Shilei Zhang

发布者：滕昕辰发布时间：2022-08-26浏览次数：10

Shilei Zhang, Ph.D.

Professor

Department of Medicinal Chemistry

Email: zhangshilei@suda.edu.cn

 

 



Biosketch

q  Education

1998.9-2002.7, Ocean Chemistry, School of Chemistry and Chemical Engineering, Ocean University of China, Undergraduate.

2002.9-2007.7, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Medicinal Chemistry, Ph.D.

 

q  Work experience

2007.7-2008.9, Department of Medicinal Chemistry, School of Pharmacy, East China University of Science and Technology, Lecturer.

2008.10-2012.1, University of New Mexico, Organic Chemistry, Postdoctoral.

2012.2-, Department of Medicinal Chemistry, School of Pharmacy, Soochow University, Professor.

 

Research Interests

q  Aryne chemistry. Our original method to generate aryne from o-diiodioarene and NaH, and the broad applications of the simple method to discovery of new reactions.

 

q  Developing efficient methods to construct privileged structures of drugs

 

q  Design and synthesis of anticancer drugs



Select Publications


1)     Luo, F.;Zhou, H.;Chen, X-B.;* Liu, X-J.; Chen, X-D.; Qian, P-F.; Wu, X-P.;*Wang, W.;*Zhang,S.* Synthesis of α‑Aryl Primary Amides from α‑Silyl Nitriles and Aryl Sulfoxides through [3,3]-Sigmatropic Rearrangement. Org. Lett. 2022, 24(8), 1700-1705.

2)     Gui, J.; Cai, X.; Chen, L.; Zhou, Y.; Zhu, W.; Jiang, Y.; Hu, M.; Chen, X.;* Hu, Y.;* Zhang, S.* “Facile and practical hydrodehalogenations of organic halides enabled by calcium hydride and palladium chloride” Org. Chem. Front. 2021, 8(17),4685-4692. (2021 Organic Chemistry Frontiers HOT articles)

3)     Sun, W.; Chen, X.; Hu, Y.*; Geng, H.; Jiang, Y.; Zhou, Y.; Zhu, W.; Hu, M.; Hu, H.; Wang, X.; Wang, X.; Zhang, S.*; Hu, Y.* “A NaH-promoted N-detosylation reaction of diverse p-toluenesulfonamides” Tetrahedron Lett.2020, 61(43), 152442.(Cover Paper)

4)     Chen, X.; Jiang, Y.; Geng, H.; Liu, X.; Huang, Y.; Lu, J.; Gao, C.; Zhang, S.*; Zhang, J.*; Wang, W.* “Aldehydes Switch Regioselectivity: a Prins Cyclization Strategy for the Synthesis of Indoline-fused THFs and Indole-fused Oxepanes” Adv. Synth. Catal.,2020, 362(13), 2620-2625.

5)     Geng, H.; Chen, X.*; Gui, J.; Zhang, Y.; Shen, Z.; Qian, P.; Chen, J.; Zhang, S.*; Wang, W.* “Practical Synthesis of C-1 Deuterated Aldehydes Enabled by NHC Catalysis” Nature Catalysis2019, 2(12), 1071-1077.

6)     Jiang, J.; Cai, X.; Hu, Y.; Liu, X.; Chen, X.; Wang, S.; Zhang, Y.; Zhang, S.* “Thermo-promoted Reactions of Anthranils with Carboxylic Acids, Amines, Phenols and Malononitrile under Catalyst-free Conditions” J. Org. Chem. 2019, 84 (4), 2022-2031.

7)     Liu, Y.; Mao, Y.; Hu, Y.; Gui, J.; Wang, L.; Wang, W.;Zhang, S.* “The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds” Adv. Synth. Catal.,2019, 361(7), 1554-1558.

8)     Jiang, J.; Hu, Y.; Cai, X.; Wang, L.; Hu, Y.; Chen, S.; Zhang, S.;* Zhang, Y. “Bis(phenylsulfonyl)methane mediated synthesis of olefins via a halogen elimination and double bond migration” Org. Biomol. Chem., 2018,16 (15), 2619-2622.

9)     Mao, Y.; Liu, Y.; Hu, Y.; Wang, L.; Zhang, S.;* Wang, W. “Pd-Catalyzed Debenzylation and Deallylation of Ethers and Esters with Sodium Hydride” ACS Catal., 2018, 8 (4), 3016-3020.

10)  Yang, J.; Qiu, G.; Jiang, J.; Hu, Y.;* Chen, S.; Zhang, S.;* Zhang Y. “Asymmetric Organocatalytic Synthesis of Benzopyran- andBenzofuran-Fused Polycyclic Acetals” Adv. Synth. Catal.,2017, 359 (13), 2184-2190.

11)  Xie, R.; Hu, Y.; Wan, H.; Hu, Y.; Chen, S.; Zhang, S.;* Zhang, Y.“An efficient synthesis of 4,6-substituted pyrrolo[3,2-d]pyrimidines by silver-catalyzed cyclization of acyetylene amine” Tetrahedron Lett.2016, 57, 2418-2421.

12)  Chen, X.; Zhang, Y.; Wan, H.; Wang, W.; Zhang, S.* “Stereoselective organocatalytic oxidation of alcohols to enals: a homologation method to prepare polyenes” Chem. Commun., 2016,3532-3535.

13)  Wang, J.; Qian, P.; Hu, Y.; Yang, J.; Jiang, J.; Chen, S.; Zhang, Y.; Zhang, S.* “Organocatalytic aldol addition reaction of cyclic hemiacetals to aldehydes” Tetrahedron Lett.2015, 56, 2875-2877.

14)  Liu, S.; Hu, Y.; Qian, P.; Hu, Y.; Ao, G.; Chen, S.; Zhang, S.;* Zhang, Y.“An efficient cascade approach to dibenzoxazepinones via nucleophilic aromatic substitution and Smiles rearrangement” Tetrahedron Lett.2015, 56, 2211-2213.

15)  Liu, S.; Zhu, S.; Wu, Y.; Gao, J.; Qian, P.; Hu, Y.; Shi, L.; Chen, S.;Zhang, S.;*Zhang, Y.“One-pot synthesis of N-aryl-nicotinamides and diaryl-amines based on a tunable Smiles rearrangement” Eur. J. Org. Chem., 2015, 3048-3052

16)  Zhu, Y.; Qian, P.; Yang, J.; Chen,S.; Hu, Y.; Wu, P.; Wang, W.; Zhang, W.; Zhang, S.* “Organocatalytic Enantioselective Michael Addition of Cyclic Hemiacetals to Nitroolefins: A Facile Access to Chiral Substituted 5- and 6-Membered Cyclic Ethers” Org. Biomol. Chem., 2015,13, 4769-4775.

17)  Liu, S.; Chen, X.; Hu, Y.; Yuan, L.; Chen, S.; Wu, P.; Wang, W.; Zhang, S.;* Zhang W. “An Efficient Method for the Production of Terminal Alkynes from 1,1-Dibromo-1-alkenes and its Application in the Total Synthesis of Natural Product Dihydroxerulin” Adv. Synth. Catal.,2015, 357, 553-560.