课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Introduction to pharmaceutical Analysis

International Pharmacopoeias and Guidelines

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Applications and Definitions

(2) The Life of Medicines

(3) The Quality of Medical Products

(4) Pharmacopoeias

(5) International Harmonization

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis

(2) Learn the life of medicines

(3) Know basic drug properties

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Applications and Definitions (30min)

2. The life of Medicines (30min)

3. The quality of medical Products (40 min)

Lecture II:

1. Overview of legislation (10 min)

2. Legislation and Regulations for industrial production (20 min)

3. Life time of drugs and drug substances (20 min)

4. Pharmacopoeias (20 min)

5. International harmonization (20 min)

6. Legislation and Regulations for pharmacy Production (20min)

7. Summary (10 min)

三、教学重点与难点

1．教学重点

(1) Know the life of medicines

(2) Learn the specific words of medicines

(3) know pharmacopoeias

(4) know the differences between drugs and compounds

2.教学难点

(1) understand the drug-related words

(2) understand what is pharmacopoeias

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the life of medicines

(2) Explain the significance of pharmacopoeias

(3) Review the major concepts and materials covering the chapter.  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapters 1 and 2; preview chapters 3 and 4

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Fundamental Chemical Properties, Buffers and pH

Fundamentals of Pharmaceutical Analysis

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) pH and pKa

(2) Partition

(3) Stereochemistry

(4) Stability

(5) Basic Laboratory Equipments

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn fundamentals of chemical properties

(3) Learn fundamentals of pharmaceutical analysis

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. pH and pKa (20min)

2. Partition (20min)

3. Stereochemistry (10 min)

4. stability testing (30min)

5. what is a pharmaceutical analysis(20min)

Lecture II:

1. how to specify quantities and concentrations (10 min)

2. Basic laboratory equipment (20 min)

3. How to make solution (20 min)

4. calibration of analytical methods  (20 min)

5. Errors, accuracy and precision (10 min)

6. statistics(10min)

7. Some words and concepts (10 min)

三、教学重点与难点

1．教学重点

(1) Know the fundamentals of chemical properties

(2) Know the fundamentals of pharmaceutical analysis

2.教学难点

(1) understand the fundamentals of chemical properties

(2) understand the fundamentals of pharmaceutical analysis  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the fundamentals of chemical properties

(2) Use case study to explain the fundamentals of pharmaceutical analysis

(3) Review the major concepts and materials covering the chapter.  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapters 3 and 4; preview chapters 5

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Titrimetric methods

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) acid-base titration

(2) acid-base titration in non-aqueous media

(3) redox titrations  

(4) Other principles of titration

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn principles of titration

(3) Learn acid-base titration(aqueous and non-aqueous)

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Introduction (20min)

2. acid base titration (20min)

3. practice the calculations (30 min)

4. summary (30min)

Lecture II:

1. acid-base titration in non-aqueous media (20 min)

2. Practice the calculation (30 min)

3. redox titration  (20 min)

4. Practice the calculation (20 min)

5. summary (10 min)

三、教学重点与难点

1．教学重点

(1) Know the principles of titration

(2) Know how to quantify using titration

2.教学难点

(1) understand the principles of titration

(2) understand how to quantify using titration

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principle of acid-base titration

(2) Use case study to explain the principle of acid-base titration in non-aqueous media

(3) Review the major concepts and materials covering the chapter.  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapters 5; preview chapters 6 and 7

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Introduction to spectroscopic methods  

UV spectrophotometry

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Electromagnetic radiation

(2) molecules and electromagnetic radiation

(3) atoms and electromagnetic radiation  

(4) principle of quantitative determination

(5) principle of identification

(6) UV absorbance

(7) Instrumentation

(8) practice

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn principles of spectroscopic methods

(3) Learn principles of UV

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Introduction (20min)

2. Electromagnetic Radiation (20min)

3. Molecules and Electromagnetic Radiation (30 min)

4. Atoms and Electromagnetic Radiation (30min)

Lecture II:

