药理专业委员会委员。

中国药理学报编委。

江苏省科技咨询专家。

国家自然科学基金委生命科学、医学部二审专家(2010-2013年)。

荣誉:

20142013年度江苏省科技奖三等奖

2010:年苏州大学医学部年度突出贡献奖

2007:苏州市科技进步二等奖

2007:苏州大学科技进步一等奖

2007:苏州大学苏鑫奖一等奖

2006:被收录于第六版美国Marquis名人录(Marquis Who’s Who)

2005:苏州大学周氏研究优异奖。

2004:苏州大学周氏教育优异奖。

1994:   宾洲医学院研究院Ogburn 优秀博士论文奖。

1993:宾洲医学院研究院研究生研究成就奖。

主持的研究项目(已完成)

2000Otsuka Pharmaceutical Co, Ltd. Japan.  The role of NF-kB in neuronal apoptosis.起止时间: 2000—2001,12。经费: 10,000 USD

2001:     Otsuka Pharmaceutical Co, Ltd. Japan. The role of mitochondria in neurodegeneration. 起止时间: 20001—2002,12。经费: 10,000 USD

2001:  National Institute of Neurological Disorders and Stroke. The role of huntingtin in vesicle transport. Co-investigator (100% effort). 起止时间: 2000--2005.12。经费: 1400,000 USD

2003ReceptoPharm Inc, Florida, USA. 蛇毒镇痛研究。起止时间: 2003—2004.12。经费: 1400,000 USD

2003:江苏省高校自然科学基金会。前列腺素A1治疗缺血性脑中风的疗效及机理研究。批准号:03KJB310123;起止时间: 2003--2005.12,研究经费:3万元。

2003:国家自然科学基金会。自噬体在舞蹈病蛋白和细胞器失能中的作用。批准号:30370506;起止时间:2004.01--2006.12,研究经费:26万元。

2003: 苏州市科技局高层人才奖。自噬体在舞蹈病蛋白和细胞器失能中的作用。起止时间: 2003--2006.12研究经费:6万元。

2004:国家自然科学基金会。抑制核因子-kB,诱导热休克蛋白-前列腺素A1药理作用在治疗脑缺血性中风中的应用。批准号:起止时间: 2004--2008.12,研究经费:22万元。

2004:江苏省自然科学基金会。抑制核因子-kB,诱导热休克蛋白-前列腺素A1药理作用在治疗脑缺血性中风中的应用。批准号:起止时间: 2004--2008.12,研究经费:7.5万元。

2004:江苏省人事厅六大人才计划。灵芝在神经退性疾病模型中促神经分化作用的研究及其应用。起止时间: 2004--2007.12研究经费6万元。

2004:  ReceptoPharm Inc, Florida, USA。蛇毒的抗肿瘤和镇痛作用研究。起止时间: 2004—2005.12研究经费20,000 USD.

2005教育部博士点专项基金。Casapase剪切huntingtin在舞蹈病致病中的作用。起止时间: 2006--2008.12研究经费6万元。

2005:苏州市科技局社会发展基金。灵芝在神经分化中的作用。起止时间: 2006--2009.12研究经费6万元。

2005:  ReceptoPharm Inc, Florida, USA。蛇毒的抗肿瘤和镇痛作用研究。起止时间: 2005—2006.12研究经费:20,000 USD.

2006: 苏州大学欧莱亚医学发展基金(重点项目) 。自噬在神经兴奋性毒性中的作用。起止时间: 2006--2009.12研究经费8万元。

2006: ReceptoPharm Inc, Florida, USA。蛇毒的抗肿瘤和镇痛作用研究。起止时间: 2006—2007.12研究经费24500 USD

2007: ReceptoPharm Inc, Florida, USA。蛇毒的抗肿瘤和镇痛作用研究。起止时间: 2006—2007.12研究经费19500 USD

2007: 国家自然科学基金会。自噬在神经兴奋性毒性中的作用及在治疗中的应用。 批准号:30772560。起止时间: 2007—2010.12,研究经费:26万元。

2008: 国家科技部863重大专项。高保真聚合每介导的突变敏感性分子开关在重大疾病诊断中的应用。科技部863计划。批准号:2008AA02Z436。起止时间: 2008—2011.12,研究经费:273万。

2009: 国家自然科学基金会重点项目:自噬与凋亡相互作用的分子机制及在细胞生存中的意义。批准号:30930035。起止时间: 2010—2013。研究经费:170万元;

2009ReceptoPharm Inc, Florida, USA。蛇毒的抗肿瘤和镇痛作用研究。起止时间: 2009—20011.12研究经费15000 USD

2010-2015 国家重大基础研究计划(973计划):神经变性的分子病理机制,批准号:2011CB51000子课题(CB510003)负责人:自噬对DA神经原死亡的调控。经费556万。

主持的研究项目(正在进行)

2012国家自然科学基金会面上项目,脑缺血时TIGAR表达的调节和对神经损伤的影响。批准号81271459,起止时间: 2012—2015。研究经费:80万元。

 

研究论文(SCI收录)

157Wang JD, Cao YL, Li Q, Yang YP, Jin M, Chen D, Wang F, Wang GH, Qin ZH, Hu LF, Liu CF. A pivotal role of c-Fos-mediated BECN1/Beclin 1 expression in dopamine D2-like receptor agonist-induced autophagy activation. Autophagy in press.

156. Li M, Zhou ZP, Sun M Cao L, Chen J, Qin YY, Gu JH, Han F, Sheng R, Wu JC, Ding Y, Qin ZH. NADPH, a pentose phosphate pathway product, might be a novel drug candidate for ischemic stroke. 2015; Stroke, in press.

155. Wu JY, Li M, Cai LJ, Sun ML, Chen D, Ren H,G, Xia Q, Tao ZT, Qin ZH, Hu QS, Wang GH. Protease Omi cleavage Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cels and cerebral injury in MCAO mice. Acta Pharmacologica Sin 2015 36(9):1043-52.

154. Liu EP, Wang Y, He XH, Guan JJ, Wang J, Qin ZH, Sun WP. Whole blood PCR amplification with pfu DNA polymerase and its application in single-nucleotide polymorphism analysis. Genet Test Mol Biomarkers 2015 Sep 11. [Epub ahead of print].

153. Xu YL, Kou JQ, Wang SZ, Chen CX, Qin ZH. Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats. Int Immunopharmacol. 2015 Set; 26(1):188-98. doi: 10.1016/j.intimp.2015.05.040.

152. Cao L, Chen J, Li M, Qin YY, Sun M, Sheng R, Han F, Wang G, Qin ZH. The endogenous level of TIGAR in brain is associated with the vulnerability of neurons to ischemic injury. Neurosci Bull 2015 Oct31(5):527-40.

151. Hou YS, Guan JJ, Xu HD, Wu F, Sheng R, Qin ZH. Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-dependent autophagy activation. Mol Cell Biol. 2015 Aug; 35(16): 2740-51.

150. Yu HP, Xie JM, Li B, Sun YH, Gao QG, Ding ZH, Wu HR, Qin ZH. TIGAR regulates DNA damage and repair through pentose phosphate pathway and Cdk5-ATM pathway. Scientific Reports, 2015 Apr 30;5:9853. doi: 10.1038/srep09853.

