课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology,  14th edition

授课年级

2018级药学英文班

授课章节

Chapter 1 Introduction

授课时间

50分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

 (1) To learn the definitions of drug, pharmacology, pharmacodynamics and pharmacokinetics.

 (2) To learn the principles of drug nomenclature.

(3) To understand the developmental history of pharmacology.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. The definitions and relationships between pharmacology and the two relevant displines of pharmacodynamics and pharmacokinetics.  [10 min]  

2. The developmental history of pharmacology.  [5 min]

3. The definition and clinical applications of drugs.   [5 min]

4. Therapeutic, adverse, and toxic effects of drugs.  [10 min]

5. Principles of drug nomenclature.  [5 min]

6. Suggestions for pharmacology study. [5 min]

3. 教学重点与难点

1. 教学重点

The definitions and relationships between pharmacology and the two relevant displines of pharmacodynamics and pharmacokinetics.  

2. 教学难点

Therapeutic, adverse, and toxic effects of drugs.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

（1）分析讨论

What is drug?

What is the relationships between pharmacodynamics and pharmacokinetics?

（2）实例讨论

The developmental history of pharmacology.

2. 实验教学：（简要列出实验内容标题）

5. 更新或补充内容提要

6. 复习思考题

1. The relationships between pharmacodynamics and pharmacokinetics.

2. The developmental history of pharmacology.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018级药学英文班

授课章节

Chapter 2 Drug Receptors & Pharmacodynamics

授课时间

150分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the types and definition of therapeutical effects and adverse reactions.

(2) To learn the definition and the significance of dose-effect relationship.

(3) To learn the basic concepts of receptor kinetics, the types of receptors, the second messengers, and the significance of receptor regulation.

(4) To learn the definition of pharmacodynamics.

(5) To understand the mechanisms of drugs’ action.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. The specificity and selectivity of drugs’ action; pharmacological effects, excitation and inhibition; therapeutic effects of drugs, etiological treatments and symptomatic treatments; adverse reactions, side reactions, toxic effects, withdrawal effects and allergic reactions.   [20 min]

2. Dose-effect relationship and dose-effect curve, efficacy, median lethal dose (LD50), potency, therapeutic index, margin of safety.   [20 min]   

3. The mechanisms of actions of drugs.  [10 min]

4. Receptor and drug: the definition and feature of receptor, significance of receptor on drug action, the definition of ligand, agonist, partial agonist, antagonist; the definition and characteristics of competitive antagonist and non-competitive antagonist; affinity, intrinsic activity, the types of receptors, the definition and types of the second messengers, receptor desensitization.  [15 min]

5. The adverse reactions.    [15 min]

6. Dose-effect relationship and dose-effect curve.   [10 min]

7. EC50, threshold dose, potency, maximal effect (Emax)  [20 min]

8. Median effect dose (ED50), median lethal dose (LD50), therapeutic index (TI), margin of safety or CSF (certain safety factor).  [10 min]

9. Introduction to receptor: The concepts and the classification of receptors. [10 min]

10. G-protein-coupled receptors, transmembrane kinase receptors, ligand gated ion channel receptors, and intracellular receptors.   [20 min]

三、教学重点与难点

1.教学重点

The specificity and selectivity of drugs’ action; pharmacological effects, excitation and inhibition; therapeutic effects of drugs, etiological treatments and symptomatic treatments; adverse reactions, side reactions, toxic effects, withdrawal effects and allergic reactions.

Receptor and drug: the definition and feature of receptor, significance of receptor on drug action, the definition of ligand, agonist, partial agonist, antagonist; the definition and characteristics of competitive antagonist and non-competitive antagonist; affinity, intrinsic activity, the types of receptors, the definition and types of the second messengers, receptor desensitization.

2.教学难点

G-protein-coupled receptors, transmembrane kinase receptors, ligand gated ion channel receptors, and intracellular receptors

四、教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment. 

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

1. The significance of the EC50/ED50.

2. For an optimal choice of a drug, either potency or Emax is crucial?

2. 实验教学：（简要列出实验内容标题）

五、更新或补充内容提要

六、复习思考题

1. The significance of the EC50/ED50.

2. For an optimal choice of a drug, either potency or Emax is crucial?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018级药学英文班

授课章节

Chapter 3 Pharmacokinetics & Pharmacodynamics

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) The ADME process of drug.

(2) The characteristic of simple diffusion.

(3) First pass elimination.

(4) The process of absorption.

(5) The significance of plasma protein binding.

(6) Two kinds of physiological barrier.

 (7) The three patterns of renal excretion.

(8) The definition of hepato-enteral circulation.

(9) How does the pH of body fluid & ionization of drugs affect the distribution of drug.

(10) The action, site and steps of drug metabolism.

(11) The definition of Tmax, Cmax, Vd, CL and the calculation methods of t1/2, AUC, F.

(12) How to use the index (Tmax, Cmax, AUC, F) to evaluate the quantity of the drug.

(13) Etiological therapy and Symptomatic therapy.

(14) The division of compartment models.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. The objectives and contents of pharmacokinetics.  [4 min]

2. The three patterns of drug transportation.   [3 min]

3. Effect of pH on the rate of simple diffusion.  [4 min]

4. The characteristics of filtration and carrier-mediated transport.  [4 min]

5. GI administration includes oral administration, sublingual administration and rectal administration.  [11 min]  

6. The hepatic first-pass effect can be avoided by use of sublingual tablets, transdermal preparations, rectal suppositories and inhalation preparations.  [4 min]

7. The route and the characteristics of injection, inhalation, transdermal administration, and local administration.   [4 min]

8.The significance of plasma protein binding and physiological barriers.  [7 min]

9. Basic concepts of pharmacokinetics and time-concentration curve.   [10 min]

10. Pharmacokinetic parameters including Tmax, Cmax, apparent volume of distribution (Vd),  elimination rate constant (k), half time (t1/2), area under the curve (AUC), bioavailability (F), and clearance (CL).   [16 min]

12. Etiological therapy and symptomatic therapy.   [10 min]

3. 教学重点与难点

1. 教学重点

The hepatic first-pass effect can be avoided by use of sublingual tablets, transdermal preparations, rectal suppositories and inhalation preparations.

2. 教学难点

Effect of pH on the rate of simple diffusion.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment. 

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1). According to Dm and DL, how to design the administration strategy?

(2). The processes of drug metabolism.

