崔京浩教授课题组

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崔京浩
, 药学博士,教授

E-mail: jhcui@suda.edu.cn

Tel & Fax: 0512-65882077

 

19927月,延边大学获得药剂学专业硕士学位,19997月,韩国江原大学药学院药剂学博士学位,20034月至20045月,日本京都药科大学药物动力学研究室做博士后研究员。20046月至20062月,日本天藤制药株式会社创药中心探索研究室担任高级研究员。20063月至今,苏州大学药学院任药剂学副教授、教授。现任世中联中药药剂委员会常务理事、副秘书长,ISRN Pharmaceutics编委;Journal of controlled release, International Journal of Pharmaceutics, Nanomedicine: Nanotechnology, Biology, and Medicine, J Drug Delivery等刊物的特约审稿人。

 

主要研究方向:

u      生物大分子药物的靶向给药系统研究

u      粘膜及经皮给药系统的研究与开发

u      口服结肠定位释药制剂

 

曹青日,药学博士,副教授

E-mail: qrcao@suda.edu.cn

Tel & Fax: 0512-69564123

19967月,延边大学药学院毕业后留校任教。19988月至20042月,韩国江原大学药学院攻读硕士和博士学位。20048月至200812月,分别在韩国希杰(CJ)株式会社药物研究所和大熊制药药物研究所任高级研究员。20093-至今,苏州大学药学院药剂学副教授。以主要研究者身份参与5项韩国省部级课题,主持和参与4项企业研究所重点课题。在SCI和国外期刊上共发表学术论文17篇,其中SCI 10 (第一作者:7),国外期刊7篇。在美国药剂学会(AAPS)、韩国药学会上发表交流论文20篇。已申请8项专利,其中6项已授权。

主要研究方向

u 新型纳米制剂与口服缓控释制剂

 

承担与参与的主要科研项目

u 受体介导的温敏性纳米载体对siRNA体内外传递及药效的影响和机制研究,国家自然科学基金面上项目 (主持),编号:81173005,资助金额:60万元,时间:2012~2015

u 肿瘤细胞核靶向p53基因聚酰胺-胺聚合物递送系统的研究,国家自然科学基金面上项目(参与),编号:81173004,资助金额:50万,时间:2012~2015

u 艾迪冻干粉针的制剂技术及药代动力学,科技部国际合作项目(苏大负责人),编号:2009DFA31330,资助金额:160万元,时间:2009~2011

 

代表性论文及专利

1. Yanhang Ma, Lin Zhou, Haoquan Zheng, Lei Xing, Chenguang Li, Jinghao Cui* and Shunai Che*pH-responsive mitoxantrone (MX) delivery using mesoporous silica nanoparticles (MSN)Journal of Materials Chemistry2011, 21, 9483-9486. IF2008: 4.65

2. Qing-Ri Cao, Jing-Hao Cui, Jun Bom Park, Hyo-Kyung Han, Jaehwi Lee, Kyung Taek Oh, Inchoon Park, Beom-Jin Lee. Effect of food components and dosing times on the oral pharmacokinetics of nifedipine in rats, Int J Pharm, 2010, 396, 39-44.( IF20093.061)

3. Yu-Ling Li, Li Zhu, Zhaozhong Liu, Ru Cheng, Fenghua Meng, Jing-Hao Cui, Shun-Jun Ji, and Zhiyuan ZhongReversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer CellsAngew. Chem. Int. Ed.2009, 48, 9914–9918.(IF2008: 10.89 )

4. Qing-Ri Cao, Eung-Seok Lee, Yun-Jaie Choi, et al. Rumen bypass and biodistribution of l-carnitine from dual-layered coated pellets in cows, in vitro and in vivo, Int J Pharm, 2008, 359(1-2): 87-93. (IF20093.061)

5. Jing-Hao Cui, Qing-Ri Cao, Beom-Jin Lee, Enhanced delivery of bifidobacteria and fecal changes following the oral administration of gastric acid resistant bifidobacteria-loaded alginate poly-l-lysine microparticles in human volunteers, Drug Delivery, 200714: 265–271. (IF2008: 1.55)

6. Qing-Ri Cao, Shan Ren, Mi-Jin Park, Yun-Jaie Choi and Beom-Jin Lee. Determination of highly soluble L-carnitine in biological samples by reverse phase high performance liquid chromatography with fluorescent derivatization, Arch Pharm Res, 200730(8), 1041-1046.(IF2009:1.074)

7. Qing-Ri Cao, Tae-Wan Kim and Beom-Jin Lee. Photoimages and the release characteristics of lipophilic matrix tablets containing highly water-soluble potassium citrate with and highly drug loadings, Int J Pharm, 2007, 339, 19-24. (IF20093.061)

8. Jing-Hao Cui, Qing-Ri Cao, Yun-Jae Choi and Beom-Jin LeeEffect of Additives on the Viability of Bifidobacteria Loaded in Alginate Poly-l-lysine Microparticles During the Freeze-drying ProcessArchives of Pharmacal Research 29 (8), 707-711, 2006. (IF2008: 1.074)

9. Qing-Ri Cao, Yun-Woong Choi, Jing-Hao Cui and Beom-Jin Lee, Formulation, release characteristics and bioavailability of novel monolithic hydroxypropyl -methylcellulose matrix tablet containing acetaminophen, Journal of Controlled Release, 2005, 108 (2-3): 351-361. (IF2008: 5.69)

10. Qing-Ri Cao, Yun-Woong ChoiJing-Hao Cui and Beom-Jin Lee, Effect of Solvents on Physical Properties and Release Characteristics of Monolithic Hydroxypropylmethylcellulose Matrix Granules and Tablets. Archives of Pharmacal Research, 2005 28:493-501. (IF2008: 1.074)

 

申请专利

1.申请人:崔京浩、朱云峰、曹青日、刘江云,专利名称:治疗呼吸道感染与炎症的金莲花提取物干粉吸入剂及其制备方法,专利申请号:201110051770.5

2.申请人:崔京浩、陈莉,专利名称:一种抗原递呈细胞靶向纳米粒子及其制备方法,专利申请号:200910201415.4

3.申请人:崔京浩、崔启华,专利名称:一种含丹皮酚活性物质的结肠靶向给药制剂及其制备方法,专利申请号:200910201417.3

4. 申请人:崔京浩、缪文俊、崔载胜,专利名称:一种卡巴拉汀缓释微球及其制备方法,专利申请号:200910201416.9

5.申请人:崔京浩、钱颖,专利名称:一种溃疡性结肠炎靶向姜黄素纳米粒的制备方法,专利申请号:200910201403.1

6.申请人:曹青日、刘妍、崔京浩,专利名称:一种富马酸奎硫平缓释片及其制备方法,专利申请号:201110314104.6

7.申请人:曹青日、刘妍、崔京浩,专利名称:一种替米沙坦固体分散体及其制备方法,专利申请号:201110110988.3

8.申请人:曹青日、崔京浩,专利名称:一种缬沙坦生物粘附性包衣微丸制剂及其制备方法,专利申请号:201010590790.5

9.申请人:曹青日、崔京浩,专利名称:扎那米韦固体脂质纳米粒的口服制剂及其制备方法,专利申请号:201010590798.1