149. Zhang XY, Zhang TT, Song DD, Zhou J, Han R, Qin ZH, Sheng R. Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells. Mol Brain. 2015 Mar 26;8(1):20. doi: 10.1186/s13041-015-0112-3.

148. Chen CX, Chen JY, Kou JQ, Xu YL, Wang SZ, Zhu Q, Yang L, Qin ZH. Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra. Evid Based Complement Alternat Med. 2015;2015:387094. doi: 10.1155/2015/387094. Epub 2015 Feb 12.

147. Guan J-J, Zhang X-D, Sun W, Qi L, Wu J-C, Qin Z-H. DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. Cell Death & Disease. 2015 Jan 29;6:e1624. doi: 10.1038/cddis.2014.546.

146. Gao F, Chen D, Si J, Hu Q, Qin Z, Fang M, Wang G. The mitochondrial protein BNP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway. Hum Mol Genet 2015 May 1; 24(9): 2528-38.

145. Sun M, Li M, Huang Q, Han F, Gu JH, Xie J, Han R, Qin ZH, Zhou Z. Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism. Neurochem Int. 2015 Jan;80:99-109. doi: 10.1016/j.neuint.2014.09.006. Epub 2014 Nov 4.

143. Wu F, Xu HD, Guan JJ, Hou YS, Gu JH, Zhen XC, Qin ZH. Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease. Neurosicence 2015 Jan 22; 284:900-11. doi: 10.1016/j.neuroscience.2014.11.004. Epub 2014 Nov 13.

142. Cui K, Kou J, Gu JH, Han R, Wang G, Zhen X, Qin ZH. Naja naja atra venom a meliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress. BMC Complementary & Alternative Medicine. 2014 Dec 2;14:461. doi: 10.1186/1472-6882-14-461.

141. Shen J, Xie Y, Sun ML, Han R, Qin ZH, He JK. Antitumor activity of cobrotoxin in human lung adenocarcinoma A549 cells and following transplantation in nude mice. Oncol Lett. 2014 Nov;8(5):1961-1965. Epub 2014 Aug 21.

140. Han R, Liang H, Qin ZH, Liu CY. Crotoxin induces apoptosis and autophagy in human lung carcinoma cells in vitro via activation of the p38MAPK signaling pathway. Acta Pharmacol Sin. 2014 Oct;35(10):1323-1332. doi: 10.1038/aps.2014.62. Epub 2014 Aug 18.

139. Xie JM, Li B, Yu HP, Gao QG, Li W, Wu HR, Qin ZH. TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy. Cancer Res. 2014 Sep 15;74(18):5127-38. doi: 10.1158/0008-5472.CAN-13-3517. Epub 2014 Aug 1.

138. Zhu J*, Kou J *, Wang S, Xu Y, Cui K, Ding Z, Han R, Qin ZH. Naja naja atra Venom Protects Manifestations of Systemic Lupus Erythematosus in MRL/lpr mice. Evidence Based Complementary and Alternative Medicine 2014:969482. doi  10.1158/0008-5472.

137. Kou JQ, Han R, Xu YL, Ding XL, Wang SZ, Chen CX, Ji HZ, Ding ZH, Qin ZH. Differential Effects of Naja naja atra Venom on Immune Activity. Evid Based Complement Alternat Med. 2014;2014:287631. doi: 10.1155/2014/287631. Epub 2014 Jun 12.

136. Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C. Preconditioning Stimuli Induce Autophagy via Sphingosine Kinase 2 in Mouse Cortical Neurons. J Biol Chem. 2014 Jul 25;289(30):20845-20857. Epub 2014 Jun 13.

135. Ding ZH, Xu LM, Wang SZ, Kou JQ, Xu YL, Chen CX, Yu HP, Qin ZH, Xie Y. Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom. Evid Based Complement Alternat Med. 2014;2014:621756. doi: 10.1155/2014/621756. Epub 2014 Apr 30.

 

134. Jin Q, Cheng J, Liu Y, Wang X, Wei S, Zhou X, Qin Z, Jia J, Zhen X. Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav Immum 2014 Aug; 40:131-42.

133. Li M, Sun M, Cao L, Gu JH, Ge J, Chen J, Han R, Ding Y, Qin ZH. A TIGAR-regulated metabolic pathway is critical for protection of brain ischemia. J Neurosci, 2014 May 28;34(22):7458-71.

131. Jiang D, Chen K, Lu X, Gao HJ, Qin ZH, Lin F. Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux. Acta Pharmacol Sin. 2014 Jan;35(1):135-42. doi: 10.1038/aps.2013.144. Epub 2013 Dec 16

130. Wang WF, Xie Y, Zhou ZH, Qin ZH, Wu JC, He JK. PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients. Acta Pharmacol Sin. 2013 Dec;34(12):1560-7. doi: 10.1038/aps.2013.163. Epub 2013 Nov 18.

129. Wang YR, Qin S, Han R, Wu JC, Liang ZQ, Qin ZH, Wang Y. Cathepsin L Plays a Role in Quinolinic Acid-Induced NF-Κb Activation and Excitotoxicity in Rat Striatal Neurons. PLoS One. 2013 Sep 20;8(9):e75702. doi: 10.1371/journal.pone.0075702.

122 Wang SZ, He H, Han R, Zhu JL, Kou JQ, Ding XL, Qin ZH. The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy. Evid Based Complement Alternat Med. 2013;2013:478049. doi: 10.1155/2013/478049. Epub 2013 Jul 25.

128. Wu F, Wang Z, Gu JH, Ge JB, Liang ZQ, Qin ZH. p38MAPK/p53-mediated Bax induction contributes to neuron degeneration in rotenone-induced cellular and rat models of Parkinson’s disease. Neurochem Intl, 2013 May 25. doi:pii: S0197-0186(13)00157-5. 10.1016/j.neuint.2013.05.006. [Epub ahead of print]

127. Wang WJ, Long LM, Yang N, Zhang QQ, Ji WJ, Zhao JH, Qin ZH, Wang Z, Chen G, Liang ZQ. NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro. Acta Pharmacol Sin. 2013 May;34(5):681-90. doi: 10.1038/aps.2013.22. Epub 2013 Apr 22.

126. Gao B, Zhang XY, Han R, Chen C, Zhang TT, Qin ZH, Sheng R. Endoplasmic reticulum stress inhibitor salubrinal inhibits autophagy activation and neuroprotection induced by brain ischemic preconditioning. Acta Pharmacologica Sinica. 2013 May;34(5):657-66. doi: 10.1038/aps.2013.34. Epub 2013 Apr 22.

125. Xu HD, Wu D, Gu JH, Ge JB, Wu JC, Han R, Liang ZQ, Qin ZH. The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions. PLoS One. 2013 May 3;8(5):e63232. doi: 10.1371/journal.pone.0063232. Print 2013.

124. Zhang XD, Qin ZH. DRAM1 regulates autophagy flux through lysosomes. PloS One, 2013 May 17;8(5):e63245. doi: 10.1371/journal.pone.0063245. Print 2013.

