朱永明教授课题组在J. Org. Chem. 发表科研论文

Palladium-catalyzed one-pot synthesis of quinazolinones via tert-butyl isocyanide insertion
Xiao Jiang,† Ting Tang,† Jin-Mei Wang,† Zhong Chen,† Yong-Ming Zhu,*,† and Shun-Ji*,‡
J. Org. Chem., 2014, 79, 5082-5087 (IF= 4.638)

Abstract: A novel palladium-catalyzed three-component reaction for the synthesis of quinazolin-4(3H)-ones from readily available 2-aminobenzamides and aryl halides via a palladium-catalyzed isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs quinazolin-4(3H)-ones in moderate to excellent yields with the advantages of operational simplicity.