Palladium-catalyzed formylation of aryl halides with tert-butyl isocyanide
Xiao Jiang,† Jin-Mei Wang,† Ying Zhang,† Zhong Chen,† Yong-Ming Zhu,*,† and Shun-Jun Ji*,‡
Org. Lett., 2014, 16, 3492-3495 (IF= 6.324)
Abstract: A novel palladium-catalyzed formylation of aryl halides with isocyanide in the presence of Et3SiH has been demonstrated, which provides a strategy toward important aldehydes with moderate to excellent yield. The advantage of this reaction includes milder conditions, convenient operation, lower toxicity, and wide functional group tolerance.