123. Guo L, Jiang YJ, Jin H, Jiang XH, Gu B, Zhang YM, Wang JG, Qin ZH, Tao J. Modulation of A-type K+ channels by the short-chain cobrotoxin through the protein kinase C-delta isoform decreases membrane excitability in dorsal root ganglion neurons. Biochem Pharmacol 2013 May 1; 85(9):1352-62.

122. Luo L, Lu AM, Wang Y, Hong A, Chen Y, Hu J, Li XQin ZhH Chronic Resistance Training Activates Autophagy and Reduces Apoptosis of Muscle Cells by Modulating IGF-1, Akt/mTOR and Akt/FOXO3a Signaling in Aged Rats. Experimental Genecology. 2013 Apr;48(4):427-36. doi: 10.1016/j.exger.2013.02.009. Epub 2013 Feb 16.

121. Wu Z, Miao M, Qiu Y, Qin Z, Wang J, Jiang Y, Ming Z, Zhang X. Association between polymorphism in PDCD1 gene and aplastic anemia in Chinese Han population. Leuk Lymphoma 2013 Oct; 54(10):2251-4.

120. Zhu KZ, Liu YL, Gu JH, Qin ZH. Anti-nociceptive and anti-inflammatory effects of orally administrated denatured Naja Naja Atra Venom in murine rheumatoid arthritis models. Evidence Based Complimentary & Alternative Medicine. 2013;2013:616241. doi: 10.1155/2013/616241. Epub 2013 Mar 24.

119. Gu JH, Ge JB, Li M, Xu HD, Wu F, Qin ZH.. Poloxamer 188 protects neurons against ischemia/reperfusion injury through preserving integrity of cell membranes and blood brain barrier. PLoS One. 2013 Apr 16;8(4):e61641. doi: 10.1371/journal.pone.0061641. Print 2013.

118. Dai GL, He JK, Xie Y, Han R, Qin ZH, Zhu LJ. Therapeutic potential of naja naja atra venom in a rat model of diabetic nephropathy. Biomed Environ Sci. 2012 Dec;25(6):630-8. doi: 10.3967/0895-3988.2012.06.004.

117. Bao HJ, Wang T, Zhang MY, Liu R, Dai DK, Wang YQ, Wang L, Zhang L, Gao YZ, Qin ZH, Chen XP, Tao LY. Poloxamer-188 Attenuates TBI-Induced Blood-Brain Barrier Damage Leading to Decreased Brain Edema and Reduced Cellular Death. Neurochem Res. 2012 Sep 26. [Epub ahead of print]

116. Qi L, Zhang XD, Wu JC, Lin F, Wang J, Difiglia M, Qin ZH. The role of chaperone-mediated autophagy in huntingtin degradation. PLoS One. 2012;7(10):e46834. doi: 10.1371/journal.pone.0046834. Epub 2012 Oct 11

115. Gu JH, Ge JB, Li M, Wu F, Zhang W, Qin ZH. Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury. Eur J Pharm Sci. 2012 Jul 28;47(4):652-660. doi: 10.1016/j.ejps.2012.07.016. [Epub ahead of print]

114. Zhang Y, Cheng Y, Ren X, Hori T, Huber-Keener KJ, Zhang L, Yap KL, Liu D, Shantz L, Qin ZH, Zhang S, Wang J, Wang HG, Shih IeM, Yang JM. Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis. Cancer Res. 2012 Aug 15;72(16):4262-75. doi: 10.1158/0008-5472.CAN-12-0139. Epub 2012 Jun 4.

113. Wu JC, Qi L, Wang Y, Kegel KB, Yoder J, Difiglia M, Qin ZH, Lin F. The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1. Acta Pharmacol Sin. 2012 Jun;33(6):743-51. doi: 10.1038/aps.2012.14. Epub 2012 Apr 30.

112. Sun YX, Dai DK, Liu R, Wang T, Luo CL, Bao HJ, Yang R, Feng XY, Qin ZH, Chen XP, Tao LY. Therapeutic effect of SN50, an inhibitor of nuclear factor-κB, in treatment of TBI in mice. Neurol Sci. 2012 Mar 23. [Epub ahead of print]

111. Sheng R, Liu XQ, Zhang LS, Gao B, Han R, Qin ZH. Autophagy Regulates Endoplasmic Reticulum Stress in Ischemic Preconditioning. Autophagy, 2012 Mar 1;8(3) 310-325.

110. Wang LH, Lin F, Wang J, Wu JC, Han R, Zhu LJ, DiFiglia M, Qin ZH. Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF. Brain Res, 2012 Apr 17; 1449:69-82. doi: 10.1016/j.brainres.2012.01.077. Epub 2012 Feb 23.

109. Wang L, Lin F, Wang J, Wu J, Han R, Zhu L, Zhang G, Difiglia M, Qin Z. Truncated N-terminal huntingtin fragment with expanded-polyglutamine (htt552-100Q) suppresses brain-derived neurotrophic factor transcription in astrocytes. Acta Biochim Biophys Sin (Shanghai). 2012 Mar;44(3):249-58. Epub 2012 Jan 9.

108. Zhang L, Zhang Y, Jiang D, Reid PF, Jiang XH, Qin Z, Tao J. Alpha-cobratoxin inhibits T-type Ca2+ channels through muscarinic M4 receptor and Go-protein bg subunits-dependent protein kinase A pathway in dorsal root ganglion neurons. Neuropharmacology 2012 Feb; 32(11):1062-72.

107. Dong XX, Wang YR, Qin S, Liang ZQ, Liu BH, Qin ZH, Wang Y. p53 Mediates autophagy activation and mitochondria dysfunction in kainic acid-induced excitotoxicity in primary striatal neurons. Neuroscience 2012 Apr 5;207:52-64. Epub 2012 Feb 3.

106. Wang JH, Xie Y, Wu JC, Han R, Reid PF, Qin ZH, He JK. Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells. Oncol Rep. 2012 May;27(5):1341-7. doi: 10.3892/or.2012.1677.  

105. Chen LL, Wu JC, Wang LH, Wang J, Qin ZH, Difiglia M, Lin F. Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes. Acta Pharmacol Sin. 2012 Mar;33(3):385-92. doi: 10.1038/aps.2011.162. Epub 2012 Jan 23.

104 Sun WP, He XH, Yu LQ, Wang DP, Qin Z-H, Fang Q, Wang J. An improved polymerase chain reaction method for genetic testing of spinocerebellar ataxia type 3. Genetika. 2011 Oct;47(10):1416-9.

103. Ye B, Xie Y, Qin ZH, Wu JC, Han R, He JK. Anti-tumor activity of CrTX in human lung adenocarcinoma cell line A549. Acta Pharmacol Sin. 2011 Nov;32(11):1397-401. doi: 10.1038/aps.2011.116. Epub 2011 Sep 26.

102. Shi GN, Liu YL, Lin HM, Yang SL, Feng YL, Reid PF, Qin ZH. Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin.Acta Pharmacol Sin. 2011 Oct;32(10):1233-8. doi: 10.1038/aps.2011.65. Epub 2011 Aug 15.

