刘峰

liufeng.JPG

姓  名:刘峰

职称职务:特聘副教授

联系电话:0512-65882569

电子邮箱:fliu2@suda.edu.cn

办公地址:苏州市工业园区仁爱路199号药学院云轩楼1125

 

个人简介:

 

一、学习工作经历

 

2012.9 — 至今:特聘副教授,苏州大学医学部药学院

2009.5 2012.8:博士后研究助理,北卡罗来纳大学教堂山分校药学院

2009.12009.5;助理研究员,中科院上海有机所

2003.9 2009.1:研究生,中科院上海有机所

1999.9    2003.7:本科, 厦门大学化学系

 

 

二、研究方向

              

1)表观遗传蛋白小分子调控剂的设计与合成

2神经疾病和癌症的靶向治疗药物研发

3)有机合成新方法在药物研发中的应用

 

三、主要学术科研成果

回国后主持国家自然科学基金青年项目和江苏省自然科学基金项目各一项,曾参与国家自然科学基金重点项目、美国NCINIH美国国防部等项目研究,发表SCI论文30余篇

(论文引用见: http://scholar.google.com/citations?user=h_j1fQYAAAAJ&hl=en

2017

31)  Qin, H.-T.; Xu, X.; Liu, F.* “Aerobic Oxidation of Alkynes into 1,2-Diketones via Organic Photoredox Catalysis” ChemCatChem 2017, DOI: 10.1002/cctc.201700061

30) Qin, H.-T.; Wu, S.-W.; Liu, J.-L.; Liu, F.* “Photoredox-Catalysed Redox-Neutral Trifluoromethylation of Vinyl Azides for the Synthesis of a–Trifluoromethylated Ketones” Chem. Commun. 2017, 53, 1696-1699.

29) Qin, H.-T.; Li, H.-Q.;* Liu, F.* “Selective histone deacetylase small molecule inhibitors: recent progress and perspectives” Expert Opin. Ther. Pat. 2017, DOI: 10.1080/13543776.2017.1276565

2016

28)  Wu, S.-W.; Liu, F.* “Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism InterrogationOrg. Lett. 2016, 18, 3642-3645.

27) Li, Z.-R.; Bao, X.-X.; Sun, J.; Shen, J.; Wu, D.-Q.; Liu, Y.-K.; Deng, Q.-H.*; Liu, F.* Iron-catalyzed trifluoromethylation of vinylcyclopropanes: facile synthesis of CF3-containing dihydronaphthalene derivatives” Org. Chem. Front. 2016, 3, 934-938.

26) Wu, S.-W.; Liu, J.-Li.; Liu, F.* “Metal-Free Microwave-Assisted Decarboxylative Elimination for the Synthesis of Olefins” Org. Lett. 2016, 18, 1-3.

2015

25) Simon, J. M.; Parker, J. S.; Liu, F.; Rothbart, S. B.; Ait-Si-Ali, S.; Strahl, B. D.; Jin, J.; Davis, I. J.; Mosley, A. L.; Pattenden, S. G. “A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin J. Biol. Chem. 2015, 290(43):26088-26102. DOI: 10.1074/jbc.M115.654459. PMID: 26338712

24)  Zhang, Y.; Xu, L.; Zhang, Z.; Zheng, L.; Li, D.; Li, Y.; Liu, F.; Yu, K.; Hou, T.; Zhen, X. “Structure-Activity Relationships and Anti-inflammatory Activities of N-Carbamothioylformamide Analogues as MIF Tautomerase Inhibitors” J. Chem. Inf. Model. 2015, 55, 1994-2004. DOI: 10.1021/acs.jcim.5b00445

23)  Shi, D.; Qin, H.; Zhu, C;* Liu, F.* Selectfluor–Bu4NI-Mediated C(sp3)–H Oxidation in Aqueous Media: Synthesis of Δ2-Isoxazolines from Oximes” Eur. J. Org. Chem. 2015, 5084-5088. DOI: 10.1002/ejoc.201500780

22) Wang, L.; Xie, L.; Ramachandran, S.; Lee, Y.; Yan, Z.; Zhou, L.; Krajewski, K.; Liu, F.; Zhu, C.; Chen, David J.; Strahl, Brian D.; Jin, J.; Dokholyan, Nikolay V.; Chen, X. Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX Chem. Biol. 2015, 22, 7, 849-861. DOI: 10.1016/j.chembiol.2015.05.014. 