1. Principle of quantitative determination (20 min)

2. Principle of identification (30 min)

3. UV absorbance  (20 min)

4. instrumentation (20 min)

5. practice (10 min)

三、教学重点与难点

1．教学重点

(1) Know the principles of spectroscopic methods including UV

(2) Know how to identify a API using UV

2.教学难点

(1) understand the principles of spectroscopic methods including UV

(2) understand how to identify a API using UV

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principle of spectroscopic methods  

(2) Use case study to explain the principle of UV

(3) Review the major concepts and materials covering the chapter.  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapters 6 and 7; preview chapters 8 and 9

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

IR spectrophotometry  

Atomic  spectrometry

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) IR spectrophotometry

(2) Instrumentation

(3) Scope

(4) instrument calibration

(5) NIR spectrophotometry

(6) atomic absorption spectrometry

(7) Instrumentation

(8) practice

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn principles of IR

(3) Learn principles of AA

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. IR spectrophotometry (20min)

2. instrumentation (20min)

3. Scope (30 min)

4. calibration (30min)

Lecture II:

1. NIR spectrophotometry (20 min)

2. AA (30 min)

3. Instrumentation  (20 min)

4. Applications (20 min)

5. summary (10 min)

三、教学重点与难点

1．教学重点

(1) Know the principles of IR and AA

(2) Know how to identify a API using IR and AA

2.教学难点

(1) understand the principles of IR and AA

(2) understand how to identify a API using IR and AA

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principle of IR

(2) Use case study to explain the principle of AA

(3) Review the major concepts and materials covering the chapter.  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapters 1-9; prepare the test.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Review and test

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

Review the concepts from chapter 1 to chapter 9.  

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

(3) Apply the knowledge to practices

二、授课内容（依据教学大纲）及时间分配

Lecture I:

Review the concepts.  

Lecture II:

Test

三、教学重点与难点

1．教学重点

(1) Know the principles pharmaceutical analysis

(2) Know the fundamentals of pharmaceutical analysis

(3) Know the principles of titrimetric methods

(4) Know the principles of spectroscopic methods.  

(5) know the principles of UV, IR and AA.  

2.教学难点

Make students understand, remember and practice properly.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some pharmaceutical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Preview chapter 9 and 10.  

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chromatographic Separation Principles

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the basic principle, classification, and parameters of chromatography

(2) Master the basic principle of normal phase chromatography

(3) Master the basic principle of reverse phase chromatography

(4) Understand the basic principle of hydrophilic interaction chromatography

(5) Understand the basic principle of chiral separations

(6) Understand the basic principle of size exclusion chromatography

(7) Understand the basic principle of ion exchange chromatography

2.技能（能力）目标：

(1) Learn basic English terms in chromatography analysis  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Apply the knowledge to practices

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. General Introduction—10 min

2. Normal Phase Chromatography—40 min

Lecture II:

3. Reverse Phase Chromatography—40 min

4. Hydrophilic Interaction Chromatography—10 min

Lecture III

5. Chiral Separations—10 min

6. Size Exclusion Chromatography—20 min

7. Ion Exchange Chromatography—20 min

三、教学重点与难点

1．教学重点

(1) The basic principle, classification, and parameters of chromatography

(2) The basic principle of normal phase chromatography

(3) The basic principle of reverse phase chromatography

2.教学难点

The calculation of parameters of chromatography.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some pharmaceutical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. What’s the core difference among various types of chromatography?  

2. How to choose a suitable type of chromatography?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Thin layer chromatography

授课时间

50分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the basic principle of thin layer chromatography

(2) Master the effects on the chromatographic behavior

(3) Know the process of thin layer chromatography

2.技能（能力）目标：

(1) Learn basic English terms in TLC analysis  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use TLC for samples analysis

二、授课内容（依据教学大纲）及时间分配

1. Introduction—5 min

2. Apparatus—5 min

3. TLC plates—5 min

4. Stationary Phases—5 min

5. Mobile Phases—5 min

6. Chromatographic Development—5 min

7. Detection—5 min

8. Application of TLC—5 min

9. Quantitative Analysis and Instrumentation—5 min

10. Summary—5 min

三、教学重点与难点

1．教学重点

(1) The basic principle of thin layer chromatography

(2) The effects on the chromatographic behavior

2.教学难点

The effects on the chromatographic behavior.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some pharmaceutical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

How to eliminate the effects on the chromatographic behavior?  

