课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH1 Nature of Analytical Chemistry

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master a typical quantitative analysis procedure

(2) Understand the application fields of analytical chemistry

(3) Understand the central role of analytical chemistry

(4) Understand the classification of analysis, solvent

(5) Understand the role of analytical chemist

2.技能（能力）目标：

(1) Learn basic English terms in analytical analysis  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Apply the knowledge to practices

二、授课内容（依据教学大纲）及时间分配

1A The Role of Analytical Chemistry  30min

1B Quantitative Analytical Methods  20min

1CA Typical Quantitative Analysis   30 min

1DAn Integral Role for Chemical Aalysis: Feedback Control Systems 20min

三、教学重点与难点

1．教学重点

(1) The role of analytical chemistry and analytical chemist

(2) The basic principle of normal phase chromatography

(3) The basic principle of reverse phase chromatography

2.教学难点

Typical quantitative analysis procedure

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT.

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) In an interactive quiz mode

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. What is your impression of Analytical Chemistry?

2. What is the procedure in a typical quantitative analysis?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH2 Chemicals, Apparatus, and Unit Operations of Analytical Chemistry

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the reagents and chemicals classification of chemistry;

(2) Grasp the Equipment and Manipulations Associated with Evaporation, Weighing, Filtration

(3) Familiar with the basic laboratory practice in Analytical Chemistry

2.技能（能力）目标：

(1) Learn basic English terms in chemicals, apparatus and unit operation  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to select unit operation for different application purpose

二、授课内容（依据教学大纲）及时间分配

2A Selecting and Handling Reagents and Other Chemicals 10min

2B Cleaning and Marking of Laboratory Ware 10min

2CEvaporating Liquids  20min

2DMeasuring Mass 10min

2E Equipment and Manipulations Associated with Weighing 10min

2F Filtration and Ignition of Solids 5min

2GMeasuring Volume 10min

2HCalibrating Volumetric Glassware 5min

2I The Laboratory Notebook 10min

2J Safety in the Laboratory 10min

三、教学重点与难点

1．教学重点

(1) The basic laboratory practice in Analytical Chemistry, including laboratory notebook and safety

(2) The Equipment and Manipulations Associated with Evaporation, Weighing, Filtration

2.教学难点

The chemicals classification of chemistry.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some unit operations

(2) Review the major concepts and materials covering the chapters.  

(3) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. What are the rules for handling reagents and solutions?

2. What are types of analytical balances?

3. What are the sources of error in weighing?

4. How to maintain a laboratory notebook?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH3 Using Spreadsheets in Analytical Chemistry

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the basic unit in Microsoft spreadsheet

(2) Grasp the basic calculation in spreadsheet

2.技能（能力）目标：

(1) Learn interfaces of Microsoft spreadsheet  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use spreadsheet for calculation

二、授课内容（依据教学大纲）及时间分配

3A Keeping Records and Making Calculations 50 min

3B More Complex Examples

三、教学重点与难点

1．教学重点

(1) The calculations in complex examples

(2) Data recording in spreadsheet

2.教学难点

Practice using spreadsheet  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method and practice

(2) Review the major concepts and materials covering the chapters

(3) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Students must take a PC and practice the calculation on it  

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Describe the use of the following Excel functions after reading about them in the Excel help facility.

(a) SQRT; (b) AVERAGE; (c) PI; (d) FACT; (e) EXP; (f) LOG

2. There are many ways to document the worksheet entries and calculations. Use a search engine to find some of these methods, and describe them in detail using a worksheet example.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH4 Calculations Used in Analytical Chemistry

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the basic unit of measurement  

(2) Understand the solution preparation and their concentration

2.技能（能力）目标：

(1) Learn basic English terms in calculations used in analytical chemistry

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to prepare required solutions

二、授课内容（依据教学大纲）及时间分配

4A Some Important Units of Measurement  20min

4B Solutions and Their Concentrations 30min

4CChemical Stoichiometry 50min

三、教学重点与难点

1．教学重点

(1) The solution and their chemical stoichiometry

2.教学难点

Solutions and Their Concentrations

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. What is the difference between molar species concentration and molar analytical concentration?

2. Show that one gram is one mole of unified atomic mass units.

3. Find the number of Na⁺ ions in 2.92 g of Na₃PO₄?

4. What is the mass in milligrams of solute in  

(a) 16.0 mL of 0.350 M sucrose (342 g/mol)?

(b) 1.92 L of 3.76 x 10^-3 M H₂O₂?

5. Sea water contains an average of 1.08 x 10³ ppm of Na⁺ and 270 ppm of SO4^2-. Calculate

(a) the molar concentrations of Na⁺ and SO4^2- given that the average density of sea water is 1.02 g/mL.

(b) the pNa and pSO₄ for sea water.

6. What mass of solid La(IO₃)₃ (663.6 g/mol) is formed when 50.0 mL of 0.250 M La³⁺ are mixed with 75.0 mL of 0.302 M IO₃^-?

7. What volume of 0.01000 M AgNO₃ would be required to precipitate all of the I^- in 200.0 mL of a solution that contained 24.32 ppt KI?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH5 Errors in Chemical Analyses

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the basic aspect of errors in analytical chemistry

(2) Understand the source of errors

2.技能（能力）目标：

(1) Learn basic English terms in Chemical Analyses

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use the errors in statistical analysis

二、授课内容（依据教学大纲）及时间分配

5A Some Important Terms  30min

5B Systematic Errors 70min

三、教学重点与难点

1．教学重点

(1) The source of systematic error;

2.教学难点

The detection of systematic error;

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Explain the difference between

(a) random and systematic error.

(b) constant and proportional error.

(c) absolute and relative error.

(d) mean and median.

2. Suggest two sources of systematic error and two sources of random error in measuring the width of a 3m table with a 1m metal rule.

