谢梅林教授课题组在Nutr. Res.发表科研论文

Chrysanthemum morifolium extract attenuates fat milk-induced fatty liver through PPARα-mediated mechanism in mice
Yan Cui, Xiaoli Wang, Jie Xue, Jiangyun Liu, Meilin Xie
Nutr. Res., 2014,34,268-275 (IF=2.585)

Abstract: Some polyphenols derived from plants may ameliorate hyperlipidemic fatty liver. Accordingly, we hypothesized that polyphenol-rich Chrysanthemum morifolium extract (CME) may exert an inhibitory effect on mouse hyperlipidemic fatty liver formation. This study aimed to examine the effects of CME on lipids in blood and liver and on peroxisome proliferator-activated receptor (PPAR)α-mediated gene expression. A mouse model with hyperlipidemic fatty liver was induced by orally feeding high-fat milk by gavage when they were simultaneously treated with 75 mg/kg to 300 mg/kg CME for 6 weeks. After CME addition, the serum total cholesterol level and hepatic weight coefficient decreased, but no significant reduction in the serum triacylglycerol level was observed. Importantly, CME might decrease hepatic lipid accumulation and sterol regulatory element binding protein (SREBP)-1c and fatty acid synthase (FAS) expression, increase hepatic PPARα, lipoprotein lipase (LPL), and cholesterol 7α-hydroxylase (CYP7A)1 expression. However, the expected reduction in hepatic diacylglycerol acyltransferase mRNA expression was not observed. These findings demonstrate that polyphenol-rich CME may prevent hyperlipidemic fatty liver in mice, and its mechanisms may be related to the modulation of SREBP-1c, FAS, LPL, and CYP7A1 expression through the PPARα-mediated pathway.