Pan Deng

Pan Deng, Ph.D.

Professor

Department of Pharmaceutical Analysis

Email: pandeng@suda.edu.cn

Biosketch

q  Education

2008-2011 Pharmaceutical analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China,

2005-2008 Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, Chin

2001-2005 Pharmacy, Shenyang Pharmaceutical University, Shenyang, China

q  Work experience

2021-present Professor, Soochow University

2020-2021  Assistant Professor, College of Pharmacy, University of Kentucky

2015-2020  Postdoctoral Researcher, University of Kentucky

2011-2015  Research Associate, Shanghai Institute of Materia Medica

q  Honors and awards

2020  University of Kentucky Center for Appalachian Research in Environmental Sciences (UK CARES) Career Development Award

2015  Scientific and Technological Award (4th Contributor), Chinese Pharmaceutical Association

2014  Shanghai Institute of Materia Medica Nova Star Program Award

2002-2004 National Merit Scholarship Awards, Shenyang Pharmaceutical University, Shenyang, China

Research Interests

q  Drug metabolism and pharmacokinetics

q  Microbial metabolism

q  Environmental exposure induced cardio-metabolic diseases

Research Fund

Granting Agency: UK-CARES Career Development Award

Date: 04/2021-02/2022

Project Title: The role of oxidized lipids and CD36 in PFOS-induced immunotoxicity

Role: PI

Granting Agency: National Natural Science Foundation of China

Date: 01/2013-12/2015

Project Title: Toosendanin bioactivation and the liver injury mechanism

Role: PI

Granting Agency: NIH/NIEHS

Date: 04/2020-04/2025

Project Title: Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk

Role: Co-I

Select Publications

Deng P*, Valentino T, Flythe MD, Moseley H, Leachman JR, Morris AJ, Hennig B*. Untargeted stable-isotope probing of the gut microbiota metabolome using 13C-labeled dietary fibers. J. Proteome Res. 2021, 20: 2904-2913

Deng P, Wang C, Wahlang B, Sexton T, Morris AJ, Hennig B. Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice. Toxicol. Appl. Pharmacol. 2020, 409: 115301

Deng P, Hoffman JB, Petriello MC, Wang CY, Li XS, Kraemer MP, Morris AJ, Hennig B. Dietary inulin decreases circulating ceramides by suppressing neutral sphingomyelinase expression and activity in mice. J Lipid Res. 2020, 61:45-53

Deng P, Barney J, Petriello MC, Morris AJ, Wahlang B, Hennig B. Hepatic metabolomics reveals that nonalcoholic steatohepatitis increases PCB 126-induced oxidative stress and metabolic dysfunction. Chemosphere. 2019, 217:140-149

Xu Y, Li L, Wang YL, Xing J, Zhou L, Zhong DF, Luo XM, Jiang HL, Chen KX, Zheng MY*, Deng P*, and Chen XY*. Aldehyde oxidase mediated metabolism in drug-like molecules: a combined computational and experimental study. J. Med. Chem. 2017; 60(7):2973-2982

Deng P, Zhong DF, Wang X, Dai Y, Zhou L, Leng Y, Chen XY. Analysis of diacylglycerols by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry: Double bond location and isomers separation. Anal Chim Acta. 2016, 925: 23-33

Deng P, Zhong DF, Yu K, Zhang YF, Wang T, Chen XY. Pharmacokinetics, metabolism, and excretion of the antiviral drug arbidol in humans. Antimicrob Agents Chemother, 2013, 57(4):1743-1755.

Deng P, Chen XY, Zhang GD, Zhong DF. Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal, 2010, 52(4):571-579.