报告题目：Functional Role of Stem Cell Markers in Hypoxia-mediated Prostate Cancer Metastasis
报 告人：戴垚博士（佛罗里达大学放疗系）
报告时间：2012年10月15日（星期一）下午2:00
报告地点：独墅湖校区二期云轩楼2301会议室

报告人简介
戴垚于2005年毕业于中国医学科学院，中国协和医科大学医药生物技术研究所，师从甄永苏院士。2006至2008年于密歇根大学放疗系从事博士后研究，2008年起在佛罗里达大学放疗系工作至今。主要研究方向为前列腺癌放疗增敏剂的研发；乏氧促进肿瘤转移的机制研究及靶向抑制信号转导分子对肿瘤转移的疗效评价等。在美期间共发表文章14篇，参与书籍撰写4部，并担任1种学术期刊的编委和9种学术期刊的审稿人。戴垚目前为美国癌症协会会员， 曾多次参加国际学术会议并做口头或海报报告，并于2010年国际肿瘤微环境会议上获得青年学者奖。至今戴垚参与了数10类课题的申请，目前为2项课题的共同负责人。

代表性论文：

1. 1.       Dai Y, Bae K, Pampo C & Siemann DW. Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation. Clin Exp Metastasis, 2012, 29: 253–261.
2. 2.       Dai Y, Bae K & Siemann DW. Impact of hypoxia on the metastatic potential of human prostate cancer cells. Int J Radiat Oncol Biol Phys, 2011, 81(2): 512-528 (Highlighted)
3. 3.       Dai Y, DeSano J, Tang WH, et al.  Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB. PLoS ONE, 2011, 5(12): e14153
4. 4.       Dai Y, DeSano J, Qu Y, et al. Natural IAP inhibitor embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer. Am J Cancer Res, 2011, 1(2): 128-143
5. 5.       Bae K, Parker NN, Dai Y, et al. E-cadherin plasticity in prostate cancer stem cell invasion. Am J Cancer Res, 2011, 1(1): 71-84
6. 6.       Dai Y & Siemann DW. BMS-777607, a small-molecule Met kinase inhibitor, suppresses hepatocyte growth factor–stimulated prostate cancer metastatic phenotype in vitro. Mol Cancer Ther, 2010, 9(6): 1554-1561.
7. 7.       Dai Y, Liu ML, Pienta K, et al. A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB. BMC Cancer, 2009, 9: 392-407
8. 8.       Dai Y, Desano J, Meng Y, et al. Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer. Int J Radiat Oncol Biol Phys, 2009, 74(4): 1217–1225
9. 9.       Dai Y, Lawrence TS & Xu L. Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B (Review). Am J Transl Res, 2009, 1(1): 1-15
10. 10.   Dai Y, Liu ML, Tang WH, et al. Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis. Clin Cancer Res, 2008, 14(23): 7701-7710
11. 11.   Meng Y, Tang WH, Dai Y, et al. Natural BH3-mimetic chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. Mol Cancer Ther, 2008, 7(7): 2192-2202