Yipeng Wang
Yipeng Wang, Ph.D.
Professor
Department of Biopharmaceutical Sciences
Email: yipengwang@suda.edu.cn
Biosketch
q Education
2005-2010, Ph.D., Kunming Institute of Zoology, Chinese Academy of Sciences, China;
2001-2005, B.S., College of Life Sciences, Liaocheng University, China.
q Work experience
2020-present, Professor, College of Pharmaceutical Sciences, Soochow University, China;
2017-2018, Visiting Scientist, Department of Laboratory Medicine, Harvard Medical School / Boston Children’s Hospital, USA;
2013-2020, Associate Professor, College of Pharmaceutical Sciences, Soochow University, China;
2010-2013, Research Associate, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, China.
q Honors and awards
2021, High-level talents in Fujian Province, China;
2017, Double Hundred Plan Leading Entrepreneurial Talents of Xiamen, Fujian Province, China;
2015, High-level talents of universities and scientific research institutions in Suzhou, Jiangsu Province, China;
2009, Gold award of P&G “Touching Lives, Improving Life” Microbiology Competition of China;
2007, Excellent student granted by the Chinese Academy of Sciences.
Research Interests
q Natural medicinal protein/peptide identification: Using biochemistry, molecular biology, and other means to identify natural medicinal proteins/peptides from various organisms, reveal the mechanism of their function and establish a natural medicinal protein/peptide resource library that provides templates for the development of novel protein/peptide drugs.
q Design and modification of medicinal peptides: Using natural peptides as templates to conduct the structure-activity relationship study, reveal the key structural parameters that affect the activity, toxicity, and stability of the peptides, and design the best peptide candidate for further drug development.
Research Fund
1. Key Research & Development Plan of Jiangsu Province (BE2022723): Development of immunomodulatory peptide Hc-CATH as a novel peptide adjuvant, 2022-2025.
2. National Natural Science Foundation of China (32070439): Study on the structural parameters and mechanisms affecting the bacterial killing rate of α-helical antimicrobial peptides from the Chinese alligator, 2021-2024.
3. National Natural Science Foundation of China (31772455): Molecular mechanism study of immunomodulatory peptide Hc-CATH against drug-resistant bacterial infection, 2018-2021.
4. National Natural Science Foundation of China (41206153): Structure-activity relationship study of Hc-CATH, a cathelicidin family antimicrobial peptide from the sea snake Hydrophis cyanocinctus, 2013-2015.
5. Natural Science Foundation of Jiangsu Province (BK20171214): Molecular mechanism study of the natural immunomodulatory peptide against methicillin-resistant Staphylococcus aureus infection, 2017-2020.
Select Publications
1. Zhu Y, Hao W, Wang X, Ouyang J, Deng X, Yu H, Wang Y*. Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug-resistant infections. Med Res Rev. 2022 42(4):1377-1422.
2. Duan Y, Ouyang J, Mo G, Hao W, Zhang P, Yang H, Liu X, Wang R, Cao B, Wang Y*, Yu H*. Defensing role of novel piscidins from largemouth bass (Micropterus salmoides) with evidence of bactericidal activities and inducible expressional delineation. Microbiol Res. 2022 256:126953.
7. Gao J, Zhang M, Zhang F, Wang Y, Ouyang J, Luo X, Yang H, Zhang D, Chen Y, Yu H*, Wang Y*. Design of sea snake antimicrobial peptide derivative with therapeutic potential against drug-resistant bacterial infection. ACS Infect Dis. 2020 6:2451-2467.
8. Qiao X, Yang H, Gao J, Cai S, Shi N, Wang M, Wang Y*, Yu H*. A small cytotoxic peptide from frog elicits potent anti-tumor immunity to prevent local tumor growth and metastases. Future Med Chem. 2019 11(19):2505-2525.
9. Chen C, Wang A, Zhang F, Zhang M, Yang H, Li J, Su P, Chen Y, Yu H*, Wang Y*. The protective effect of fish-derived cathelicidins on bacterial infections in zebrafish, Danio rerio. Fish Shellfish Immunol. 2019 92:519-527.
10. Qiao X, Yang H, Gao J, Zhang F, Chu P, Yang Y, Zhang M, Wang Y*, Yu H*. Diversity, immunoregulatory action and structure-activity relationship of green sea turtle cathelicidins. Dev Comp Immunol. 2019 98:189-204.
