张利生, 山东聊城市人。2004年在中科院动物研究所获得理学博士学位,方向为体细胞重编程回复全能性的研究。之后在美国安利集团所属的Van Andel研究所,Loyola University Chicago试验药理学系工作。现在希望之城洛杉矶国家医学中心从事针对肝脏病理生理信号通路及肝癌诊断治疗的基础及应用基础研究。该医疗中心是美国国立癌症研究院(National Cancer Institution)指定的40所癌症综合中心之一,也是美国国立综合癌症网络的创立会员和中央数据协调中心。希望之城国家医疗中心以领先的临床治疗技术和创新的基础研究转化工作而闻名。曾在1978合成人胰岛素并拥有该项技术的世界专利。其本人已发表24篇科研论文。三篇文章的影响因子>10。是包括Xenotransplantation, World Journal of Gastroenterology, Journal of Genetics and Genomics 等国际知名SCI期刊的特邀审稿人。
代表性论文:
1.Zhang L, Yang L, Liu X, Chen W, Chang L, Chen L, Loera S, Chu P, Huang W, Liu Y, Yen Y.MiR-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1.Hepatology. 2012 doi: 10.1002/hep.26162(IF2011=11.665)
2.Zhang L, Wang YD, Chen WD, Wang X, Lou G, Liu N, Lin M, Forman BM, Huang W. Promotion of Liver regeneration/repair by Farnesoid X Receptor in both liver and intestine in mice. Hepatology 2012 56:2336-2343(IF2011=11.665)
3.Zhang L, Huang X, Meng Z, Dong B, Shiah S, Moore DD, Huang W. Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol. 2009 23:137-145.(IF2009=5.257)
4.Zhang L, Li T, Yu D, Forman BM, Huang W. FXR protects lung from LPS induced acute injury. Mol Endocrinol. 2012 26:27-36(IF2011=4.544)
5.Zhang L, Kang L, Bond W, Zhang N. (2009) Interaction between syntaxin 8 and HECTd3, a HECT domain ligase. Cell Mol Neurobiol. 29(1):115-121. (IF2009=2.107)
6.Wei-Dong Chen , Yan-Dong Wang , Lisheng Zhang, Steven Shiah, Meihua Wang a, Fan Yang, Donna Yu, Barry M. Forman, Wendong Huang. (2010) Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating Foxm1b transcription. Hepatology. 51(3):953-962(IF2010=10.840)