许国强


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姓  名:许国强
职称职务:特聘教授
联系电话:0512-65882370
电子邮箱:gux2002@suda.edu.cn
办公地址:云轩楼1313
 
个人简介:

学习经历:

1991.8-1996.7            复旦大学,本科(包括一年军训

1996.8-1999.7            复旦大学,理学硕士

1999.8-2002.12   美国OhioAkron大学理学博士

 

研究经历:

2003.1-2005.12   美国纽约州康奈尔大学化学和化学生物系,博士后

2006.1-2011.7   美国纽约市康奈尔大学Weill医学院药理学系,博士后

2011.7-2013.2           美国纽约市康奈尔大学Weill医学院药理学系,助理研究教授

2013.2-至今                    苏州大学特聘教授、医学部药学院博士生导师

 

主要研究方向:

Ÿ 蛋白质组学

Ÿ 蛋白质翻译后修饰

Ÿ 疾病治疗分子机制

 

主要研究成果:

主要从事生物大分子的翻译后修饰及功能的研究,建立了多种新颖独特的高通量方法研究蛋白质在信号传导通路中的翻译后修饰,并探索其生理功能。解决了长期以来蛋白质泛素化研究中缺乏高通量鉴定关键技术的难题。在Nat. Biotechnol.Nat. Commun.FASEB J.PNASJBCProteomics等杂志上发表英文论文近60篇。

 

代表性论文:

1.   Duan, W.; Chen, S.; Zhang, Y.; Li, D.; Wang, R.; Chen, S.; Li, J.; Qiu, X.; Xu, G.* Protein C-terminal enzymatic labeling identifies novel caspase cleavages during the apoptosis of multiple myeloma cells induced by kinase inhibition. Proteomics 2016, 16, 60-69.

2.   Liu, Y.; Huang, X.; He, X.; Zhou, Y.; Jiang, X.; Chen-Kiang, S.; Jaffrey, S.R.,* Xu, G.* A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function. FASEB J. 2015, 29, 4829-4839.

3.   Liu, Y.; He, X.; Sui, Y.; Yu, R.; Xu, G.* Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition. FEBS Lett. 2015, 589, 2233-2240.

4.   Zhang, Z.; Zhou, L.; Zhou, Y.; Liu, J.; Xing, X.; Zhong, J.; Xu, G.; Kang, Z.; Liu, J.* Mitophagy induced by nanoparticle-peptide conjugates enabling an alternative intracellular trafficking route. Biomaterials 2015, 65, 56-65.

5.   Sui, Y. #; Liu, Y.#; Xu, G.* A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades. Biochem. Biophys. Res. Commun. 2015, 461, 653-658 (#: co-first authors).

6.   Deglincerti, A.; Liu, Y.; Colak, D.; Hengst, U.; Xu, G.*; Jaffrey, S. R.* Coupled local translation and degradation regulate growth cone collapse. Nat. Commun. 2015, 6, 6888. doi: 10.1038/ncomms7888.

7.   Tao, Z.; Wang, H.; Xia, Q.; Li, K.; Li, K.; Jiang, X.; Xu, G.; Wang, G.*; Ying, Z.* Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum. Mol. Genet. 2015, 24, 2426-2441.

8.   Xu, G.; Deglincerti, A.; Paige, J. S.; Lundquist, M. R.; Jaffrey, S. R. Profiling lysine ubiquitination by selective enrichment of ubiquitin remnant-containing peptides. Meth. Mol. Biol. 2014, 1174, 57-71.

9.   Xu, G.; Jiang, X.; Jaffrey, S. R. A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition. J. Biol. Chem. 2013, 288, 29573-29585.

10. Yoon, Y.; McKenna, M. C.; Rollins, D. A.; Song, M.; Nuriel, T.; Gross, S. S.; Xu, G.; Glatt, C. E. Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 11624-11629.

11. Xu, G.; Jaffrey, S. R. Proteomic identification of protein ubiquitination events. Biotech. Genet. Eng. Rev. 2013, 29, 73-109.

