张学农

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张学农,男,1962年出生,博士,教授、博士生导师。2003.8~ 作为学科带头人引进苏州大学药学院;现为国家发改委价格评审中心专家成员、国家药审中心新药审评专家库成员,国家执业药师工作专家库首批入选专家、中国药学会药剂学分会委员,江苏省药学会药剂学会副主任委员。国家教育部、国家自然基金评审专家、江苏省人事厅、科技厅和教育厅评审专家。《抗感染药学》副主编,《中国药物警戒》常务编委,《中国药学杂志》。《Biomaterials》、《ACS Appl. Mater. Interfaces和《Int J Pharm.等期刊审稿人江苏省“333高层次人才培养工程中青年科学技术带头人和江苏省六大高峰人才。 主持国家自然科学基金、国家科技部科技型中小企业技术创新基金、国家科技支撑计划和江苏省社会发展项目等。申请发明专利10余项,授权6项。指导学生论文中,4篇江苏省优秀硕士论文,5篇获苏州大学优秀硕士论文,1篇获江苏省高校本科毕业论文二等奖,2篇获三等奖。获江苏省中医药科技进步二等奖1项,苏州市科学技术进步奖二等奖1项,三等奖2项。苏州大学周氏科研奖2次,陈金荣生命科学奖3次。获得2017年度苏州大学“我最喜爱的老师”称号。

 

 

联系地址:

苏州大学医学部药学院 药剂学教研室,

苏州市工业园区仁爱路199 邮编:215123

联系电话&传真:0512-65882087

E-mailzhangxuenong@163.com

zhangxuenong@suda.edu.cn

主要研究方向:

1、靶向递药系统的研究

 以紫杉醇、阿霉素及基因等为模型药物,制备和研究质量可控、性质稳定的多功能性(包括温度/pH敏感性、受体介导、抗体修饰)纳米粒、脂质体、聚合物胶束智能型等靶向给药系统,并进行细胞和动物体内的靶向性与药效学评价。口服药物的吸收机制与生物利用度提高研究:采用纳米药物载体和定位释药系统,进行改善难溶性药物、膜通透性差和具有吸收窗药物的生物利用度研究,并阐明其机制。以国家重点学科-放射医学为平台,核素标记、荧光标记和医学影像等技术研究给药系统的药代动力学与靶向性特征。

2、缓控释新材料与新技术

以现代丝绸国家工程实验室和放射医学国家重点学科为依托,从家蚕中提取纯化得到丝素蛋白,经修饰与改性合成成为新型良好生物相容性与可降解高分子材料,用于微球、经皮给药系统的药物载体,用于多肽和核酸类和镇痛类药物的新药研究。以天然壳聚糖为材料通过修饰与改性合成的生物可降解和功能性高分子为载体材料,设计优化新型缓控释给药系统,并采用分子影像、PET-CT等先进技术探索药物-机体、药物-细胞相互作用的评价技术。

主持科研项目

1.   主持“CD147ab介导联合PD-L1化疗/免疫协同ROS敏感型智能肿瘤靶向递送系统”,批准号:8177318355万。2018.1-2021.12

2.   主持“cRGD修饰性共转运抗肿瘤药物与siRNA自组装聚合物胶束递药系统的研究”2012年国家自然基金资助(编号:81273463),67万。2013.1-2016.12

3.   主持“人源性低密度脂蛋白介导-pH/还原双敏感性二元聚合体胶束的构建及其基因递送逆转耐药机制研究项目”,批准号:8157178858万。2016.1-2019.12

4.   江苏省科技支撑计划-社会发展,生物工程药物-环孢素A自乳化纳米粒冻干制剂的成型技术及新药研发(BE2011670),30

5.   新型抗肿瘤纳米缓控释给药系统新药研究获国家科技部科技型中小企业技术创新基金(2007.7.1-2009.6.30),立项代码:07C26223201333,资助经费60万。

6.   现代制剂技术在中药制剂中应用的适应性研究国家科技支撑计划课题(2006.102009.10),编号:2006BAI09B00,项目经费620万,协作单位负责人

 

近五年发表的代表性论文

1.        Yang SD, Wang Y, Ren ZX, Chen MT, Chen WL, Zhang*. Stepwise  pH/reduction- responsive polymeric conjugates for enhanced drug delivery to tumor. Materials Science & Engineering C. 2018,82: 234-243  IF 4.16 二区