3. Name three types of systematic errors.

4. Describe at least three systematic errors that might occur while weighing a solid on an analytical balance.

5. Describe at least three ways in which a systematic error might occur while using a pipet to transfer a known volume of liquid.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH6 Random Errors in Chemical Analysis

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the Statistical Treatment of Random Errors  

(2) Grasp the Standard Deviation of Calculated Results

(3) Familiar with Reporting Computed Data

2.技能（能力）目标：

(1) Learn basic English Random Errors in Chemical Analysis

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to random errors in chemical analysis

二、授课内容（依据教学大纲）及时间分配

6A The Nature of Random Errors 20min

6B Statistical Treatment of Random Errors 30min

6CStandard Deviation of Calculated Results  30min

6DReporting Computed Data 20min

三、教学重点与难点

1．教学重点

(1) Statistical Treatment of Random Errors

(2) Standard Deviation of Calculated Results

2.教学难点

Standard Deviation of Calculated Results

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Distinguish between

(a) the sample standard deviation and the population standard deviation.

(b) the meaning of the word “sample” as it is used in a chemical and in a statistical sense.

2. The standard deviation in measuring the diameter d of a sphere is 60.02 cm. What is the standard deviation in the calculated volume V of the sphere if d = 2.15 cm?

3. Calculate a pooled estimate of s from the following spectrophotometric analysis for NTA (nitrilotriacetic acid) in water from the Ohio River:

4. Estimate the absolute deviation and the coefficient of variation for the results of the following calculations. Round each result so that it contains only significant digits. The numbers in parentheses are absolute standard deviations.

(a) y = 3.95(± 0.03) + 0.993(± 0.001) - 7.025(± 0.001) = -2.082

(b) y = 15.57(± 0.04) + 0.0037(± 0.0001) + 3.59(± 0.08) = 19.1637

(c) y = 29.2(± 0.3) + 2.034(± 0.02) + 10217 = 5.93928 x 10-16

5. Six bottles of wine of the same variety were analyzed for residual sugar content with the following results:

(a) Evaluate the standard deviation s for each set of data.

(b) Pool the data to obtain an absolute standard deviation for the method.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH7 Statistical Data Treatment and Evaluation

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the concept and practice of confidence intervals

(2) Grasp the concept and practice of hypothesis testing

(3) Grasp the concept and practice of detection of gross errors

2.技能（能力）目标：

(1) Learn basic English terms in Statistical Data Treatment and Evaluation

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use statistical data treatment and evaluation

二、授课内容（依据教学大纲）及时间分配

7A Confidence Intervals 20min

7B Statistical Aids to Hypothesis Testing 30min

7CAnalysis of Variance 30min

7DDetection of Gross Errors 20min

三、教学重点与难点

1．教学重点

(1) Statistical Aids to Hypothesis Testing

(2) Analysis of Variance

2.教学难点

Confidence Intervals

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Describe in your own words why the confidence interval for the mean of five measurements is smaller than that for a single result.

2. Discuss how the size of the confidence interval for the mean is influenced by the following (all the other factors are constant):

(a) the standard deviation s.

(b) the sample size N.

(c) the confidence level.

3. An atomic absorption method for the determination of the amount of iron present in used jet engine oil was found from pooling 30 triplicate analyses to have a standard deviation s = 3.6 μg Fe/mL. If s is a good estimate of σ, calculate the 95 and 99% confidence intervals for the result 18.5 μg Fe/mL if it was based on (a) a single analysis, (b) the mean of two analyses, and (c) the mean of four analyses.

4. How many replicate measurements are needed to decrease the 95 and 99% confidence limits for the analysis described in Problem 3 to ± 2.2 mg Fe/mL?

5. The level of a pollutant in a river adjacent to a chemical plant is regularly monitored. Over a period of years, the normal level of the pollutant has been established by chemical analyses. Recently, the company has made several changes to the plant that appear to have increased the level of the pollutant. The Environmental Protection Agency (EPA) wants conclusive proof that the pollutant level has not increased. State the relevant null and alternative hypotheses and describe the type I and type II errors that might occur in this situation.

6. Sir William Ramsey, Lord Rayleigh, prepared nitrogen samples by several different methods. The density of each sample was measured as the mass of gas required to fill a particular flask at a certain temperature and pressure. Masses of nitrogen samples prepared by decomposition of various nitrogen compounds were 2.29280, 2.29940, 2.29849, and 2.30054 g. Masses of “nitrogen” prepared by removing oxygen from air in various ways were 2.31001, 2.31163, and 2.31028 g. Is the density of nitrogen prepared from nitrogen compounds significantly different from that prepared from air? What are the chances of the conclusion being in error? (Study of this difference led to the discovery of the inert gases by Lord Rayleigh).

7. Four analysts perform replicate sets of Hg determinations on the same analytical sample. The results in ppb Hg are shown in the following table:

(a) State the appropriate hypotheses.

(b) Do the analysts differ at the 95% confidence level? At the 99% confidence level (Fcrit 5 5.95)? At the 99.9% confidence level (Fcrit 5 10.80)?

(c) Which analysts differ from each other at the 95% confidence level?

8. Apply the Q test to the following data sets to determine whether the outlying result should be retained or rejected at the 95% confidence level.

(a) 85.10, 84.62, 84.70

(b) 85.10, 84.62, 84.65, 84.70

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH8 Sampling, Standardization, and Calibration

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the principle and practice of sampling in analytical chemistry  

(2) Grasp the principle and practice of Figures of Merit for Analytical Methods

2.技能（能力）目标：

(1) Learn basic English terms in sampling, standardization, and calibration

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to design an sampling protocol

二、授课内容（依据教学大纲）及时间分配

8A Analytical Samples and Methods 20min

8B Sampling  30min

8C Automated Sample Handling 10min

8D Standardization and Calibration 20min

8E Figures of Merit for Analytical Methods 20min

三、教学重点与难点

1．教学重点

(1) Sampling;

(2) Standardization and Calibration

(3) Figures of Merit for Analytical Methods

2.教学难点

Sampling

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Describe the steps in a sampling operation.

2. What factors determine the mass of a gross sample?

3. Changes in the method used to coat the tablets in Problem 8-6 lowered the percentage of rejects from 5.6% to 2.0%. How many tablets should be taken for inspection if the permissible relative standard deviation in the measurement is to be

(a) 20%? (b) 12%? (c) 7%? (d) 2%?