21) Zhang, Z.; Liu, F.* CuX2-mediated oxybromination/aminochlorination of unsaturated amides: synthesis of iminolactones and lactams” Org. Biomol. Chem. 2015, 13, 6690-6693. DOI: 10.1039/c5ob00520e

20) Dong, K.; Qin, H.; Liu, F.*; Zhu, C.*Oxime-Mediated Oxychlorination and Oxybromination of Unactivated Olefins” Eur. J. Org. Chem. 2015, 1419-1422. DOI: 10.1002/ejoc.201403538

2014

19) Liu, C.; Yu, Y.; Liu, F.; Wei, X.; Wrobel, J. A.; Gunawardena, H. P.; Zhou, L.; Jin, J.; Chen, X. “A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing” Nat. Commun. 2014, 5:5733. DOI: 10.1038/ncomms6733.

18) Dong, K.; Qin, H.; Bao, X.; Liu, F.*; Zhu, C.* “Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin” Org. Lett. 2014, 16, 5266-5268.

17) Sundriyal, S.; Malmquist, N. A.; Caron, J.; Blundell, S.; Liu, F.; Chen, X.; Srimongkolpithak, N.; Jin, J.; Charman, S. A.; Scherf, A.; Fuchter, M. J. “Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-Stage Antimalarial Compounds” ChemMedChem, 2014, 9, 2360-2373.

16) Lehnertz, B.; Pabst, C.; Su, L.; Miller, M.; Liu, F.; Yi, L.; Zhang, R., Krosl, J., Yung, E., Kirschner, J., Rosten, P., Underhill, T. M., Jin, J., Hébert, J., Sauvageau, G., Humphries, R. K., Rossi, F. M. “The methyltransferase G9a regulates HoxA9-dependent transcription in AML”  Genes Dev. 2014, 28, 317-327.

15) Konze, K. D.; Pattenden, S. G.; Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Simon, J. M.; Davis, I. J.; Vedadi, M.; Jin, J.A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a” ChemMedChem, 2014, 9, 549-553.

14) Liu, F.*; Li. C. “ Total synthesis of (S)-14-azacamptothecin”, Org. Biomol. Chem. 2014, 12, 637-642.

2013

13) Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Xiong, Y.; Korboukh, V.; Huang, X. P.; Allali-Hassani, A.; Janzen, W. P.; Roth, B. L.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Vedadi, M.; Jin, J. “Discovery of an in vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP” J. Med. Chem. 2013, 56, 8931-8942.

12) Konze, K. D.; Ma, A.; Li, F.; Barsyte-Lovejoy, D.; Parton, T.; MacNevin, C. J.; Liu, F.; Gao, C.; Huang, X. P.; Kuznetsova, E.; Rougie, M.; Jiang, A.; Pattenden, S. G.; Norris, J. L.; James, L. I.; Roth, B. L.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Hahn, K. M.; Wang, G. G.; Vedadi, M.; Jin, J. “An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1”, ACS Chemical Biology, 2013, 8, 1324-1334.

11Liu, F.; Li, F.; Ma, A.; Dobrovetsky, E.; Dong, A.; Gao, C.; Korboukh, I.; Liu, J.; Smil, D.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Schapira, M.; Vedadi, M.; Jin, J. “Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors” J. Med. Chem. 2013, 56, 2110-2124.

