张熠

PERSONAL DATA

Name:  Zhang Yi

Mailing address: Department of Pharmacology, Medical College of Soochow University, 199 Renai Road, Su Zhou 215123, China

Telephone: 00 86-512-65882090 (Office)

00 86-512-65208583 (Home)

00 86-13862167476 (Mobile)

E-mail Address:  zhangyi@suda.edu.cn, yxz29@psu.edu.

 

EDUCATION

2007.9-2012.5 Ph.D. of Pharmacology

Department of Pharmacology

Medical College of Soochow University

2001.9-2004.7 M.S of Pharmacology

Department of Pharmacology

Medical College of Soochow University

1995.9-1999.7 B.A of Pharmacy

Su Zhou Medical college

 

PROFESSIONAL EXPERIENCE

2013.7-present   Associate  Professor

Department of Pharmacology, Medical College of Soochow University

2010.4-2012.4  Visiting scholar

Department of Pharmacology Penn State Medical Center

2007.7-2013.6  Lecture

Department of Pharmacology, Medical College of Soochow University

2004.7-2007.6 Teaching and Research Assistant

Department of Pharmacology Medical College  of  Soochow University

 

AWARDS

1. Young Teacher Award, Suzhou University (2006)

2. Research Innovation Award, Medical college of Suzhou University (2008)

3. AFCR--USCACA Scholar Award (2012)

4.  Jiangsu outstanding doctoral dissertation award  (2013)

5. Chinese Pharmacological Society Scholar Award  (2014)

 

 

 

GRANT SUPPORT:

1.   Natural Science Foundation of Jiangsu provincial Colleges and Universities  2008-2010

2.   Medical department of Soochow University Graduate School Innovation Fund  2008-2010

3.   Natural Science Foundation of Jiangsu Province of China (BK2010224)  2010-2013

4.   Natural Science Foundation of China (81072146)  2010-2013

5.   Natural Science Foundation of China (81101913)  2011-2014

6.   Natural Science Foundation of college universities in Jiangsu Province (12KJD310005) 2012-2014

7.   Natural Science Foundation of Suzhou basic research (SYS201319)  2013-2016

8.   Natural Science Foundation of China (81473240) 2014-2018

9.   Natural Science Foundation of Jiangsu Province of China (BK20141197) 2014-2017

10. China Postdoctoral Science Foundation (2014M550308) 2014-2017

11. Special Financial Grant by China Postdoctoral Science Foundation (2015T80585) 2015-2017

12. Jiangsu “Qing Lan” Project  2016-2019

13. Natural Science Foundation of China 817737492018-2021

 

 

   SCIENTIFIC SOCIETY  

     American Association for Cancer Research

     Chinese Pharmacological Association

China Anti-aging Association

 

RESEARCH AND ACADEMIC EMPLOYMENT 

Editorial Board: BioMed Research International, 2012-

Editorial Board: ZHONGHUA ZHONGLIU FANGZHI ZAZHI, 2013-

 

PUBLICATIONS  

1.      Cheng Ji, Qiong-Hua Xu, Ling-Chuan Guo, Yi-Jie Ren, Hong-Han Zhang, Wei-Dong Zhu, Zhi-Jun Ming, Yun-Sheng Yuan, Xin-Cong Ren, Yan Cheng, Jin-Ming Yang*, Yi Zhang*. eEF-2 Kinase-targeted miR-449b Confers Radiation Sensitivity to Cancer Cells, Cancer Lett, 2018 Apr 1;418:64-74.  *(Corresponding author)

2.      Yi Zhang*, Yi-Jie Ren, Ling-Chuan Guo, Cheng Ji, Jian Hu, Hong-Han Zhang,Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Yun-Sheng Yuan, Xingcong Ren, Jianxun, Song, and Jin-Ming Yang*. Nucleus Accumbens-Associated Protein-1 Promotes Glycolysis and Survival of Hypoxic Tumor Cells via the HDAC4-HIF-1α Axis, Oncogene, 2017 Jul 20;36(29):4171-4181. *(Corresponding author) 

3.      Yi-Jie Ren, Xiao-Hui Wang, Cheng Ji, Yi-Di Guan, Xian-Jiu Lu, Xian-Rong Liu,Hong-Han Zhang, Ling-Chuan Guo, Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Jin-Ming Yang, Yan Cheng, Yi Zhang*.  Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol, Front. Pharmacol, 07 November 2017,00804.    