101. Zhang Y, Cheng Y, Ren X, Zhang L, Yap KL, Wu H, Patel R, Liu D, Qin ZH, Shih IM, Yang JM. NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response. Oncogene. 2012 Feb 23;31(8):1055-64. doi: 10.1038/onc.2011.290. Epub 2011 Jul 11.

100. Zhang Y, Zhang L, Wang F, Zhang Y, Wang J, Qin ZH, Jiang XH, Tao J. Activation of M3 muscarinic receptors inhibits T-type Ca2+ channel currents via pertussis toxin-sensitive protein kinase C pathway in small doesal root ganglion neurons. Cell Signaling 2011, 23:1057-1067.

99. Zhang L, Zhang Y, Liu XY, Qin ZH, Yang JM. Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells. Acta Pharmacol Sin. 2011 Mar;32(3):361-7.

98. Zhu BS, Xing CG, Lin F, Fan XQ, Zhao K, Qin ZH. Blocking NF-kB nuclear translocation leads to p53-related autophagy activation and cell apoptosis. World J Gastroenterol 2011 Mar; 32(3):361-7.

97. Han F, Chen YX, Lu YM, Huang JY, Zhang GS, Tao RR, Ji YL, Liao MH, Fukunaga K, Qin ZH. Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells. J Pineal Res. 2011 51(1):124-35.

96. Luo CL, Li BX, Li QQ, Chen XP, Sun YX, Bao HJ, Dai DK, Shen YW, Xu HF, Ni H, Wan L, Qin ZH, Tao LY, Zhao ZQ. Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice. Neuroscience. 2011 Jun 16;184:54-63.

95. Xiang B, Fei X, Zhuang W, Fang Y, Qin Z, Liang Z. Cathepsin L is elevated in nigral dopamine neurons in Parkinson’s disease and is involved in 6-OHDA-induced apoptotic death of SH-SY5Y neuroblastoma cells. Brain Res 2011 Apr;1387:29-38.

94. Sheng R, Zhang LS, Han R, Gao B Liu XQ, Qin ZH (2011) Combined Prostaglandin E1 and lithium induces bcl-2 and heat shock proteins while inhibits p53 in a rat model of cerebral ischemia. Acta Pharmacolgic Sinica 32(3):303-10.

93. Zhang HL, Xu M, Wei C, Qin AP, Liu CF, Hong LZ, Zhao XY, Liu J, Qin ZH. Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-κB signaling pathway. Neuroscience. 2011 Mar 10;176:381-95.

92. Li L, Wang X, Fei X, Xia L, Qin Z, Liang Z. Parkinson’s disease involves autophagy and abnormal distribution of cathepsin L. Neurosci Lett 2011 Feb1;489:62-7.

91. Yu YX, Gu ZL, Yin JL, Chou WH, Kwok CY, Qin ZH, Liang ZQ (2010). Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. Chin Med J (Engl). 123:1915-1923.

90. Qin AP, Zhao XY, Qin YY, Wang X, Qin ZH, Zhang HL. Autophagy activation contributes to death of astrocytes induced by oxygen and glucose deprivation. Autophagy 2010; 6:738-753.

89. Luo CL, Chen XP, Yang R, Sun YX, Li QQ, Bao HJ, Cao QQ, Ni H, Qin ZH, Tao LY. Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway. J Neurosci Res. 2010; 88:2847-2858.

88. Sheng R, Zhang LS, Qin ZH. Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophgy 2010; 6: 482-494.

87. Wu S, Li Y, Xu Y, Li Q, Chu Y, Huang R. A salmonella enterica sercovar Typhi plasmid induces rapid and massive apoptosis in infected macrophagy. Cell Mol Immunol 2010 Jul; 7(4):271-8.

86. Dong J, Zhang Q, Huang Q, Chen H, Shen Y, Fei X, Zhang T, Diao Y, Wu Z, Qin Z, Lan Q, Gu X. Glioma stem cells involves in tumor tissue remodeling in a xenograft model. J Neurosurg 2010 Aug;113(2):249-60.

85. Jia YL, Li J, Qin ZH, Liang ZQ. Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells. J Asian Nat Prod Res 2010; 11:918-928.

84. Xing CG, Zhu BS, Fan XQ, Liu HH, Hou, Zhao K, Qin ZH. Effects of LY294002 on the invasiveness of human gastric cancer in nude mice. World J Gastroenterol 2009; 28:5044-52.

83. Wang Y, Cao Y, Dong XX, Liang ZQ, Han R, Wu JC, Gu ZL, Qin ZH. NF-kB-mediated p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. Eur J Neurosci 2009; 30(12):2258-70.

82. Li J, Qin ZH, Liang ZH. The prosurvival role of autophagy in resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer 2009; 9, No. 215.

81. Zhao YD, Huang Q, ZhangTY, Dong J, Wang AD, Lan Q, Gu XS, Qin ZH. Ultrastructural studies of glioma stem/progenitor cells. Ultrastructural Pathol 2009; 32:241-245.

80. Ni H, Jiang YW, Tao LY, Qin ZH, Wu XR. Zinc trnsporter-3 expression and long-term cognitive impairments in a rat model of neonatal concurrent seizure. Neural Regen Res 2009; 4:618-622.

79. Zhao YD, Zhang TY, Huang Q, Wang AD,Dong J, Lan Q, Qin ZH. Ultrastructure of human neural stem/progenitor cells and neurospheres. Neural Regen Res 2009; 4:365-370.

78. Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, Difiglia M. Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol 2009; 29:6106-16.

77. Zhang XD, Wang Y, Wu JC, Lin F, Han R, Han F, Fukunaga F, Qin ZH. Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondria dysfunction in rat striatum. Neurosci Res 2009 Dec; 87(16): 3600-3610.

76. Wang LH, Lin F, Wu JC, Qin ZH. High efficiency adenovirus-mediated expression of truncated N-terminal htt fragment (htt552) in primary astrocytes. Acta Biochmica & Biophysica 2009 Apr; 41(4):325-34..

75. Fei XF, Qin ZH, Xiang B, Li LY, Han F, Fukunaga K, Liang ZQ. Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. Brain Res, 2009 Apr6; 54(3):224-32.

74. Zhang XD, Wang Y, Wang Y, Zhang X, Han R, Wu JC, Liang ZQ, Gu ZL, Han F, Fukunaga K, Qin ZH. P53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy 2009; 5(3):339-350.

73. Cheng BC, Zhou XP, Zhu Q, Gong S, Qin ZH,  Reid PF, Yin QZ, Jiang XH. Cobratoxin inhibits Pain-Evoked Discharge of Neurons in Thalamic Parafascicular Nucleus in rats: involvement of cholinergic and serotonergic systems. Toxicon 2009; 54:224-232.

72. Liu YL, Lin HM, Zou R, Wu JC, Han R, Raymond LN, Reid PF, Qin ZH. Suppression of complete Freund’s adjuvant-induced adjuvant arthritis by Cobratoxin. Acta Pharmacoligica Sinica 2009; 30:219-227.