12. Xu, G.; Jaffrey, S. R. Comprehensive profiling of protein ubiquitination for drug discovery. Curr. Pharm. Des. 2013, 19, 3315-3328.

13. Li H., Wan A., Xu G., Ye D. Small changes huge impact: the role of thioredoxin 1 in the regulation of apoptosis by S-nitrosylation. Acta Biochim. Biophys. Sin. 2013, 45, 153-161.

14. Xu, G.; Jaffrey, S. R. The new landscape of protein ubiquitination. Nat. Biotechnol. (News & Views) 2011, 29, 1098-1100.

15. Xu, G.; Shin, S. Y.; Jaffrey, S. R. Chemoenzymatic labeling of protein C-termini for positive selection of C-terminal peptides. ACS Chem. Biol. 2011, 6, 1015-1020.

16. Xu, G.; Jaffrey, S. R. N-CLAP: global profiling of N-termini by chemoselective labeling of the a amine of proteins. Cold Spring Harb. Protoc. 2010, 11, pdb.prot5528.

17. Xu, G.; Paige, J. S.; Jaffrey, S. R. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Nat. Biotechnol. 2010, 28, 868-873.

18. Xu, G.; Shin, S. Y.; Jaffrey, S. R. Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 19310-19315.

19. Paige, J. S.; Xu, G.; Stancevic, B.; Jaffrey, S. R. Nitrosothiol reactivity profiling identifies S-nitrosylated proteins with unexpected stability. Chem. Biol. 2008, 15, 1307-1316.

20. Narayan, M.; Welker, E.; Zhai, H.; Han, X.; Xu, G.; McLafferty, F. W.; Scheraga, H. A. Detecting native folds in mixtures of proteins that contain disulfide bonds. Nat. Biotechnol. 2008, 26, 427-429.

21. Xu, G.; Narayan, M.; Kurinov, I.; Ripoll, D. R.; Welker, E.; Khalili, M.; Ealick, S. E.; Scheraga, H. A. A localized specific interaction alters the unfolding pathways of structural homologues. J. Am. Chem. Soc. 2006, 128, 1204-1213.

22. Xu, G.; Narayan, M.; Scheraga, H. A. The oxidative folding rate of bovine pancreatic ribonuclease is enhanced by a covalently attached oligosaccharide. Biochemistry 2005, 44, 9817-9823.

23. Xu, G.; Zhai, H.; Narayan, M.; McLafferty, F. W.; Scheraga, H. A. Simultaneous characterization of the reductive unfolding pathways of RNase B isoforms by top-down mass spectrometry. Chem. Biol. 2004, 11, 517-524.

24. Xu, G.; Narayan, M.; Welker, E.; Scheraga, H. A. Characterization of the fast-forming intermediate, des [30-75], in the reductive unfolding of onconase. Biochemistry 2004, 43, 3246-3254.

 

主要邀请报告:

1.      Profiling of protein ubiquitination and its potential application in drug discovery. The 11th International Symposium on Futures in Drug Research and Development, Gyeongsan, South Korea, 2014, Jan, 17.

2.      The function of cereblon ubiquitination in human disease. International Symposium on Current Trends and Future Prospects in Pharmaceutical Sciences, Pokhara, Kaski, Nepal, 2014, July 6-7.

 

科研项目:

1.   国家自然科学基金面上项目:ADAM12的水解功能在小细胞肺癌增殖和转移中的分子机制研究,2015-2018

2.   国家重大科学研究计划(973计划)子课题,生物钟对下丘脑GnRH网络的调控,2014-2016(骨干成员参与)。

3.   国家自然科学基金面上项目:来那度胺治疗多发性骨髓瘤的分子机制研究,2013-2016

 

人才项目:

2012  入选中组部第三批青年千人计划

2013  入选江苏省高层次创新创业人才(双创计划

2014  入选江苏省双创计划团队核心成员

2013  获人社部高层次留学人才回国资助

2013  江苏省“333高层次人才工程第三层次培养对象

2012  苏州工业园区第三届金鸡湖双百人才计划——海外高层次领军人才