报告题目：“Thinking, Interactive, and Productive” to win the competition in neuroendocrine axis."

报 告 人：赵晟 博士  (Lance J. Kriegsfeld教授的实验室Associate specialist，美国加州大学伯克利分校心理学系，Helen Wills神经科学研究所，神经生物学研究实验室)

报告时间：2012年9月7日（星期五）下午3：00

报告地点：独墅湖校区二期药学院云轩楼2301室

报告摘要：

Neuroendocrine axes provide ideal tractable model systems organized hierarchically involving multiple organs including nervous system and periphery to regulate biological processes and behavior, such as sexual motivation, reproductive behaviors, stress responsiveness, mood and emotions, energy storage and expenditure, etc. As a very active scientific field, the related researches expand our knowledge about how the nervous system and the periphery coordinate to maintain homeostasis and achieve optimal biological functioning. The investigation also provides the fundamental principle and experimental supports for new drug design, disease treatment, and heath care.

My primary research interests are the neural and endocrine mechanisms that drive motivated behaviors and their underlying physiology, as well as the pathological changes. My work investigates interactions among the circadian, nervous, endocrine, and reproductive systems. I will use the well-established animal models and genetic tools combining biochemical, molecular and behavioral approaches to study the mechanisms and interactions involved in the neuroendocrine and the master circadian pacemaker, the suprachiasmatic nucleus (SCN) of the anterior hypothalamus.

赵晟简介：

1993-1997：四川大学生物化学系本科   生物化学专业           

1995：国家高级程序员考试认证软件工程师 

1997- 2002: 中国科学院上海生命科学院生物化学及细胞生物学研究所分子生物学实验室，宋建国教授的实验室生物化学和分子生物学专业博士研究生（研究涉及领域：信号传导；生物化学；细胞分子生物学）

2003-2006：美国斯坦福大学人文科学学院心理学系和生物学系Russell D. Fernald教授的实验室博士后（研究涉及领域：神经生物学；内分泌学；行为学；生殖生物学；细胞分子生物学）

2006-现在：Lance J. Kriegsfeld教授的实验室Associate specialist，美国加州大学伯克利分校心理学系，Helen Wills神经科学研究所，神经生物学研究实验室（研究涉及领域：神经生物学；内分泌学；行为学；生殖生物学；癌症研究和细胞分子生物学）

代表性论文：

1.       Zhao S, Kelm RJ Jr, Fernald RD (Mar 2010) Regulation of Gonadotropin Releasing Hormone 1 Gene Transcription by Members of the Purine-Rich Element Binding Protein Family., American Journal of Physiology. Endocrinology and Metabolism, 298(3), E524-533.

2.       Zhao S, Zhu E, Yang C, Bentley GE, Tsutsui K, and Kriegsfeld LJ (Feb 2010) RFamide-Related Peptide and Messenger Ribonucleic Acid Expression in Mammalian Testis: Association with the Spermatogenic Cycle., Endocrinology, 151(2), 617-627.

3.       Zhao S and Kriegsfeld LJ (Jan 2009) Daily changes in GT1–7 cell sensitivity to GnRH secretagogues that trigger ovulation., Neuroendocrinology, 89(4), 448-457.

4.       Zhao S, Korzan WJ, Chen CC, Fernald RD (Jan 2008) Heterogeneous nuclear ribonucleoprotein A/B and G inhibits the transcription of gonadotropin releasing hormone 1., Molecular and cellular neuroscience, 37(1), 69-84.

5.       Zhao S* and Fernald RD. (Oct 2005) Comprehensive algorithm for quantitative real-time polymerase chain reaction. Journal of Computational Biology. 12(8), 1045-1062.

6.       Zhao S, Yang YN, Song JG. (Apr 2004) Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells. Journal of Cellular Physiology. 199(1), 47-56.

7.       Zhao S, Du XY, Chen JS, Zhou YC, Song JG. (Oct 2002) Secretory phospholipase A(2) inhibits epidermal growth factor-induced receptor activation. Experimental Cell Research. 279(2), 354-364.

8.       Zhao S, Du XY, Chai MQ, Chen JS, Zhou YC, Song JG. (Apr 2002) Secretory phospholipase A(2) induces apoptosis via a mechanism involving ceramide generation. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 1581(3), 75-88.

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