报告题目：SUMO化修饰中枢神经系统作用研究进展
报 告 人：李勇（上海交通大学医学院教授）
报告时间：2016年6月7日（星期二）下午4:00
报告地点：苏州金陵观园国际酒店文源厅

李勇教授介绍

Research Interests
Trafficking and regulation of ion channels and receptors

Education
Jul. 2003 Ph.D. in Neuroscience，Department of Neurobiology & Biophysics, University of Science and Technology of China, Hefei, Anhui, China
Jul. 1999 Master’s Degree in Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, Jiangsu, China

Editorial Activities
2011-present Editorial Board Member | International Journal of Biochemistry and Molecular Biology

Research Experience
Mar. 2009 – Present
Professor
Department of Biochemistry and Molecular Cell Biology,Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine Shanghai,China
Jul. 2006 – Mar. 2009
Research Associate
Research on function and regulation of neuronal ionchannels and “BDNF hypothesis” of Rett Syndrome at Department of Neurobiology, Evelyn F. McKnight Brain
Institute and Civitan International Research Center, School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA
Jan. 2004 – Jun. 2006
Postdoctoral Fellow
Research on function and regulation of neuronal ionchannels at Department of Neurobiology, Evelyn F.McKnight Brain Institute and Civitan International Research
Center, School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA
Jul. 2003 – Dec. 2003
Postdoctoral Fellow
Research on synaptic plasticity and glutamate receptor at Department of Brain and Cognitive Neuroscience, Massachusetts Institute of Technology, Cambridge, Massachusetts

Awards and Honors
2008 Post Doctoral Fellowship Awards International Rett Syndrome Foundation
2004 The Excellent Doctoral Dissertation, Chinese Academy of Sciences
2004 The Postdoctoral Career Enhancement Award, University of Alabama at Birmingham, USA
2003 Outstanding Fellow, International Brain Research Organization
2003 President Scholarship Award, Chinese Academy of Sciences
2003 Outstanding Graduate Students, University of Science and Technology of China
2002 Qiushi Scholarship, Qiu Shi Science & Technologies Foundation

Selected Publications (# Corresponding Author)
1. Wang Y, Wang Y, Zhang H, Gao Y, Huang C, Zhou A, Zhou Y, Li Y#. (2016).Sequential posttranslational modifications regulate PKC degradation. Mol Biol Cell. 27:410-20.
2. Liu F, Zhou Q, Zhou J, Sun H, Wang Y, Zou X, Feng L, Hou Z, Zhou A, Zhou Y, Li Y#. (2015). 14-3-3 promotes surface expression of Cav2.21B Ca2+ Channels. Journal of Biological Chemistry. 290:2689-2698.
3. Sun H, Lu L, Zuo Y, Wang Y, Jiao YF, Zeng WZ, Huang C, Zhu MX, Zamponi GW,Zhou T, Xu TL, Cheng JK, Li Y#. (2014). Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation. Nature Communications. 5:4980 doi: 10.1038/ncomms5980.
4. Song DD, Li Y, Tang D, Huang LY, Yuan YZ. (2014). Neuron-glial communication mediated by TNF-α and glial activation in dorsal root ganglia in visceral inflammatory hypersensitivity. Am J Physiol Gastrointest Liver Physiol. 306:G788-95.
5. Yang R, Cui HJ, Wang H, Wang Y, Liu JH, Li Y, Lu Y. (2014). N-stearoyltyrosine protects against glutamate-induced oxidative toxicity by an apoptosis-inducing factor (AIF)-mediated caspase-independent cell death pathway. J Pharmacol Sci. 124:169-179.
6. Sun C, Qiao H, Zhou Q, Wang Y, Wu Y, Zhou Y, Li Y#. (2013). Modulation of GluK2a Subunit-containing Kainate Receptors by 14-3-3 Proteins. Journal of Biological Chemistry. 288:24676-90.
7. Huang C, Li WG, Zhang XB, Wang L, Xu TL, Wu D, Li Y#. (2013). Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABA receptors. Neuropharmacology. 65:1-11.
8. Wang L, Li WG, Huang C, Zhu MX, Xu TL, Wu DZ, Li Y#. (2012). Subunit-specific inhibition of glycine receptors by curcumol. Journal of pharmacology and experimental therapeutics. 343:371-379.
9. Li Y#*, Liu X*, Wu Y*, Xu Z, Li H, Griffith LC, Zhou Y#. (2011). Intracellular regions of the eag potassium channel play a critical role in generation of voltage-dependent currents. Journal of Biological Chemistry. 286:1389-1399.
10. Zeng WZ, Liu DS, Duan B, Song XL, Wang X, Wei D, Jiang W, Zhu MX, Li Y, Xu TL. (2013). Molecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death. Journal of
Neuroscience. 33:7066-7078.
11. Qian A, Song D, Li Y, Liu X, Tang D, Yao W, Yuan Y. (2013). Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid. Mol Pain. 9:15
12. Wang H, Jiang W, Yang R, Li Y. (2011). Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain. NeuroReport. 22:244-248.
13. Li Y, Calfa G, Inoue T, Amaral MD, Pozzo-Miller L. (2010). Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons. Journal of Neurophysiology. 103:2846-2856.
14. Gong N, Li Y, Cai GQ, Niu RF, Fang Q, Wu K, Chen Z, Lin LN, Xu L, Fei J, Xu TL. (2009). GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation. Journal of Neuroscience.
29:15836-15845. (highlighted in “Faculty of 1000”, 2009) 15. Lu R*, Li Y*, Zhang Y*, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q. (2009). Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is due to ligand-selective internalization. Journal of Biological Chemistry. 284:13233-43. (*co-first author)
16. Li Y, Wu Y, Li R, Zhou Y. The role of 14-3-3 dimerization in its modulation of the CaV2.2 Channel. Channels, 2007, 1:1, e1-e2
17. Li Y, Wu Y, Zhou Y. Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins. Neuron, 2006, 51: 755-771. (highlighted in “Faculty of 1000”, 2006).
18. Li Y, Wu LJ, Legendre P, Xu TL. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. Journal of Biological Chemistry, 2003, 278:38637-38645.
19. Li Y, Li YF, Xu TL. Amiloride inhibition of glycinergic mIPSCs in mechanically dissociated rat spinal neurons. Neuroscience Letters, 2003, 349:17-20.
20. Li Y, Xu TL. State-dependent cross-inhibition between anionic GABAA and glycine ionotropic receptors in rat hippocampal neurons. NeuroReport, 2002, 13:223-226.
21. Wu LJ, Li Y, Xu TL. Corelease and interaction of two inhibitory cotransmitters in rat sacral dorsal commissural neurons. NeuroReport, 2002, 13:977-981.
22. Li YF, Wu LJ, Li Y, Xu TL. Mechanisms of proton modulation of glycinergic response in rat sacral dorsal commissural neurons. The Journal of Physiology (London), 2003, 552: 73-87.
23. Li YF, Li Y, Xu TL. Inhibition of glycine response by amiloride in rat spinal neurons.Neuroscience Letters, 2003, 345:173-176.
24. Pei L, Li Y, Zhang GY, et al. Mechanisms of regulation of tyrosine phosphorylation of NMDA receptor subunit 2B after cerebral ischemia/reperfusion. Acta Pharmacologica Sinica, 2000, 21:695-700.
25. Pei L, Li Y, Zhang GY, et al. Changes and mechanisms of protein-tyrosine kinase and protein-tyrosine phosphatase activities after brain ischemia/reperfusion. Acta Pharmacologica Sinica, 2000, 21:715-720.