2. 实验教学：（简要列出实验内容标题）

5. 更新或补充内容提要

6. 复习思考题

1. What does first pass elimination mean?

2. According to the elimination kinetics of drugs, how to guide the rational administration?

3. How to use the index (Tmax, Cmax, AUC, F) to evaluate the quantity of the drugs?

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018级药学英文班

授课章节

Chapter 4 Drug Biotransformation

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the key procedures of drug biotransformation.

(2) To learn the roles of biotransformation in drug disposition.

(3) To learn the major organs where drug biotransformation occurs.

(4) To understand the enzymes involved in biotransformation.

技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. The roles of biotransformation.   [20 min]

2. Human Liver P450 Enzymes.   [30 min]

Induction & inhibition of P450.

3. Toxicity of Acetaminophen.   [30 min]

三、教学重点与难点

1.教学重点

Human Liver P450 Enzymes

2.教学难点

Induction & inhibition of P450.

四、教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment. 

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Why is biotransformation necessary for some drugs?

Where does drug biotransformation occur?

2. 实验教学：（简要列出实验内容标题）

五、更新或补充内容提要

六、复习思考题

What is the major roles of biotransformation?

What are the enzymes involved in biotransformation?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018级药学英文班

授课章节

Chapter 5 Development & Regulation of Drugs

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the variations in drug responsiveness.

(2) To learn the mechanisms of receptor regulation.

(3) To understand the factors of geriatric considerations.

(4) To understand the selectivity of drugs.

2.技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Variations in drug responsiveness: alteration in concentration of drug that reaches the receptor; variations in concentration of an endogenous receptor ligand; alterations in number or function of receptors; changes in components of response distal to the receptor.   [10 min]

2. Receptor regulation: synthesis and degradation, covalent modification, association with other regulatory proteins, relocalization within the cell; be subject to feedback by their own signaling outputs.   [10 min]

3. Geriatric considerations: decreasing oral absorption; decreasing plasma protein concentration; decreasing muscle mass; increasing body fat; decreasing liver/renal function; multiple drugs; multiple diseases.   [10 min]

4. Selectivity of drug: drugs are only selective - rather than specific - in their actions; selectivity can be measured by comparing binding affinities of a drug to different receptors or by comparing ED50s for different effects of a drug in vivo; in drug development and in clinical medicine, selectivity is usually considered by separating effects into two categories: beneficial or therapeutic effects versus toxic effects.  [10 min]

三、教学重点与难点

1.教学重点

Variations in drug responsiveness: alteration in concentration of drug that reaches the receptor; variations in concentration of an endogenous receptor ligand; alterations in number or function of receptors; changes in components of response distal to the receptor.

2.教学难点

Receptor regulation: synthesis and degradation, covalent modification, association with other regulatory proteins, relocalization within the cell; be subject to feedback by their own signaling outputs.

四、教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment. 

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Why is biotransformation necessary for some drugs?

Where does drug biotransformation occur?

2. 实验教学：（简要列出实验内容标题）

五、更新或补充内容提要

六、复习思考题

What is the major role of biotransformation?

What are the enzymes involved in biotransformation?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 6 Introduction to autonomic pharmacology

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. To learn the classification, distribution, and physiological functions of receptors.

2. To learn the basic actions and classification of drugs acting on the efferent nerve system.

3. To understand the synthesis, storage, release and elimination of neurotransmitter.

2. 技能（能力）目标：

1. To describe the pharmacological actions of the cholinergic and adrenergic receptors.  

2. 授课内容（依据教学大纲）及时间分配

1. The efferent nervous system: Autonomic nervous system (ANS), somatic motor nervous system. (20 min)

2. The anatomy of the autonomic nervous system. (10 min)

3. Neurotransmitters and actions.  (40 min)

4. Classification and function of autonomic receptors. (30)

3. 教学重点与难点

3. 教学重点

1. The classification, distribution, and physiological functions of receptors

2. The basic actions and classification of drugs acting on the efferent nerve system

4. 教学难点

（1）The pharmacological actions of the cholinergic and adrenergic receptors  

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

6. 复习思考题

1. Describe the pharmacological actions of the cholinergic and adrenergic receptors.

2. Description of the classification of neurotransmitters in ANS.

7. 学习资源、课外自主学习参考

The ANS in the physiopathology of the eye.  

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 7 Cholinoceptor activating & cholinesterase- inhibiting drugs

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the Classification of cholinoceptor-activating drugs, chemical structures and mechanism of action.

(2) To learn the pharmacological effects of cholinoceptor-activating drugs.

(3) To learn the classification and physiologic function of efferent nerve.

(4) To understand major adverse reactions of cholinoceptor-activating drugs.

(5) To understand the pharmacological effects and therapeutic applications of cholinersterase-inhibiting drugs.

2. 技能（能力）目标：

(1) To describe the pharmacological effects of cholinoceptor-activating drugs.

(2) To describe the pharmacological effects of cholinersterase-inhibiting drugs.  

2. 授课内容（依据教学大纲）及时间分配

1. The classification and actions of the cholinergic receptor. (15 min)

2. Classification of cholinoceptor-activating drugs. (10 min)

3. Pharmacological effects of the direct-acting drugs (acetylcholine)  (30 min)

4. Adverse reactions of cholinoceptor-activating drugs.   (10)

5. The indirect-acting drugs (cholinesterase inhibitor )  (35 min)

3. 教学重点与难点

5. 教学重点

(1) The classification of cholinoceptor-activating drugs, chemical structures and mechanism of action

(2) The pharmacological effects of cholinoceptor-activating drugs

(3) The classification and physiologic function of efferent nerve

(4) The major adverse reactions of cholinoceptor-activating drugs

(5) The pharmacological effects and therapeutic applications of cholinersterase-inhibiting drugs.

6. 教学难点

（1）The pharmacological effects and therapeutic applications of cholinersterase-inhibiting drugs.  

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

6. 复习思考题

1. To describe Pharmacological effects of cholinoceptor-activating drugs.  

2. To describe Pharmacological effects of cholinersterase-inhibiting drugs.   

3. To describe the therapeutic applications of cholinersterase-inhibiting drugs.

7. 学习资源、课外自主学习参考

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 8 Cholinoceptor-blocking drugs

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the pharmacological actions and therapeutic uses of cholinoceptor-bloking drugs.

(2) To learn the major adverse reactions of cholinoceptor-bloking drugs.

(3) To understand major adverse reactions of cholinoceptor-activating drugs.

(4) To understand the classification and structure of cholinoceptor- bloking drugs.

(5) To understand the mechanisms of action of cholinoceptor-bloking drugs.