2.        Yang SD+, Ren ZX, Chen MT, Wang Y,You BG, Chen EL, Qu CX, Liu Y, Zhang XN* Nucleolin-Targeting AS1411-Aptamer-Modified Graft Polymeric Micelle with Dual pH/Redox Sensitivity Designed To Enhance Tumor Therapy through the Codelivery of Doxorubicin/TLR4 siRNA and Suppression of Invasion. Mol Pharmac 2018, Jan 2;15(1):314-325. doi: 10.1021/acs.molpharmaceut. IF 4.44

3.        Qu CX,Li JZ, Zhou YJ,Yang SD, Chen WL, Li F,You BG, Liu Y,and Zhang XN.Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma.The AAPS Journal2018 20:34 DOI: 10.1208/s12248-018-0195-8

4.        Yuan ZQ+, Chen WL+, You BQ, Liu Y, Shu-di Yanga, Li JZa , Zhu WJ, Zhou XF, Liu C, ZhangXN*.Multifunctional nanoparticles co-delivering EZH2 siRNA and etoposide for synergy therapy of orthotopic non-small-cell lung tumor, Journal of Controlled Release, 2017,268:198-211,一区 IF 7.79

5.        Zhu WJ#, Yang SD#, Qu CX, Zhu QL, Chen WL, Li F, Yuan ZQ, Liu Y, You BG, Zhang XN*. Low-density lipoprotein-coupled micelles with reduction and pH dual sensitivity for intelligent co-delivery of paclitaxel and siRNA to breast tumor. Int J Nanomed  2017,12: 3375—3393 IF 4.30 二区

6.        Chen WL, Li F,Tang Y,Yang SD,Li JZ,Yuan ZQ,Liu Y,Zhou XF,Liu C,Zhang XN*.Stepwise pH-responsive nanoparticles for enhanced cellular uptake and on-demand intracellular release of doxorubicin.Int J Nanomed  2017,12: 4241-4256  IF 4.30 二区

7.        Yang, SD#, Zhu WJ#, Zhu QL,Chen WL, Ren ZX, Li F,Yan ZQ, Li JZ,Liu Y, Zhou XF, Liu C, Zhang XN*. Binary-copolymer system base on low-density lipoprotein-coupled N-succinyl chitosan lipoic acid micelles for co-delivery MDR1 siRNA and paclitaxel, enhances antitumor effects via reducing drug. Biomed Mater Res B Appl Biomater. 2017, 105(5): 1114-1125 IF 3.19 二区

8.        Zhang CG#, Yang SD#, Zhu WJ#, You BG, Liu Y, Yuan ZQ, Chen WL, Li JZ, Zhou XF, Liu C, Zhang XN*. Distinctive polymer micelle designed for siRNA delivery and reversal of MDR1 gene-dependent multidrug resistance.J Biomed Mater Res B Appl Biomater. 2017 ,105(7):2093-2106. IF 3.19二区

9.        Li F#, Chen WL#, You BG,  Liu Y, Yang SD, Yuan ZQ, Zhu WJ, Li JZ, Qu CX, Zhou YJ, Zhou XF, Liu C, Zhang XN*. Enhanced cellular internalization and on-demand intracellular release of doxorubicin by stepwise pH/reduction-responsive nanoparticles. ACS Appl. Mater. Interfaces, 2016 ;8(47):32146-32158  IF 7.14 一区

10.    Chen WL#,Yang SD#,Li F#,Li JZ,Yuan ZQ, Zhu WJ, Liu Y, Zhou XF, Liu C, Zhang XN*. Tumor microenvironment-responsive micelles for pinpointed intracellular release of doxorubicin and enhanced anti-cancer efficiency. Int J Pharm. 2016,511: 728740.IF 3.994 二区

11.    Chen WL#Yuan ZQ#, Liu YYang SD, Zhang CG, Li JZ, Zhu WJ, Li F, ZhouXF, Lin YM, ZhangXN*.  Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro. Int J Nanomed.2016, 11:325-336, IF 4.30 二区

12.    Zhu R #, Zhang CG#, Liu Y, Yuan ZQ, Chen WL, Yang SD , Li JZ, Zhu WJ, Zhou XF, YouBG*, Zhang XN*. CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells. Scientific Reports. 2015, doi: 10.1038/srep17904. SCI三区,IF 4.26

