Rui Sheng
Rui Sheng, Ph.D.
Professor
Department of Pharmacology
Email: sheng_rui@163.com; shengrui@suda.edu.cn
Biosketch
q Education
2001/9-2006/12 Soochow University Cardiovascular Pharmacology Ph.D.
1997/9-2000/6 China Pharmaceutical University Neuropharmacology M.S.
1992/9-1997/6 China Pharmaceutical University Pharmacology B.S.
q Work experience
2013/8-2013/10 David Geffen School of Medicine, University of California, Los Angeles
2011-2012 Stroke and Neurovascular Regulation laboratory, Harvard Medical School
2000 –present Soochow University, Department of Pharmacology
q Honors and awards
[1] New drug targets and strategies for stroke prevention and treatment. Outstanding Scientific Research Achievement Award (Science and Technology) in Universities. First Prize. Ministry of Education of China (2018).
[2] Chinese Pharmacological Society Outstanding Young Pharmacologist Award. Chinese pharmacological society (2013)
[3] Cold Spring Harbor Asia meeting GSK fellowship. Cold Spring Harbor Asia meeting (2013)
[4] Suzhou Science and Technology Progress Award. Second Prize. Suzhou Science and Technology Bureau (2012)
[5] 12th Higher Institution Awards for Young Teachers. Third Prize. Fok Ying Tong Education Foundation (2010)
[6] 6th World Stroke Congress Scholarship for Young Physicians. World Stroke Organization (2008).
Research Interests
q The molecular mechanisms and therapeutic drugs of cardiovascular diseases including stroke, myocardial infarction and heart failure.
q The role of autophagy and endoplasmic reticulum stress in cardiovascular diseases.
Research Fund (only P.I. of NSFC)
[1] Natural Science Foundation of China, 8217130678, TIGAR regulates the crosstalk of endoplasmic reticulum, mitochondria and nucleus to mediate neuroprotection during cerebral ischemia, 2022－2025, principal investigator.
[2] Natural Science Foundation of China, 81973315, Discovery of cardiac positive inotropic effect of NADPH in heart failure and study of its underlying mechanisms, 2020－2023, principal investigator.
[3] Natural Science Foundation of China, 81673421, The role and mechanism of ER-resident TIGAR and its regulation on GRP78 in cerebral preconditioning, 2017－2020, principal investigator..
[4] Natural Science Foundation of China, 81373402, The role and mechanisms of sphingosine kinase 2 in cerebral preconditioning-induced autophagy activation, 2014 – 2017, principal investigator.
[5] Natural Science Foundation of China, 81173057, Different roles of endoplasmic reticulum stress-induced autophagy in ischemic preconditioning and fatal ischemia, 2012 – 2014, principal investigator.
[6] Natural Science Foundation of China, 30801391, The role of autophagy and endoplasmic reticulum stress in cerebral ischemic preconditioning and drug intervention, 2009 – 2011, principal investigator.
Select Publications (first author/corresponding author)
[1] Koju N, Qin ZH*, Sheng R*. Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe? Acta Pharmacol Sin. 2022 Jan 11.
[2] She J, Sheng R*, Qin ZH*. Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors. Aging Dis. 2021 Dec 1;12(8):1879-1897. (*corresponding author)
[3] Li JY#, Li QQ#, Sheng R. The role and therapeutic potential of exosomes in ischemic stroke. Neurochem Int. 2021 Sep 25;151:105194. (*corresponding author)
[4] Li QQ#, Li JY #, Zhou M#, Qin ZH, Sheng R* Targeting neuroinflammation to treat cerebral ischemia - The role of TIGAR/NADPH axis. Neurochem Int 2021 Sep;148:105081. (*corresponding author)
[5] Tang J#, Chen L#, Qin ZH, Sheng R*. Structure, regulation, and biological functions of TIGAR and its role in diseases. Acta Pharmacol Sin. 2021 Jan 28. (*corresponding author)
[6] Chen JL, Wang XX, Chen L, Tang J, Xia YF, Qian K, Qin ZH, Waeber C, Sheng R*. A Sphingosine Kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy. Neuropharmacology. 2020;181:108326. (*corresponding author)
[7] Chen L#, Xia YF#, Shen SF, Tang J, Chen JL, Qian K, Chen Z, Qin ZH, Sheng R*. Syntaxin 17 inhibits ischemic neuronal injury by resuming autophagy flux and ameliorating endoplasmic reticulum stress. Free Radic Biol Med. 2020; 160:319-333. (*corresponding author)
[8] Sheng R*, Qin ZH. History and Current Status of Autophagy Research. Adv Exp Med Biol. 2019; 1206:3-37.