2.技能（能力）目标：

(1) To describe the pharmacological actions and therapeutic uses of cholinoceptor-bloking drugs.

2. 授课内容（依据教学大纲）及时间分配

1. Classification and structure of cholinoceptor-bloking drugs. (5 min)

2. The structure and pharmacokinetics of muscarinic receptor-blocking drugs. (5 min)

3. The mechanism of action of muscarinic receptor-blocking drugs.  (15 min)

4. Pharmacological effects of muscarinic receptor-blocking drugs. (25)

5. The therapeutic applications of muscarinic receptor-blocking drugs. (20 min)

6. Adverse effects of muscarinic receptor-blocking drugs.  (10 min)

7. Ganglion-blocking drugs.  (20 min)

3. 教学重点与难点

7. 教学重点

(1) The pharmacological actions and therapeutic uses of cholinoceptor-bloking drugs

(2) The major adverse reactions of cholinoceptor-bloking drugs

8. 教学难点

(1) The pharmacological actions of the cholinergic and adrenergic receptors  

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

6. 复习思考题

(1) To describe the muscarinic receptor subgroups and their antagonists.  

(2) To describe the pharmacological effects of atropine.  

(3) To describe the clinical uses of muscarinic blocking drugs.

7. 学习资源、课外自主学习参考

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 9 Adrenoceptor Activating Drugs

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) Distribution of the adrenoceptor subtypes.

(2) Effects of stimulation of different adrenergic receptors.

(3) To learn the effect of sympathomimetic drugs on cardiavascular system.

(4) To learn the cardiovascular clinical use of sympathomimetic drugs.

(5) To understand the effect of sympathomimetic drugs on eye, respiratory tract, gastrointestinal tract, genitourinary tract, and exocrine glands system.

(6) To learn the actions and clinical uses of NA, AD, ISOP and DA.

(7) To understand the effects and clinical uses of ephedrine, mephentermin, metaraminol and phenylephrine.

2.技能（能力）目标：

(1) To describe the pharmacological mechanism of cardiovascular application of sympathomimetic drugs.

2. 授课内容（依据教学大纲）及时间分配

1. Identification of adrenoceptors.  [5 min]

2. Molecular mechanism of sympathomimetic action.   [10 min]

3. Receptor regulation.   [10 min]

4. Effects of stimulation of α- and β–adrenergic receptors   [10 min]

5. The effect of sympathomimetic drugs on cardiovascular system.   [5 min]

6. The effect on other organs.   [5 min]

7. Cardiovascular applications.   [15 min]

8. Pulmonary applications.   [5 min]

9. Other applications.    [5 min]

10. Classification of adrenergic drugs  [5 min]

11. Discussion ofαand β-R agonists: adrenaline dopamine ephedrine   [5 min]

12. Discussion of α-R agonists: noradrenaline mephentermin, metaraminol and phenylephrine  [5 min]

13. Discussion of β–R agonists ：isoproterenol   [5 min]

3. 教学重点与难点

1. 教学重点

(1) The effect of sympathomimetic drugs on cardiavascular system.

(2) The cardiovascular clinical use of sympathomimetic drugs.

(3) The effect of sympathomimetic drugs on eye, respiratory tract, gastrointestinal tract, genitourinary tract, and exocrine glands system.

(4) The actions and clinical uses of NA, AD, ISOP and DA.

2. 教学难点

(1) The pharmacological mechanisms of cardiovascular application of sympathomimetic drugs.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

6. 复习思考题

1. How many types can adrenergic receptors be classified?

2. What different functions are there between α1–R and α2–R?

3. What is the pharmacological mechanism of cardiovascular application of sympathomimetic drugs?

4. Why is Adrenaline used in the treatment of anaphylactic shock and should be first choice?

7. 学习资源、课外自主学习参考

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 10 Adrenoceptor Antagonist Drugs

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the actions and clinical use of phentolamine.

(2) To understand the adverse effects of α-adrenergic blockers.

(3) To understand the pharmacological action of α1 receptor blockers.

(4) To learn the pharmacological action and clinical use of β-R blockers ISA.

(5) To understand the adverse effects of β-adrenergic blockers.

2.技能（能力）目标：

(1) To describe the pharmacological mechanism of cardiovascular application of sympathomimetic drugs.

2. 授课内容（依据教学大纲）及时间分配

1. Classification of anti-adrenergic drugs.   [10 min]

2. Pharmacological effects after blocking adrenergic receptors.   [10 min]

3. Effects not related to the blocking of β receptor.   [10 min]

4. Pharmacological effects and therapeutic applications of α-R blockers including phentolamine, tolazoline, phenoxybenzamine, and prazosin.    [15 min]

5. Classification of β-adrenergic blockers.    [10min]

6. Pharmacological effects of β-adrenergic blockers.   [15 min]

7. Therapeutic applications of β-adrenergic blockers.   [10 min]

8. Adverse effects of β-adrenergic blockers.   [10 min]

9. Features of selective β1 receptor blockers and β-adrenergic blockers with ISA.  [10 min]

3. 教学重点与难点

3. 教学重点

(1) The action and clinical use of phentolamine.

(2) The adverse effects of α-adrenergic blockers.

(3) The pharmacological action and clinical use of β-R blockers ISA.

(4) The pharmacological action of α1 receptor blockers..

4. 教学难点

(1) The pharmacological action and clinical use of β-R blockers ISA.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

6. 复习思考题

1. Why can phentolamine not be used in constitutional hypertension?

2. Can β-adrenergic blockers be used for heart failure clinically?

3. What are effects of rennin angiotensin system on the blood pressure?

7. 学习资源、课外自主学习参考

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 21 Introduction to the Pharmacology of CNS Drugs

授课时间

50分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the actions and clinical use of phentolamine.

(2) To understand the adverse effects of α-adrenergic blockers.

(3) To understand the pharmacological action of α1 receptor blockers.

(4) To learn the pharmacological action and clinical use of β-R blockers ISA.

(5) To understand the adverse effects of β-adrenergic blockers.

2.技能（能力）目标：

(1) To describe the pharmacological mechanism of cardiovascular application of sympathomimetic drugs.

