Xinchen Teng, Ph.D.

Associate Professor

Department of Biopharmaceutical Sciences

Email: xcteng@suda.edu.cn

Biosketch

q  Education

05/2010 – 09/2013

Postdoctoral fellow in the Department of Molecular Microbiology & Immunology, Johns Hopkins University, School of Public Health, USA 

09/2004 – 05/2010

Ph.D. in Biochemistry, Cellular and Molecular Biology, Johns Hopkins University, School of Medicine, USA 

09/2001 – 06/2004  

Master in Bioinorganic Chemistry, Fudan University, China 

09/1998 – 06/2001

Bachelor in Chemistry, Fudan University, China

q  Work experience

10/2013 – present   

Associate Professor, Soochow University College of Pharmaceutical Sciences, China

q  Honors and awards

12/2022  First Prize in Teaching Competition for International Students in Jiangsu Province

12/2021  Advanced Individual in Educational Management of Foreign Students in Jiangsu Province

08/2020  Second Prize in Undergraduate Teaching Competition in Jiangsu Province

12/2015  First Prize in the 14th Teaching Competition of Soochow University

09/2014  Doctors' Program of Jiangsu Province, China

06/2011  Election to the Phi Beta Kappa Society, USA

Research Interests

Dr. Teng's lab is mainly engaged in the study of nutrient-sensing pathways controlling cell growth and programmed cell death mechanisms. These pathways have significant implications for understanding diseases, including cancer and neurodegeneration.

Research Fund

q  Screening and mechanism study of novel TORC1 regulators that sense specific amino acid signals. National Natural Science Foundation of China (31970550, 01/2020-12/2023) 

q  The role of KCTD proteins in regulating TORC1 signaling pathway and tumorigenesis. National Natural Science Foundation of China (31401197, 01/2015-12/2017) 

q  Regulation of TORC1 by KCTD11. Natural Science Foundation of Jiangsu Province (BK20140318, 07/2014-06/2017)

Select Publications

q  Research articles

Stolp ZD, Kulkarni M, Liu Y, Zhu C, Jalisi A, Lin S, Casadevall A, Cunningham KW, Pineda FJ, Teng X, Hardwick JM* (2022) Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization, Cell Rep. 39:110647 

Yang X, Wang G, Cao T, Zhang L, Ma Y, Jiang S, Teng X, Sun X* (2019) Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia, J Biol Chem. 294, 12921-12932. 

Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM (2018) KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect, Ann Neurol. 84, 766-780 

Chen X, Wang G, Zhang Y, Dayhoff-Brannigan M, Diny NL, Zhao M, He G, Sing CN, Metz KA, Stolp ZD, Aouacheria A, Cheng WC, Hardwick JM*, Teng X* (2018) Whi2 is a conserved negative regulator of TORC1 in response to low amino acids, PLoS Genetics. 14, e1007592 

Teng X, Dayhoff-Brannigan M, Cheng W-C, Gilbert CE, Wheelan SJ, Dunham MJ, Boeke JD, Pineda FJ and Hardwick JM (2013) Genome-wide consequences of deleting any single gene, Mol Cell. 52, 485-494

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM (2011) Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential, J Cell Biol.195, 263-76 

Teng X, Cheng W-C, Qi B, Yu T-X, Ramachandran K, Boersma MD, Hattier T, Lehmann PV, Pineda FJ and Hardwick JM (2011) Gene-dependent cell death in yeast, Cell Death Dis.2, e188 

Cheng W-C, Teng X, Park HK, Tucker CM, Dunham MJ and Hardwick JM (2008) Fis1-deficiency selects for compensatory mutations responsible for cell death and growth control defects, Cell Death Differ. 15, 1838-1846 

q  Reviews

Teng X, Aouacheria A, Lionnard L, Metz KA, Soane L, Kamiya A, Hardwick JM* (2019) KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders, CNS Neurosci Ther. 25, 887-902. 

Teng X* and Hardwick JM* (2018) Whi2: a new player in amino acid sensing, Curr Genet. 65, 701-709. 

Teng X, Yau E, Sing C, Hardwick JM (2018) Whi2 signals low amino acid availability to halt yeast growth and cell death, FEMS Yeast Res. 18, foy095 

Teng X* and Hardwick JM* (2015) Cell death in genome evolution, Semin Cell Dev Biol. 39, 3-11 

Teng X* and Hardwick JM* (2014) Genome evolution in yeast reveals connections between rare mutations in human cancers, Microb Cell. 1, 206-209 

Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM and White K (2010) Mitochondrial involvement in cell death of non-mammalian eukaryotes, Biochim Biophys Acta. 1813, 597-607  

Teng X and Hardwick JM (2010) The apoptosome at high resolution, Cell. 141, 404-406 

q  Book Chapters

Teng X and Hardwick JM (2013) The extrinsic cell death pathway, Molecular Oncology. 353-366 

Teng X and Hardwick JM (2013) Quantification of genetically controlled cell death in budding yeast, Methods Mol Biol.1004, 161-70 

Teng X and Hardwick JM (2009) Reliable method for detection of programmed cell death in yeast, Methods Mol Biol. 552, 335-342