[9] Zhu J, Wang YF, Chai XM, Qian K, Zhang LW, Peng P, Chen PM, Cao JF, Qin ZH, Sheng R*, Xie H*. Exogenous NADPH ameliorates myocardial ischemia-reperfusion injury in rats through activating AMPK/mTOR pathway. Acta Pharmacol Sin. 2019 Nov 27. (*co-corresponding author).
[10] Song DD, Zhou JH, Sheng R*. Regulation and function of sphingosine kinase 2 in diseases. Histol Histopathol. 2018, May; 33(5):433-445. (*corresponding author).
[11] Song DD, Zhang TT, Chen JL, Xia YF, Qin ZH, Waeber C, Sheng R*. Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain. Cell Death Dis. 2017 Jul 6;8(7): e2912 (*corresponding author)
[12] Zhou JH, Zhang TT, Song DD, Xia YF, Qin ZH, Sheng R*. TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis. Sci Rep. 2016; 6:27096. (*corresponding author)
[13] Sheng R*, Qin ZH. The divergent roles of autophagy in ischemia and preconditioning. Acta Pharmacol Sin. 2015;36(4):411-20(*corresponding author).
[14] Zhang XY, Zhang TT, Song DD, Zhou J, Han R, Qin ZH, Sheng R*. Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells. Mol Brain. 2015;8:20(*corresponding author).
[15] Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem 2014; 289(30): 20845-57.
[16] Gao B, Zhang XY, Han R, Zhang TT, Chen C, Qin ZH, Sheng R*. The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning. Acta Pharmacol Sin 2013;34(5):657-66. (*corresponding author)
[17] Sheng R, Gu ZL, Xie ML. Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy. Int J Cardiol 2013;162(3):199-209.
[18] Sheng R, Liu XQ, Zhang LS, Gao B, Han R, Wu YQ, Zhang XY, Qin ZH. Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning. Autophagy 2012; 8(3): 310-325.
[19] Sheng R, Zhang LS, Han R, Gao B, Liu XQ, Qin ZH. Combined Prostaglandin E1 and lithium induces bcl-2 and heat shock proteins while inhibits p
[20] Sheng R, Zhang LS, Han R, Liu XQ, Gao B, Qin ZH. Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophagy 2010, 6: 482-94.
[21] Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY. Epigallocatechin gallate protects H
[22] Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY. EGCG inhibits proliferation of cardiac fibroblasts in the rats with cardiac hypertrophy. Planta Medica. 2009, 75:113-20.
[23] #Wen YD, #Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Kohji F, Qin ZH*. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 2008; 4(6): 762-9. (# co-first author)
[24] Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY. EGCG inhibits cardiomyocyte apoptosis in pressure overload induced cardiac hypertrophy rats and protects cardiomyocyte from oxidative stress. Acta Pharmacol Sin 2007, 28(2): 191-201.
[25] Sheng R, Liu GQ. EDT，a tetrahydroacridine derivative, inhibits cerebral ischemia and protects rat cortical neurons against glutamate and NO-induced injury. Acta Pharmacol Sin 2003; 24(5): 390-393.