[6-26]Ca2+-activated ion channels: Structure, function and diseases

学术报告

[6-26]Ca2+-activated ion channels: Structure, function and diseases

时间：2013-06-25来源：苏州大学药学院本科教学网点击：0

报告题目：Ca²⁺-activated ion channels: Structure, function and diseases
报告人：Huanghe Yang博士（Postdoctoral Scholar, University of California, San Francisco）
报告时间：2013年6月26日（星期三）9:30
报告地点：独墅湖校区二期云轩楼2301室

Huanghe Yang博士简历

●Education / Training

INSTITUTION AND LOCATION	DEGREE (if applicable)	MM/YY	FIELD OF STUDY
Zhengzhou University, Zhengzhou, China	B.S.	09/91-07/95	Chemistry
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China	M.S.	09/98-07/01	Physical Chemistry
Case Western Reserve University, Cleveland, OH	N/A	08/02-08/03	Chemistry
Case Western Reserve University, Cleveland, OH (Mentor: Jianmin Cui)	N/A	09/03-07/04	Biomedical Engineering
Washington University, Saint Louis, MO (Mentor: Jianmin Cui)	Ph.D.	08/04-05/08	Biomedical Engineering
Univ. of California, San Francisco, CA (Mentor: Lily Yeh Jan)	Postdoc	12/08-Present	Physiology

●Positions and Employment

1995-1998 Chemical engineer, Nanyang Institute of Commodity Inspection, Nanyang, China

2001-2002 Assistant Professor, Dalian Institute of Chemical Physics

Chinese Academy of Sciences, Dalian, China

2008.06-11 Research Associate, Lab of Jianmin Cui, the Cardiac Bioelectricity and Arrhythmia Center

Department of Biomedical Engineering,Washington University, Saint Louis, MO

●Selected peer-reviewed publications

1. Sun, X., Shi, J., Delaloye, K., Yang, X., Yang, H., Zhang, G., Cui, J. (2013). The interface between membrane-spanning and cytosolic domains in BK channels is involved in b subunits modulation of gating. J. Neurosci. (Accepted).

2. Yang, J., Yang, H., Sun, X., Delaloye, K., Yang, X, Moller, A., Shi, J., Cui, J. (2013). Interaction between residues in the Mg2+-binding site regulates BK channel activation. J. Gen. Physiol. 141:217-28. PMID: 23359284.

3. Yang, H.*, Kim, A.*, David, T., Palmer, D., Jin, T., Tien, J., Huang, F., Cheng, T., Coughlin, S. ., Jan, Y.N., and Jan, L.Y. (2012). TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.Cell PMID: 23021219. Feature as PaperFlick in Cell (http://www.cell.com/abstract/S0092-8674%2812%2901104-X#Summary). (* equal contribution).

4. Huang, F., Zhang, H., Wu M., Yang, H., Kudo, M., Peters, CJ, Woodruff, P.G., Solberg, O.D., Donne, M.L., Huang, X., Sheppard, D., Fahy, J.V., Wolters, P.J., Hogan, B.L.M., Finkbeiner, W.E., Li, M., Jan, Y.N., Jan, L.Y., and Rock, J.R. (2012). TMEM16A-CaCC modulates mucin secretion and airway smooth muscle contraction. Proc. Natl. Acad. Sci. U S A. 109(40):16354-9. PMID: 22988107.

5. Berg, J., Yang, H., and Jan, L.Y. (2012). Ca²⁺-activated Cl^- channels at a glance. J. Cell Sci. 125, 1367-1371.PMID: 22526416.

6. Yang, J.*, Krishnamoorthy, G.*, Saxena, A.*, Zhang, G., Shi, J., Yang, H., Delaloye K., Sept D. & Cui J. An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca²⁺ sensing. Neuron 66, 871-83 (2010). PMID: 20620873.(* equal contribution).

7. Cui, J., Yang, H. & Lee, U. Molecular mechanisms of BK channel activation. Cell. Mol. Life Sci. 66, 852-75 (2009). PMID: 19099186.

8. Yang, H., Shi, J., Zhang, G., Yang, J. Delaloye, K. & Cui, J. Activation of Slo1 BK channels by Mg²⁺ coordinated between the voltage sensor and the RCK1 domains. Nat. Struct. Mol. Biol. 15, 1152-9 (2008). PMID: 18931675.

9. Yang, H.*, Zhang, G.*, Shi, J., Lee, U., Delaloye, K. & Cui, J. Subunit-specific Effect of the Voltage Sensor Domain on Ca²⁺ Sensitivity of BK Channels. Biophys. J. 94, 4678-87 (2008). PMID:18339745.(* equal contribution).

10. Yang, H.*, Hu, L.*, Shi, J., Delaloye, K., Horrigan, F. T., & Cui, J. Mg²⁺ Mediates Interaction between the Voltage-Sensor and Cytosolic Domain to Activate BK channels. Proc. Natl. Acad. Sci. U S A. 104 18270-75 (2007). PMID: 17984060. (* equal contribution).

11. Yang, H.*, Hu, L.* B. S., Shi, J. & Cui, J. Tuning Magnesium Sensitivity of BK Channels by Mutations. Biophys. J. 91, 2892-900 (2006). PMID: 16877509.(* equal contribution).

12. Hu, L., Yang, H., Shi, J. & Cui, J. Effects of Multiple Metal Binding Sites on Calcium and Magnesium-dependent Activation of BK Channels. J. Gen. Physiol. 127, 35-50 (2006). PMID: 16344323.

13. Du, W.*, Bautista, J. F.*, Yang, H., Diez-Sampedro, A., You, S. A., Wang, L., Kotagal, P., Luders, H. O., Shi, J., Cui, J., Richerson, G. B. & Wang, Q. K. Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nat. Genet. 37, 733-8 (2005). PMID: 15937479. (* equal contribution).

●Patent

Yang, H., Tian, H., Xu, D., Sun, X. & Zhang, T., A Silver-based Catalyst for High-efficient Hydrogen Peroxide Decomposition, Chinese Patent: 00-1-14830.3 (2001).