4. The data in the table below were obtained during a colorimetric determination of glucose in blood serum.

(a) Assuming a linear relationship between the variables, find the least-squares estimates of the slope and intercept.

(b) What are the standard deviations of the slope and intercept? What is the standard error of the estimate?

(c) Determine the 95% confidence intervals for the slope and intercept.

(d) A serum sample gave an absorbance of 0.413. Find the 95% confidence interval for glucose in the sample.

5. The following table gives the sample means and standard deviations for six measurements each day of the purity of a polymer in a process. The purity is monitored for 24 days. Determine the overall mean and standard deviation of the measurements and construct a control chart with upper and lower control limits. Do any of the means indicate a loss of statistical control?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH9 Aqueous Solutions and Chemical Equilibria

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the principle and practice of Chemical Equilibria  

(2) Familiar with the principle and practice of buffer solution

2.技能（能力）目标：

(1) Learn basic English terms in aqueous solutions and chemical equilibria

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to prepare chemical equilibria

二、授课内容（依据教学大纲）及时间分配

9A The Chemical Composition of Aqueous Solutions 30min

9B Chemical Equilibrium 40min

9CBuffer Solutions 30min

三、教学重点与难点

1．教学重点

(1) The Chemical Composition of Aqueous Solutions

(2) Chemical Equilibrium

2.教学难点

Buffer Solutions

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

 1. Briefly describe or define and give an example of

 (a) an amphiprotic solute.

 (b) a differentiating solvent.

 (c) a leveling solvent.

 (d) a mass-action effect.

 2. Generate the solubility-product expression for

 (a) CuBr. (d) La(IO₃)₃. (b) HgClI. (e) Ag₃AsO₄. (c) PbCl₂.

 3. What CrO₄^2- concentration is required to

 (a) initiate precipitation of Ag₂CrO₄ from a solution that is 4.13 x 10^-3 M in Ag⁺?

 (b) lower the concentration of Ag⁺ in a solution to 9.00 x 10^-7 M?

 4. Define buffer capacity.

 5. What mass of sodium formate must be added to 500.0 mL of 1.00 M formic acid to produce a buffer solution that has a pH of 3.50?

 6. What volume of 0.200 M HCl must be added to 500.0 mL of 0.300 M sodium mandelate to produce a buffer solution with a pH of 3.37?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH10 Effect of Electrolytes on Chemical Equilibria

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the principle and practice of Chemical Equilibria  

(2) Familiar with the calculations of Activity Coefficients

2.技能（能力）目标：

(1) Learn basic English terms in effect of electrolytes on Chemical Equilibria

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to solve an chemical equilibria

二、授课内容（依据教学大纲）及时间分配

10A The Effect of Electrolytes on Chemical Equilibria 50min

10B Activity Coefficients 50min

三、教学重点与难点

1．教学重点

(1) The Effect of Electrolytes on Chemical Equilibria;

(2) Activity Coefficients

2.教学难点

Activity Coefficients

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

 1. Make a distinction between

 (a) activity and activity coefficient.

 (b) thermodynamic and concentration equilibrium constants.

 2. Explain why the activity coefficient for dissolved ions in water is usually less than that for water itself.

 3. Calculate the solubilities of the following compounds in a 0.0333 M solution of Mg(ClO4)2 using (1) activities and (2) molar concentrations:

 (a) AgSCN.

 (b) PbI₂.

 (c) BaSO₄.

 (d) Cd2Fe(CN)₆.

 Cd₂Fe(CN)₆(s) ↔ 2Cd²⁺ + Fe(CN)₆^4-

 K_sp = 3.2 x 10^-17

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH11 Solving Equilibrium Problems for Complex Systems

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the principle and practice of Multiple-Equilibrium Problems Using a Systematic Method  

(2) Familiar with the Separation of Ions by Control of the Concentration of the Precipitating Agent

2.技能（能力）目标：

(1) Learn basic English terms in equilibrium

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to solve equilibrium problems

二、授课内容（依据教学大纲）及时间分配

11A Solving Multiple-Equilibrium Problems Using a Systematic Method 50min

11B Calculating Solubilities by the Systematic Method 20min

11CSeparation of Ions by Control of the Concentration of the Precipitating Agent 30min

三、教学重点与难点

1．教学重点

(1) Solving Multiple-Equilibrium Problems Using a Systematic Method

(2) Calculating Solubilities by the Systematic Method

2.教学难点

Solving Multiple-Equilibrium Problems Using a Systematic Method

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Why are simplifying assumptions restricted to relationships that are sums or differences?

2. Why do molar concentrations of some species appear as multiples in charge-balance equations?

3. Calculate the molar solubility of PbS in a solution in which [H₃O⁺] is held constant at (a) 3.0 3 10^-1 M and (b) 3.0 x 10^-4 M.

4. What mass of AgBr dissolves in 200 mL of 0.200 M NaCN?

5. Calculate the molar solubility of ZnCO₃ in a solution buffered to a pH of 7.00.

6. Silver ion is being considered for separating I^- from SCN^- in a solution that is 0.040 M in KI and 0.080 M in NaSCN.

(a) What Ag+ concentration is needed to lower the I- concentration to 1.0 x 10^-6 M?

(b) What is the Ag⁺ concentration of the solution when AgSCN begins to precipitate?

(c) What is the ratio of SCN^- to I^- when AgSCN begins to precipitate?

(d) What is the ratio of SCN^- to I^- when the Ag⁺ concentration is 1.0 x 10^-3 M?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH12 Gravimetric Methods of Analysis

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the principle and practice of Precipitation Gravimetry

(2) Familiar with the Applications of Gravimetric Methods

2.技能（能力）目标：

(1) Learn basic English terms in gravimetric methods of analysis

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use gravimetric methods for chemical analysis

二、授课内容（依据教学大纲）及时间分配

12A Precipitation Gravimetry 30min

12B Calculation of Results from Gravimetric Data 30min

12CApplications of Gravimetric Methods 40min

三、教学重点与难点

1．教学重点

(1) Applications of Gravimetric Methods;

(2) Calculation of Results from Gravimetric Data

2.教学难点

Precipitation Gravimetry

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

 1. What are the structural characteristics of a chelating agent?

 2. What is peptization and how is it avoided?

 3. Treatment of a 0.2500 g sample of impure potassium chloride with an excess of AgNO₃ resulted in the formation of 0.2912 g of AgCl. Calculate the percentage of KCl in the sample.