13.    Yuan ZQ, Li JZ, Liu Y, Chen WL, Yang SD, Zhang CG, Zhu WJ, Zhou XF, Liu C, ZhangXN*.Systemic delivery of micelles loading with paclitaxel using N-succinyl-palmitoyl-chitosan decorated with cRGDyK peptide to inhibit non-small-cell lung cancer. Int J Pharm. 2015  15;492(1-2):141-51. IF 3.994 二区

14.    Zhu QL#, Zhou Y#, Guan M, Zhou XF, Yang SD,Liu Y,Chen WL, Zhang CG, YuanZQ, Liu C,Zhu AJ,Zhang XN*.Low-density lipoprotein-coupled N-succinyl chitosan nanoparticles co-delivering siRNA and doxorubicin for hepatocyte-targeted therapy. Biomaterials, 2014,35(22):5965-5976IF 8.4 一区

15.    BeiYY#,Yuan ZQ#, Zhang L#,Zhou XF, Chen WL, Xia P, Liu Y, You BG, Hu XJ, Zhu QL, Zhang CG, Zhang XN*, Jin Y. Novel Self-assembled Micelles based on Palmitoyl-trimethyl-chitosan for Efficient Delivery of Harmine to Liver Cancer. Expert Opinion on Drug Delivery, 2014,11(6): 843-854IF 5.66 二区

16.    Zhang CG#,Zhu QL#,Zhou Y#, Liu Y, Chen WL, Yuan ZQ, Yang SD, Zhou XF, Zhu AJ, Zhang XN*, Jin Y*. N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein (LDL) for targeted loaded-osthole delivery to -(LDLr)-rich tumors. Int J Nanomed ,2014, 9:2919-2932  IF 4.30,二区

17.    Bei YY#, Zhou XF#, You BG, Yuan ZQ, Chen WL, Xia P, Liu Y, Jin Y, Hu XJ, Zhu QL, Zhang CG, Zhang XN*, Zhang L*. Application of the central composite design to optimize the preparation of novel micelles of harmine. Int J Nanomed. 2013, 8:1795-1808,二区,IF  4.30

18.    Liu Y#, Wang XQ#, Ren WX, Chen YL, Yu Y, Zhang JK, Bawudong D, Gu JP, Xu XD, Zhang XN*. Novel albendazole-chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats. J Biomed Mater Res B Appl Biomater. 2013 101B(6): 998-1005.二区,IF 2.881

19.    Zhang GY#, Zhou XF#, Zhou XY, Wen QY, You BG, Liu Y, Zhang XN*, Jin Y.Effect of alginate-chitosan sustained release microcapsules for transhepatic arterial embolization in VX2 rabbit liver cancer model. J Biomed Mater Res A. 2013 ,101(11):3192-3200. 二区,IF 3.263

20.    Zhu QL#, Zhou Y#, Guan M, Yu DJ, Zhou XF, Liu Y, Xu JY, Wu Y, Gu ZL, Xing KL, Zhu AJ, Chen WL, Shi LS, Zhang XN*, Zhang Q.Hepatocyte-targeted delivery using pH-sensitive liposomes loaded with lactosyl-norcantharitin phospholipid complex: preparation, characterization, and therapeutic evaluation in vivo and in vitro.  Curr Med Chem. 2012, 19(33):5754-5763 二区 3.455

21.    Guan M, Zhou Y, Zhu QL, Liu Y, Bei YY,Zhang XN*Zhang Q. N-Trimethyl Chitosan Nanoparticle–encapsulated Lactosyl-Norcantharidin for Liver Cancer Therapy with High Targeting Efficacy. Nanomedicine: Nanotechnol. 2012,8:1172-1181,IF 5.671,一区

22.    Ding XY, Hong CJ, Liu Y, Gu ZL, Xing KL, Zhu AJ, Chen WL, Shi LS, Zhang XN*, Zhang Q Pharmacokinetics, tissue distribution, and metabolites of polyvinylpyrrolidone coated norcantharidin chitosan nanoparticle formulation in rats and mice by LC-MS/MS. Int J Nanomed ,2012:7 1723-1735 IF 4.32二区

23.    Guan M, Zhu QL, Liu Y, Bei YY, Gu ZL, Zhang XN*Zhang Q. Uptake and Transport of a Novel Anticancer Drug Delivery System Lactosyl-norcantharidin-associated N-trimethyl Chitosan Nanoparticles across Intestinal Caco-2 Cell Monolayers. Int J Nanomed ,2012,7:1921-1930IF 4.32,二区