Jianwen Wang

Jianwen Wang, Ph.D.

Professor

Department of Biopharmaceutical Sciences

Email: jwwang@suda.edu.cn

Biosketch

q  Education

1983-1987, Botany, Department of Biology, Xiamen University, China. B.Sc.

1987-1990, Plant Physiology and Biochemistry, Department of Biology, Xiamen University, China. M.Sc.

1998-2001, Biotechnology for Secondary Metabolites, Department of Biological Sciences & Technology, Nanjing University, China. Ph.D.

q  Work experience

1990-1998 Research Assistant. Institute of Ecology, the Chinese Academy of Sciences, China

2001-2003 Post Doctor. Environmental Sciences, Nanjing University, China

2003-2004 Research Associate. Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong

2008-2009 Academy visitor. Institute of Biomedical and Life Sciences, University of Glasgow, UK

2004 -date Professor. School of Pharmaceutical Sciences, Soochow University, China

Research Interests

q  Biosynthesis of pharmaceutically important secondary metabolites in palnts and fungi.

q  Biotechnologic production for natural products by cell cultures.

Research Fund

1.    The artemisinin biosynthesis mediated by nitric oxide induced by endophytic fungi in Artemisia annua. National Natural Science Foundation of China（No. 30772731, 2008.1-2010.12）.

2.    The regulation of fungal endophytes on trichome development and artemisinin biosynthesis in trichomes of Artemisia annua L. National Natural Science Foundation of China（No. 81273487, 2013.1-2016.12）.

3.    The regulation of fungal differentiation and hypocrellin of Shiria bambusicola by reactive oxygen species. National Natural Science Foundation of China（No. 81473183, 2015.1-2018.12）

4. The bacteria associated with fungal fruiting body activate hypocrellin biosynthesis of Shiria bambusicola. National Natural Science Foundation of China（No.81773696, 2018.1-2021.12）

5. Nitric oxide-mediated production of hypocrellins, photodynamic therapy photosensitizers by the medicinal fungus Shiria bambusicola. National Natural Science Foundation of China（No.82073955, 2021.1-2024.12）

Select Publications

1.        X. P. Li, L. L. Zhou, Y. H. Guo, J. W. Wang*. 2021. The signaling role of extracellular ATP in co‑culture of Shiraia sp. S9 and Pseudomonas fulva SB1 for enhancing hypocrellin. Microbial Cell Factories 20:144.

2.        L. P. Zheng, X. P. Li, L. L. Zhou, J.W. Wang*. 2021.Endophytes in Artemisia annua L.: new potential regulators for plant growth and artemisinin biosynthesis, Plant Growth Regulation 95:293–313.

3.        H. Tian, X.P. Li, J. Zhao, H.W. Gao, Q. M. Xu*, J.W. Wang*. 2021. Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L. Phytochemistry 185 (2021) https://doi.org/10.1016/j.phytochem.2021.112682

4.        Y. J. Ma, J. Xia, Y. Wang, J.W. Wang*. 2020.Stimulation of tanshinone production in Salvia miltiorrhiza hairy roots by β-cyclodextrin-coated silver nanoparticles. Sustainable Chemistry and Pharmacy 14 (2020) https://doi.org/10.1016/j.scp.2020.100271

5.        Y. J. Ma, L.P. Zheng, J.W. Wang*. 2019. Bacteria associated with Shiraia fruiting bodies influence fungal production of hypocrellin A. Frontiers in Microbiology10: 2023.

6.        Y. J. Ma, C.S. Lu, J.W. Wang*. 2018. Effects of 5-azacytidine on growth and hypocrellin production of Shiraia bambusicola. Frontiers in Microbiology 9:2508

7.        C. X. Sun, Y. J. Ma, J.W. Wang*. 2018. Improved hypocrellin A production in Shiraia bambusicola by light-dark shift. Journal of Photochemistry and Photobiology B: Biology 182: 100-107

8.        C. H. Wang, X.Y. Lei, J. Xia, J.W. Wang*. 2018. Effect of down-regulating 1-deoxy-d-xylulose-5-phosphate reductoisomerase by RNAi on growth and artemisinin biosynthesis in Artemisia annua L. Plant Growth Regulation 84: 549–559

9.        X.Y. Lei, M.Y. Zhang, Y. J. Ma, J.W. Wang *. 2017. Transcriptomic responses involved in enhanced production of hypocrellin A by addition of Triton X‑100 in submerged cultures of Shiraia bambusicola. Journal of Industrial Microbiology & Biotechnology 44(10): 1415-1429

10.    C. X. Sun, Y. J. Ma, J.W. Wang*. 2017. Enhanced production of hypocrellin A by ultrasound stimulation in submerged cultures of Shiraia bambusicola. Ultrasonics Sonochemistry 38: 214-224