 4. What mass of AgI can be produced from a 0.512 g sample that assays 20.1% AlI₃?

 5. A 0.2121 g sample of an organic compound was burned in a stream of oxygen, and the CO₂ produced was collected in a solution of barium hydroxide. Calculate the percentage of carbon in the sample if 0.6006 g of BaCO₃ was formed.

 6. A 0.6407 g sample containing chloride and iodide ions gave a silver halide precipitate weighing 0.4430 g. This precipitate was then strongly heated in a stream of Cl₂ gas to convert the AgI to AgCl; on completion of this treatment, the precipitate weighed 0.3181 g. Calculate the percentage of chloride and iodide in the sample.

 7. A 50.0 mL portion of a solution containing 0.200 g of BaCl₂•2H₂O is mixed with 50.0 mL of a solution containing 0.300 g of NaIO₃. Assume that the solubility of Ba(IO₃)₂ in water is negligibly small and calculate

 (a) the mass of the precipitated Ba(IO₃)₂.

 (b) the mass of the unreacted compound that remains in solution.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH13 Titrations in Analytical Chemistry

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the basic aspect of titration; understand the titration process

2.技能（能力）目标：

(1) Learn basic English terms in titrations

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to calculation a titration curve

二、授课内容（依据教学大纲）及时间分配

13A Some Terms Used in Volumetric Titrations 20min

13B Standard Solutions 40min

13CVolumetric Calculations 60min

13DGravimetric Titrations 20min

13E Titration Curves 60min

三、教学重点与难点

1．教学重点

(1) Sampling;

(2) Standardization and Calibration

(3) Figures of Merit for Analytical Methods

2.教学难点

Sampling

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

 1. Distinguish between

 (a) the equivalence point and the end point of a titration.

 (b) a primary standard and a secondary standard.

 2. How many millimoles of solute are contained in

 (a) 2.95 mL of 0.0789 M KH₂PO₄?

 (b) 0.2011 L of 0.0564 M HgCl₂?

 (c) 2.56 L of a 47.5 ppm solution of Mg(NO₃)₂?

 (d) 79.8 mL of 0.1379 M NH₄VO₃ (116.98 g/mol)?

 3. A 0.4126-g sample of primary-standard Na₂CO₃ was treated with 40.00 mL of dilute perchloric acid. The solution was boiled to remove CO₂, following which the excess HClO₄ was back-titrated with 9.20 mL of dilute NaOH. In a separate experiment, it was established that 26.93 mL of the HClO₄ neutralized the NaOH in a 25.00-mL portion. Calculate the molarities of the HClO₄ and NaOH.

 4. Titration of the I2 produced from 0.1142 g of primary-standard KIO3 required 27.95 mL of sodium thiosulfate. Calculate the concentration of the Na₂S₂O₃.

 5. The ethyl acetate concentration in an alcoholic solution was determined by diluting a 10.00 mL sample to 100.00 mL. A 20.00 mL portion of the diluted solution was refluxed with 40.00 mL of 0.04672 M KOH. After cooling, the excess OH₂ was back-titrated with 3.41 mL of 0.05042 M H2SO4. Calculate the amount of ethyl acetate (88.11 g/mol) in the original sample in grams.

 6. A solution was prepared by dissolving 7.48 g of KCl • MgCl₂ • 6H₂O (277.85 g/mol) in sufficient water to give 2.000 L. Calculate

 (a) the molar analytical concentration of KCl • MgCl₂ in this solution.

 (b) the molar concentration of Mg²⁺.

 (c) the molar concentration of Cl₂.

 (d) the weight/volume percentage of KCl •MgCl₂ •6H₂O.

 (e) the number of millimoles of Cl₂ in 25.0 mL of this solution.

 (f ) the concentration of K⁺ in ppm.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH14 Principles of Neutralization Titrations

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the basic aspect of neutralization titration

(2) Understand the titration curve for weak acids/bases

2.技能（能力）目标：

(1) Learn basic English terms in neutralization titrations

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to design a titration

二、授课内容（依据教学大纲）及时间分配

14A Solutions and Indicators for Acid/Base Titrations 20min

14B Titration of Strong Acids and Bases 30min

14CTitration Curves for Weak Acids 30min

14DTitration Curves for Weak Bases 10min

14E The Composition of Solutions During Acid/Base Titrations 10min

三、教学重点与难点

1．教学重点

(1) Composition of Solutions During Acid/Base Titrations;

(2) The generation of titration curves for weak acids/bases

2.教学难点

The generation of titration curves for weak acids/bases

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

 1. Why does the typical acid/base indicator exhibit its color change over a range of about 2 pH units?

 2. What variables can cause the pH range of an indicator to shift?

 3. What is the pH of an aqueous solution that is 3.00% HCl by mass and has a density of 1.015 g/mL?

 4. Calculate the pH of an ammonia solution that is

 (a) 1.00 x 10^-1 M NH3.

 (b) 1.00 x 10^-2 M NH3.

 (c) 1.00 x 10^-4 M NH3.

 5. Calculate the equilibrium concentration of methyl ammonia in a solution that has a molar analytical CH₃NH₂ concentration of 0.120 and a pH of 11.471.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH15 Complex Acid/Base Systems

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the basic aspect of Polyfunctional Acids and Bases

(2) Grasp the titration process of Polyfunctional Acids/Bases

2.技能（能力）目标：

(1) Learn basic English terms in Complex Acid/Base Systems

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to design calculation the titration curve

二、授课内容（依据教学大纲）及时间分配

15A Mixtures of Strong and Weak Acids or Strong and Weak Bases 10min

15B Polyfunctional Acids and Bases 10min

15CBuffer Solutions Involving Polyprotic Acids 10min

15DCalculation of the pH of Solutions of NaHA 20min

15E Titration Curves for Polyfunctional Acids 10min

15F Titration Curves for Polyfunctional Bases 10min

15GTitration Curves for Amphiprotic Species 20min

15HComposition of Polyprotic Acid Solutions as a Function of pH 10min

三、教学重点与难点

1．教学重点

(1) Polyfunctional Acids and Bases;

(2) Titration Curves for Polyfunctional Acids

(3) Figures of Merit for Analytical Methods

2.教学难点

Calculation of the pH of Solutions of NaHA

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

 1. As its name implies, NaHA is an “acid salt” because it has a proton available to donate to a base. Briefly explain why a pH calculation for a solution of NaHA differs from that for a weak acid of the type HA.

