药物分析与药物代谢研究室(谢洪平教授)

 

 

 

 

 

 

 

谢洪平,博士,教授, 博士生导师,教育部科技奖评审专家、江苏省科技厅评审专家,担任Analytica Chimica Acta、Analytical and Bioanalytical Chemistry、Journal of Pharmaceutical and Biomedical Analysis、Analytical Sciences等国际学术期刊特邀审稿人、《抗感染药学》和《苏州大学学报(医学版)》编委。获地厅级一等奖2项、二等奖3项、获得校级教学成果奖1项,指导研究生获得校级优秀学位论文、指导本科生获得省级优秀论文(二等奖)各1篇。主持(或主研)科研项目共10项,其中国家级3项、省部级4项、市厅级项目1项、与企业合作研究项目2项。在国内外重要学术刊物上发表了80余篇学术论文,其中SCI收录21篇,EI收录9篇。

 

研究方向1   药物质量评价与质量控制

以色谱分析和光谱分析为基础,研究药物及其制剂的质量评价方法和质量标准。利用光谱全谱分析结合药物信息学技术,研究药物快速在线分析和无损分析方法,建立药物的过程质量控制系统。

研究方向2  体内药物与代谢产物分析

探讨药物及其代谢产物的预处理分离、富集技术,建立灵敏度高、专属性强的体内药物分析方法,研究药物代谢动力学及其生物等效性。探讨药物(毒物)对内源性代谢物谱的影响,以生物信息学和药物信息学为基础,研究药物代谢组学,评价和预测药物的毒性和有效性。

研究方向3    免疫分析与基因分析

以磁性纳米粒为基础,研究超顺磁性、无荧光吸收的新型纳米载体材料。基于纳米粒和等离子体共振,研究长寿命荧光和高灵敏的化学发光标记体。建立类均相、高灵敏时间免疫分析和电致化学发光新方法,设计新型荧光基因探针和免疫探针,开发新的生物药物和临床检验诊断试剂。

 

目前承担项目

•国家自然科学基金,基于正交投影的代谢组学及其中药肝毒性评价与预测,2000年。

•江苏省普通高校研究生科研创新基金,基于代谢组学的中药药效评价,2011年。

•企业合作项目:1)基于药食同源的功能饮料开发研究; 2)天然麻制品的抗菌性成分研究及其新产品开发。

 

近五年主要成果

•Hong-Ping Xie, et al. Chemometrics classification of traditional Chinese medicines by their origins of grown places using NIR reflectance spectra. Analytical Sciences, 2006,22:1111-1116.(SCI收录)

•Xue Jiang, et al. Optimized extraction for steroidal saponins and its on-line quality control with near infrared spectroscopy. Chinese Journal of Analytical Chemistry, 2006, 34: S171-S174. (SCI收录)

•Li Ren, et al. Typing SNP based on the near-infrared spectroscopy and artificial neural network. Spectrochimica Acta Part A, 2009, 73: 106-111(EI、SCI收录)

•Li Ren, et al. The determination for the three genotypes of D16S539 locus based on near-infrared spectroscopy and chemical pattern recognition, Analytica Chimica Acta, 2009, 638: 202–208(EI、SCI收录)

•Hong-Ping Xie, et al. Fast Determination of the Release Degree of Compound Sulfamethoxazole Tablets by Using Circulation Release System Combined with Ultraviolet Spectral Net Analyte Signal Method, Analytical Sciences, 2009, 25: 1461-1465.(SCI收录)

•Xiao-Hong Gu, et al. Preparation of chlorogenic acid surface-imprinted magnetic nanoparticles and their usage in separation of Traditional Chinese Medicine,Analytica Chimica Acta, 2010, 675: 64-70(EI、SCI收录)

•Xiao-Hong Gu, et al. Preparation of chlorogenic acid surface-imprinted magnetic nanoparticles and their usage in separation of Traditional Chinese Medicine,Analytica Chimica Acta, 2010, 675: 64-70(EI、SCI收录)

•Hong-Yuan Mou, et al. On-line Dissolution Determination of Baicalin in Solid Dispersion Based on Near Infrared Spectroscopy and Circulation Dissolution System, Chemometrics and Intelligent Laboratory Systems, 2011, 105: 38-42.(二区,SCI、EI收录)

•Zai-Zhen Wu, et al. Studies on Short Tandem Repeats Genotyping and its Expert System Based on Ultraviolet Spectroscopy - Principal Discriminant Variate, Chemometrics and Intelligent Laboratory Systems, 2011, 105: 181-187.(二区,SCI收录)

•Rong Xu, et al. Preparation and characterization of polyelectrolyte coated fluorescent silica nanoparticles by adsorbing europium chelate, Chinese Journal of Luminescence, 2011, 32(5): 476-481. (EI收录)

•Xue-Jiao Wang, et al. Genotyping of STR Locus Based on Ultraviolet Spectroscopy Combined with Artificial Neural Network, Chinese Journal of Analytical Chemistry, 2011(SCI源刊).