2. 授课内容（依据教学大纲）及时间分配

1. Classification of anti-adrenergic drugs.   [10 min]

2. Pharmacological effects after blocking adrenergic receptors.   [10 min]

3. Effects not related to the blocking of β receptor.   [10 min]

4. Pharmacological effects and therapeutic applications of α-R blockers including phentolamine, tolazoline, phenoxybenzamine, and prazosin.    [15 min]

5. Classification of β-adrenergic blockers.    [10min]

6. Pharmacological effects of β-adrenergic blockers.   [15 min]

7. Therapeutic applications of β-adrenergic blockers.   [10 min]

8. Adverse effects of β-adrenergic blockers.   [10 min]

9. Features of selective β1 receptor blockers and β-adrenergic blockers with ISA.  [10 min]

3. 教学重点与难点

1. 教学重点

(1) The action and clinical use of phentolamine.

(2) The adverse effects of α-adrenergic blockers.

(3) The pharmacological action and clinical use of β-R blockers ISA.

(4) The pharmacological action of α1 receptor blockers..

2. 教学难点

(1) The pharmacological action and clinical use of β-R blockers ISA.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

6. 复习思考题

1. Why can phentolamine not be used in constitutional hypertension?

2. Can β-adrenergic blockers be used for heart failure clinically?

3. What are effects of rennin angiotensin system on the blood pressure?

7. 学习资源、课外自主学习参考

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 22Sedative and hypnotics

授课时间

50分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) Master Chemical Classification of Sedative-Hypnotics

(2) Master Pharmacodynamics of Sedative-Hypnotics

(3) Master Tolerance; Psychologic & Physiologic Dependence of Sedative-Hypnotics

(4) Master Antagonists of Sedative-Hypnotics

(5) Master Clinical Toxicology of Sedative-Hypnotics

(6) Master Pharmacokinetics of Sedative-Hypnotics

2.技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Differences between Sedative and Hypnotic Drugs.  (5 min)

2. Chemical Classification: Benzodiazepines; Barbiturates; Newer Hypnotics (5 min)

3. Pharmacokinetics: Absorption and distribution; Biotransformation; Excertion

(5 min)

4. Pharmacodynamics (5 min)

5. Tolerance; Psychologic & Physiologic Dependence (5 min)

6. Benzodiazepine Antagonists: Flumazenil (5 min)

7. Clinical Pharmacology of Sedative-Hypnotics (20 min)

1. Treatment of Anxiety States

2. Treatment of Sleep Problems

3. Direct Toxic Actions

3. 教学重点与难点

1. 教学重点

(1) Chemical Classification of Sedative-Hypnotics

(2) Pharmacodynamicsof Sedative-Hypnotics

(3) Antagonists of Sedative-Hypnotics

2. 教学难点

(1) Tolerance; Psychologic & Physiologic Dependence

(2) Clinical Toxicology of Sedative-Hypnotics

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

实验教学：

5. 更新或补充内容提要

Introduce structure of sleep

Dosages of drugs used commonly for sedation and hyponosis

6. 复习思考题

1. The multiple sites in GABA receptor for Sedative-Hypnotic Drugs.

What are the advantages and Disadvantages of benzodiazepines for treatment of anxiety states

7. 学习资源、课外自主学习参考

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. David E. Golan, 4^th Edition, 2016

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 24Antiseizure drugs

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) Master Seizure types

(2) Master Drugs Used in Partial Seizures & Generalized Tonic-Clonic Seizures

(3) Master Drugs Used in Generalized Seizures

(4) Master Antiseizures classification

(5)Understand Drug mechanisms

(6) Understand Drug chemistry

2.技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Introduction and seizure types. (10 min)

2. Drug chemistry and mechanisms  (10 min)

3. Pharmacokinetics  (10 min)

4. Drugs Used in Partial Seizures & Generalized Tonic-Clonic Seizures (20 min)

1. Phenytoin; (2) Carbamazepine; (3) Phenobarbital

Mechanism of Action; clinical use; Pharmacokinetics; Drug Interactions; Toxicity

5. Drugs Used in Generalized Seizures (30 min)

(1) Ethosuximide; (2) Valproic Acid & Sodium Valproate; (3) Benzodiazepines

Mechanism of Action; clinical use; Pharmacokinetics; Drug Interactions; Toxicity

6. antiseizures classification (20 min)

1. TONIC-CLONIC & PARTIAL SEIZURES

Carbamazepine. Phenytoin, valproic acid

2. ABSENCE SEIZURES

Ethosuximide, valproic acid, clonazepam

3. MYOCLONIC SEIZURES

_{Valproic acid, clonazepam, nitrazepam, or other benzodiazepines}

3. 教学重点与难点

1. 教学重点

(1) Drugs Used in Partial Seizures & Generalized Tonic-Clonic Seizures

(2) Drugs Used in Generalized Seizures

(3) Antiseizures classification

2. 教学难点

(1) Seizure types

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

Drug development for Epilepsy   

6. 复习思考题

1. The seizure classification in clinic

2. The usage of phenytoin and its mechanisms in anti-seizure

7. 学习资源、课外自主学习参考

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. David E. Golan, 4^th Edition, 2016

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 31 Opoid analgesics and antagonists

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the major pharmacological effects, clinical applications, and the major side effects of morphine.

(2) To understand the mechanisms of opioid.

(3) To understand the major pharmacological effects and clinical applications of codeine, pethidine, and pentazoin.

2.技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Classes of analgesic drugs.  [5 min]

2. Discovery of opioid and morphine.  [5 min]

3. Morphine receptor: distribution and the action mechanism of morphine. [7 min]

4. Pharmacological effects of morphine. [20 min]

5. Analgesia and sedation, Respiratory depression, Emesis and nausea, Cough reflex, Miosis.  [8 min]

6. Cardiovascular system, Smooth muscle. [5 min]

7. Tolerance and physical dependence, addiction. [5 min]

8. Clinical applications and side effects of morphine.  [5min]

9. Pharmacokinetics of morphine. [5min]

10. Major pharmacological effects and clinical applications of codeine, pethidine, Methadone Fentanyl pentazoin.   [20 min]

11. Opioid Antagonists—Naloxone: clinic use and research use.  [5 min]

12. Drug abuse. [10 min]

3. 教学重点与难点

1. 教学重点

The major pharmacological effects, clinical applications, and the major side effects of morphine.

2. 教学难点

The mechanisms of opioid

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

Discovery and harm of opium

6. 复习思考题

1. What are the pharmacological effects and clinic uses of morphine? Which main side effect of morphine limits its wide uses?

2. Compared with morphine, can you tell the clinic uses of pethidine？

3. Please compare the analgesic effects of aspirin and morphine.

4. How many classes of analgesics are currently in clinic use? How are these drugs selected?

7. 学习资源、课外自主学习参考

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. David E. Golan, 4^th Edition, 2016

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 36 Nonsterodal anti-inflammatory drug

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the pharmacological effects, clinical applications and adverse effects of aspirin and acetaminophen.