 2. Why is it impossible to titrate all three protons of phosphoric acid in aqueous solution?

 3. Suggest an indicator that could be used to provide an end point for the titration of the first proton in H₃AsO₄.

 4. What mass (g) of dipotassium phthalate must be added to 750 mL of 0.0500 M phthalic acid to give a buffer of pH 5.75?

 5. What is the pH of the buffer formed by adding 100 mL of 0.150 M potassium hydrogen phthalate to  

 (a) 100.0 mL of 0.0800 M NaOH?

 (b) 100.0 mL of 0.0800 M HCl?

6. Briefly explain why curve B cannot describe the titration of a mixture consisting of H₃PO₄ and NaH₂PO₄.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH16 Applications of Neutralization Titrations

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the Typical Applications of Neutralization Titrations  

2.技能（能力）目标：

(1) Learn basic English terms in applications of neutralization titrations

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to explain the theory under an application

二、授课内容（依据教学大纲）及时间分配

16A Reagents for Neutralization Titrations  50min

16B Typical Applications of Neutralization Titrations 50min

三、教学重点与难点

1．教学重点

(1) Reagents for Neutralization Titrations;

(2) Typical Applications of Neutralization Titrations

2.教学难点

Typical Applications of Neutralization Titrations

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

 1. Why is nitric acid seldom used to prepare standard acid solutions?

 2. Give two reasons why KH(IO₃)₂ is preferred over benzoic acid as a primary standard for a 0.010 M NaOH solution.

 3. A NaOH solution was 0.1019 M immediately after standardization. Exactly 500.0 mL of the reagent was left exposed to air for several days and absorbed 0.652 g of CO₂. Calculate the relative carbonate error in the determination of acetic acid with this solution if the titrations were performed with phenolphthalein.

 4. A 50.00-mL sample of a white dinner wine required 24.57 mL of 0.03291 M NaOH to achieve a phenolphthalein end point. Express the acidity of the wine in grams of tartaric acid (H2C4H4O6; 150.09 g/mol) per 100 mL. (Assume that two hydrogens of the acid are titrated.)

5. A 0.1401-g sample of a purified carbonate was dissolved in 50.00 mL of 0.1140 M HCl and boiled to eliminate CO₂. Back-titration of the excess HCl required 24.21 mL of 0.09802 M NaOH. Identify the carbonate.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH17 Complexation and Precipitation Reactions and Titrations

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the principle and practice of Complexation and Precipitation Reactions and Titrations  

(2) Familiar with its applications

2.技能（能力）目标：

(1) Learn basic English terms in complexation and precipitation reactions and titrations

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to give a example of application

二、授课内容（依据教学大纲）及时间分配

17A The Formation of Complexes  30min

17B Titrations with Inorganic Complexing Agents  20min

17C Organic Complexing Agents 30min

17D Aminocarboxylic Acid Titrations 20min

三、教学重点与难点

1．教学重点

(1) The Formation of Complexes;

(2) Organic Complexing Agents

2.教学难点

Organic Complexing Agents EDTA

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) The basic theory and analysis principle are taught by teaching method via PPT

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

 1. Describe three general methods for performing EDTA titrations. What are the advantages of each?

 2. In what respect is the Fajans method superior to the Volhard method for the titration of chloride ion?

 3. Why does the charge on the surface of precipitate particles change sign at the equivalence point of a titration?

 4. The Zn in a 0.7457 g sample of foot powder was titrated with 22.57 mL of 0.01639 M EDTA. Calculate the percent Zn in this sample.

 5. A 50.00-mL aliquot of a solution containing iron(II) and iron(III) required 10.98 mL of 0.01500 M EDTA when titrated at pH 2.0 and 23.70 mL when titrated at pH 6.0. Express the concentration of each solute in parts per million.

 6. Calculate conditional constants for the formation of the EDTA complex of Fe2- at a pH of (a) 6.0, (b) 8.0, and (c) 10.0.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH18 Introduction to Electrochemistry

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Learn how to write oxidation/reduction reactions in electrochemical cells

(2) Introduction of Galvanic cell and electrolytic cell

(3) Calculation of electrode potentials and cell potential

2.技能（能力）目标：

(1) Learn basic English terms in electrochemistry  

(2) Improve the skills in listening and speaking English in electrochemistry

二、授课内容（依据教学大纲）及时间分配

Lecture I:

18.1 The Fundamental Concepts of Redox Reactions—50 min

Lecture II:

18.2 Electrochemical Cells—50 min

Lecture III:

18.3 Electrode Potentials—50 min

三、教学重点与难点

1．教学重点

(1) Use Nernst equation to calculate electrode potentials

(2) Calculation of cell potential

2.教学难点

The calculation of electrode potentials  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some analytical methods

(2) Review the major concepts and materials covering the chapters

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. How to identify oxidizing agent and reducing agent on the left side of a reaction equation?  

2. How to write half reactions for an electrochemical cell?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH19 Applications of Standard Electrode Potentials

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Learn the relationship between equilibrium constant and stand cell potential and how to calculate equilibrium constant for a reaction

(2) Learn how to construct a redox titration curve

(3) Learn how to choose a proper redox indicator for a titration

2.技能（能力）目标：

(1) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(2) Be able to apply for standard electrode potentials

二、授课内容（依据教学大纲）及时间分配

Lecture I:

19.1 Calculating Potentials of Electrochemical Cells—40 min

19.2 Determining Standard Potentials Experimentally—10 min

Lecture II:

19.3 Calculating Redox Equilibrium Constants—20 min

19.4 Constructing Redox Titration Curves—30 min

Lecture III:

19.4 Constructing Redox Titration Curves—30 min

19.5 Oxidation/Reduction Indicators—20 min

三、教学重点与难点

1．教学重点

(1) Relationship between equilibrium constant and stand cell potential

(2) Redox titration curve

2.教学难点

How to construct a titration curve?