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

High performance liquid chromatography

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the basic principle, classification, and parameters of HPLC

(2) Be familiar with the chromatographic separation process

(3) Master the stationary phases, mobile phases, and detectors

(4) Know the pump and injector

2.技能（能力）目标：

(1) Learn basic English terms in HPLC analysis  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use HPLC for samples analysis

二、授课内容（依据教学大纲）及时间分配

1. Introduction—20 min

2. The chromatographic separation process—20 min

3. The column—20 min

4. Pumps—10 min

5. Detectors—30 min

6. Injectors—10 min

7. Mobile phases—25 min

8. Solvent for sample preparation—5 min

9. Reporting the results—5 min

10. Summary—5 min

三、教学重点与难点

1．教学重点

(1) The principles HPLC analysis

(2) The stationary phases, mobile phases, and detectors

2.教学难点

The effects on the chromatographic behavior.   

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some pharmaceutical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

How to choose the stationary phases, mobile phases, and detectors for HPLC analysis?

How to optimize the HPLC conditions?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Gas chromatography

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the basic principle, classification, and parameters of GC

(2) Be familiar with the chromatographic separation process

(3) Master the injection system and detectors

(4) Know the Apparatus

2.技能（能力）目标：

(1) Learn basic English terms in GC analysis  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use GC for samples analysis

二、授课内容（依据教学大纲）及时间分配

1. Introduction—10 min

2. Apparatus—10 min

3. Temperature—10 min

4. carrier gas—10 min

5. Stationary phases—10 min

6. Selectivity in GC—10 min

7. Column—15 min

8. Injection system—20 min

9. Detectors—30 min

10. Derivatization—10 min

11. The use of GC—5 min

12. More advanced GC techniques—5 min

13. Summary—5 min

三、教学重点与难点

1．教学重点

(1) The principles GC analysis

(2) The injection methods and detectors

2.教学难点

The effects on the chromatographic behavior.

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some pharmaceutical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

How to choose the injection methods and detectors for GC assay?

How to optimize the GC conditions?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Capillary Electrophoresis

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the basic principle and theory of CE

(2) Master the implications of EOF

(3) Know various types of CE

(4) Master the principle of MEKC

(5) Know the applications of CE  

2.技能（能力）目标：

(1) Learn basic English terms in CE analysis  

(2) Improve the skills in listening and speaking English in electrophoresis assay

(3) Master the practices of CE

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Principle and theory—30 min

2. Electroosmotic flow—20 min

Lecture II:

3. Instrumentation—20 min

4. The capillary—10 min

5. Sample introduction—10 min

6. Capillary zone electrophoresis—10 min

Lecture III:

7. Micellar electrokinetic chromatography—20 min

8. Chiral separations—10 min

9. Coated capillaries—10 min

10. Non-aqueous CE—5 min

11. Summary—5 min

Lecture IV

Review -50 min

三、教学重点与难点

1．教学重点

(1) The basic principle and theory of CE

(2) The implications of EOF

(3) The principle of MEKC

(4) The effects on the electrophoretic behaviors

2.教学难点

The basic principle and theory of CE, as well as the implications of EOF.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some pharmaceutical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

How to choose the types of CE analysis?

