何慧

何慧.jpg

姓        名:何慧

职称职务:副教授

联系电话:0512-65882985

电子邮箱:hhe@suda.edu.cn

办公地址:云轩楼1329

个人简介:

 

一、学习工作经历

 

1. 学历背景:

1998.9-2002.7   江西师范大学化学系,学士

2002.9-2005.9   厦门大学化学系,硕士

2007.8-2010.9   香港中文大学化学系,博士

 

2. 工作经历:

2005.9-2007.7   莆田出入境检验检疫局,助理工程师

2012.4-2013.8   香港中文大学化学系,博士后

2013.8-至今     苏州大学药学院,副教授

 

二、研究方向

(1) 智能型光敏药物的设计合成及其药效研究

(2) 智能型荧光探针的设计合成及其生物成像应用

 

三、  主要研究成果

主要从事有机光敏药物和荧光探针分子的设计合成,探索它们在癌细胞光动力学治疗和荧光分子成像方面的应用。

1. 代表性学术论文:

(1)     Zhu, A.; Miao, K.; Deng, Y.; Ke, H.; He, H.; Yang, T.; Guo, M.; Li, Y.; Guo, Z.; Wang, Y.; Yang, X.; Zhao, Y.; Chen, H. Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. ACS Nano 2015, 9, 7874-7885.

(2)     Guo, M.; Huang, J.; Deng, Y.; Shen, H.; Ma, Y.; Zhang, M.; Zhu, A.; Li, Y.; He, H.; Wang, Y.; Yang, X.; Zhang, Z.; Chen, H. pH-responsive cyanine-grafted graphene oxide for fluorescence resonance energy transfer-enhanced photothermal therapy. Adv. Funct. Mater. 2015, 25, 59-67.

(3)     He, H.; Lo, P.-C.; Ng, D. K. P. A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy. Chem. Eur J. 2014, 20, 6241-6245.

(4)     Wan, Z.; Mao, H.; Guo, M.; Li, Y.; Zhu, A.; Yang, H.; He, H.; Shen, J.; Zhou, L.; Jiang, Z.; Ge, C.; Chen, X.; Yang, X.; Liu, G.; Chen, H. Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics 2014, 4, 399-411.

(5)     Guo, M.; Mao, H.; Li, Y.; Zhu, A.; He, H.; Yang, H.; Wang, Y.; Tian X.; Ge, C.; Peng, Q.; Wang, X.; Yang, X.; Chen, X.; Liu, G.; Chen, H. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials 2014, 35, 4656-4666.

(6)     He, H.; Ng, D. K. P. Differential detection of Zn2+ and Cd2+ ions by BODIPY-based fluorescent sensors. Chem. Asian J. 2013, 8, 1441-1446.

(7)     He, H.; Liu, J.-Y.; Ng, D. K. P. A phthalocyanine-based fluorescent sensor for Zn2+ ion. J. Porphyrins Phthalocyanines 2013, 17, 99-103.

(8)     He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Synthesis and in vitro photodynamic activities of pegylated distyryl BODIPY derivatives. J. Med. Chem. 2011, 54, 3097-3102.

(9)     He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties. Chem. Commun. 2011, 47, 4748-4750.

(10) He, H.; Ng, D. K. P. A ratiometric near-infrared pH-responsive fluorescent dye based on distyryl BODIPY. Org. Biomol. Chem. 2011, 9, 2610-2613.

(11) Li, A.-F.; He, H.; Ruan, Y.-B.; Wen, Z.-C.; Zhao, J.-S.; Jiang, Q.-J.; Jiang, Y.-B. Oxidative cyclization of N-acylhydrazones. Development of highly selective turn-on fluorescent chemodosimeters for Cu2+. Org. Biomol. Chem. 2009, 7, 193-200.

(12) Wen, Z.-C.; Yang, R.; He, H.; Jiang, Y.-B. A highly selective charge transfer fluoroionophore for Cu(II). Chem. Commun. 2006, 106-108.

2. 承担的科研与人才项目:

(1)  国家自然科学基金青年科学基金项目“pH可激活型肿瘤靶向性光敏剂的设计合成及其光动力活性研究81402779),2015-2017

(2)  江苏省自然科学基金青年科学基金项目靶向性可激活双功能型光敏剂在肿瘤成像与光动力治疗中的应用BK20140369),2015-2017

(3)  江苏省高校自然科学基金面上项目肿瘤靶向性氟硼二吡咯类光敏剂的合成及光动力活性研究14KJB350004),2014-2016

(4)  江苏省双创博士项目,2015

(5)  苏州市高等院校、科研院所紧缺高层次人才引进资助计划2015-2019