4.      Zhang Y*, Yang WQ, Zhu H, Zhou L, Ren YJ, Ren XC, Zhang L, Wang JR, Liu YB, Yang JM.  Regulation of Autophagy by miR-30d Impacts Sensitivity of Anaplastic Thyroid Carcinoma to Cisplatin, Biochem Pharmacol, 2014 Feb 15;87(4):562-70. *(Corresponding author)      

5.      Ren YJ, Zhang Y*. An update on RNA interference-mediated gene silencing in cancer therapy. Expert Opin Biol Ther, 2014 Nov;14(11):1581-92.  *(Corresponding author) 

6.      Xiao-yuan Liu, Li Zhang, JianPing Wu, Lei Zhou, Yi-Jie Ren, Wei-Qiong Yang, Zi-Jun Ming, Bo Chen, Jianrong Wang, Yi Zhang* and Jin-Ming Yang*.  Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma.  PLoS One, 2013 Nov 26;8(11):e81345.  *(Corresponding author)     

7.      Zhang Y*, Yang JM*.  Altered energy metabolism in cancer: An unique opportunity for therapeutic intervention.  Cancer Biol Ther, 2013 Feb 1; 14(2):81-9. (*Corresponding author)   

8.      Zhang Y, Cheng Y, Ren XC, Hori T, Huber-Keener KJ, Zhang L, Yap KL, Liu D, Shantz L, Qin ZH, Zhang SP, Wang JR, Wang HG, Shih IM and Yang JM:  Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis.   Cancer Res, 72(16): 4262-4275, 2012.   

9.      Zhang Y, Cheng Y, Ren XC, Zhang L, Yap KL, Wu H, Patel R, Liu DX, Qin ZH, Shih IM and Yang JM*:  NAC1 Modulates Sensitivity of Ovarian Cancer Cells to Cisplatin via Altering the HMGB1-Mediated Autophagic Response.  Oncogene, 31(8): 1055-1064, 2012.     

10.  Yang WQ, Zhang Y*.  RNAi-mediated gene silencing in cancer therapy.  Expert Opin Biol Ther, 2012 Nov; 12(11):1495-504. (Invited Review, *Corresponding author)    

11.   Zhang Y, Jay W. Yang, Xingcong Ren and Jin-Ming Yang. NAC1 and HMGB1 enter a partnership for manipulating autophagy. Autophagy, 2011 Dec 1;7(12).  

12.   Zhang Y*, Cheng Y, Zhang L, Ren X, Huber-Keener KJ, Lee S, Yun J, Wang HG, Yang JM. Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression. Biochem Biophys Res Commun, 2011 Oct 14; 414(1):129-34. (* Corresponding author)   

13.   Zhang Y#, Zhang L#, Liu XY, Qin ZH, Yang JM. Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells. Acta Pharmacol Sin, 2011, Mar;32(3):361-7. (# contributed equally to this study)  

14.  Zhang Y*, Yang JM. The impact of cellular senescence in cancer therapy: is it true or not? Acta Pharmacol Sin, 2011 Oct; 32(10):1199-207. (* Corresponding author)  

15.  Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM.  Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy, 2013 Feb 1;9(2):208-19

16.  Yan Cheng, Ugir Hossain Sk, Yi Zhang, Xingcong Ren, Li Zhang, Kathryn J. Huber-Keener, Yuan-Wan Sun, Jason Liao, Shantu Amin, Arun K. Sharma, and Jin-Ming Yang. Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death. PLoS One, 2012;7(4):e35104.

17.  Cheng Y, Zhang Y, Zhang L, Ren XC, Huber-Keener KJ, Liu XY, Zhou L, Liao J, Keihack H, Yan L, Rubin E, Yang JM. MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther, 2012 Jan;11(1):154-64.

18.  Cheng Y, Ren X, Zhang Y, Patel R, Sharma A, Wu H, Robertson GP, Yan L, Rubin E, Yang JM. eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer Res, 2011 Apr 1;71(7):2654-63.

19.  Zhang L, Ren XC, Cheng Y, Huber-Keener KJ, Liu XP, Zhang Y, Yuan YS, Yang J, Liu CG, Yang JM: Identification of Sirtuin 3, a Mitochondrial Protein Deacetylase, as a New Contributor to Tamoxifen Resistance in Breast Cancer Cells. Biochem Pharmacol, 86(6): 726-733, 2013.

20.  Shan Y, Cheng Y, Zhang Y, Guan FQ, Sun H, Ren XC, Chen Y, Feng X, Yang JM: Triticuside A, a Dietary Flavonoid, Inhibits Proliferation of Human Breast Cancer Cells via Inducing Apoptosis. Nutr Cancer, 65(6): 891-899, 2013.

21.  Huber-Keener KJ, Liu X, Wang Z, Wang YQ, Freeman W, Wu S, Planas-Silva MD, Ren XC, Cheng Y, Zhang Y, Vrana K, Liu CG, Yang JM and Wu RL: Differential Gene Expression in Tamoxifen-resistant Breast Cancer Cells Revealed by a New Analytical Model of RNA-Seq Data. PLoS One,7(7): e41333, 2012

22.  Huber-Keener KJ, Evans BR, Ren X, Cheng Y, Zhang Y, Hait WN, Yang JM: Phosphorylation of Elongation Factor-2 Kinase Differentially Regulates the Enzyme's Stability under Stress Conditions. Biochem Biophys Res Commun, 424(2): 308-14, 2012.