(2) To understand the pharmacological action and clinical application of ibuprofen.

(3) To understand the identical characters of anti-inflammatory drugs.

(4) To understand the differences between the non-selective and selective COX-2 inhibitor.

2.技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. NSAIDs and their common characters.   20 min

1) Antipyretic Effect:

(1). Decrease high fever body temperature to normal level, has no effect on normal body temperature.

(2). Mechanism: Inhibit pyrogen–induced production of prostaglandins in the hypothalamus.

2). Anti-Analgesic Effect

(1). N-anesthesia Anti-analgesic drugs don’t cause euphoria, tolerance, respiratory depression.

(2). The intensity of Anti-analgesic effect are lower than pethidine.

(3). Effect on chronic dull pain and no effect on sharp pain.

(4). Mechanism : Inhibit the synthesis of prostaglandins and alleviate  analgesic action. The action site is mainly in peripheral.

3). Anti-inflammatory Effect

(1). All NSAIDs but acetaminophen can alleviate inflammation.

(2). Locally inhibit the synthesis of PG

2. Aspirin.  30 min

About Aspirin   

Mechanism of aspirin  COX-1,COX-2   

Antipyretic-Analgesic and Anti-inflammatory effects    

Inhibition of Platelet Aggregation and thrombosis.    

Side effects  

3. Acetaminophen. 10 min

Comparison with aspirin.

4. The pharmacological effects and clinical applications of ibuprofen. 10 min

5. The identical characters of anti-inflammatory drugs. Selective COX-2.  10 min

6. Other anti-inflammatory drugs, including to clofenami acid, nimesulide, piroxicam, naproxen.   20 min

3. 教学重点与难点

1. 教学重点

To learn the pharmacological effects, clinical applications and adverse effects of aspirin and acetaminophen.

2. 教学难点

(4) To understand the differences between the non-selective and selective COX-2 inhibitor.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

The history and new use of aspirin in clinic.  

6. 复习思考题

1). What are the pharmacological effects, clinic uses and the main side effects of aspirin and ibuprofen?

2).  What are the the difference in modifying body temperature between aspirin and chlorpromazine.

7. 学习资源、课外自主学习参考

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. David E. Golan, 4^th Edition, 2016

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018级药学英文班

授课章节

Chapter 15 Diuretic Agents

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the classification of diuretics.

(2) To learn the mechanism of diuretics.

(3) To learn the pharmacological effects and clinical applications of diuretics.

(4) To understand the major adverse reactions of diuretics.

(5) To understand the renal urinary physiology and site of action of diuretics.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Introduction  (30 min)

(1) Discovery

The early diuretic measures

The discovery of thiazide diuretics and other diuretics

(2) Renal urinary physiology and site of action of diuretics

Renal Glomerulus, Renal Tubules, Proximal Convoluted Tubule,

Ascending Loop of Henle, Distal Convoluted Tubule and Collecting Duct

2. Classification of diuretics  (5 min)

(1) Loop or high-ceiling diuretics

(2) Thiazides and related agents

(3) Potassium-sparing diuretics

(4) Carbonic anhydrase inhibitors

3. Loop or high-ceiling Diuretics   (15 min)

(1) Pharmacological effects

Diuretic effects, Effects on renal hemodynamics

(2) Pharmacokinetics, Adverse Effects, Drug interactions

4. Thiazides and related agents   (15 min)

(1) Pharmacological Effects

Mechanism of action

Effect against diabetes insipidus, Depressor effects

(2) Pharmacokinetics, Adverse Effects

5. Potassium-sparing diuretics   (5 min)

(1) Spironolactone (antisterone)

(2) Triamterene and amiloride

6. Carbonic anhydrase inhibitors   (2 min)

7. Osmotic diuretics   (3 min)

Therapeutic applications

8. Summary (5 min)

三、教学重点与难点

1.教学重点

Classification of diuretics  (5 min)

(1) Loop or high-ceiling diuretics

(2) Thiazides and related agents

(3) Potassium-sparing diuretics

(4) Carbonic anhydrase inhibitors

2.教学难点

Renal urinary physiology and site of action of diuretics

Renal Glomerulus, Renal Tubules, Proximal Convoluted Tubule,

Ascending Loop of Henle, Distal Convoluted Tubule and Collecting Duct

四、教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Which kind of diuretics can cause potassium depletion?

The history and development of treatment strategies of diuretics.     

2. 实验教学：（简要列出实验内容标题）

五、更新或补充内容提要

六、复习思考题

1. How are the diuretics classified?  Please give an example for each group.

2. Which diuretics can conserve potassium and how can this property be utilized?

3. What are the similarities and differences between the loop diuretics and thiazides?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology,  14th edition

授课年级

2018级药学英文班

授课章节

Chapter 11  Agents Used in Cardiac Arrhythmias

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. To learn the standard (Singh & Vaughan Williams) classification system for antiarrhythmic drugs.

2. To learn the mechanisms of different antiarrhythmic drugs.

3. To learn the pharmacological actions, clinical applications and adverse effects of different antiarrhythmic drugs.

4. To learn the therapeutic indications and toxicities of the major prototypic drugs in each antiarrhythmic drug class.

5. To understand the electrophysiological background of anti-arrhythmic drugs.

6. To understand the therapeutic principle of swift arrhythmia and the reasonable application of drugs.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. The electrophysiology background of arrhythmias (Proarrhythmias).   (20 min)

Membrane Potential of Cardiac Cell.

Fast and slow responses.

Membrane responsibility and conductivity speed.

Effective refractory period.

2. The electrophysiology mechanism of Arrhythmias.  (20 min)

(1).Abnormal impulse generation (automatic or triggered).

Delayed after-depolarisation and Early after-depolarizations.

(2).Abnormal impulse conduction.

Re-entry, Abnormal pacemaker activity and Heart block.

3. The basic electrophysiology effect of antiarrhythmic Drugs.  (10 min)

4. The classification of anti-arrhythmic drugs (Singh-Vaughan Williams Classification). (10 min)

Sodium Channel Blockers.

βreceptor Blockers.

Potassium Channel Blockers.

Calcium Channel Blockers.

