Zhenqing Zhang
Zhenqing Zhang Ph.D.
Professor
Department of Pharmaceutical Analysis
Email: z_zhang@suda.edu.cn
Biosketch
q Education
1996.09-2000.06, Ocean University of China, Bachelor
2000.09-2006.06, Ocean University of China, Ph. D.
q Work experience
2006.08-2009.10, Rensselaer Polytechnic Institute, Postdoc.
2009.10-2012.08, Baxter Healthcare, Research Scientist
2012.08-current, Soochow University, Professor
q Honors and awards
2012, Jiangsu Specically-appointed Professor
2013, Jiangsu Innovative and Entrepreneurial Talent
2017, Jiangsu “Six Top Talents”
2021, China Biochemical Pharmaceutical Industry Association (CBPIA) “Zhang Tianmin Carbohydrate drug Outstanding Young Sicentist”
Research Interests
q Quality Control, structural modification and new application of Heparins
Heparin related medicines inludes heparin, low molecular weight heparins, synthetic heparin oligosaccharides, Sulodexide, etc. They are all carbohydrate drugs with complicated compositions, structures and sequences, while they are widely used as anticoagulants in clinic. China is the major country to produce and export raw materials and API. The final products has also formed scales in China. Thus, they are very important medicines. Our lab has very rich experiences about heparin related materials, and we have helped several companies to get LMWHs production approved. Now we still focus on the innovative developments about new analytical methods, quality control, structural elucidation, strucutural modifications and new applications of them.
q Development of Carbohydrate drugs with chemical modification
Another research interest of our lab is development of carbohydrate drugs. We have deeply participated in the development of oligomannate, one of the most famous anti-AD medicines. We are now developing different oligouronic acid drugs for neuron-protection, oxidized maltose to carry Fe, some polysaccharide-based pharmaceutical excipients and so on.
q Structure activity relationship of TCM polysaccharides
The third interest of our lab is structure activity relationship of TCM polysaccharides. Polysaccharide is one of the most important active ingredients in TCM. The complexity of their structure and functional mechanism limit their applications. Our lab focuses on the elucidation of the complicated structures and the relationships between the structure and anti-biabetes, anti-inflammation, anti-oxidation, anti-cancer, et.al.
Research Funds
1. National Natural Science Foundation of China, Glycomics in heparin related drugs, (81673388), PI
2. National Natural Science Foundation of China, Sequencing analysis of complex proteoglycans, (81473179), PI
3. Jiangsu Specially appointed Professor funding, PI
4. Funds from industrial areas.
Selected Publications
1. W. Zhu, L. Chen, N. Yan, L. Yi, Y. Sun, Y. Ouyang, D. Liu, Z. Zhang*, Sequencing analysis of heparin reducing terminals with orthogonal chromatographic approaches, Journal of Chromatography A. 2022, 1677, 463318.
2. N. UI Ain, S. Wu, X. Li, D. Li, Z. Zhang*, Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review, Materials, 2022, 15, 3654.
3. F. Wu, N. Yan, Y. Guo, X. Yu, L. Yi, Y. Ouyang, X. Wang, Z. Zhang*, Pattern of Specific Oxidation of Konjac Glucomannan with TEMPO/NaBr/ NaClO system, Carbohdyrate Research, 2022, 515, 108558.
4. L. Chen, W, Zhu, N. Yan, Y. Guo, L. Yi, Y Ouyang, Z. Zhang*,Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS, Jounral of Pharmaceutical and Biomedical Analysis, 2022, 212, 114616
5. J. Lu, Q. Pan, J. Zhou, Y. Weng, K. Chen, L. Shi, G. Zhu, C. Chen, L. Li, M. Geng, Z. Zhang*, Pharmacokinetics, distribution and excretion study of sodium oligomannate, a recently approved anti-Alzheimer’s disease drug in China, Jounral of Pharmaceutical Analysis. 2022, 12, 145-155.
6. L. Chen, Y. Ouyang, N. Yan, Y. Guo, L. Yi, Y. Sun, D. Liu, Z. Zhang*, Comprehensive analysis of heparinase derived heparin-products using two-dimensional liquid chromatography coupled with Q-TOF mass spectrometry, Journal of Chromatography A. 2021, 1643, 462049.
7. B. Xie,† L. Yi,†Y. Zhu, X. Chang, J. Hao, L. Pang, Y. Ouyang, S. Yuan, Z. Zhang* Structural elucidation of a novel branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system, Carbohydrate Polymers, 2021, 251, 117080.