How to optimize the CE conditions based on the basic principle of CE?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chapter 16_Mass spectrometry

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Basic theory of mass spectrometry

(2) Different types of mass spectra

(3 Instrumentation

(4) Chromatography coupled with mass spectrometry

(5) Applications of mass spectrometry

(6) Advanced mass spectrometry technology

2.技能（能力）目标：

(1) Learn basic English terms in mass spectrometry  

(2) Learn principles of mass spectrometry

(3) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Basic theory of mass spectrometry (20 min)

(2) Electron ionization (15 min)

(3) Identification using electron ionization spectra (15 min)

Lecture 2:

(4) Characterization of totally unknown using electron ionization spectra (30 min)

(5) Chemical ionization (10 min)

(6) Electrospray ionization (10 min)

Lecture 3:

(7) Atmospheric pressure chemical ionization (10 min)

(8) High-resolution mass spectrometry (15 min)

(9) Instrumentation (25 min)

Lecture 4

(10) Chromatography coupled with mass spectrometry (20 min)

(11) Quantitative GC-MS and LC-MS (5 min)

(12) Areas of usage and performance (5 min)

(13) Matrix assisted laser desorption/ionization mass spectrometry (10 min)

(14) Inductively coupled plasma mass spectrometry (10 min)

三、教学重点与难点

1．教学重点

(1) The principles of mass spectrometry

(2) The approaches of ionization

(3) The advanced mass spectrometry technology

(4) Identification using mass spectrometry

2.教学难点

(1) Characterization of unknown substances using mass spectrometry

(2) Principles of advanced mass spectrometry technology

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustrations of the theory and instrumentation of mass spectrometry

(2) Examples of mass spectra and case studies

(3) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of the mass spectrometry

六、复习思考题

Review chapter 16

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chapter 17_Miscellaneous chemical techniques

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Ion-selective electrode

(2) Paper chromatography

(3) Supercritical fluid chromatography

(4) Gel electrophoresis

(5) Iso-electric focusing

(6) NMR spectroscopy

(7) Raman spectrometry

2.技能（能力）目标：

(1) Learn basic English terms in the miscellaneous chemical techniques

(2) Learn principles of the covered miscellaneous chemical techniques

(3) Be able to choose the appropriate approach for specific purpose  

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Ion-selective electrode (13 min)

(2) Paper chromatography (12 min)

(3) Supercritical fluid chromatography (15 min)

(4) Gel electrophoresis (10 min)

Lecture 2:

(5) Iso-electric focusing (15 min)

(6) NMR spectroscopy (20 min)

(7) Raman spectrometry (15 min)

三、教学重点与难点

1．教学重点

(1) The principles of the covered miscellaneous chemical techniques

(2) The characteristics of each chemical technology

2.教学难点

(1) The principles of supercritical fluid chromatography and NMR

(2) How to choose the appropriate approach for specific purpose.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustrations of the principles of the covered miscellaneous chemical techniques

(2) Examples of typical spectra and case studies

(3) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of the miscellaneous chemical techniques

六、复习思考题

Review chapters 17

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chapter 18_Sample preparation

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) The significance of sample preparation during pharmaceutical analysis

(2) Principles of strategies for sample preparation

(3) Optimization and trouble-shooting for each strategy

2.技能（能力）目标：

(1) Learn basic English terms in sample preparation  

(2) Learn principles of commonly used sample preparation strategies

(3) Learn how to optimize and trouble shoot each preparation strategy

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Importance of sample preparation (5 min)

(2) Main strategies for sample preparation (10 min)

(3) Recovery and enrichment (15 min)

(4) Protein precipitation (10 min)

(5) Liquid-liquid extraction fundamentals (10 min)  

Lecture 2:

(6) Liquid-liquid extraction theory (15 min)

(7) Liquid-liquid extraction solvents (10 min)

(8) Calculation of recovery (15 min)

(9) Multiple extractions (10 min)

Lecture 3:

(10) LLE with back-extraction (10 min)

(11) Solid-liquid extraction fundamentals (10 min)

(12) The SPE column, its conditioning and equipment (15 min)

(13) Reversed-phase SPE (15 min)

Lecture 4:

(14) Secondary interactions (10 min)

(15) Ion exchange SPE (15 min)

