仇晓琰

仇晓琰.JPG
姓  名:仇晓琰

职称职务:特聘副教授

联系电话:0512-65883325

电子邮箱:xqiu@suda.edu.cn

办公地址:云轩楼1325

 

个人简介:

一、学习工作经历

1、学历背景:

1995.91999.6, 北京大学,本科学士

1999.92001.6, Rensselaer Polytechnic Institute,硕士

2001.92007.5, 耶鲁大学,博士

 

2、工作经历:

2007.72011.9, 宾夕法尼亚大学,医学院生物物理与生化系,博士后

2011.92012.10, 加州大学旧金山分校,药学院药物化学系,博士后

2013.1- 苏州大学,药学院,副教授

 

二、研究方向

(1) 多肽配体的设计和发现

(2) 受体信号传导活性的调控

(3) 靶向抗癌药物的研发

 

三、主要研究成果

以多肽结构和活性为研究对象先后在JACSPNAS等杂志上发表十多篇研究论文。

 

代表性论文:

1. Li J., Qiu X.J. Quantification of Membrane Protein Self-Association with a High-Throughput Compatible Fluorescence Assay, Biochemistry 2017; 56(14): 1951-1954.

2. Li J., Qiu X. Studies of Conformational Change of The C-Terminal Amphipathic Helix of The Influenza A M2 Protein by FRET, Progress in Biochemistry and Biophysics 2016; 43(8): 796-800.

3. Lanci C.J., MacDermaid C.M., Kang S.G., Acharya R., Noth B., Yang X., Qiu X.J., Degrado W.F., Saven J.G. Computational design of a protein crystal, PNAS 2012; 109(19): 7304-7309.

4. Ghosh A., Qiu J., Degrado W.F., Hochstrasser R.M. Tidal surge in the M2 proton channel sensed by 2D IR spectroscopy, PNAS 2011; 108(15): 6115-6120.

5. Wang J., Qiu J.X., Soto C., Degrado W.F. Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus, Current Opinion in Structural Biology 2011; 21(1): 68-80.  (Review) 

6. Tang J., Yin H., Qiu J., Tucker M.J., DeGrado W.F., Gai F. Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide, J. Am. Chem. Soc. 2009; 131(11): 3816-3817.

7. Goodman J.L., Petersson E.J., Daniels D.S., Qiu J.X., Schepartz A. Biophysical and structural characterization of a robust octameric beta-peptide bundle, J. Am. Chem. Soc.  2007; 129(47): 14746-14751.

8. Petersson E.J., Craig C.J., Daniels D.S., Qiu J.X., and Schepartz A. Biophysical characterization of a beta-peptide bundle: comparison to natural proteins, J. Am. Chem. Soc.  2007; 129(17): 5344-5345.

9. Daniels D.S., Petersson E.J., Qiu J.X., and Schepartz A. High resolution structure of a beta-peptide bundle, J. Am. Chem. Soc. 2007; 129(6): 1532-1533.

10. Qiu J.X., Petersson E.J., Matthews E.E., and Schepartz A. Toward beta-amino acid proteins: a cooperatively folded beta-peptide quaternary structure, J. Am. Chem. Soc.  2006; 128: 11338-11339.

11. Hart S.A., Bahadoor A.B.F., Matthews E.E., Qiu X.J., and Schepartz A. Helix macrodipole control of beta-peptide 14-Helix stability in water,  J. Am. Chem. Soc.  2003; 125(14): 4022-4023.