Before 2013

10Siarheyeva, A.; Senisterra, G.; Allali-Hassani, A.; Dong, A.; Dobrovetsky, E.; Wasney, Gregory A.; Chau, I.;   Marcellus, R.; Hajian, T.; Liu, F.; Korboukh, I.; Smil, D.; Bolshan, Y.; Min, J.; Wu, H.; Zeng, H.; Loppnau, P.; Poda, G.; Griffin, C.; Aman, A.; Brown, Peter J.; Jin, J.; Al-awar, R.; Arrowsmith, Cheryl H.; Schapira, M.; Vedadi, M. "An Allosteric Inhibitor of Protein Arginine Methyltransferase 3" Structure 2012, 20, 1425-1435.

 9Liu, F.; Barsyte-Lovejoy, D.; Allali-Hassani, A.; He, Y.; Herold, J. M.; Chen, X.; Yates, C. M.; Frye, S. V.; Brown, P. J.; Huang, J.; Arrowsmith, C. H.; Jin, J. “Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines”. J. Med. Chem. 2011, 54, 6139-6150.

 8Yost, J. M.; Korboukh, I.; Liu, F.; Gao, C.; Jin, J.  “Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code”. Curr.Chem.Genomics 2011, 5, 72-84. (共同第一作)

7Vedadi, M#.; Barsyte-Lovejoy, D#.; Liu, F#.; Rival-Gervier, S.; Allali-Hassani, A.; Labrie, V.; Wigle, T. J.; DiMaggio, P. A.; Wasney, G. A.; Siarheyeva, A.; Dong, A.; Tempel, W.; Wang, S.-C.; Chen, X.; Chau, I.; Mangano, T.; Huang, X.-P.; Simpson, C. D.; Pattenden, S. G.; Norris, J. L.; Kireev, D. B.; Tripathy, A.; Edwards, A.; Roth, B. L.; Janzen, W. P.; Garcia, B. A.; Petronis, A.; Ellis, J.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Jin, J. “A Chemical Probe Selectively Inhibits G9a and GLP Methyltransferase Activity in Cells”. Nature Chem. Biol.2011, 7, 566-574. (共同第一作,Highlighted by News and Views:Nature Chemical Biology, 2011, 7, 499-500 and SciBX, 2011, 4(31), doi:10.1038/scibx.2011.890

6Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wigle, T. J.; Wasney, G. A.; Dong, A.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Norris, J. L.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Janzen, W. P.; Arrowsmith, C. H.; Frye, S. V.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. “Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines”. J. Med. Chem. 2010, 53, 5844-5857.

 5Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wasney, G. A.; Dong, A.; Barsyte, D.; Kozieradzki, I.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. “Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a”. J. Med. Chem. 2009, 52, 7950-7953.

 4Ju, Y.; Liu, F.; Li. C. “Palladium-Catalyzed Sequential Cyanation/N-Addition/ N-Arylation in One-Pot: Efficient Synthesis of Luotonin A and Its Derivatives”. Org. Lett. 2009, 11, 3582-3585.

 3Liu, F.; Li. C. “Intramolecular Formal [4 + 2] Cycloaddition of Nitriles with Amides Triggered by TMSOTf/Et3N: Highly Efficient Construction of Pyrrolo[1,2-a]pyrimidin-4(6H)-ones”. J. Org. Chem. 2009, 74, 5699-5702.

 2Liu, F.; Liu, K.; Yuan, X.; Li. C. “5-Exo versus 6-Endo Cyclization of Primary Aminyl Radicals: An Experimental and Theoretical Investigation”. J. Org. Chem. 2007, 72, 10231-10234.

1Zhan, Z.; Lang, K.; Liu, F.; Hu, L. “Water Effects on SmI2 Reductions: A Novel Method for the Synthesis of Alkyl Thiols by SmI2-Promoted Reductions of Sodium Alkyl Thiosulfates and Alkyl Thiocyanates”. Syn. Commun.2004, 34, 3203.