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of standard electrode potentials

(2) Review the major concepts and materials covering the chapters

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

Under what circumstance is the curve for an oxidation/reduction titration asymmetric about the equivalence point?  

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH20 Applications of Oxidation/Reduction Titrations

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Know auxiliary oxidizing and reducing reagents

(2) Know common standard reducing agents and their calculations

(3) Know common standard oxidizing agents and their calculations

2.技能（能力）目标：

(1) Learn basic English terms in oxidation titrations  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture II:

20.1 Auxiliary Oxidizing and Reducing Reagents—20 min

20.2 Applying Standard Reducing Agents—30 min

Lecture II:

20.3 Applying Standard Oxidizing Agents—50 min

三、教学重点与难点

1．教学重点

(1) Properties of different standard reducing and oxidizing agents

(2) Redox reaction calculation

2.教学难点

The applications of standard oxidizing and reducing agents

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Review the major concepts and materials covering the chapters.  

(2) Work on problems with students together to emphasize the basic principles covered in the chapters

(3) Test could push students usually

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

What are the properties of some usual standard oxidizing and reducing agents and their applications?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH21 Potentiometry

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Know what are reference electrodes and indicator electrodes

(2) Types of indicator electrodes and ion concentration with cell potential

(3) Potentiometric titrations and potentiometric determination of equilibrium constants

2.技能（能力）目标：

(1) Learn basic English terms in potentiometry

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

21.1 General Principles—10 min

21.2 Reference Electrodes—30 min

21.3 Liquid-Junction Potentials—10 min

Lecture II:

21.4 Indicator Electrodes—50 min

Lecture III:

21.4 Indicator Electrodes—30 min

21.5 Direct Potentiometry—20 min

Lecture IV:

21.6 Potentiometric Titrations—20 min

21.7 Potentiometric Determination of Equilibrium Constants—30 min

三、教学重点与难点

1．教学重点

(1) Calculation of ion concentration with cell potential

(2) Calculation of equilibrium constant with cell potential

2.教学难点

Calculation of equilibrium constant with cell potential

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of potentiometry

(2) Review the major concepts and materials covering the chapters

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Describe indicator electrode and reference electrode.

2. Describe the source of pH dependence in a glass membrane electrode.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH22 Bulk Electrolysis

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Know the different between E_applied and E_cell in an electrolytic cell and their calculations

(2) Know polarization of electrodes

(3) Electrogravimetric methods and coulometric methods

2.技能（能力）目标：

(1) Learn basic English terms in bulk electrolysis

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

22.1 The Effect of Current on Cell Potential—40 min

22.2 The Selectivity of Electrolytic Methods—10 min

Lecture II:

22.3 Electrogravimetric Methods—20 min

22.4 Coulometric Methods—30 min

三、教学重点与难点

1．教学重点

(1) Calculation of E_applied with IR drop and overvoltage

(2) Electrogravimetric and coulometric calculation

2.教学难点

Electrode polarization and overvoltage

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of bulk electrolysis

(2) Review the major concepts and materials covering the chapters

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. What are the concentration polarization and kinetic polarization?

2. What is IR drop?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH23 Voltammetry

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Know common types of voltammetric electrodes

(2) Understand hydrodynamic voltammetry and its current calculation

(3) Applications of hydrodynamic voltammetry and polarography

2.技能（能力）目标：

(1) Learn basic English terms in voltammetry

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

二、授课内容（依据教学大纲）及时间分配

Lecture I:

23.1 Excitation Signals In Voltammetry—10 min

23.2 Voltammetric Instrumentation—15 min

23.3 Hydrodynamic Voltammetry—25 min

Lecture II:

23.3 Hydrodynamic Voltammetry—10 min

23.4 Polarography—10 min

23.5 Cyclic Voltammetry—10 min

21.6 Pulse Voltammetry—10 min

21.7 Stripping Methods—10 min

三、教学重点与难点

1．教学重点

(1) Calculation of E_applied and current of hydrodynamic voltammetry

2.教学难点

Calculation of voltammetric currents

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of voltammetry

(2) Review the major concepts and materials covering the chapters

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Why is a high supporting electrolyte concentration used in most electroanalytical procedures?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

Introduction to Spectrochemical Methods

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Learn the basic principles that are necessary to understand measurements made with electromagnetic radiation, particularly those dealing with the absorption of UV, visible, and IR radiation.

(2) Introduce the nature of electromagnetic radiation and its interactions with matter.

2.技能（能力）目标：

(1) Learn basic English terms in spectrochemical methods.  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences.

(3) Apply the knowledge to practices.

二、授课内容（依据教学大纲）及时间分配

Lecture I:

24A Properties of Electromagnetic Radiation—30 min

24B Interaction of Radiation and Matter—30 min

Lecture II:

24C Absorption of Radiation—30 min

Lecture III & IV

24D Emission of Electromagnetic Radiation—30 min

三、教学重点与难点

Absorption law: Beer-Lambert law.

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some spectrochemical methods.

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters.

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts.

(2) Discuss the complicated concepts.

(3) Solve problems together with students.

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section.

六、复习思考题

1. What is the relationship between absorbance and transmittance?

2.  How does an electronic transition resemble a vibrational transition? How do they differ?

3. Identify factors that cause the Beer’s law relationship to be nonlinear.

4. Describe the differences between “real” deviations from Beer’s law and those due to instrumental or chemical factors.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

Instruments for Optical Spectrometry

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

1. Learn the characteristics of the components common to optical instruments.

2. Learn the characteristics of typical instruments designed for UV, visible, and IR absorption spectroscopy.

2.技能（能力）目标：

(1) Learn basic English terms in optical spectrometry.

