谢梅林教授课题组

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谢梅林 教授,博导

1984年苏州医学院本科毕业后留校从事药理学的教学和科研工作,1990年获得药理学硕士学位,1998年获中国中医科学院心血管病学专业博士学位,2001年完成博士后研究工作。1999年入选苏州市首批跨世纪高级人才培养对象,2002年入选江苏省“333工程培养对象,现为中国药理学会抗炎免疫药理专业委员会委员,江苏省药理学会常务理事,中国老年学学会衰老与抗衰老科学委员会理事,教育部学位和研究生教育评估专家,2007年度江苏省科技计划项目特聘咨询专家。为《Planta Medica》、《Acta Pharmacologica Sinica》、     《中国药理学通报》和《中国动脉硬化杂志》等期刊的特邀审稿专家。

谢梅林教授长期从事防治高脂相关性疾病的药物作用及其机制的研究,阐明了蛇床子素对脂肪肝的治疗作用可能是通过激动核受体PPARα/γ所致,近年来在国内外发表学术论文90多篇,有20多篇被SCI/SCIE收录,主编和参编教材、著作5部,获得省部级科技进步奖4项,新药证书1件,授权发明专利4项。培养硕/博士研究生30余人。

 

目前承担的科研情况

  1.国家自然科学基金项目(81173067)PPARα/γ信号通路在蛇床子素治疗高脂性脂肪性肝炎中的作用,2012-201545万元

  2.苏州市科技基础设施建设项目(SWG0903):苏州市防治高脂性疾病药物研究重点实验室,2009-2012,40万元

  3.浙江省自然科学基金课题(Y2100755):蛇床子素调节肝细胞和脂肪细胞内脂肪酸代谢的研究,与湖州师范学院联合申报,2011-2013,5万元

 

近五年的发明专利

  1.蛇床子素的用途及用于治疗脂肪肝的制剂,发明专利号:ZL200510038908.2

  2.蛇床子素在制备防治心肌纤维化药物中的应用,发明专利号:ZL201010135307.4

  3.一种姜提取物、其制备方法及应用,发明专利号:ZL200610038764.5

  4.降血脂药物组合物,发明专利号:ZL02112488.4

 

近五年代表文章

1.         Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice. Toxicology and Applied Pharmacology, 2011, 256: 168-173.

2.         Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression. European Journal of Pharmacology, 2011, 666: 183-188.

3.         Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats. Planta Medica, 2011, 77: 231-235.

4.         Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress. Phytotherapy Research, 2011, 25:638-643.

5.         Aspirin inhibits MMP-9 mRNA expression and release via the PPARα/γ and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomedicine & Pharmacotherapy, 2010, 64: 118-123.

6.         Osthole regulates hepatic PPARα- mediated lipogenic gene expression in alcoholic fatty liver murine. Phytomedicine,2010,17: 669-673.

7.         Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPAR/γ and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology, 2009,83(1):18-25.

8.         Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARα/γ and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages. Inflammation, 2009,32:233-241.

9.         Inhibitory effect of osthole on alcohol-induced fatty liver in mice. Digestive and Liver Disease, 2009,41:127-133.

10.     Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARa/γ in fat milk-induced fatty liver rats. Journal of Asian Natural Products Research, 2008, 10 (8): 797-802.

11.     Osthole improves fat milk-induced fatty liver in rats: Modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression. Planta Medica, 2007,73(8): 718-724.

12.     Therapeutic effect of osthole on hyperlipidemic fatty liver in rats. Acta Pharmacologica Sinica 2007,28(3):398-403.

 

课题组成员

薛洁:讲师,主要从事调脂药物药理学和心血管药理学的研究,目前主持武器装备预研基金(2011年),江苏省博士后基金(2011年)和苏州大学青年基金(2009年)各1项。

代表论文:

Xue JieZhang KepingZhu LujiaXie MeilinZhang Hongquan. Inhibitory effect of Qushuanling capsule on thrombus         formation and platelet aggregation in rats. Submitted.

Xue JieHua YinanXie MeilinGu Zhenlun. Aspirin inhibits MMP-9 mRNA expression and release via the PPARα/γ and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomedicine & Pharmacotherapy, 2010, 64: 118-123.

Xue JieXie MeilinGu Zhenlun. Mechanism for regulating cholesterol metabolism by protocatechualdehyde, ursolic acid and quercetin. Asian Journal of Traditional Medicines200612):1-4.