11. Wang A, Zhang F, Guo Z, Chen Y, Zhang M, Yu H*, Wang Y*. Characterization of a cathelicidin from the Colubrinae snake Sinonatrix annularis. Zool Sci. 2019 36(1):68-76.
12. Zhang F, Guo ZL, Chen Y, Li L, Yu HN*, Wang YP*. Effects of C-terminal amidation and heptapeptide ring on the biological activities and advanced structure of amurin-9KY, a novel antimicrobial peptide identified from the brown frog, Rana kunyuensis. Zool Res. 2019 40(3):198-204.
13. Qi RH, Chen Y, Guo ZL, Zhang F, Fang Z, Huang K, Yu HN*, Wang YP*. Identification and characterization of two novel cathelicidins from the frog Odorrana livida. Zool Res. 2019 40(2):94-101.
14. Shi N, Cai S, Gao J, Qiao X, Yang H, Wang Y*, Yu H*. Roles of polymorphic cathelicidins in innate immunity of soft-shell turtle, Pelodiscus sinensis. Dev Comp Immunol. 2019 92:179-192.
15. Feng L, Shi N, Cai S, Qiao X, Chu P, Wang H, Long F, Yang H, Yang Y, Wang Y*, Yu H*. De novo Molecular Design of Novel Octapeptide that Inhibits In Vivo Melanogenesis with Great Transdermal Ability. J Med Chem. 2018 61(15):6846-6857.
16. Cai S, Qiao X, Feng L, Shi N, Wang H, Yang H, Guo Z, Wang M, Chen Y, Wang Y*, Yu H*. Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. J Med Chem. 2018 61(5):2075-2086.
17. Guo Z, Qiao X, Cheng R, Shi N, Wang A, Feng T, Chen Y, Zhang F, Yu H*, Wang Y*. As-CATH4 and 5, two vertebrate-derived natural host defense peptides, enhance the immuno-resistance efficiency against bacterial infections in Chinese mitten crab, Eriocheir sinensis. Fish Shellfish Immunol. 2017 71:202-209.
18. Wang A, Chen Y, Yu H*, Wang Y*. Novel cathelicidins with potent antimicrobial, biofilm inhibitory, and anti-inflammatory activities from the frog Fejervarya multistriata. Asian Herpetol Res. 2017 8(3):199-212.
19. Chen Y, Cai S, Qiao X, Wu M, Guo Z, Wang R, Kuang Y, Yu H*, Wang Y*. As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host anti-microbial immune responses. Biochem J. 2017 474(16):2861-2885.
20. Yu H*, Wang C, Feng L, Cai S, Liu X, Qiao X, Shi N, Wang H, Wang Y*. Cathelicidin-trypsin inhibitor loop conjugate represents a promising antibiotic candidate with protease stability. Sci Rep. 2017 7(1):2600.
21. Yu H*, Wang H, Liu X, Feng L, Qiao X, Cai S, Shi N, Wang Y*. Identification, eukaryotic expression and structure & function characterizations of β-defensin like homologues from Pelodiscus sinensis. Dev Comp Immunol. 2017 68:108-117.
22. Yu H*, Cai S, Gao J, Wang C, Qiao X, Wang H, Feng L, Wang Y*. Express sequence tag analysis-identification of anseriformes trypsin genes from full-length cDNA library of the duck (Anas platyrhynchos) and characterization of their structure and function. Biochemistry (Moscow). 2016 81(2):152-162.
23. Yu H*, Liu X, Wang C, Qiao X, Wu S, Wang H, Feng L, Wang Y*. Assessing the potential of four cathelicidins for the management of mouse candidiasis and Candida albicans biofilms. Biochimie. 2016 121:268-277.
24. Wei L, Gao J, Zhang S, Wu S, Xie Z, Ling G, Kuang Y, Yang Y, Yu H*, Wang Y*. Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity, and Special Mechanism. J Biol Chem. 2015 290(27):16633-16652.
25. Yu H*, Lu Y, Qiao X, Wei L, Fu T, Cai S, Wang C, Liu X, Zhong S, Wang Y*. Novel Cathelicidins from Pigeon Highlights Evolutionary Convergence in Avain Cathelicidins and Functions in Modulation of Innate Immunity. Sci Rep. 2015 5:11082.
