Yanli Liu
Yanli Liu, Ph.D.
Professor
Department of Microbial and Biochemical Pharmacy
Email: ylliu18@suda.edu.cn
Biosketch
q Education
1999-2003 B.S. Liaoning Normal University, 2003
2003-2008 Ph.D. Northeast Normal University, 2008
q Work experience
2018 – present: Distinguished Professor, College of Pharmaceutical Sciences,
Soochow University, Suzhou, Jiangsu 215123, P.R. China
2017 – 2017: Visiting Professor, Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada
2012 – 2014: Visiting Scholar, Postdoctoral Fellow, Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada
2009 – 2018 Jun: Lecturer, Associate Professor, College of Life Science, Central China Normal University, Wuhan, Hubei 430079, P.R. China
q Honors and awards
Hubei Chenguang Talented Youth Development Foundation, 2016, Biochemistry and Molecular Biology
Six-talent Professorship of Jiangsu province, 2019, Biotechnology and the new pharmaceutical industry
Third prize of Young Scientists Forum, 2019, National Academic Conference of Biochemistry and Molecular Biology Society
Research Interests
q Structural and Functional Study of Epigenetic Regulation Protein
q Structural and Functional Study of Disease Associated Protein
q Structure Based Drug Design and Screening
Research Fund
q National Natural Science Foundation of China (grant number 32271309), Mechanistic study of PHIP in the recognition of methylated histone H3K4 and discovery of its specific antagonist, 01/2023 to 12/2026, Principal investigator.
q National Natural Science Foundation of China (grant number 31500613), Molecular basis for the recruitment of MLL fusion protein by RNA polymerase II-associated PAF1 complex, 01/2016 to 12/2018, Principal investigator.
q Natural Science Foundation, Hubei Province, P.R. China (grant number 2009CDB234), Role of aquaporin-3 in the lipoatrophy, 12/2009 to 12/2010, Principal investigator.
Select Publications
q Yanli Liu*,#, Aman Iqbal#, Weiguo Li#, Zuyao Ni#, Yalong Wang#, Jurupula Ramprasad, Karan Joshua Abraham, Mengmeng Zhang, Dorothy Yanling Zhao, Su Qin, Peter Loppnau, Honglv Jiang, Xinghua Guo, Peter J Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T. Bedford, Jack F. Greenblatt and Jinrong Min*, A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II, Nature Communications, 2022, 13:5453, PMID: 36114190.
q Yanli Liu*, Xiajie Yang, Mengqi Zhou, Yinxue Yang, Fangzhou Li, Xuemei Yan, Mengmeng Zhang, Zhengguo Wei, Su Qin, Jinrong Min*, Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain, Journal of Biological Chemistry, 2022, 298(3):101623, PMID: 35074427.
q Renato Ferreira de Freitas#, Yanli Liu#, Magdalena M. Szewczyk, Naimee Mehta, Fengling Li, David McLeod, Carlos Zepeda-Velázquez, David Dilworth, Ronan P. Hanley, Elisa Gibson, Peter J. Brown, Rima Al-Awar, Lindsey I. James, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Jinrong Min, Masoud Vedadi, Matthieu Schapira*, Abdellah Allali-Hassani#*, Discovery of small-molecule antagonists of the PWWP domain of NSD2, Journal of Medicinal Chemistry, 2021, 64(3): 1584-1592, PMID: 33522809.
q Mengmeng Zhang#, Ming Lei#, Su Qin, Aiping Dong, Ally Yang, Yanjun Li, Peter Loppnau, Timothy R. Hughes, Jinrong Min*, Yanli Liu*, Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains, BBA - Gene Regulatory Mechanisms, 2021, 1864(3): 194688, PMID: 33556623.
q Cheng Dong#, Yanli Liu#, Tian-Jie Lyu#, Serap Beldar, Kelsey N. Lamb, Wolfram Tempel, Yanjun Li, Zoey Li, Lindsey I. James, Su Qin*, Yun Wang*, Jinrong Min*, Structural basis for the binding selectivity of human CDY chromodomains, Cell Chemical Biology, 2020, 27(7): 827-838, PMID: 32470319.
q Yanli Liu#, Su Qin#, Tsai-Yu Chen#, Ming Lei#, Shilpa S. Dhar, Jolene Caifeng Ho, Aiping Dong, Peter Loppnau, Yanjun Li, Min Gyu Lee*, Jinrong Min*, Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4, Nature Communications, 2019, 10: 36, PMID: 30604749.
q Yanli Liu, Su Qin, Ming Lei, Wolfram Tempel, Yuzhe Zhang, Peter Loppnau, Yanjun Li, Jinrong Min*, Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1, Journal of Biological Chemistry, 2017, 292(14): 5655-5664, PMID: 28223359.
q Yanli Liu, Li Li, Jinrong Min*, Structural biology: HDAC6 finally crystal clear, Nature Chemical Biology, 2016, 12(9): 660-661, PMID: 27538024.
q Yanli Liu, Wolfram Tempel, Qi Zhang, Xiao Liang, Peter Loppnau, Su Qin*, Jinrong Min*, Family-wide characterization of histone binding abilities of human CW domain-containing proteins,Journal of Biological Chemistry, 2016, 291
q Yanli Liu#, Ke Liu#, Su Qin, Chao Xu, Jinrong Min*, Epigenetic targets and drug discovery Part 1: histone methylation, Pharmacology & Therapeutics, 2014, 143
q Su Qin#, Yanli Liu#, Wolfram Tempel, Mohammad S. Eram, Chuanbing Bian, Ke Liu, Guillermo Senisterra, Lissete Crombet, Masoud Vedadi, Jinrong Min*, Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1, Nature Communications, 2014, 5: 3952, PMID: 24853335.