71. Wang SL, Yao HH, Guo LL, Dong L, Li SG, Gu YP, Qin ZH. Selection of optimal sites for TGF-β1 gene silencing by chitosan–TPP nanoparticle-mediated delivery of shRNA. J Cancer Cell Sci 2009;190:8-14.

70. Lu YM, Han F, Shioda N, Moriguchi S, Shirasaki Y, Qin ZH, Fukunaga K. Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled eNOS and ameliorated by DY9836, a novel calmodulin antagonist. Mol Pharmacol 2009; 75: 101-112.

69. Zhao Y Huang Q, Zhang T, Dong J, Wang A, Lan Q, Gu X, Qin Z. Ultrastructural studies of glioma stem cell/progenitor cells. Ultrastruct Pathol 2008 Nov-Dec;32(6):241-5.

68. Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, DiFiglia M. A function of huntingtin in guanine exchange on Rab 11. NeuroReport 2008;19: 1643-7.

67. Wang X, Qin, ZH, Shi H, Qin AP, Zhang HL. Protective effect of GKAB is associated with inhibition of NIK/IKK/IkB/NF-kB signaling pathway in a rat model of permanent focal cerebral ischemia. Brain Res 2008; 1234:8-15.

66. Han R, Gao B, Sheng R, Zhang LS, Zhang HL, Gu ZL, Qin ZH. Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia. Acta Pharmacologica Sinica 2008; 29:1141-1149.

65. Wen YD, Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Fukunaga K, Qin ZH. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophgy 2008; 4:762-769.

64. Zhang L, Gu ZL, Qin ZH, Liang ZQ. Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro.

Acta Pharmacol Sin. 2008 Jul;29(7):800-7.

63. Han F, Raie Alisa Ali, Shioda N, Qin ZH, Fukunaga K. Accumulation of beta-amyloid in the brain microvessels accompanies increased hyperphosphorylated tau proteins following microsphere embolism in aged rats. Neuroscience 2008; 153:414-427.

62. Li LY, Fei XF, Qin ZH, Liang ZQ. Bilobalide inhibits 6-OHDA–induced activation of NF-κB and loss of dopaminergic neurons in Rat Substantia Nigra. Acta Pharmacological Sinica  2008; 29:539-547.

61. Qian JJ, Cheng YB, Yang YP, Mao CJ, Qin ZH, Li K Liu CF. Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP(+)-induced neurotoxicity in PC12 cells. Neurosci Lett 2008; 435: 142-146.

60. Zhu BS, Xing CG, Yao HH, Lin F, Liang ZQ, Qin ZH. LY294002 induces p53-dependent apoptosis of SGC7901 gastric cancer cells. Acta Pharmacol Sin 2008; 29: 489-498.

59. Han F, Shioda N, Moriguchi S, Qin ZH, Fukunaga K. The vanadium (IV) compound rescues septo-hippocampal cholinergic neurons from neurodegeneration in olfactory bulbectomized mice. Neuroscience 2008; 151: 671-679.

58. Wang Y, Han R, Liang ZQ, Wu JC, Zhang XD, Gu ZL, Qin ZH. An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the AMPA receptor agonist kainic acid. Autophagy 2008; 4: 214-226.

57. Han F, Shioda N, Moriguchi S, Qin ZH, Fukunaga K. Downregulation of Glutamate Transporters Associates with an Elevation of Extracellular Glutamate Concentration Following Rat Microsphere Embolism. Neurosci Lett 2007; 430: 275-280.

56. Lu YM, Shioda N, Han F, Moriguchi S, Kasahara J, Shirasaki Y, Qin ZH, Fukunaga K. Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomycytes. Biochemical Pharmacol 2007; 74(12):1727-37.

55. Yang YP, Liang ZQ, Gao B, Jia YL, Qin ZH. Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells. Acta Pharmacologica Sinica 2008; 29: 123-134.

54. Zhang HL, Gu ZL, Savitz SI, Han F, Fukunaga K, Qin ZH. Neuroprotective effects of prostaglandin A1 in rat models of permanent focal cerebral ischemia are associated with NF-kB inhibition and PPAR-g upregulation. J Neurosci Res 2008; 86: 1132-1141.

53. Zhu Q, Wu DC, Zhou XP, Gong S, Cheng BC, Qin ZH, Reid PF, Jiang XH. The inhibitory effect of Crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats. Toxicon 2008; 51: 102-111.

52. Wu JC, Lin F, Qin ZH. Sequestration of GAPDH to Aggregates Formed by Mutant Huntingtin. Acta Biochem Biophys Sinica 2007; 39885-890.

51. He JK, Yu SD, Zhu HJ, Wu JC, Qin ZH. Triptolide inhibits NF-kB activation and reduces injury of the donor lung induced by ischemia/reperfusion. Acta Pharmacologica Sinica 2007; 28: 1919-1923.

50. Xu XH, Hua YN, Zhang HL, Wu JC, Miao YZ, Han R, Gu ZL, Qin ZH. Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia1. Acta Pharmacologica Sinica 2007; 28: 1097-1104.

49. Yan CH, Yang YP, Qin ZH, Gu ZL, Reid P, Liang ZQ. Autophagy is involved in cytotoxic effects of crotoxin in MCF-7 cells. Acta Pharmacological Sinica 2007; 271297-1302.

48. Liang ZQ, Wang XX, Wang Y, Chen RW, Chuang DM, Chase TN, Qin ZH. NF-kB-Dependent Cyclin D1 Induction Associated with N-Methyl-D-Aspartate Receptor-Mediated Apoptosis in Rat Striatum.  J Neurosci Res 2007; 85:1295-1309.

47. Liang ZQ, Li YL, Zhao XL, Han R, Wang XX, Wang Y, Chase TN, Bennett M C, Qin ZH. NF-kB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53. Brain Res 2007; 145:190-203.

46. Fang L, Wang Y, Qin ZH, A cleave site of thrombin existed in huntingtin. Acta Biochimica Biophysica Sinica 2007; 39(1): 15-18.

45. Tao LY, Chen CP, Qin ZH. Could NF-kB and caspase-3 be markers for estimation of post-interval of human traumatic brain Injury? Forensic Science International 2006; 162174–177.

44. Xu XH, Zhang HL, Han R, Gu ZL, Qin ZH. Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia. Brain Res 2006; 110:154-162.

43. Zhu Y, Gu ZL, Liang ZQ, Zhang HL, Qin ZH. Prostaglandin A1 inhibits the rise in intracellular calcium concentration,TXA2 production and platelet activation. Acta Pharmacological Sinica 2006; 27:549-554.

42. Yan CH, Liang ZQ, Gu ZL, Yang YP, Reid P, Qin ZH. Contributions of autophagic and apoptotic mechanisms to crotoxin-induced death of K562 cells. Toxicon 2006; 47:521-530.

41. Chen ZX, Zhang HL, Gu ZL, Chen BW, Han R, Reid PF, Raymond LN, Qin ZH. A long form a-neurotoxin from cobra venom produces potent opioid-independent analgesia. Acta Pharmacologica Sinica 2006; 27 (4): 402-408.

40. Zhang HL, Han R, Chen ZX, Chen BW, Gu ZL, Reid PF, Raymond LN, Qin ZH. Opiate and Acetylcholine-independent Analgesic Actions of Crotoxin. Toxicon 2006; 48:175-182.