(16) Mixed-mode SPE (15 min)

(17) Normal phase SPE (10 min)

三、教学重点与难点

1．教学重点

(1) The principles of liquid-liquid extraction

(2) The principles of solid-liquid extraction

2.教学难点

(1) How to choose the appropriate separation method in a specific case

(2) How to evaluate the separation efficiency

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustrations of the separation principles

(2) Derivation steps of recovery and enrichment

(3) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of the mechanisms of sample preparation

六、复习思考题

Review chapters 18

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chapter 19_Analytical chemical characteristics of selected drug substances

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

Analytical chemical characteristics of  

(1) Amitriptyline and mianserin

(2) Morphine and codeine

(3) Ibuprofen and naproxen  

(4) Furosemide

(5) Paracetamol

(6) Neutral drugs

2.技能（能力）目标：

(1) Learn basic English terms in analytical chemical characteristics  

(2) Learn the significance of chemical characteristics of drugs

(3) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Amitriptyline and mianserin (15 min)

(2) Morphine and codeine (15 min)

(3) Ibuprofen and naproxen (20 min)

Lecture 2:

(4) Furosemide (20 min)

(5) Paracetamol (15 min)

(6) Neutral drugs (15 min)

三、教学重点与难点

1．教学重点

(1) Analytical chemical characteristics of drugs

(2) The impact of the physiochemical functionalities on analytical chemical work

2.教学难点

(1) The relationship between the molecular structure and the physiochemical functionalities of a drug

(2) How to choose the appropriate titration method to determine the concentration of a drug

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Molecular structures of the drugs

(2) Examples of characteristic spectra of the drugs

(3) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of the analytical chemical characteristics of drugs

六、复习思考题

Review chapters 19

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Quantification and Quality of Analytical Data

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Peak Height and Peak Area

(2) External Standard Calibration

(3) Internal Standard Calibration

(4) Standard Addition Calibration

(5) Normalization Calibration

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn various aspects of calibration methods

(3) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Course Introduction (5 min)

2. Peak Height and Peak Area (10 min)

3. External Standard Calibration (25 min)

4. Internal Standard Calibration (10 min)

Lecture II:

1. Internal Standard Calibration (10 min)

2. Standard Addition (15 min)

3. Normalization (15 min)

4. Case Study (10 min)

三、教学重点与难点

1．教学重点

(1) The aspects of different calibration methods

2.教学难点

(1) How to choose appropriate calibration methods  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustrations of chromatogram of different standards

(2) Examples of different calibration methods

(3) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapter 20

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Quantification and Quality of Analytical Data

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Validation

(2) System Suitability

(3) What is Pharmaceutical Raw Materials, how is it Produced and why must it be Controlled

(4) The Pharmacopoeias

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn principles of validation

(3) Learn concept of pharmaceutical raw materials

(4) Learn main contents of pharmacopoeia

(5) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Validation of analytical procedures (10min)

2. Accuracy (10min)

3. Precision (10 min)

4. Specificity (10min)

5. Detection Limit(10min)

Lecture II:

1. Quantification Limit (10 min)

2. Linearity and Range (10 min)

3. Robustness (10 min)

4. Test Methods in the European Pharmacopeia  (5 min)

5. System Suitability (10 min)

6. Summary of Chapter 20 (5 min)

三、教学重点与难点

1．教学重点

(1) The principles of Validation

(2) Concept of Pharmaceutical Raw Material

(3) Pharmacopoeias content

2.教学难点

(1) understand the principles of Validation

(2) understand the monographs in the pharmacopoeias

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustrations of analytical characteristics used in validation of an analytical procedure

(2) Use case study to explain the principles of validation

(3) Illustrations of monographs in the pharmacopoeias  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapters 20 and 21

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chemical Analysis of Drug Substances

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Contaminants in Raw Materials

(2) Requirements in a Maximum Content and Why

(3) Identification Procedures of Pharmaceutical Raw Materials

(4) Techniques used for the Identification of Well Defined Chemical Compounds

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn contaminants in raw materials

