郑龙太

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郑龙太男,197410月出生,博士,苏州大学药学院药理系副教授。

联系电话:15195610351.  Email: zhenglongtai@suda.edu.cn

1. 教育经历:

1993.9-1998.7:延边大学医学院,临床医学,学士

2000.9-2003.7:延边大学医学院, 药理学,  硕士

2004.3-2006.2:韩国庆熙大学医学院,药理学,博士

2. 工作经历:

1998.7-2004.2:延边大学医学院,药理教研室,助教

2006.3-2007.2:韩国庆熙大学医学院,药理学,博士后

2008.3-2009.12: 韩国庆北大学医学院,药理学,博士后

2010.1-至今:  苏州大学药学院,药理系,副教授

3. 项目:

1) 国家自然科学基金面上项目:肿瘤微环境中MFG-E8对神经胶质瘤发展的作用及其机制研究(81372688),基金委,主持人,2013.1-2017.12

2) 组织蛋白酶D介导小胶质细胞凋亡与活化机理研究(S813200311)教育部开放课题,主持人。

3) 组织蛋白酶D介导小胶质细胞凋亡与活化机理研究(Q313404710)主持人,苏州大学自然科学基金预研项目。

4)精神分裂症前额叶功能紊乱的机制(NFSC重点项目,81130023),基金委,主要参与人。

4. 研究方向

神经炎症:1.神经胶质细胞(microgliaastrocytes)激活调控的机制。

          2.胶质细胞介导神经炎症在神经退行性疾病中作用。

          3.发现新的治疗神经炎症靶点及其抑制剂。

5. 发表文章

(1)Gu R, Zhang F, Chen G, Han C, Liu J, Ren Z, Zhu Y, Waddington JL, Zheng LT*, Zhen X*.Clk1 deficiency promotes neuroinflammation and subsequent dopaminergic cell death through regulation of microglial metabolic reprogramming. Brain Behav Immun. 2016 Oct 18. pii: S0889-1591(16)30484-6. (通讯作者)

(2)Zhang Y, Gu R, Jia J, Hou T, Zheng LT*, Zhen X*. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity suppresses microglia-mediated inflammatory responses. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1134-1144. (通讯作者)

(3)Chen H, Han C, Wu J, Liu X, Zhan Y, Chen J, Chen Y, Gu R, Zhang L, Chen S, Jia J, Zhen X*, Zheng LT*, Jiang B. Accessible Method for the Development of Novel Sterol Analogues with Dipeptide-like Side Chains That Act as Neuroinflammation Inhibitors. ACS Chem Neurosci. 2016 Mar 16;7(3):305-15. (通讯作者)

(4)Gan P, Zhang L, Chen Y, Zhang Y, Zhang F, Zhou X, Zhang X, Gao B, Zhen X, Zhang J*, Zheng LT*. Anti-inflammatory effects of glaucocalyxin B in microglia cells. J Pharmacol Sci. 2015 May;128(1):35-46. (通讯作者)

(5) Liu TY, Yang XY, Zheng LT, Wang GH, Zhen XC. Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death. J Neurochem. 2016 Nov 27

(6) Wang Y, Guo L, Jiang HF, Zheng LT, Zhang A, Zhen XC. Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity. CNS Neurosci Ther. 2016 May;22(5):368-77.

(7)Xu Z, Wu J, Zheng J, Ma H, Zhang H, Zhen X, Zheng LT*, Zhang X*. Design, synthesis and evaluation of a series of non-steroidal anti-inflammatory drug conjugates as novel neuroinflammatory inhibitors. Int Immunopharmacol. 2015 Apr;25(2):528-37. (通讯作者)

(8)Wu J, Du J, Gu R, Zhang L, Zhen X, Li Y, Chen H, Jiang B*, Zheng LT*. Inhibition of neuroinflammation by synthetic androstene derivatives incorporating amino acid methyl esters on activated BV-2 microglia. ChemMedChem . 2015.10, 610-616. (通讯作者)

(9) Wu Z, Li L, Zheng LT, Xu Z, Guo L, Zhen X. Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation. J Neurochem. 2015 Sep;134(5):904-14.

(10)Zhou X, Gan P, Hao L, Tao L, Jia J, Gao B, Liu JY, Zheng LT*, Zhen X*. Antiinflammatory effects of orientin-2"-O-galactopyranoside on lipopolysaccharide-stimulated microglia. Biol Pharm Bull. 2014;37(8):1282-94. (通讯作者)

(11)Xu L, Zhang Y, Zheng LT, Qiao C, Li Y, Li D, Zhen X, Hou T. Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays. J Med Chem. 2014 May 8;57(9):3737-45.

(12)Jeon H, Zheng LT, Lee S, Lee WH, Park N, Park JY, Heo WD, Lee MS, Suk K.

(13)Comparative analysis of the role of small G proteins in cell migration and cell death: cytoprotective and promigratory effects of RalA. Exp Cell Res. 2011 Aug 15;317(14):2007-18. 

(14)Zhang H, Ye N, Zhou S, Guo L, Zheng L, Liu Z, Gao B, Zhen X, Zhang A. Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile. J Med Chem. 2011 Jul 14;54(13):4324-38.

(15) Zheng LT, Lee S, Yin GN, Mori K, Suk K: Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells. Journal ofNeurochemistry 2009, 111(5):1238-1251. 

(16)Zheng LT, Uhm YK, Kim J-W, Yim SV: Association of Glutathione S-Transferase (GSTM1 and GSTT1) Gene Deletions in Korean Patients with Alcohlism. Experimental Neurobiology  2009, 18(1): 32-36.

(17)Zheng LT, Hwang J, Ock J, Lee MG, Lee WH, Suk K: The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide production. Journal of Neurochemistry 2008, 107(5):1225-1235. 

(18)Zheng LT, Ryu GM, Kwon BM, Lee WH, Suk K: Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity. European journal of pharmacology 2008, 588(1):106-113.

(19)Zheng LT, Ock J, Kwon BM, Suk K: Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.International immunopharmacology 2008, 8(3):484-494.