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences.

(3) Be able to use instruments for Optical Spectrometry.

二、授课内容（依据教学大纲）及时间分配

Lecture I:

 25A Instrument Components—30 min

 Lecture II:

 25B Ultraviolet/Visible Photo meters and Spectrophoto meters—30 min

 Lecture III:

25C Infrared Spect rophoto meters—30 min

三、教学重点与难点

Components of various instruments used in optical spectroscopy.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of optical spectrometry.

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters.

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts.

(2) Discuss the complicated concepts.

(3) Solve problems together with students.

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section.

六、复习思考题

1. Describe the differences between the following pairs of terms and list any particular advantages possessed by one over the other:

   1. solid-state photodiodes and phototubes as detectors for electromagnetic radiation.  

   2.  phototubes and photomultiplier tubes.  

   3. filters and monochromators as wavelength selectors.  

   4. conventional and diode-array spectrophotometers.

2. Why do quantitative and qualitative analyses often require different monochromator slit widths?

3. Why are photomultiplier tubes unsuited for the detection of infrared radiation?

4. Why is iodine sometimes introduced into a tungsten lamp?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

Molecular Absorption Spectrometry

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

1. Introduce the absorption of ultraviolet, visible, and infrared radiation.

2. Learn the principles and applications of molecular absorption spectrometry.

2.技能（能力）目标：

(1) Learn basic English terms in molecular absorption spectrometry.  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences.

(3) Apply the knowledge to practices.

二、授课内容（依据教学大纲）及时间分配

 Lecture I:

 26A Ultraviolet and Visible Molecular Absorption Spectroscopy—30 min

 Lecture II:

 26B Automated Photometric and spectrophotometric Methods—30 min

 Lecture III:

 26C Infrared Absorption Spectroscopy—30 min

三、教学重点与难点

1. 教学重点

1. Absorption characteristics of some common organic chromophores.

2. Some characteristic infrared absorption peaks.

2.教学难点

The applications of molecular absorption spectrometry.   

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of molecular absorption spectrometry.

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters.

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. What minimum requirement is needed to obtain reproducible results with a single-beam spectrophotometer?

2. What experimental variables must be controlled to assure reproducible absorbance data?

3. What is (are) advantage(s) of the multiple standard addition method over the single-point standard addition method?

4. The logarithm of the molar absorptivity for acetone in ethanol is 2.75 at 366 nm. Calculate the range of acetone concentrations that can be used if the absorbance is to be greater than 0.100 and less than 2.000 with a 1.50-cm cell.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

Molecular Fluorescence Spectroscopy

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

1. Learn the principal of molecular fluorescence methods.

2. Introduce the usage of molecular fluorescence spectroscopy.

2.技能（能力）目标：

(1) Learn basic English terms in molecular fluorescence methods.

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences.

(3) Be able to use molecular fluorescence methods for samples analysis.

二、授课内容（依据教学大纲）及时间分配

Lecture I & II:

27A Theory of Molecular Fluorescence—30 min

27B Effect of Concentration on Fluorescence Intensity—30 min

Lecture III:

27C Fluorescence Instrumentation—30 min

27D Applications of Fluorescence Methods—30 min

Lecture IV:

27E Molecular Phosphorescence Spectroscopy—30 min

27F Chemiluminescence Methods—30 min

三、教学重点与难点

Theory of molecular fluorescence: fluorescence emission and its affecting factors.

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of molecular fluorescence methods.

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters.

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts.

(2) Discuss the complicated concepts.

(3) Solve problems together with students.

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Why is spectrofluorometry potentially more sensitive than spectrophotometry?

2. Why do some absorbing compounds fluoresce while others do not?

3. Explain why molecular fluorescence often occurs at a longer wavelength than the exciting radiation.

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

Atomic Spectroscopy

授课时间

100分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

1. Learn the principle of atomic spectroscopy.  

2. Learn the atomic emission and atomic absorption methods.

2.技能（能力）目标：

(1) Learn basic English terms in atomic spectroscopy.

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences.

(3) Apply the knowledge to practices.

二、授课内容（依据教学大纲）及时间分配

 Lecture I & II:

 28A Origins of Atomic Spectra—30 min

 28B Production of Atoms and Ions—30 min

 Lecture III:

 28C Atomic Emission Spectrometry—30 min

 28D Atomic Absorption Spectrometry—30 min

 Lecture IV:

28E Atomic Fluorescence Spectrometry—30 min

三、教学重点与难点

Production of atoms and ions.

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of atomic spectroscopy.

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters.

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts.

(2) Discuss the complicated concepts.

(3) Solve problems together with students.

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Describe the basic differences among atomic emission, atomic absorption, and atomic fluorescence spectroscopy

2. Why is atomic emission more sensitive to flame instability than atomic absorption?

3. Why are ionization interferences usually not as severe in the ICP as they are in flames?

4. Why is source modulation used in atomic absorption spectroscopy?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

Mass Spectrometry

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

1. Learn the principles that are common to all forms of mass spectrometry.

2. Introduce the components that constitute a mass spectrometer.

2.技能（能力）目标：

(1) Learn basic English terms in mass spectrometry.

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences.

(3) Be able to use mass spectrometry for samples analysis.

二、授课内容（依据教学大纲）及时间分配

Lecture I & II:

29A Principles of Mass Spectrometry—30 min

29B Mass Spectrometers—30 min

Lecture III:

29C Atomic Mass Spectrometry—30 min

Lecture IV:

29D Molecular Mass Spectrometry—30 min

三、教学重点与难点

1. Principles of mass spectrometry.

2. Time-of-flight(TOF) mass analyzers.

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of mass spectrometry.

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters.

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts.

(2) Discuss the complicated concepts.

(3) Solve problems together with students.

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. Name three characteristics of inductively coupled plasmas that make them suitable for atomic mass spectrometry.

