Nano/micro-particulate delivery systems can provide a few functionalities to bio-actives, e.g. targeted delivery, extended effects, improved stability, enhanced solubility, enhanced bioavailability and reduced side effects. Mechanistic understanding of the formation of the nano/micro-particulates and their interaction with bio-environment is crucial for rational design of these delivery systems. My research interests include understanding physical and chemical mechanisms that determine the engineering of aforementioned particulate delivery systems with optimal functionalities, the interplay between the particulate delivery systems and bio-membranes or cells, as well as the mechanisms that control the release of the bio-actives. The goal is to rationally design nano/micro-particulates for optimal delivery of various bio-actives including small molecules, proteins, peptides and siRNA via different administration routes like pulmonary, peroral and injection. The engineering technologies include emulsion solvent diffusion method, spray-drying, electrohydrodynamics, spray-freeze drying and high pressure homogenization6
