任海刚

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    名:任海刚

职称职务:副教授

联系电话:65882627

电子邮箱:rhg@suda.edu.cn

办公地址:云轩楼2404

 

个人简介:

一、学习工作经历

1、学历背景:

2001.09-2005.07              西南科技大学生物工程专业,学士

2005.09-2010.07             中国科学技术大学神经生物学专业,博士

2、工作经历:

2010.07~2012.02             西南科技大学生命科学与工程学院讲师

2012.03~2013.06             苏州大学医学部药学院讲师

2013.07~                             苏州大学医学部药学院副教授

二、研究方向

1、帕金森氏病的病理学机制研究

2、神经退行性疾病相关蛋白的功能研究

 

二、主要的研究成果

1、代表性学术论文:

[1]D. Guo, Z. Ying, H. Wang, D. Chen, F. Gao, H. Ren, G. Wang, Regulation of autophagic flux by CHIP. Neurosci Bull 31 (2015) 469-479. (Co-corresponding author)

[2]L. Zhou, H. Wang, P. Wang, H. Ren, D. Chen, Z. Ying, G. Wang, Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax. Neuroscience 243 (2013) 14-21.

[3]H. Ren, K. Fu, C. Mu, X. Zhen, G. Wang, L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener 7 (2012) 40.

[4]K. Fu, H. Ren, Y. Wang, E. Fei, H. Wang, G. Wang, DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene 31 (2012) 1311-1322.

[5]H. Ren, K. Fu, D. Wang, C. Mu, G. Wang, Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. J Biol Chem 286 (2011) 35308-35317.

[6]H. Ren, K. Fu, C. Mu, B. Li, D. Wang, G. Wang, DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells. Cancer Lett 297 (2010) 101-108.

[7]B. Li, Q. Hu, H. Wang, N. Man, H. Ren, L. Wen, N. Nukina, E. Fei, G. Wang, Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death Differ 17 (2010) 1773-1784.

[8]T. Zhou, S. Wang, H. Ren, X.R. Qi, S. Luchetti, W. Kamphuis, J.N. Zhou, G. Wang, D.F. Swaab, Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain 133 (2010) 3069-3079.

[9]J. Fan, H. Ren, N. Jia, E. Fei, T. Zhou, P. Jiang, M. Wu, G. Wang, DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J Biol Chem 283 (2008) 4022-4030.

[10]J. Fan, H. Ren, E. Fei, N. Jia, Z. Ying, P. Jiang, M. Wu, G. Wang, Sumoylation is critical for DJ-1 to repress p53 transcriptional activity. FEBS Lett 582 (2008) 1151-1156. (Co-first author)

 

2、主持课题:

1、国家自然科学基金面上项目:Omi/HtrA2调控线粒体生物合成参与神经退变的机制研究(31471012),80万,2015.01-2018.12

2、中国博士后科学基金面上项目(2014M551648),5万,2014-2016

3、国家自然科学基金青年基金项目:帕金森病相关蛋白DJ-1调控线粒凋亡通路的机制研究(31100768),22万,2012.1-2014.12。已结题。