Haigang Ren
Haigang Ren, Ph.D.
Professor
Department of Pharmacology
Email: rhg@suda.edu.cn
Biosketch
q Education
2001-2005 Southwest University of Science and Technology, B.S.
2005-2010 University of Science and Technology of China, Ph.D.
q Work experience
2010-2012 Southwest University of Science and Technology, Lecturer
2012-2013 Soochow University, Lecturer
2013-2021 Soochow University, Associate Professor
2021-Now Soochow University, Professor
q Honors and awards
2017 Suzhou Science and Technology Progress Award, Second Prize
2021 Suzhou Medical Association Medical Science and Technology Award, First Prize
2021 Acta Pharmacologica Sinica Outstanding Paper Awards
Research Interests
q Pathological mechanism and neuropharmacological research of Parkinson's disease
q Functions and molecular mechanisms of neurodegenerative disease-related proteins
q Screening of small molecule compounds with neuroprotective effect
Research Fund
2022-2025 National Natural Sciences Foundation of China (32170987) ￥58,0000
2020-2023 National Natural Sciences Foundation of China (31970966) ￥58,0000
2015-2018 National Natural Sciences Foundation of China (31471012) ￥80,0000
2012-2014 National Natural Sciences Foundation of China (31100768) ￥22,0000
Select Publications
[1] Lin Z, Chen C, Yang D, Ding J, Wang G*, Ren H*,DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65,Cell Death Dis, 12(2021): 715
[2] Ren H#, Zhai W#, Lu X*, Wang G*,The Cross-Links of Endoplasmic Reticulum Stress, Autophagy, and Neurodegeneration in Parkinson's Disease,Front Aging Neurosci, 13(2021): 691881.
[3] Xu Q#, Zhang SS#, Wang RR, Weng YJ, Cui X, Wei XT, Ni JJ, Ren HG*, Zhang L*, Pei YF*, Mendelian Randomization Analysis Reveals Causal Effects of the Human Gut Microbiota on Abdominal Obesity,J Nutr, 151(2021) 1401-1406.
[4]Wang R, Sun H, Ren H*, Wang G*, α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome,Sci China Life Sci. 63(2020) 1850-1859.
[5] X Xu#, R Wang#, Z Hao, G Wang, C Mu, J Ding, W Sun*, H Ren*, DJ-1 regulates tyrosine hydroxylase expression through CaMKKβ/CaMKIV/CREB1 pathway in vitro and in vivo,J Cell Physiol, 235 (2020) 869-879.
[6]Wang R#, Sun H#, Wang G*, Ren H*. Imbalance of Lysine Acetylation Contributes to the Pathogenesis of Parkinson's Disease,Int J Mol Sci, 21(2020):7182.
[7] D.K. Guo#, Y. Zhu#, H.Y. Sun, X.Y. Xu, S. Zhang, Z.B. Hao, G.H. Wang, C.C. Mu, H.G. Ren*, Pharmacological activation of REV-ERBalpha represses LPS-induced microglial activation through the NF-kappaB pathway, Acta Pharmacol Sin, 40 (2019)26-34.
[8] D. Wu, Z. Hao, H. Ren*, G. Wang*, Loss of VAPB Regulates Autophagy in a Beclin 1-Dependent Manner, Neurosci Bull, 34 (2018) 1037-1046.
[9] D. Guo#, S. Zhang, H. Sun, X. Xu, Z. Hao, C. Mu, X. Xu, G. Wang*, H. Ren*, Tyrosine hydroxylase down-regulation after loss of Abelson helper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice, J Biol Chem, 293 (2018) 5090-5101.
[10] D. Chen#, Y.P. Li#, Y.X. Yu, T. Zhou, C. Liu, E.K. Fei, F. Gao, C.C. Mu, H.G. Ren*, G.H. Wang*, Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells, Acta Pharmacol Sin, 39 (2018) 597-606.
[11] Y.F. Pei#, H.G. Ren#, L. Liu, X. Li, C. Fang, Y. Huang, W.Z. Hu, W.W. Kong, A.P. Feng, X.Y. You, W. Zhao, H. Shen, Q. Tian, Y.H. Zhang, H.W. Deng*, L. Zhang*, Genomic variants at 20p11 associated with body fat mass in the European population, Obesity, 25 (2017) 757-764.
[12] K. Fu#, Y. Wang#, D. Guo, G. Wang*, H. Ren*, Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2,Neurosci Bull, 33 (2017) 685-694.
[13] D. Guo, Z. Ying, H. Wang, D. Chen, F. Gao, H. Ren*, G. Wang*, Regulation of autophagic flux by CHIP, Neurosci Bull, 31 (2015) 469-479.
[14] H. Ren, K. Fu, C. Mu, X. Zhen, G. Wang*, L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL, Mol Neurodegener, 7 (2012) 40.
[15] H. Ren, K. Fu, D. Wang, C. Mu, G. Wang*, Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL, J Biol Chem, 286 (2011) 35308-35317.
[16] H. Ren, K. Fu, C. Mu, B. Li, D. Wang, G. Wang*, DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells, Cancer Lett, 297 (2010) 101-108.
[17] J. Fan#, H. Ren#, E. Fei, N. Jia, Z. Ying, P. Jiang, M. Wu, G. Wang*, Sumoylation is critical for DJ-1 to repress p53 transcriptional activity, FEBS Lett, 582 (2008) 1151-1156.