26. Yu H*, Qiao X, Wang C, Cai S, Liu X, Feng L, Wang H, Wang Y*. Identification and Characterization of Novel Antioxidant Peptides Involved in Redox Homeostasis of Frog, Limnonectes fragilis. Protein Pept Lett. 2015 22(9):776-84.
27. Ling G, Gao J, Zhang S, Xie Z, Wei L, Yu H*, Wang Y*. Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design. PLoS ONE. 2014 27 9(3):e93216.
28. Ling G, Li L, Gao J, Yu H, Wang Y*, Zhou J*. Geographically distinct expression profile of host defense peptides in the skin of the Chinese Odorous frog, Odorrana margaretae. Asian Herpetol Res. 2013 4(4):288-297.
29. Yu H*, Cai S, Gao J, Zhang S, Lu Y, Qiao X, Yang H, Wang Y*. Identification and polymorphism discovery of the cathelicidins, Lf-CATHs in ranid amphibian (Limnonectes fragilis). FEBS J. 2013 280(23):6022-6032.
30. Li Z, Zhang S, Guang H, Gao J, Guo H, He W, Wang Y*, Yu H*. Structural and functional characterization of CATH_BRALE, the defense molecule in the ancient salmonoid, Brachymystax lenok. Fish Shellfish Immunol. 2013 34(1):1-7.
31. He W, Feng F, Huang Y, Guang H, Zhang S, Li Z, Liu J, Wang Y*, Yu H*. Host defense peptides in skin secretions of Odorrana tiannanensis: proof for other survival strategy of the frog than merely antimicrobial. Biochimie. 2012 94(3):649-655.
32. Cui H, Wang Y, Wang Y, Qin S*. Genome-wide analysis of putative peroxiredoxin in unicellular and filamentous cyanobacteria. BMC Evol Biol. 2012 16;12(1):220.
33. Zhang S, Guo H, Shi F, Wang H, Li L, Jiao X, Wang Y*, Yu H*. Hainanenins: A novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis. Peptides. 2012 33(2):251-257.
34. Wang Y, Zhang Z, Chen L, Guang H, Li Z, Yang H, Li J, You D, Yu H*, Lai R*. Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris. PLoS ONE. 2011 6(7):e22120.
35. Yang H, Wang Y, Xiao Y, Wang Y, Wu J, Liu C, Ye H, Li F, Yu H*, Lai R*. A bi-functional anti-thrombosis protein containing both direct-acting fibrin(ogen)olytic and plasminogen-activating activities. PLoS ONE. 2011 14 6(3):e17519.
36. Wang Y, Lu Z, Feng F, Zhu W, Guang H, Liu J, He W, Chi L*, Li Z, Yu H*. Molecular cloning and characterization of novel cathelicidin-derived myeloid antimicrobial peptide from Phasianus colchicus. Dev Comp Immunol. 2011 35(3):314-22.
37. Feng F, Chen C, Zhu W, He W, Guang H, Li Z, Wang D, Liu J, Chen M, Wang Y*, Yu H*. Gene cloning, expression, and characterization of avian cathelicidin orthologue, Cc-CATHs, from Coturnix coturnix. FEBS J. 2011 278(9):1573-84.
38. Wu J, Wang Y, Liu H, Yang H, Ma D, Li J, Li D, Yu H*, Lai R*. Two immunoregulatory peptides with antioxidant activity from tick salivary glands. J Biol Chem. 2010 28 285(22):16606-13.
39. Lu Z, Wang Y, Zhai L, Wang H, Che Q, Du S, Wang D, Feng F, Liu J, Lai R*, Yu H*. Novel cathelicidin-derived antimicrobial peptides from Equus asinus. FEBS J. 2010 277(10):2329-39.
40. Ma D, Wang Y, Yang H, Wu J, An S, Gao L, Xu X, Lai R*. Anti-thrombosis repertoire of blood-feeding horsefly salivary glands. Mol Cell Proteomics. 2009 8(9):2071-9.
41. Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D*, Lai R*. Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. PLoS ONE. 2008 16 3(9):e3217.
42. Liu X, Wang Y, Cheng L, Song Y, Lai R*. Isolation and cDNA cloning of cholecystokinin from the skin of Rana nigrovittata. Peptides. 2007 28 (8):1540-4.