39. Kim,YJ, Sapp E, Cuiffo BG, Sobin L, Yoder J, Kegel KB, Qin ZH, Detloff P, Aronin N, DiFiglia M. Lysosomal proteases are involved in generation of N-terminal huntingtin fragments. Neurobiol Disease 2006; 22:346-356.

38. Wang Y, Gu ZL, Cao Y, Liang ZQ, Han R, Bennett MC, Qin ZH. Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum. Brain Res 2006; 1071:245-249.

37. Kegel KB, Sapp E, Yoder J, Cuiffo B, Sobin L, Kim YJ, Qin ZH, Hayden M R, Aronin N, Scott D, Isenberg G, Goldmann WH, DiFiglia M. Huntingtin associates with acidic phospholipids at the plasma membrane. J Biol Chem 2005; 280:36464-36473.

36. Liang ZQ, Wang XX, Wang Y, Chuang DM, DiFiglia M, Chase TN, Qin ZH. Susceptibility of Striatal Neurons to Excitotoxic Injury Correlates with Basal Levels of Bcl-2 and the Induction of P53 and c-Myc Immunoreactivity. Neurobiol of Disease 2005; 20: 562-573.

35 Cai D, Mataraza JM. Qin ZH, Huang ZP, Huang J, Chiles TC, Carnahan D, Kempa K, Ren Z. Highly Efficient Molecular Delivery into Mammalian Cells Using Carbon Nanotube Spearing. Nat Methods 2005; 2: 449-454.

34. Zhang HL, Huang ZH, Gu ZL, Zhu Y, Liang ZQ, Han R, Wang XX, Chase TN, Qin ZH. Neuroprotective effects of prostaglandin A1 in animal models of focal ischemia. Brain Res 2005;1039: 203-206.

33. Tao LY, Chen XP, Qin ZH. A fatal chronic ketamine poisoning. J Forensic Sci  2005; 50:173-176.

32. Cao Yi, Gu ZL, Lin F, Han R, Qin ZH. Caspase-1 inhibitor Ac-YVAD-CHO attuneates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Acta Pharmacol Sin 2005; 26: 150-154.  

31. Qin ZH, Wang Y, Sapp E, Cuiffo B, Kegel KB, Aronin N DiFiglia M. Huntingtin bodies sequester vesicle associated proteins by a polyproline-dependent interaction. J Neurosci, 2004; 24:269-281.

30. Qin ZH, Wang Y, Cuiffo B, Kegel KB, Aronin N, DiFiglia M. Autophagy regulates processing amino terminus huntingtin fragments. Hum Mol Gen 2003; 12:3231-3244.

29. Chen RW, Qin ZH, Ren M, Kanai H, Chalecka-Franaazek E, Chuang DM. Regulation of c-Jun N-terminal kinase and p38 kinase in cultured brain neurons: Role of glutamate and lithium. J. Nerochem. 2003; 84:566-575.

28. Wang XX, Qin ZH, Leng Y, Wang Y, Jin X, Chase TN, Bennett MC. Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells. J. Neurochem 2002; 83:1094-1102.

27. Kegel KB, Meloni AR, Yi Y, Kim YJ, Doyle E, Sapp E, Wang Y, Qin ZH, Chen J D, Aronin N, DiFiglia M. Huntingtin is present in nuclear bodies and nuclear matrix and interacts with the transcriptional corepressor C-terminal binding protein. J. Biol Chem. 2002; 277: 7466-7476.

26. Kim YK, Yi Y, Sapp E, Wang Y, Cuffo B, Kegel K, Qin ZH, Aronin N, DiFiglia Ma. N-terminal fragments of wild-type and mutant human huntingtin produced by caspase-3 cleavage are present in normal and Huntington’s disease brains, associated with membranes, and undergo proteolysis. Proc Natl Acad Sci USA 2001; 98: 12784-12789.

25. Wei HF, Qin ZH, Senatorov VV, Wei W, Wang Y, Qian Y, Chuang DM. Lithium suppress excitotocity-induced striatal lesions in a rat model of Huntington’s disease. Neuroscience 2001; 106: 603-612.

24. Qin ZH, Wang Y, Kikly KK, Sapp E, Kege l K, Aronin N, DiFiglia M. Pro-Caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation. J. Biol. Chem. 2001; 276: 8079-8086.

23. Qin ZH, Chen RW, Wang Y, Chuang DM, Chase TN. Prostaglandin A1 protects striatal neurons against excitotoxic injury in rat striatum. J. Pharmacol. Exp. Ther. 2001; 297: 78-87.

22. Nakai M, Qin ZH, Wang Y, Chase TN. NMDA and non-NMDA receptor-stimulated IkB-a degradation: Differential effects of the caspase-3 inhibitor DEVD.CHO, free radical scanvenger OPC-14117 and ethanol. Brain Res. 2000; 859: 207-216.

21. Qin ZH, Wang Y, Chase TN. A caspase-3-like protease is involved in NF-kB activation induced by stimulation of N-Methyl-D-aspartate receptors in rat striatum. Mol. Brain Res. 2000; 80: 111-122.

20. Nakai M, Qin ZH, Chen JF, Wang Y, chase TN. Kainic acid-induced apoptosis is associated with NF-kB activation. J. Neurochem. 2000; 74: 647-658.

19. Wang Y, Qin ZH, Nakai M, Chen RW, Chuang DM, Chase TN. Co-stimulation of c-AMP-linked metabotropic receptors protects in rat striatum attenuates excitotoxin-induced nuclear factor-kB activation and apoptosis. Neuroscience 2000; 94: 1154-1162.

18. Lou YQ, Hattori A, Munoz J, Qin ZH, Roth GS. Instrastriatal dopamine injection induces apoptosis through oxidation-involved activation of transcription factors AP-1 and NF-kB in rats. Mol. Pharmacol. 1999; 56: 254-264.

27. Lammers CH, D’Soula U, Qin ZH, Lee SH, Yajima S, Mouradian M. Regulation of dopamine receptors by estrogen. Synapse 1999; 34: 222-227.

16. Qin ZH, Chen RW, Wang Y, Nakai M, Chuang DM, Chase TN. NF-kB nuclear translocation up-regulates c-Myc and p53 during N-methyl-D-aspartate receptor-mediated apoptosis. J. Neurosci. 1999; 19: 4023-4033.

15. Nakai M, Qin ZH, Wang Y, Chase TN. The free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kB activation and apoptosis in rat striatum. Mol. Brain Res. 1999; 64: 59-68.

14. Lammers CH, D’Soula U, Qin ZH, Lee SH, Yajima S, Mouradian M. Regulation of striatal dopamine receptors by corticosterone. An in vivo and in vitro study. Mol. Brain Res. 1999; 69: 281-285.

13. Qin ZH, Wang Y, Nakai M, Chase TN. Nuclear factor -kB contributes to excitotoxin-induced apoptosis. Mol Pharmacol. 1998; 53: 33-42.