(3) Learn how to check the identity of pharmaceutical raw materials

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. What is a Pharmaceutical Raw Material (10 min)

2. How is a Pharmaceutical Raw Material produced (10 min)

3. Why must a Pharmaceutical Raw Material be Controlled (10 min)

4. The Pharmacopoeias (20 min)  

Lecture II:

1. Contaminants in well defined chemical compounds (20 min)

2. Contaminants in mixtures of organic compounds (5 min)

3. Overview of the indentification procedures (5 min)

4. Infrared absorption sepctrophotometry (10min)

5. Ultraviolet and visible absorption spectrophotometry (10 min)

Lecture III:

1. Thin-Layer Chromatography (10 min)

2. Melting point (5 min)

3. Polarimetry  (10 min)

4. High performance liquid chromatography (15 min)

5. Chloride and sulfate identification (10 min)

三、教学重点与难点

1．教学重点

(1) Contaminants in raw materials

(2) Identity check of pharmaceutical raw materials

2.教学难点

(1) The requirements in a maximum content and why

(2) How to choose appropriate identification techniques

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the types of impurities found in raw materials

(2) Illustrations of different identification methods

(3) Review the major concepts and materials covering the chapter.  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapter 21

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chemical Analysis of Drug Substances

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Main Purity Tests for Well Defined Chemical Compounds

(2) Purity Tests for Raw Materials of the Type of Mixtures of Organic Compounds

(3) Identification of the Raw Materials of the Type of Mixtures of Organic Compounds  

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical raw materials purity tests  

(2) Learn main purity test methods  

(3) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Introduction (5 min)

2. Appearance of Solution (10min)

3. Absorbance (5 min)

4. Acidity/Alkalinity (5 min)

5. Optical Rotation (5 min)

6. Related Substances (20 min)

Lecture II:

1. Foreign Anions (15 min)

2. Cationic Impurities (10 min)

3. Loss on Drying  (10 min)

4. Determination of Water (15 min)

Lecture III:

1. Oxidizing Substances (5 min)

2. Acid Value (5 min)

3. Hydroxyl Value (5 min)

4. Iodine Value (5 min)

5. Peroxide Value (5 min)

6. Saponification Value (5 min)

7. Other tests (5 min)

8. Identification of the raw materials of the type of mixtures of organic compounds (15 min)

三、教学重点与难点

1．教学重点

(1) Know how to test for impurities in pharmaceutical raw materials

2.教学难点

(1)  How to test purity for different types of pharmaceutical raw materials

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustrations of different purity test  

(2) Use case study to explain different purity test for different raw materials

(3) Review the major concepts and materials covering the section.  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapter 21

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chemical Analysis of Drug Substances

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Purity Determination of Pharmaceutical Raw Materials

(2) Control Compounds for Which no Pharmacopoeia Monograph Exists

(3) Ph. Eur. and USP Update

2.技能（能力）目标：

(1) Learn how to determine purity of pharmaceutical raw materials

(2) Learn how to control compounds for which no pharmacopoeia monograph exists

(3) Learn how are Ph. Eur. and USP updated

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Acid-Base Titration in Aqueous Environment (10min)

2. Acid-Base Titration in a Non-Aqueous Environment (10min)

3. Redox Titration (5 min)

4. High Performance Liquid Chromatography (10min)

5. UV Spectrophotometry (5 min)

6. Compounds no Pharmacopoeia Monograph Exists (5 min)

7. How are Ph. Eur. and USP Updated (5 min)

Lecture II:

Test

三、教学重点与难点

1．教学重点

(1) How to determine purity of pharmaceutical raw materials

2.教学难点

(1) Different methods for purity determination of pharmaceutical raw materials

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain different methods for purity determination

(2) Review the major concepts and materials covering the chapter.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review chapters 20, 21

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

Pharmaceutical Analysis I

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis.

