[10-27]Rationale Design of Antibiotics

报告题目:Rationale Design of Antibiotics

报 告 人:Professor: Courtney C. Aldrich

Department of Medicinal Chemistry, University of Minnesota





B.S. University of Missouri, St. Louis 1994, Chemistry

Ph.D. University of California, Los Angeles 2001, Chemistry


University of Minnesota, Campus [Twin Cities]

·          Associate Professor, Department of Medicinal Chemistry July 2013-present

·          Associate Director, Center for Drug Design July 2005-July 2013

Chinese Academy of Medical Sciences & Peking Union Medical College

·          Union Scholar Chair Professor Nov 2015-present

Postdoctoral appointments

·          University of Minnesota, Department of Microbiology & Immunology 2002-2004

·          Max Planck Institute for Molecular Physiology 2001- 2002

Editorships/Journal Reviewer Experience

·          Editor-in-Chief, ACS Infectious Diseases, 2015–present

·          Editorial Advisory Board, Journal of Medicinal Chemistry, 2012–present

·          Editorial Advisory Board, ACS Medicinal Chemistry Letters, 2015–present

·          Editorial Advisory Board, Current Topics in Medicinal Chemistry, 2012–2014

Publications: over 90 peer reviewed articles in a number of top journals, like J. Am. Chem. Soc.; Org. Lett.; J. Med. Chem.; J. Biol.Chem.; Angew. Chem. Int. Ed.et al.

selected articles:

1)      Okon, A.; Han, J.; Dawadi, S.; Demostheneous, C.; Aldrich, C. C.; Gupta, M.; Wagner, C. R.* Design of Anchimerically Activated ProTide as an Inhibitor of Cap-dependent Translation and an Inducer of Chemosensitization in Mantle Cell Lymphoma J. Med. Chem. 2017, in press, doi: 10.1021/acs.jmedchem.7b00916

2)      Liu, F.; Dawadi, S.; Maize, K. M.; Dai, R.; Park, S. W.; Schnappinger, D.; Finzel, B. C.*; Aldrich, C. C.* Structure-Based Optimization of PLP-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis. J. Med. Chem. 2017, 60, 5507–5520.

3)      Eiden, C. G.; Maize, K. M.; Finzel, B. C.; Lipscomb, J. D.*; Aldrich, C. C.* Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation. J. Am. Chem. Soc. 2017, 139, 7132–7135.

4)      Fiers, W. D.; Dodge, G. J.; Sherman, D. H.; Smith, J. L.; Aldrich, C. C.* Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis. J. Am. Chem. Soc. 2016, 138, 16024–16036

5)      Buonomo, J. A. Aldrich, C. C.* Recyclable Mitsunobu Reactions: A Catalytic Phosphorous and Fully Catalytic System. Angew. Chem. Int. Ed. 2015, 54, 13041–13044.