5. The mechanisms by which different antiarrhythmic drugs are thought to act. (15 min)

6. The anti-arrhythmic drugs used commonly for clinical application. (10 min)

7. The therapeutic principle of swift arrhythmia and the reasonable application of drugs. (10 min)

8. Summary. (5 min)

3. 教学重点与难点

1. 教学重点

The classification of anti-arrhythmic drugs (Singh-Vaughan Williams Classification).  

2. 教学难点

The electrophysiology mechanism of Arrhythmias.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

（1）分析讨论

Which drug is used together with quinidine in the treatment of atrial flutter? Why?

（2）实例讨论

Although major development in the past decade has achieved in the therapy of arrhythmias, currently available drugs is hazardous, unpredictable, and often ineffective. The therapeutic index of antiarrhythmic drugs is very narrow. Physicians prescribing these agents must be thoroughly familiar with the indications, contraindications, toxicities and pharmacological properties of the drug used. The selection of a particular drug therapy should be based on the "clinical value" by an assessment of benefits and risks of treatment.

2. 实验教学：（简要列出实验内容标题）

5. 更新或补充内容提要

6. 复习思考题

1. How many types of antiarrhythmic drugs and what are the prototypic agents in each group?

2. Definition: Cinchonism

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology,  14th edition

授课年级

2018级药学英文班

授课章节

Chapter 14  Antihypertensive Drugs

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the major  types  of  antihypertensive  drugs  and  their  mechanisms.

(2) To understand the name of the prototype drugs of each major type.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Review of the physiology of blood pressure regulation.   [20 min]

2. Pathophysiology of hypertension.   [20 min]

3. Individual introduction of the major types of antihypertensive drugs.  [50 min]

(1)Sympathoplegic agents

Centrally acting sympatholegic drugs: clonidine,  methyldopa

Ganglion blocking agents: trimethaphan

Adrenergic neuron-blocking agents: guanethidine, reserpine

Adrenergic blockers: propranolol, prazosin

(2)Agents that block production or action of angiotensin

Angiotensin Converting Enzyme Inhibitors: captopril

Angiotensin Receptor blockers: losartan

(3)Diuretics: hydrochlorothiazide

(4)Direct vasodilators

Calcium Channel Blockers: nifedipine

Peripheral Vasodilators: hydralazine, nitroprusside, minoxidil

4. Summary.   [10 min]

3. 教学重点与难点

1. 教学重点

The first line therapy of antihypertensive drugs  

2. 教学难点

The regulation of hypertension by RAAS system

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Case-study: Antihypertensive Drugs

The physiological bases of blood pressure regulation.

Major organs related to blood pressure regulation.

2. 实验教学：（简要列出实验内容标题）

5. 更新或补充内容提要

6. 复习思考题

1. The pharmacological bases of diuretics in treating hypertension.

2. Difference and similarities between ACEI and Ang II receptor antagonists in their actions and side effects.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 12 Vasodilators and the treatment of angina pectoris

授课时间

100 min

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1)To learn the pharmacological effects, therapeutic applications and major adverse reactions of antianginal agents.

(2) To learn the mechanisms of relief of symptoms of angina pectoris by antianginal agents.

(3) To know the classification of antianginal agents.

2. 技能（能力）目标：

(1) To train the abilities how to learn systematically and to achieve mastery through a comprehensive study of the subject;

(2) To train the ability how to co-operation with others in group study;

(3) To train the ability to deliver a presentation;

(4) To train the creative thinking by learning the drug history of discovery of Nitrates and Nitrites.

2. 授课内容（依据教学大纲）及时间分配

I. Introduction 10 min

[Angina pectoris]

[The types of angina pectoris]

II. Pathophysiology of angina pectoris 7 min

III. Basic pharmacological action of drugs used to treat angina pectoris 3 min

IV. Drugs used to treat angina pectoris

●Nitrates and Nitrites40 min

[History]

[Pharmacological action]

[Mechanism of relief of symptoms of angina pectoris]

[Molecular Mechanism of relaxing smooth muscle ]

[Pharmacokinetics]

[Clinical use]

[Toxicity & Tolerance]

●Beta-adrenoceptor blocking drugs (β blockers) 20 min

[Mechanism of relief of symptoms of angina pectoris]

[Therapeutic applications]

[Beneficial effect of the combination of β-blockers and nitrates]

[Adverse effects]

●Calcium channel blocking drugs(Calcium channel blockers ) 30 min

[ Classification of calcium channel blockers]

[Pharmacokinetics]

[Pharmacological action]

[Clinical use]

[Mechanisms of relief of symptoms of angina pectoris]

[Adverse effects]

3. 教学重点与难点

1. 教学重点

(1)The pharmacological effects, therapeutic applications and major adverse reactions of antianginal agents.

(2)  Actionmechanism of Nitrates and Nitrites, β blockers and calcium channel blockers in the treatment of angina pectoris.

(3) Beneficial effect of the combination of β-blockers and nitrates or the combination of β-blockers and calcium channel blockers.

(4) The differences of Nitrates and Nitrites, β blockers and calcium channel blockers in the application of angina pectoris.

2. 教学难点

(1)  Action mechanism of Nitrates and Nitrites, β blockers and calcium channel blockers in the treatment of angina pectoris.

(2) Beneficial effect of the combination of β-blockers and nitrates or the combination of β-blockers and calcium channel blockers.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：

Animation;

Images;

Graphs and tables;

Video

B. 互动教学：

2. 实验教学：

5. 更新或补充内容提要

The application of asprin in the treatment of angina pectoris.

6. 复习思考题

1. Why are Nitrates and Nitrites, β blockers and calcium channel blockers used to treat angina pectoris.

2. What are the beneficial effect of the combination of β-blockers and nitrates or the combination of β-blockers and calcium channel blockers?

3. Please  describe the differences of Nitrates and Nitrites, β blockers and calcium channel blockers in the application of angina pectoris.

4. Can β blockers be used to treat unstable angina? Why?

7. 学习资源、课外自主学习参考

Learn more at

http://www.heart.org

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018药学

授课章节

Chapter 13 Drugs used in heart failure

授课时间

200 min

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1).To learn the pharmacological effects, therapeutic applications and major adverse reactions of cardiac glycosides.

(2). To learn the action mechanisms of cardiac glycosides, renin—angiotensin—aldosterone system inhibitors , β-adrenoceptor blockers,  Diuretics in the treatment of heart failure.

(3). To know the action mechanisms of the other drugs used in heart failure.

(4). To know the classification of drugs used in heart failure.