2. What function does the ICP torch serve in mass spectrometry?

3. What are the ordinate and the abscissa of an ordinary mass spectrum?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH31 Introduction to Analytical Separations

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the basic principle, classification, and parameters of chromatography

(2) Master the basic principle of normal phase chromatography

(3) Master the basic principle of reverse phase chromatography

(4) Understand the basic principle of hydrophilic interaction chromatography

(5) Understand the basic principle of chiral separations

(6) Understand the basic principle of size exclusion chromatography

(7) Understand the basic principle of ion exchange chromatography

2.技能（能力）目标：

(1) Learn basic English terms in chromatography analysis  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Apply the knowledge to practices

二、授课内容（依据教学大纲）及时间分配

Lecture I:

31.1 Separation by Precipitation—40 min

31.2 Separation of Species by Distillation—10 min

Lecture II:

31.3 Separation by Extraction—30 min

31.4 Separating Ions by Ion Exchange—20 min

Lecture III & IV

3.5 Chromatographic Separation—100 min

三、教学重点与难点

1．教学重点

(1) The basic principle, classification, and parameters of chromatography

(2) The basic principle of normal phase chromatography

(3) The basic principle of reverse phase chromatography

2.教学难点

The calculation of parameters of chromatography.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some analytical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. What’s the core difference among various types of chromatography?  

2. How to choose a suitable type of chromatography?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH32 Gas Chromatography

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Master the analysis principle and analysis object of gas chromatography

(2) Understand the structure and application of gas chromatography instrument

(3) Familiar with the practical application of gas chromatography

2.技能（能力）目标：

(1) Learn basic English terms in GC analysis  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use GC for samples analysis

二、授课内容（依据教学大纲）及时间分配

Lecture I & II:

32.1 Instruments for Gas-Liquid Chromatography—100 min

Lecture III:

32.2 Gas Chromatographic Columns and Stationary Phases—50 min

Lecture IV:

32.3 Applications of Gas-Liquid Chromatography—40 min

32.4 Gas-Solid Chromatography—10 min

三、教学重点与难点

1．教学重点

(1) The separation principle and instrument structure of gas chromatography.

(2) Grasp the stationary phases and the range of analytes suitable for gas chromatography.

2.教学难点

The effects on the chromatographic behavior.  

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some Chromatographic methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

How to eliminate the effects on the chromatographic behavior?  

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH33 High-Performance Liquid Chromatography

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the analysis principle and analysis object of high-performance liquid chromatography

(2) Understand the structure and application of high-performance liquid chromatography instrument

(3) Know well the practical application of high-performance liquid chromatography

2.技能（能力）目标：

(1) Learn basic English terms in HPLC analysis  

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use HPLC for samples analysis

二、授课内容（依据教学大纲）及时间分配

Lecture I & II:

33.1 Instrumentation—75 min

Lecture II & III:

33.2 Partition Chromatography—75 min

Lecture IV:

33.3 Adsorption Chromatography—5 min

33.4 Ion Chromatography—10 min

33.5 Size-Exclusion Chromatography—10 min

33.6 Affinity Chromatography—5 min

33.7 Chiral Chromatography—10 min

33.8 Comparison of High-Performance Liquid Chromatography and Gas Chromatography—10 min

三、教学重点与难点

1．教学重点

(1) The separation principle and instrument structure of high-performance liquid chromatography.

(2) The stationary phases, mobile phases, and detectors

2.教学难点

The effects on the chromatographic behavior.   

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some pharmaceutical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

How to choose the stationary phases, mobile phases, and detectors for HPLC analysis?

How to optimize the HPLC conditions?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003

课程名称

Analytical Chemistry

所属学科

药学

教材名称

Fundamentals of Analytical Chemistry, by Douglas Skoog Stanley Crouch, International Edition, 2013

授课年级

第三学期

授课章节

CH34 Miscellaneous Separation Methods

授课时间

200分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Grasp the analysis principle and analysis object of miscellaneous separation methods, including supercritical fluid separations, planar chromatography, capillary electrophoresis, capillary electrochromatography and field-flow fractionation.  

(2) Understand the instrument structures and application of different separation methods

(3) Know well the practical application of high-performance liquid chromatography

2.技能（能力）目标：

(1) Learn basic English terms in miscellaneous separation methods

(2) Improve the skills in listening and speaking English in Pharmaceutical Sciences

(3) Be able to use miscellaneous separation methods for samples analysis

二、授课内容（依据教学大纲）及时间分配

Lecture I:

34.1 Supercritical Fluid Separations—50 min

Lecture II:

34.2 Planar Chromatography—50 min

Lecture III:

34.3 Capillary Electrophoresis—50 min

Lecture IV:

34.4 Capillary Electrochromatography—30 min

34.5 Field-Flow Fractionation—20 min

三、教学重点与难点

1．教学重点

(1) The separation principle of miscellaneous separation methods.

(2) Grasp the instrument structure, methods of application and the range of analytes suitable for different separation methods.

2.教学难点

The effects on the separation behavior.

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Use case study to explain the principles and applications of some pharmaceutical methods

(2) Review the major concepts and materials covering the chapters.  

(3) Work on problems with students together to emphasize the basic principles covered in the chapters

(4) Test could push students usually.

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Ask questions during case studies before and after introducing basic concepts

(2) Discuss the complicated concepts

(3) Solve problems together with students

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amount of materials in each section

六、复习思考题

1. List some of the advantageous properties of supercritical CO2 as a mobile phase for chromatographic separations.

2. What important property of supercritical fluids is related to their densities?

3. Compare supercritical fluid chromatography with other column chromatographic methods.

4. What is the effect of pH on the separation of amino acids by electrophoresis? Why?

5. What is electroosmotic flow? Why does it occur?

6. How could electroosmotic flow be repressed? Why would one want to repress it?

7. What is the principle of separation by capillary zone electrophoresis?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. Analytical Chemistry, by Jessica Carol, NY Research Press, 2016

2. Analytical Chemistry (7th Edition), by Gary D. Christian, Purnendu K. Dasgupta, and Kevin A. Schug, Wiley, 2013

3. Analytical Chemistry, by Frederic P Miller, Agnes F Vandome, John McBrewster, Alphascript Publishing, 2009

4. Analytical Chemistry, by Séamus P J Higson, OUP Oxford, 2003