12. Wang Y, Qin ZH, Nakai M. Chase TN. Glutamate metabotropic receptor agonist 1S,3R-ACPD induces internucleosomal DNA fragmentation and striatal cell death in rat brain. Brain Res. 1997; 772: 45-56.

16. Qin ZH, Wang Y, Chase TN. Stimulation of NMDA receptors induces apoptosis in rat brain. Brain Res. 1996; 725: 166-176.

11. Qin ZH, Zhou LW, Zhang SP, Wang Y, Weiss B. D2 antisense oligonucleotide inhibits the synthesis of functional pool of D2 dopamine receptors. Mol. Pharmacol. 1995; 48: 730-737.

10. Qin, ZH, Zhou LW, Weiss B. D2 dopamine receptor mRNA is altered to a greater extent by blockade of glutamate receptors than by blockade of dopamine receptors. Neuroscience 1994; 60: 97-114.

9. Zhou LW, Zhang SP, Qin ZH, Weiss B. In vivo administration of an oligonucleotide antisense to the D2 dopamine receptor mRNA inhibits D2 dopamine receptor-mediated behavior and the expression of D2 dopamine receptors in mouse striatum. J. Pharmacol. Exp. Ther. 1994; 268: 1015-1023.

8. Chen JF, Aloyo VJ, Qin ZH, Weiss B. Irreversible blockade of dopamine receptors by fluphenazine-N-mustaed increases D2 dopamine receptor mRNA and proenkephalin mRNA and decreases D1 dopamine receptor mRNA and mu and delta opiate receptors in rat striatum. Neurochem. Intl. 1994; 25: 355-366.

7. Qin ZH, Weiss B. Dopamine receptor blockade increases the levels of D2 dopamine receptor mRNA and glutamic acid decarboxylase mRNA in mouse substantia nigra. Eur. J. Pharmacol. Mol. Pharmacol. 1994; 269: 25-33.

6. Qin ZH, Chen JF, Weiss B. Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis and level of gene expression of D1 and D2 dopamine receptors. J. Neurochem. 1994; 62: 411-420.

5. Qin ZH, Zhang SP, Weiss B. Dopaminergic and glutamatergic blocking drugs differentially regulate gene expression of glutamic acid decarboxylase in mouse brain. Mol. Brain Res. 1994; 21: 293-302.

4. Weiss B, Zhou LW, Zhang SP, Qin ZH. Antisense oligonucleotide inhibits D2 dopamine receptor-mediated behavior and D2 mRNA. Neuroscience 1993; 55: 607-612.

3. Chen JF, Qin ZH, Szele F, Bai G, Weiss B. Neuronal localization and modulation of the D2 dopamine receptor mRNA in brain of normal and 6-hydroxydopamine lesioned mice. Neuropharmacology 1991; 30: 927-941.

2. Zhou LW, Qin ZH, Weiss B. Down regulation of stereotyped behavior and production of latent locomotor behaviors in mice treated continuously with quinpirol. Neuropsychopharmacology 1991; 4: 47-55.

1. 石琳,秦正红,(1984) 用荧光探针DPH研究青心酮对血小板膜流动性的影响。中国药理学报19: 535-537.

 

综述 (SCI收录)

23 Sheng R, Qin ZH. The divergent roles of autophagy in ischemia and preconditioning. Acta Pharmacol Sin. 2015 Apr;36(4):411-420. doi: 10.1038/aps.2014.151.

22 Lin F, Qin ZH. Degradation of misfolded proteins by autophagy: is it a strategy for Huntington's disease treatment? J Huntingtons Dis. 2013;2(2):149-57. doi: 10.3233/JHD-130052.

21 Le WD, Qin ZH. New horizon in autophagy research. Acta Pharmacol Sin. 2013 May;34(5):583-4. doi: 10.1038/aps.2013.53. No abstract available.

20 Wang Y, Qin ZH. Coordination bwtween autophagy and other cellular activities. Acta Pharmacologica Sinica 2013 May;34(5):585-94. doi: 10.1038/aps.2012.194. Epub 2013 Mar 11.

19. Xu F, Gu JH, Qin ZH. Neuronal autophagy in cerebral ischemia. Neurosci Bull. 2012 Oct;28(5):658-66. doi: 10.1007/s12264-012-1268-9. Epub 2012 Sep 12.

18. Zhang XD, Qin ZH, Wang J. The role of p53 in cell metabolism. Acta Pharmacologica Sinica 2010; 31 :1208-1212.

17. Wang Y, Qin ZH. Molecular mechanisms of excitotoxicity. Apoptosis 2010; 151382-1402.

16 Wang Y, Lin F, Qin ZH. The role of post-translational modifications of huntingtin in the pathogenesis of Huntington’s disease. Neurosci Bull 2010 Apr; 26(2):153-62.

15. He XH, Lin F, Qin ZH. Current understanding on the pathogenesis of polyglutamine diseases. Neurosci Bull 2010 Aug; 26(3):247-56.

14. Wang SL, Qin ZH. Strategies for short hairpin RNA delivery in cancer gene therapy. Expert Opion Biol Ther 2009; 9:1357-68.

13. Liu XQ, Sheng R, Qin ZH. Molecular mechanisms of preconditioning. Acta Pharmacologica Sinica 2009; 301071-1080.

12. Zhang LS, Sheng R, Qin ZH. The lysosomes and neurodegenerative diseases. Acta Biochemica & Biophysica (2009) in press.

11. Dong XX, Wang Y, Qin ZH. Molecular mechanisms of excitotoxicity and their relavence to neurodegenerative diseases. Acta Pharmacologica Sinica 2009; 30:379-387.

10. Zhuang W, Qin Z, Liang Z. The role of autophagy in sensitizing malignant glioma cells to radiation therapy. Acta Biophs Sin (Shanghai) 2009 May; 41(5):341-51.

9. Qin ZH, Tao LY, Chen X. Dual roles of NF-kB in cell survival and implications of NF-kB inhibitors in neuroprotective therapy. Acta Pharmacol Sin 2007; 28:1859-1872.

8. Fei XF, Qin ZH, Liang ZQ. Contribution of CDP/Cux,a transcriptional factor, to cell cycle progression. Acta Biochemica et Biophysica Sinica 2007; 39:723-930。

7. Wang LH, Qin ZH. Animal models of Huntington’s disease: their implications in uncovering pathogenic mechanisms and developing therapies. Acta Pharmacologica Sinica 2006; 27:1297-1302.

6. Wu JC, Liang ZQ, Qin ZH. Quality Control System of the Endoplasmic Reticulum and Related Diseases. Acta Biochemica & Biophysica Sinica 2006; 38 (4):219-226.

5. Yang YP, Liang ZQ, Gu ZL, Qi n ZH., Molecular mechanism and regulation of autophagy. Acta Pharmacol Sin 2005; 121421-1434.

4. Rubinsztein DC., DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky A. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 2005; 1:11-22.

3. Lin F, Gu ZL, Qin ZH. The Role of autophagy in cell metabolism and disease. Progress Biochem Biophys 2005; 32:298-203.

2. Qin ZH, Wang J, Gu ZL. Development of novel therapies for huntington’s disease:  hope and challenge. Acta Pharmacol Sin 2005; 26: 129-142.