2. 技能（能力）目标：

(1) To train the abilities how to learn systematically and to achieve mastery through a comprehensive study of the subject;

(2) To train the ability how to co-operation with others in group study;

(3) To train the ability to deliver a presentation;

(4) To train the creative thinking by learning the drug history of cardiac glycosides and the development of drugs used in heart failure.

2. 授课内容（依据教学大纲）及时间分配

I. Introduction 5 min

[Heart failure]

II. Pathophysiology of angina pectoris 20 min

III. Classification of drugs used in heart failure 5 min

IV. Drugs used to treat heart failure

●Cardiac glycosides 70 min

[History]

[Pharmacological action and Mechanisms of  action]

[Pharmacokinetics]

[Clinical use]

[Adverse effects and toxicity treatment]

●renin—angiotensin—aldosterone system inhibitors30 min

[Therapeutic effects of Angiotensin Converting enzyme (ACE) inhibitors in heart failure]

[Therapeutic effects of Angiotensin receptor blockers in heart failure]

●Beta-adrenoceptor blocking drugs (β blockers)20 min

[Therapeutic effects of β blockers in heart failure]30 min

●Other agents used in CHF20 min

(1) Diuretics: Hydrochlorothiazide, Spironolactone

(2) Vasodilators: hydralazine, isosorbide dinitrate

(3) β1-selective adrenoceptor agonists

(4) Phosphodiesterase(PDE)inhibitors

(5) Calcium channel blockers

3. 教学重点与难点

1. 教学重点

(1). The pharmacological effects, therapeutic applications and major adverse reactions of cardiac glycosides.

(2). The action mechanisms of cardiac glycosides, renin—angiotensin—aldosterone system inhibitors , β-adrenoceptor blockers,  Diuretics in the treatment of heart failure.

(3). The action mechanisms of the other drugs used in heart failure.

2. 教学难点

(1)  The mechanisms of positive inotropic effect of cardiac glycosides.

(2)Electrical effects of cardiac glycosides.

(3) The action mechanisms of cardiac glycosides, renin—angiotensin—aldosterone system inhibitors  and β-adrenoceptor blockers in the treatment of heart failure.

4. 教学方法选择

3. 理论课堂教学

A. 多媒体教学：

Animation;

Images;

Graphs and tables;

Video

B. 互动教学：

4. 实验教学：

Effects of drugs on ventricular stroke output of isolated heart of frog in situ

5. 更新或补充内容提要

The application of renin—angiotensin—aldosterone system inhibitors and β-adrenoceptor blockers in the treatmentof heart failure induced by myocardial infarction.

6. 复习思考题

1. What are the therapeutic mechanisms of cardiac glycosides, renin—angiotensin—aldosterone system inhibitors  or β-adrenoceptor blockers in the treatment of heart failure.

2. Why do cardiac glycosides bring about inotropic effect?

3. What are the therapeutic mechanisms of cardiac glycosides in supraventricular arrhythmias ? 4. What are the drug therapy for  digoxin-induced  arrhythmias ?

7. 学习资源、课外自主学习参考

Learn more at

http://www.heart.org

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018级药学英文班

授课章节

Chapter 33 Agents used in anemia

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

To understand the clinical application and major adverse reactions of iron, folic acid, and vitamin B12.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Diminished Production/Replacement of RBC’s Anemia[20 min]

Microcytic anemia – deficiency of Fe

Megaloblastic anemia/Macrocytic anemia- deficiency of folic acid and B12

Normocytic anemia – deficiency of Erythropoietin

2. Iron.   [20 min]

Factors influencing iron absorption

Mechanism of Iron Absorption

Therapeutic uses of Iron

Iron Preparations

Toxicity of Iron Overdose

3. Folic Acid[20 min]

Enzymatic reactions that use folates

Therapeutic Uses of Folic Acid

4.Vitamin B12(Cyanocobalamin)-Pernicious anemia[20 min]

Enzymatic reactions that use vitamin B12

Mechanism for VitB12

Therapeutic Uses of B12

4. Normocytic anemia -Hematopoietic growth factors[10 min]

Sites of action for EPO

Therapeutic Uses

5.Summary[10 min]

三、教学重点与难点

1.教学重点

Microcytic anemia –Fe

Megaloblastic anemia/Macrocytic anemia- folic acid and B12

Normocytic anemia –Erythropoietin

2.教学难点

Enzymatic reactions that use folates and vitamin B12

四、教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Case study－Agents used in anemia

What type of anemia should they be used, respectively?

2. 实验教学：（简要列出实验内容标题）

五、更新或补充内容提要

六、复习思考题

What are the representative drugs used in anemia?

What type of anemia should they be used, respectively?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018级药学英文班

授课章节

Chapter 34 Drugs Used in Disorders of Coagulation

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1). To learn the pharmacological action, clinical application, and adverse reaction of heparin, coumarin derivatives, streptokinase, urokinase, vitamin K, aspirin.

(2). To understand the pharmacological action, clinical application of direct thrombin inhibitors clopidogrel, ticlopidine, glycoprotein IIb/IIIa inhibitors and dipyridamole.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Review of the regulation of coagulation and fibrinolysis.   [10 min]

2. Anticoagulants

Heparin: source and chemistry. pharmacological action and feature, mechanism of action, clinical application, adverse reaction, and intoxication prevention.  [20 min]

coumarin derivatives (e.g., dicoumarol ,warfarin) : chemistry. pharmacological action and feature, mechanism of action, clinical application, adverse reaction, and intoxication prevention. interaction of drugs.  [20 min]

3.fibrinolysis drugs: streptokinase, urokinase. mechanism of action and feature, clinical application, adverse reaction.  [10 min]

4.anti-platelet drugs: aspirin, Clopidogrel, Ticlopidine, Glycoprotein IIb/IIIa inhibitors and dipyridamole, mechanism of action, clinical application and assess.   [10 min]

5.  Drugs used in bleeding disorder (vitamin K): source, mechanism of action, clinical application, and adverse reaction.  [10 min]

3. 教学重点与难点

3. 教学重点

To compare heparin with warfarin in treating thromboembolic disorder.

4. 教学难点

Review of the regulation of coagulation and fibrinolysis.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1). The discovery of heparin.

(2). The discovery of aspirin.

2. 实验教学：（简要列出实验内容标题）

5. 更新或补充内容提要

6. 复习思考题

1.What are the therapeutic applications of heparin?