8. P. Qiu, F. Wu, L. Yi, L. Chen, Y. Jin, X Ding, Y. Ouyang, Y. Yao, Y. Jiang, Z. Zhang*, Structure characterization of a heavily fucosylated chondroitin sulfate from sea cucumber (H. leucospilota) with bottom-up strategies, Carbohydrate Polymers, 2020, 240, 116337.
9. J. Hao, F. Wu, R. Tang, Y. Sun, D. Liu,* Z. Zhang* Preparation of 1,4-linked α-D-glucuronans from starch with 4-acetamide-TEMPO/NaClO2/NaClO system, International Journal of Biological Macromolecules, 2020, 151:740-746.
10. Y. Meng, L. Yi, L. Chen, J. Hao, D. Li, J. Xue*, N. Xu, Z.Zhang*. Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricate, Chinese Journal of Natural Medicines. 2019, 17(10): 0792-0800.
11. Y. Ouyang, M. Zhu, X.Wang, L. Yi, Y. Yao, J. Fareed, R. J Linhardt*, Z. Zhang*, Systematic analysis of enoxaparins from different sources with online one and two-dimensional chromatography, Analyst. 2019, 144, 3746-3755.
12. Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y.Yao, Z. Zhang*, R.J. Linhardt*, Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications, Journal Medicinal Chemistry, 2019, 62, 1067-1073.
13. Y. Ouyang, X. Han, Q. Xia, J. Chen, S. Velagapudi, K. Xia, Z. Zhang* and R.J Linhardt* Negative-ion Mode Capillary Isoelectric Focusing-Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides, Analytical Chemistry, 2019, 91, 846-853.
14. R. Cheng, X. Tang, A. Long, J. Mwangi, R. Lai, R. Sun, C. Long, Z. Zhang*. Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis. Zoological Research. 2019, 40(3): 205-210.
15. F. Wu，K. Dong, M. Zhu, Q. Zhang, B. Xie, D. Li, H.Gan, Z. Zhang* Development of a method to analyze the complexes of enoxaparin and plateletfactor 4 with size-exclusion chromatography, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 668-671.
16. Y. Ouyang, X. Han, Y. Yu, J. Chen, L. Fu, F. Zhang, R. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, Z. Zhang*, K. Xia*. Chemometric analysis of porcine, bovine and ovine heparins, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 345-352.
17. Y. Lin, Q. Zhang, Y. Meng, J. Hao, B. Xie, H. Gan, D. Li, K. Dong, Z. Zhang* Qualitative and quantitative analysis of 2, 5-anhydro-D-mannitol in low molecular weight heparins with high performance anion exchange chromatography hyphenated quadrupole time of flight mass spectrometry, Journal of Chromatography A. 2018, 1569:160-167.
18. Z. Liu, Y. Xiong, L. Yi, R. Dai, Y. Wang, M. Sun, X. Xiao, Z. Zhang*, S. Yuan*, Endo-β-1,3-glucanase digestion combined with the HPAEC-PAD-MS/MS analysis reveals the structural differences between two laminarins with different bioactivities, Carbohydrate Polymers, 2018, 194, 339-349.
19. R. Tang1, J. Hao1, R.Zong, F. Wu, Y. Zeng, Z. Zhang*, Oxidation pattern of curdlan with TEMPO-mediated system, Carbohydrate Polymers, 2018, 186, 9-16.
20. Y. Ouyang, Y. Zeng, L. Yi, H. Tang, D. Li, R. Linhardt, Z. Zhang* Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors, Journal of Chromatography A. 2017, 1522(3): 56-61.
21. Y. Rong, N Xu, B Xie, J Hao, L Yi, R Cheng, D Li, R. J. Linhardt, Z. Zhang*, Sequencing analysis of β-glucan from highland barley with high performance anion exchange chromatography coupled to quadrupole time – of – flight mass spectrometry, Food Hydrocolliods, 2017, 73, 235-242.
22. X. Sun, L. Tao, L. Yi, Y. Ouyang, N. Xu, D. Li, R. Linhardt, Z. Zhang* N-glycans released from glycoproteins using a commercial kit andcomprehensively analyzed with a hypothetical database, Journal of Pharmaceutical Analysis, 2017, 7(2): 87-94.
23. L. Tao, F. Song, N. Xu, D. Li, R.J. Linhardt, Z. Zhang*, New Insights into the Action of Bacterial Chondroitinase AC I and Hyaluronidase on Hyaluronic Acid, Carbohydrate Polymers, 2017, 158: 85-92.
24. J. Hao, S. Xu, N. Xu, D. Li, R.J Linhardt, Z. Zhang*, Impact of Degree of Oxidation on the Physicochemical Properties of Microcrystalline Cellulose, Carbohydrate Polymers,2017, 155, 483-490.