1. Qin ZH, Gu ZL. Huntingtin processing in pathogenesis of Huntington disease. Acta Pharmacol Sin 2004; 25: 1243-1249.

 

教材和专著:

15 秦正红,乐卫东主编:自噬-生物学和疾病(第二版)。科学出版社。2015年出版。

14 王燕,秦正红,神经免疫药理基础。高等药理学,丁健主编。2013年科学出版社。

13 秦正红,自噬与神经退行性疾病。10000个医学难题, 张旭主编。 2011年人民卫生出版社.

12 秦正红,乐卫东主编:自噬-生物学和疾病(第一版)。科学出版社。2011年出版。

11 张惠灵, 秦正红,早老性痴呆的发病机理及治疗。 老年药理和治疗学,张洪泉主编,2009年人民卫生出版社。

10 林芳, 秦正红, 17 抗帕金森氏病药. 全国高等医学院规划教材: 新编护理药理学. 张洪泉主编. 2008年人民卫生出版社.

9. Zheng-Hong Qin, (2007) Pharmacological, cellular and molecular therapies for Huntington disease, in The Basal Ganglia Pathophysiology. Recent Advances319-347. Ed by Giuseppe Di Giovanni. Published by Transword Research Network, India.

8. Zheng-Hong Qin, (2005) Chapter 22 Opioid analgelsics & antagonists, drugs of abuse. 全国高等医学院英文规划教材(8年制) Pharmacology, Editor: Hong-Hao Zhou, Science Press.

7. Zheng-Hong Qin, (2005) Chapter 21 Nonsteroidal anti-inflammatory drugs, antirheumatic drugs, nonstreoidal analgesics, & drugs used in gout. 全国高等医学院英文规划教材(8年制)  Pharmacology, Editor: Hong-Hao Zhou, Science Press.

6. Zheng-Hong Qin, (2005) Chapter 19 Drugs for Parkinsonism and other movement disorders. 全国高等医学院英文规划教材(8年制) Pharmacology, Editor: Hong-Hao Zhou, Science Press.

5. 张惠灵,秦正红,(2005) 13 抗神经退行性疾病药。 全国高等药学院规划教材:药理学,  刘国卿主编,Science Press.

4. 林芳,秦正红,(2005) 12 抗癫痫药。 全国高等药学院规划教材:药理学,刘国卿主编,Science Press.

3. 林芳,秦正红,(2005) 11 抗精神病药。 全国高等药学院规划教材:药理学,刘国卿主编,Science Press.

2. 秦正红,顾振纶,(2004) 蛋百质构型异常,聚合体形成和神经退行性病变。神经药理学新论,pp 180-202。朱兴族主编,人民卫生出版社。

1石琳,秦正红,(1989) 膜脂质流动性的测定。药理学总论,pp: 723-732。杨藻宸主编,人民卫生出版社。

 

已授权发明专利:

1. 一种治疗脑缺血性中风的制剂。中国专利。第一发明人。专利号:ZL03158207.9

2快速检测非小细胞性肺癌表皮生长因子受体基因点突变方法。中国专利。第三发明人。专利号:ZL200410103223.7

3 一种简便快速的检测IT15基因突变的方法。中国发明专利。第一发明人。专利号:专利号:ZL200510041523.1

4 一种灵芝提取物的制备方法和应用。中国专利。第一发明人。专利号: ZL200410065623.3

5. 检测ATXN3基因CAG重复序列动态突变的引物及其PCR扩增方法。中国发明专利。第一发明人,专利号:ZL200910182735.X

6. 衣霉素在制备治疗缺血性脑中风药物中的应用。中国发明专利。第一发明人,专利号:ZL201110053030.5

7.眼镜蛇短链神经毒素(cobrotoxin)在制备治疗关节炎药物中的用途。中国发明专利。第一发明人,专利号:200910144909.3。国际PTC专利申请中。

8. 眼镜蛇毒物理改性方法和在制备镇痛和免疫抑制药中的应用。中国发明专利,第一发明人,专利号: 201110065634.1

9 检测苯丙酮酸尿症PAH基因7个热点突变位点的试剂盒及其PCR扩增方法。中国发明专利,第一发明人,专利号: 201010234581.7

10 一种用于检测VYP2C19基因分型的试剂盒。中国发明专利,第二发明人,专利号:201010591109.9

11 一种用于华法令个体化用药相关基因SNP检测试剂盒及其PCR扩增方法。中国发明专利,第一发明人,专利号:201010234597.8

12胆碱能M3M4受体激动剂在制备新型镇痛药物中的应用。中国发明专利,第二发明人,专利号: 201110072563.8

13.一种蛇毒凝胶剂的制备方法。中国发明专利,第一发明人,专利号201260567886.0

14.物理改性后的眼镜蛇毒在制备治疗免疫衰老和相关疾病药物中的应用。中国发明专利,第一发明人,专利号: 201210393122.2

15. 眼镜蛇毒在制备治疗急慢性肾病药物中的用途。中国发明专利,第一发明人,申请号201210228609.5

16. 8眼镜蛇心脏毒素在制备治疗系统性红斑狼疮药物中的应用。中国发明专利,专利号为201310655867.6

17. 一种在口腔中快速溶解的膜剂及其制备方法。中国发明专利,第一发明人,z专利号201310113501.6.

 

申请中的专利:

1. Methods of production and use of crotoxin as an analgesic. USA 专利。第二发明人。

3 眼睛蛇神经毒素(cobrotoxin)在制备免疫抑制药物中的用途。中国发明专利,第一发明人,申请号: 20101017466.9

4 眼镜蛇蛇毒在制备免疫调节剂中的应用。中国发明专利,第一发明人,申请号/专利号: 2013106999359

4眼镜蛇短链神经毒素(cobrotoxin)在制备鞘内镇痛药中的用途。中国发明专利,第一发明人,申请号: 201110072186.8

5物理改性后的眼镜蛇蛇毒在制备治疗关节炎药物中的应用。中国发明专利,第一发明人,申请号:20111036196.X

6 物理改性后的眼镜蛇蛇毒在制备治疗肺肺纤维化药物中的用途。中国发明专利,第一发明人,申请号201110443384.0

7. 眼镜蛇心脏毒素在制备治疗系统性红斑狼疮药物中的应用。中国发明专利,申请号为201310655867.6

9. NADPH作为制备用于防治脑缺血性中风药物方面的应用。中国发明专利,第一发明人,申请号201310226937.6

10. NADPH在制备抗疲劳保健皮和抗疲劳综合症药物中的应用。中国发明专利,第一发明人,申请号:缺。

11. NADPH在制备治疗心脏血管疾病药物中的应用。中国发明专利,第一发明人,申请号:201510086547.2.

12. NADPH在制备治疗心脏疾病药物中的应用。中国发明专利,第一发明人,申请号:201510086548.7.

13. 一种离子交换和疏水层析结合分离纯化眼镜蛇毒神经毒素的方法。中国发明专利,第一发明人,申请号:已有.

14.一种离子交换和反相层析结合分离纯化眼镜蛇毒神经毒素的方法。中国发明专利,第一发明人,申请号:已有.