授课年级

2018级药学全英班

授课章节

Chemical analysis of final pharmaceutical products

授课时间

250分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Quality control of final pharmaceutical products

(2) Monographs and chemical testing

(3) Identification of the active pharmaceutical ingredient

(4) Assay of the active pharmaceutical ingredient

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn the assay and identification of the active ingredient  

(4) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Quality control of final pharmaceutical products (30min)

2. Monographs and chemical testing (60min)

3. Identification of the active pharmaceutical ingredient: IR, UV (60 min)

Lecture II:

1. Identification of the active pharmaceutical ingredient: HPLC (30 min)

2. Assay of the active pharmaceutical ingredient (70 min)

三、教学重点与难点

1．教学重点

(1) Know the monographs and chemical testing

(2) Learn the specific words of medicines

(3) Know the identification of the active pharmaceutical ingredient

(4) Know the assays for the active pharmaceutical ingredient

2.教学难点

(1) Understand the drug-related words

(2) Understand how to identify and assay for the active pharmaceutical ingredient

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the identification and assay of the active pharmaceutical ingredient

(2) Explain the significance of monographs

(3) Review the major concepts and materials covering the chapter

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review sessions 22.1-22.4; preview sessions 22.5, 23.1-23.3

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

药物分析（Pharmaceutical Analysis）

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis, Steen Honore Hansen, Stig Pedersen-Bjergaard, Knut Einar Rasmussen, 2012.

授课年级

本科三年级第二学期

授课章节

Analysis of drugs in biological fluids

授课时间

250分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Chemical tests for final pharmaceutical products

(2) Analysis of drugs in biological fluids

(3) The biological matrix

(4) Bioanalytical methods

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn the identification of related substances

(3) Know the importance of drug analysis in drug development

(4) Learn the applications of bio-analytical methods  

(5) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Test for related substances (30min)

2. Uniformity of content (30min)

3. Dissolution (20 min)

4. Drug development and therapeutic drug monitoring (30 min)

5. Forensic, toxicology and doping control analysis (20 min)

6. The biological matrix (20 min)

Lecture II:

1. Sampling methods and sample preparation (10 min)

2. Protein precipitation (10 min)

3. Liquid-liquid extraction (20 min)

4. Solid-phase extraction (20 min)

5. Separation and detection (20 min)

6. Calibration and quantification (20min)

三、教学重点与难点

1．教学重点

(1) Know the chemical tests for final pharmaceutical products

(2) Learn the specific words of medicines

(3) Know drug analysis in biological fluids

(4) Learn the bio-analytical methods

2.教学难点

(1) Understand the applications of chemical tests

(2) Understand when to use what bio-analytical method

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the life of medicines

(2) Explain the significance of drug analysis in biological fluids

(3) Review the major concepts and materials covering the chapter.  

(4) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review sessions 22.5, 23.1-23.3; preview session 23.4

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules

课程名称

药物分析（Pharmaceutical Analysis）

所属学科

药学

教材名称

Introduction to Pharmaceutical Chemical Analysis, Steen Honore Hansen, Stig Pedersen-Bjergaard, Knut Einar Rasmussen, 2012.

授课年级

本科三年级第二学期

授课章节

Analysis of drugs in biological fluids

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Examples of sample preparation

(2) Examples of quantitative determination

(3) Examples of identification

2.技能（能力）目标：

(1) Learn basic English terms in pharmaceutical analysis  

(2) Learn from real-life examples of drug analysis

(3) Improve the skills in listening and speaking of English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

1. Examples of sample preparation (30min)

2. Examples of quantitative determination (30min)

3. Examples of identification (30 min)

4. Summary (10 min)

三、教学重点与难点

1．教学重点

(1) Study the real-life sample preparation cases

(2) Learn the applications of quantitative determination methods

(3) Know the procedures of identification

2.教学难点

(1) Understand the rationale behind each case study

(2) Understand the choice of analysis method is decided by drug properties

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the drug analysis methods

(2) Review the major concepts and materials covering the chapter.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Review session 23.4

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules