肿瘤分子生物学研究室(张熠 副教授)

张熠.jpg 张熠,苏州大学药理学副教授。主要从事肿瘤药理学的研究。迄今为止,在国内外权威期刊如Cancer ResOncogeneAutophagyMolecular Cancer TherapyBiochemical PharmacologyCancer Biology Therapy等发表论文20余篇,其中第一/通讯作者10余篇;获江苏省优秀博士论文,中美抗癌协会-亚洲癌症研究基金会(USCACA-AFCRScholar Award,中国药理学会-施维雅青年药理学家奖;江苏省高校青蓝工程优秀青年骨干教师培养对象;目前已申请中国发明专利3项;现主持国家自然科学基金面上项目,江苏省自然科学基金面上项目,中国博士后特别资助项目;中国博士后一等资助项目;江苏省高校自然科学基金项目,苏州市医疗卫生科技项目;社会兼职:现任国家自然科学基金通讯评审专家,中国药理学会肾脏药理专业委员会委员,BioMed Research International杂志编委,《中华肿瘤防治杂志》青年编委。

E-mail Address:  zhangyi@suda.edu.cn, yzhang25b@gmail.com.

Research Interests研究方向

1)肿瘤的发生和恶化的机制

2)抗肿瘤药物耐药性产生机理和信号传导通路变化

3)肿瘤治疗新靶点的发现和新药研发

GRANT SUPPORT主持课题基金

1. 国家自然科学基金面上项目(项目编号:81473240

2. 江苏省自然科学基金面上项目(项目编号:BK20141197

3. 国家博士后特别资助项目(项目编号:2015T80585

4. 国家博士后基金(一等)资助项目(项目编号:2014M550308

5. 苏州市科技发展计划(应用基础研究医疗卫生,SYS201319 

6. 江苏省高校自然科学基金(12KJD310005

7. 国家自然科学基金青年项目 81101913/H1622)  

     Publications论文发表

1. Yi Zhang*, Yi-Jie Ren, Ling-Chuan Guo, Cheng Ji, Jian Hu, Hong-Han Zhang,Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Yun-Sheng Yuan, Xingcong Ren, Jianxun, Song, and Jin-Ming Yang. Nucleus Accumbens-Associated Protein-1 Promotes Glycolysis and Survival of Hypoxic Tumor Cells via the HDAC4-HIF-1α Axis, Oncogene, 2017, In Press, doi:10.1038/onc.2017.51. *(Corresponding author)  

2. Cheng Ji, Qiong-Hua Xu, Ling-Chuan Guo, Yi-Jie Ren, Hong-Han Zhang, Wei-Dong Zhu, Zhi-Jun Ming, Yun-Sheng Yuan, Xin-Cong Ren, Yan Cheng, Jin-Ming Yang, Yi Zhang*. eEF-2 Kinase-targeted miR-449b Confers Radiation Sensitivity to Cancer Cells, Mol Cancer Ther, 2017, In Press. *(Corresponding author)

3. Zhang Y*, Yang WQ, Zhu H, Zhou L, Ren YJ, Ren XC, Zhang L, Wang JR, Liu YB, Yang JM.  Regulation of Autophagy by miR-30d Impacts Sensitivity of Anaplastic Thyroid Carcinoma to Cisplatin, Biochem Pharmacol, 2014 Feb 15;87(4):562-70. *(Corresponding author)      

4. Ren YJ, Zhang Y*. An update on RNA interference-mediated gene silencing in cancer therapy. Expert Opin Biol Ther, 2014 Nov;14(11):1581-92.  *(Corresponding author)  

5. Xiao-yuan Liu, Li Zhang, JianPing Wu, Lei Zhou, Yi-Jie Ren, Wei-Qiong Yang, Zi-Jun Ming, Bo Chen, Jianrong Wang, Yi Zhang* and Jin-Ming Yang.  Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma.  PLoS One, 2013 Nov 26;8(11):e81345.  *(Corresponding author)

6. Zhang Y*, Yang JM*.  Altered energy metabolism in cancer: An unique opportunity for therapeutic intervention.  Cancer Biol Ther, 2013 Feb 1; 14(2):81-9. (*Corresponding author)    

7. Zhang Y, Cheng Y, Ren XC, Hori T, Huber-Keener KJ, Zhang L, Yap KL, Liu D, Shantz L, Qin ZH, Zhang SP, Wang JR, Wang HG, Shih IM and Yang JM:  Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis.   Cancer Res, 72(16): 4262-4275, 2012.    

8. Zhang Y, Cheng Y, Ren XC, Zhang L, Yap KL, Wu H, Patel R, Liu DX, Qin ZH, Shih IM and Yang JM*:  NAC1 Modulates Sensitivity of Ovarian Cancer Cells to Cisplatin via Altering the HMGB1-Mediated Autophagic Response.  Oncogene, 31(8): 1055-1064, 2012.     

9. Yang WQ, Zhang Y*.  RNAi-mediated gene silencing in cancer therapy.  Expert Opin Biol Ther, 2012 Nov; 12(11):1495-504. (Invited Review, *Corresponding author)     

10.  Zhang Y, Jay W. Yang, Xingcong Ren and Jin-Ming Yang. NAC1 and HMGB1 enter a partnership for manipulating autophagy. Autophagy, 2011 Dec 1;7(12).   

11.  Zhang Y*, Cheng Y, Zhang L, Ren X, Huber-Keener KJ, Lee S, Yun J, Wang HG, Yang JM. Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression. Biochem Biophys Res Commun, 2011 Oct 14; 414(1):129-34. (* Corresponding author)    

12.  Zhang Y#, Zhang L#, Liu XY, Qin ZH, Yang JM. Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells. Acta Pharmacol Sin, 2011, Mar;32(3):361-7. (# contributed equally to this study)   

13. Zhang Y*, Yang JM. The impact of cellular senescence in cancer therapy: is it true or not? Acta Pharmacol Sin, 2011 Oct; 32(10):1199-207. (* Corresponding author)  

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