报告题目：Kir2.1 current and membrane potential oscillation
报 告 人：陈魁豪 （纽约州立大学奥尔巴尼分校）
报告时间：2018年10月18日（星期四）上午9:00
报告地点：独墅湖校区二期云轩楼2301室
报告人简介：
陈魁豪 博士，2014年博士毕业于华中科技大学同济医学院药理学专业，毕业后前往美国纽约州立大学奥尔巴尼分校从事博士后工作，主要研究方向是心血管离子通道，包括TRP、钠、钾离子通道的生理药理学特性，目前的研究兴趣集中在Kir2.1钾通道在心脏起搏中的作用。近4年来，共发表SCI论文13篇，其中一作论文6篇。
报告摘要：
In hypokalemia, human cardiomyocytes and skeletal muscles exhibit two levels of membrane potential, which causes electrical activity disorders, such as arrhythmia. It was found that Kir2.1 current non-linearly counterbalances with an inward current, such as hypokalemia-induced K2P1, HCN current, inducing spontaneous two levels of membrane potential in iPSC cardiomyocytes and transfected HEK293 cells. In addition, based on the Kir2.1 inward rectification-controlled precise balance with HCN2 current, we engineered pacemaking cells by co-expressing Nav1.5/Cav3.1, Kir2.1 and HCN2 channels in HEK293 cells. In summary, first, the hypothesis that Kir2.1 current non-linearly counterbalances with an inward background current reveals a new mechanism of two levels of membrane potential and excitability; second, precise balance of Kir2.1 and HCN2 initiates spontaneous rhythmic action potentials and forms the origin of pacemaking activity.