1. Smart Albumin-Biomineralized Nanocomposites for Multimodal Imaging andPhotothermal Tumor Ablation
Y. Wang, T. Yang, H. T. Ke, A. J. Zhu, Y. Y. Wang, J. X. Wang, J. K. Shen,G. Liu, C. Y. Chen, Y. L. Zhao, H. B. Chen.*
Adv. Mater. 2015, In press, DOI: 10.1002/adma.201500229
Abstract: Multimodal imaging-guided cancer therapy dramatically advances the new field ofcancer theranostics. Nevertheless, so far smart theranostic agents have been exploredwith limited success for multimodal imaging-guided tumor ablation. In this study, wereport smart cyanine-grafted gadolinium oxide nanocrystals (Cy-GdNCs) as cancertargetednanocomposites through albumin-based biomineralization strategy fortrimodal near-infrared fluorescence/photoacoustics/ magnetic resonance imaging andpH-responsive photothermal tumor ablation. The nanocomposites exhibit remarkabletrimodal imaging features with high imaging sensitivity, precise anatomical localization,and enhanced spatial resolution for comprehensive tumor detection and treatmentguidance. Meanwhile, Cy-GdNCs exhibit pH-responsive photothermal effect throughpH-dependent non-radiative transition upon near-infrared irradiation, which triggersevere cell damage in lysosomal environment after their enhanced endocytosis, and
thus generate effective photothermal efficacy with tumor ablation. The nanocompositesas a nanoplatform can also biomineralize other metal nanocrystals and simultaneouslyintegrate various functional organic molecules for extensive theranostic applications.Our proof-of-concept design of nanocomposites represents a novel approach for bothmultimodal imaging and cancer therapy, which may provide new insights towardsprecise cancer theranostics.
2. A theranostic prodrug delivery system based on Pt(IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug
J. W. Li, Z. L.Lyv, Y. L. Li, H. Liu, J. K. Wang, W. J. Zhan,H. Chen,*H. B. Chen,* X. M. Li.*
Biomaterials, 2015, 51, 12-21
Abstract: Due to their high NIR-optical absorption and high specific surface area, graphene oxide and graphene oxide-based nanocomposites have great potential in both drug delivery and photothermal therapy. In the work reported herein we successfully integrate a Pt(IV) complex (c,c,t-[Pt(NH3)2Cl2(OH)2]), PEGylated nano-graphene oxide (PEG-NGO), and a cell apoptosis sensor into a single platform to generate a multifunctional nanocomposite (PEG-NGO-Pt) which shows potential for targeted drug delivery and combined photothermal-chemotherapy under near infrared laser irradiation (NIR), and real-time monitoring of its therapeutic efficacy. Non-invasive imaging using a fluorescent probe immobilized on the GO shows an enhanced therapeutic effect of PEG-NGO-Pt in cancer treatment via apoptosis and cell death. Due to the enhanced cytotoxicity of cisplatin and the highly specific tumor targeting of PEG-NGO-Pt at elevated temperatures, this nanocomposite displays a synergistic effect in improving the therapeutic efficacy of the Pt drug with complete destruction of tumors, no tumor recurrence and minimal systemic toxicity in comparison with chemotherapy or photothermal treatment alone, highlighting the advantageous effects of integrating Pt(IV) with GO for anticancer treatment.
