Xiaohui Sun
Xiaohui Sun, Ph.D.
Associate Professor
Department of Pharmacology
Email: sunxiaohui@suda.edu.cn
Biosketch
q Education
2003-2007 Ph.D. in Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology
2000-2003 M.D. in Inorganic Chemistry, Department of Chemistry, Huazhong University of Science and Technology
1996-2000 B.S. in Fine Chemistry, Department of Chemistry, Huazhong University of Science and Technology
q Work experience
2014-date Associate Professor, College of Pharmaceutical Sciences, Soochow University
2013-2014 Research Associate, Department of Cancer Biology & Pharmacology, University of Illinois College of Medicine at Peoria
2010-2013 Postdoctoral Research Associate, Department of Biomedical Engineering, Washington University in St. Louis
2008-2010 Postdoctoral Scientist, Department of Cardiovascular Medicine, University of Oxford
2007-2008 Postdoctoral Research Fellow, College of Life Science & Technology, Huazhong Univerisity of Science and Technology
Research Interests
q Structure, function and pharmacology of ion channels, especially TRP channels and BK-type Ca2+ and voltage-dependent K+ channels
q Role of ion channels in neuroinflammation
Research Fund
31400924, National Natural Science Foundation of China, PI 2015/01-2017/12
Select Publications
1. Xiaoying Yang#, Guiqin Wang#, Ting Cao, Li Zhang, Yunzhi Ma, Shuhui Jiang, Xinchen Teng, Xiaohui Sun*, Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia, J. Biol. Chem., 2019, 294(35): 12921-12932. doi: 10.1074/jbc.RA118.006425
2. Yelena Nersesyan, Lusine Demirkhanyan, Deny Cabezas-Bratesco, Victoria Oakes, Ricardo Kusuda, Tyler Dawson, Xiaohui Sun, Chike Cao, Alejandro Martin Cohen, Bharath Chelluboina, Krishna Kumar Veeravalli, Katharina Zimmermann, Carmen Domene, Sebastian Brauchi, Eleonora Zakharian, Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1, Cell Rep., 2017, 21(6):1681-1691. doi: 10.1016/j.celrep.2017.10.063
3. Xiaohui Sun, Eleonora Zakharian，Regulation of the temperature-dependent activation of Transient Receptor Potential Vanilloid 1 by phospholipids in planar lipid bilayers, J. Biol. Chem., 2015, 290(8): 4741-4747. doi: 10.1074/jbc.M114.611459
4. Xiaohui Sun, Jingyi Shi, Kelli Delaloye, Xiao Yang, Huanghe Yang, Guohui Zhang, Jianmin Cui, The interface between membrane-spanning and cytosolic domains in Ca2+-dependent K+ channels is involved in beta subunit modulation of gating, J. Neurosci., 2013, 33(27): 11253-11261. doi: 10.1523/JNEUROSCI.0620-13.2013
5. Ling Xiao#, Xiaoqin Xiong#, Xiaohui Sun#, Yanhong Zhu, Hao Yang, Huabing Chen, Lu Gan, Huibi Xu, Xiangliang Yang, Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles, Biomaterials, 2011, 32(22): 5148-5157. doi: 10.1016/j.biomaterials.2011.03.071
6. Xiaohui Sun, Jiuping Ding, Hui Li, Na Pan, Lu Gan, Xiangliang Yang, Huibi Xu, Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation, J. Pharmacol. Exp. Ther., 2007, 323(1): 391-397. doi: 10.1124/jpet.107.125567