2.To compare heparin with warfarin in treating thromboembolic disorder. (include Pharmacokinetics and Mechanism of action)

3. What can be done in treating a hemorrhagic disorder caused by excessive doses of heparin or warfarin?  

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药理学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018 药学

授课章节

Chapter 38  Thyroid & Antithyroid Drugs

授课时间

50分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

 (1) To learn the pharmacological effects, clinical applications and adverse reactions of antithyroid drugs.

(2) To understand the effects of thyroid hormones.

(3) To understand the mechanisms of action of iodides.

2. 技能（能力）目标：

2. 授课内容（依据教学大纲）及时间分配

1. Biosynthesis of Triiodothyronine (T3) and thyroxine (T4); oxidation and  iodination; formation of Thyroxine (T4) and Triiodothyronine (T3); secretion, transportation and  degradation of T3 and T4.   [10 min]

2. The effects and clinical uses of thyroid hormones. [15 min]

3. Anti-thyroid Drugs  [25 min]                        

(1) Thioureas

(2) Iodides

(3) Radioiodine  

(4) β-receptor blocking agents

3. 教学重点与难点

1. 教学重点

（1）The effects and clinical uses of thyroid hormones.

（2）The effects and clinical uses of Anti-thyroid Drugs

2. 教学难点

4. 教学方法选择

1. 理论课堂教学

1. 多媒体教学：

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：

1）Talk about the effects and clinical uses of thyroid hormones.

2）Talk about the effects and clinical uses of Anti-thyroid Drugs

2. 实验教学：

5. 更新或补充内容提要

6. 复习思考题

What the effects and clinical uses of Thioureas?

7. 学习资源、课外自主学习参考

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药理学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018 药学

授课章节

Chapter 39  Adrenocorticosteroids & Adrenocortical Antagonists

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the major pharmacological effects and therapeutic applications of glucocorticoids.   

(2) To learn the major adverse reactions of glucocorticoids.

(3) To learn the physiological effects of glucocorticoids.

(4) To understand the anti-inflammatory mechanisms of glucocorticoids.

(5) To understand the clinical uses of glucocorticoids.

(6) To understand the structure-activity relationships of glucocorticoids.

2. 技能目标

2. 授课内容（依据教学大纲）及时间分配

1. The definition of glucocorticoids, chemical structure and structure-activity relationships of glucocorticoids.   [15min]

2. Pharmacological effects of glucocorticoids.   [20min]

Anti-inflammatory effect, Immunosuppressive effects, Antishock effects, Other effects

3. Therapeutic applications.    [25min]        

Replacement therapy, Severe infections or inflammations, Autoimmune and allergic diseases, Anti-shock therapy, Hematologic disease, Topical administration.

4. Adverse effects.    [20min]                                        

5. Pharmacological effects of mineralocorticoids.   [10min]

6. Corticotropin and inhibitors.   [10min]

3. 教学重点与难点

1.教学重点

（1）Pharmacological effects of glucocorticoids

2. Adverse effects of glucocorticoids

2.教学难点

4. 教学方法选择

1.理论课堂教学

A. 多媒体教学：

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：

What the developmental history of therapy for hypothyroidism?

2.实验教学：

5. 更新或补充内容提要

The treatment strategies for hyperadrenocorticism.

6. 复习思考题

1. To describe the pharmacological actions of corticosteroids.

2. What are the major adverse effects caused by long-term and overdose therapy of glucocorticoids?

3. Can the corticosteroids be used to treat peptic ulcers? Why?

7. 学习资源、课外自主学习参考

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019

Oxford Textbook of Clinical Pharmacology and Drug Therapy

David Grahame-Smith , Jeffrey Aronson. Edition: 3  

Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series)

Springhouse , 2008 Edition: 3Rev Ed.

课程名称

Pharmacology IV

所属学科

药理学

教材名称

Basic & Clinical Pharmacology, 14th edition

授课年级

2018 药学

授课章节

Chapter 41  Pancreatic Hormones & Antidiabetic Drug

授课时间

50分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To learn the pharmacological actions and therapeutic uses of insulin and antidiabetic drugs.

(2) To learn the major adverse reactions of insulin and oral antidiabetic drugs.

(4) To understand the definition and treatment of four types Diabetes.

(5) To understand the principal types and duration of action of insulin preparations.  

(6) To understand the mechanisms of action of insulin and oral antidiabetic drugs.

2. 技能目标

2. 授课内容（依据教学大纲）及时间分配

1. Diabetes mellitus involves an inability to regulate plasma glucose within the normal range. Diabetes mellitus are characterized by insulin deficiency, and diabetes mellitus lead to hyperglycemia.   [5 min]

2. Definition and treatment of four types Diabetes: Insulin-dependent diabetes, Non insulin-dependent diabetes, Gestational Diabetes Mellitus (GDM) and Other specific types.  [5 min]

3. Pharmacological effects, therapeutic applications and adverse reactions of insulin.  [10 min]  

4. Principal types and duration of action of insulin preparations (classification and representative drugs).   [5 min]

5. Classification of insulin delivery system: Regular injections, Portable pen injections, Continuous subcutaneous insulin infusion devices and Inhaled insulin.  [5 min]

6. Classification and representative drugs of antidiabetic drugs.  [5 min]

7. Pharmacological actions, adverse reactions, mechanism of action and clinical uses of antidiabetic drugs.   [15 min]

(1) Insulin Secretagogues: Sulfonylureas; Meglitinides

(2) Insulin Sensitisers: Biguanides; Thiazolidinediones

(3) Alpha-glucosidase inhibitors

(4) Peptide analogs: Glucagon-like peptide analogs, DPP-4 inhibitors, Amylin analogues.

3. 教学重点与难点

1.教学重点

（1）Pharmacological actions, adverse reactions, mechanism of action and clinical uses of Sulfonylureas;

（2）Pharmacological actions, adverse reactions, mechanism of action and clinical uses of Thiazolidinediones;

2.教学难点

4. 教学方法选择

1.理论课堂教学

A. 多媒体教学：

By using multimedia including PPT, cartoon, video in the teaching learning process, we convey vast information and provide many sources from which student can access the information. The Multimedia approach may improve the teaching learning process, provide the opportunity for the students to gain mastery of competencies and skills, and enable the students to get access to information in dynamic environment.

B. 互动教学：

What the developmental history of therapy for hypothyroidism?

2.实验教学：

5. 更新或补充内容提要

The developmental history of treatment strategies for diabetes mellitus..  

6. 复习思考题

1. To describe the pharmacological actions of insulin.   

2. What are the major adverse effects of insulin?   

3. To state the classification of antidiabetic drugs.

7. 学习资源、课外自主学习参考

朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019