梁中琴教授课题组

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梁中琴  教授,博士生导师。

主要从事肿瘤及神经退行性疾病的基础研究,包括开展自噬/Cathepsin L信号传导机制在肿瘤侵袭迁移及多巴胺神经元死亡中的研究。近年来先后主持国家自然科学基金四项、江苏省自然科学基金、江苏省高校基金各一项,作为主要成员参与973项目一项。发表SCI 收录论文四十余篇,担任多个国内、国际刊物的审稿专家。获江苏省科学技术三等奖及江苏医学科技奖二等奖各一次,主持校药理学精品课程,参编药理学教科书6部,优秀教学成果奖3次。

 

主持的国家自然科学基金项目:

1.国家自然科学基金(81373430):Cathepsin L在调控电离辐射诱导的脑胶质瘤侵袭迁移中的作用,2013.1-2017.12

2.国家自然科学基金(81072656):Cathepsin L信号在调节胶质瘤干细胞辐射抗性中的作用,2010.01-2013.12

3.国家自然科学基金(30873052):Cathepsin L激活在多巴胺能神经元死亡中的作用,2009.01-2011.1230

4.国家自然科学基金(30672452):自噬/溶酶体途径在多巴胺能神经元死亡中的作用及药物干预,2007.01-2008.01

 

5年来的代表论文:

1.Xiong Y, Ji W, Fei Y, Zhao Y, Wang L, Wang W, Han M, Tan C, Fei X, Huang Q, Liang Z*. Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells. Cell Signal. 2017 Jan; 29:181-191.  

2.Wang W, Long L, Wang L, Tan C, Fei X, Chen L, Huang Q, Liang Z*. Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro. Cancer Lett. 2016 Feb 28;371(2):274-84.

3.Fei Y, Xiong Y, Zhao Y, Wang W, Han M, Wang L, Tan C, Liang Z*. Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells. Brain Res. 2016 Sep 1;1646:580-8.

4.Han ML, Zhao YF, Tan CH, Xiong YJ, Wang WJ, Wu F, Fei Y, Wang L, Liang ZQ*.Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells.Acta Pharmacol Sin. 2016 Dec;37(12):1606-1622.

5.Li L, Gao L, Song Y, Qin ZH, Liang Z*. Activated cathepsin L is associated with the switch from autophagy to apoptotic death of SH-SY5Y cells exposed to 6-hydroxydopamine. Biochem Biophys Res Commun. 2016 Feb 12;470(3):579-85.

6.Wang L, Long L, Wang W, Liang Z*. Resveratrol, a potential radiation sensitizer for glioma stem cells both in vitro and in vivo. J Pharmacol Sci. 2015 Dec;129(4):216-25

7.Zhang QQ, Wang WJ, Li J, Yang N, Chen G, Wang Z, Liang ZQ*.Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage. Acta Pharmacol Sin. 2015 Sep;36(9):1113-25.

8.Yang N, Wang P, Wang WJ, Song YZ, Liang ZQ*. Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-κB signaling pathway. Acta Pharmacol Sin. 2015 Mar;36(3):400-10.

9.Zhang Q, Han M, Wang W, Song Y, Chen G, Wang Z, Liang Z*.Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factorβmediated epithelialmesenchymal transition. Oncol Rep. 2015 Apr;33(4):1851-9.

10.Wang YX, Xu SQ, Chen XH, Liu RS, Liang ZQ*. Autophagy involvement in olanzapine-mediated cytotoxic effects in human glioma cells. Asian Pac J Cancer Prev. 2014;15(19):8107-13.

11.Lu Y, Wang WJ, Song YZ, Liang ZQ*. The protective mechanism of schisandrin A in d-galactosamine-induced acute liver injury through activation of autophagy. Pharm Biol. 2014 Oct;52(10):1302-7.

12.Wang WJ, Long LM, Yang N, Zhang QQ, Ji WJ, Zhao JH, Qin ZH, Wang Z, Chen G, Liang ZQ*. NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro.Acta Pharmacol Sin. 2013 ;34(5):681-90.

13.Tan CH, Qian XQ, Jia RD, Wu M , Liang ZQ*. Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells. ONCOLOGY REPORTS. 2013,30: 2529-2535.

14.Zhuang W, Long L, Zheng B, Ji W, Yang N, Zhang Q, Liang Z*.Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy. Cancer Sci. 2012 ;103(4):684-90.

15.Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z*. Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int J Cancer. 2011 Dec 1;129(11):2720-31.

16.Zhuang W, Li B, Long L, Chen L, Huang Q, Liang ZQ*. Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy. Brain Res. 2011 ,31;1371:7-15.

17.Xiang B, Fei X, Zhuang W, Fang Y, Qin Z, Liang Z. Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells. Brain Res. 2011 .28;1387:29-38.

18.Li L, Wang X, Fei X, Xia L, Qin Z, Liang Z*.Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. Neurosci Lett. 2011 ,1;489(1):62-7.