报告题目：NIK promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action
报 告 人：盛亮 博士 (密西根大学Research fellow)
报告时间：2013年3月14日（星期四）下午2:00
报告地点：独墅湖校区二期云轩楼2301会议室
报告摘要：
The canonical IKKβ/NF-k1 pathway has been well documented to promote insulin resistance; however, the noncanonical NIK/NF-kB2 pathway is poorly understood in obesity. Additionally, the contribution of counterregulatory hormones, particularly glucagon, to hyperglycemia in obesity remains unclear. Here we show that NIK promotes glucagon responses in obesity. Hepatic NIK was abnormally-activated in mice with dietary or genetic obesity. Systemic deletion of NIK decreased glucagon responses and hepatic glucose production (HGP). Obesity is associated with increased glucagon responses, and liver-specific inhibition of NIK decreased glucagon responses and HGP and protected against hyperglycemia and glucose intolerance. Conversely, hepatocyte-specific overexpression of NIK increased glucagon responses and HGP. In isolated livers and primary hepatocytes, NIK also promoted glucagon action and glucose production, at least in part by increasing CREB stability. Therefore, overactivation of liver NIK in obesity promotes hyperglycemia and glucose intolerance by increasing the hyperglycemic response to glucagon and other factors that activate CREB.
报告人简介：
盛亮，江苏苏州人，2003年获中国药科大学药学学士学位；2008年获中国药科大学药理学博士学位，并于同年成为密西根大学Research fellow至今。近年来，盛亮在Nature Medicine, The Journal of Biological Chemistry, British Journal of Pharmacology, European Journal of Pharmacology 等杂志上发表多篇论文，单篇最高影响因子为22.4(2011).
代表性论文：
Sheng, Liang; Zhou, Yingjiang; Chen, Zheng; Ren, Decheng; Cho, Kae Won; Jiang, Lin; Shen, Hong; Sasaki, Yoshiteru; Rui, Liangyou. NFkB-inducing kinase(NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon actin. Nature Medicine Volume: 18, Pages: 943–949 (2012)
Sheng, Liang; Cho, Kae Won; Zhou Yingjiang; Shen, Hong; Rui, Liangyou. Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid β-oxidation. The Journal of Biological Chemistry. 2011 Nov 4;286(44):38128-35
Sheng, Liang; Qian, Zhiyu; Shi Yun; Yang Lina; Xi, Liang; Zhao, Bohua; Xu Xiaole; and Ji,Hui Crocetin improves the insulin resistance induced by high-fat diet in rats. British Journal of Pharmacology 2008 July; 154(5): 1016–1024.
Sheng, Liang; Qian, Zhiyu; Zheng, Shuguo; Xi, Liang. Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase. European Journal of Pharmacology vol. 543 issue 1-3 August 14, 2006. p. 116-122