Hui He

Hui He, Ph.D.

Professor

Department of Medicinal Chemistry

Email: hhe@suda.edu.cn

Biosketch

q  Education

1998.09-2002.07  Jiangxi Normal University, B.S.

2002.09-2005.09  Xiamen University, M.S.

2007.08-2010.09  The Chinese University of Hong Kong, Ph.D.

q  Work experience

2005.09-2007.07  Fujian Entry-Exit Inspection and Quarantine Bureau (Putian Bureau), Assistant Engineer

2012.04-2013.08  The Chinese University of Hong Kong, Postdoctor

2013.08-present   Soochow University, Associate Professor, Professsor

q  Honors and awards

1.        First prize for teaching and educating people of China Construction Bank in Soochow Universtiy (2021)

2.        Second prize of excellent academic paper of natural science in Suzhou (2020)

3.        First prize of excellent academic paper of natural science in Suzhou (2018)

4.        Doctor of entrepreneurship and innovation in Jiangsu Province (2014)

5.        High-level talents of universities and scientific research institutes in Suzhou (2014)

Research Interests

q  Design and synthesis of functional photosensitizers

q  Tumor phototherapy and synergistic therapy

Research Fund

1.        Construction of near-infrared nanosized photosensitizers with self-generated oxygen for tumor synergistic therapy, National Natural Science Foundation of China (2020-2023)

2.        Design, synthesis and antitumor activities of near-infrared photosensitizers with self-generated oxygen, National Natural Science Foundation of China (2018-2021)

3.        Design and synthesis of pH-activatable and tumor-targeted photosensitizers for photodynamic therapy, National Natural Science Foundation of China (2015-2017)

4.        Targeted and activatable photosensitizers for tumor imaging and photodynamic therapy, Natural Science Foundation of Jiangsu Province (20154-2017)

5.        Synthesis of tumor-targeted photosensitizers based on boron dipyrromethenes for photodynamic therapy, Natural Science Foundation for Colleges and Universities in Jiangsu Province (2014-2016)

Select Publications

1.        Guo, Z.^#; He, H.^#; Zhang, Y.^#; Rao, J.^#; Yang, T.; Li, T.; Wang, L.; Shi, M.; Wang, M.; Qiu, S.; Song, X.; Ke, H.; Chen, H. Heavy-atom-modulated supramolecular assembly increases antitumor potency against malignant breast tumors via tunable cooperativity. Adv. Mater. 2021, 33, 2004225.

2.        Zhang, Y.; Shi, M.; Yan, Z.; Zhang, S.; Wang, M.; Xu, H.; Li, H.; Ying, Y.; Qiu, S.; Liu, J.*; Yang, H.; Chen, H.; He, H.*; Guo, Z.* Ultrastable near-infrared nonlinear organic chromophore nanoparticles with intramolecular charge transfer for dually photoinduced tumor ablation. Adv. Healthc. Mater. 2020, 9, 2001042.

3.        Yan, Z.; Wang, M.; Shi, M.; He, Y.; Zhang, Y.; Qiu, S.; Yang, H.; Chen, H.; He, H.*; Guo, Z.* Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy. J. Mater. Chem. B 2020, 8, 6886-6897.

4.        Ye, S.; Rao, J.; Qiu, S.; Zhao, J.; He, H.*; Yan, Z.; Yang, T.; Deng, Y.; Ke, H.; Yang, H.; Zhao, Y.; Guo, Z.*; Chen, H.* Rational design of conjugated photosensitizers with controllable photoconversion for dually cooperative phototherapy. Adv. Mater. 2018, 30, 1801216.

5.        He, H.^#; Ji, S.^#; He, Y.; Zhu, A.; Zou, Y.; Deng, Y.; Ke, H.; Yang, H.; Zhao, Y.; Guo, Z.; Chen, H. Photoconversion-tunable fluorophore vesicles for wavelength-dependent photoinduced cancer therapy. Adv. Mater. 2017, 29, 1606690.

6.        Guo, Z.^#; Zou, Y.^#; He, H.^#; Rao, J.; Ji, S.; Cui, X.; Ke, H.; Deng, Y.; Yang, H.; Chen, C.; Zhao, Y.; Chen, H. Bifunctional platinated nanoparticles for photoinduced tumor ablation. Adv. Mater. 2016, 28, 10155-10164.

7.        He, H.; Lo, P.-C.; Ng, D. K. P. A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy. Chem. Eur. J. 2014, 20, 6241-6245.

8.        He, H.; Ng, D. K. P. Differential detection of Zn²⁺ and Cd²⁺ ions by BODIPY-based fluorescent sensors. Chem. Asian J. 2013, 8, 1441-1446.

9.        He, H.; Liu, J.-Y.; Ng, D. K. P. A phthalocyanine-based fluorescent sensor for Zn²⁺ ion. J. Porphyr. Phthalocya. 2013,17, 99-103.

10.    He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives. J. Med. Chem. 2011, 54, 3097-3102.

11.    He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties. Chem. Commun. 2011, 47, 4748-4750.

12.    He, H.; Ng, D. K. P. A ratiometric near-infrared pH-responsive fluorescent dye based on distyryl BODIPY. Org. Biomol. Chem. 2011, 9, 2610-2613.