课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Microbiology introduction

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To understand the basic concepts of microbe and microbiology

(2) To understand the methods, goals and advantages of microbiology studying

(3) To understand the scope of microbes and general characteristics and cell structures of microorganisms

(4) To know about the relationship between microbes and human

2. 技能（能力）目标：

(1) To know about the basic methods and procedures of microbiology study

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Definition of microbe and microbiology (2 min)

(2) General Characteristics of Microorganisms and Their applications (5 min）

(3) The Cellular Organization of Microorganisms (10 min）

(4) Microbial Dimensions(4 min)

(5) Human Use of Microorganisms (5 min)

(6) General classification of Microorganisms (4 min)

(7) Microbial Roles in Infectious Diseases (5 min)

(8) Evolution of Microorganisms (5 min)

(9) Methods of Microbial Investigation (10 min)

Lecture 2:

(10) Prokaryotic Profiles: The Bacteria and Archaea (4 min)

(11) The Structure of a Generalized Bacterial Cell (5 min)

(12) Cell Extensions and Surface Structures: Flagellum, Fimbriae and Pili, Bacterial Surface Coating, or Glycocalyx (5 min)

(13) The Cell Envelope, Structure of Cell Walls, The Gram-Positive Cell Wall, Gram-negative Cell Wall (10 min)

(14) Cell Membrane Structure (5 min)

(15) Bacterial Internal Structure: Cell Cytoplasm (Chromosomes and Plasmids, Ribosomes, inclusions, Cytoskeleton, bacterial endospore (12 min)

(16) Bacterial Shapes (4 min)

(17) Other Prokaryotes (5 min)

Lecture 3

(18) External Structures: Cilia and Flagella, The Glycocalyx, Cell Wall, Cytoplasmic Membrane (6 min)

(19) Internal Structures: Nucleus (3 min)

(20) Internal Structures: Endoplasmic Reticulum, Golgi Apparatus, Mitochondria, Chloroplasts (10 min)

(21) Ribosomes: Protein Synthesizers (3 min)

(22) Cytoskeleton (2 min)

(23) Eukaryotic-Prokaryotic Comparisons (8 min)

(24) Fungi: Organization of Microscopic Fungi, Reproductive Strategies and Spore Formation (12 min)

(25) Protists: Algae, Protozoa (4 min)

(26) The Parasitic Helminths (2 min)

三、教学重点与难点

1.教学重点

(1) General classification of microorganisms

(2) Cell structures of different microbes

2.教学难点

(1) The similarity and difference of the cell structures and organelles functions of prokaryotic cells and eukaryotic cells

(2) The general methods to investigate and study microbes

四、教学方法选择

1. 理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Examples of common microbes and their sizes comparation

(2)  Illustrations of cellular organelles and unique structures of microbes

(3) Work on problems with students together to emphasize the basic principles covered in the chapter

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Strat the lesson with some quick questions to give rise the interest of students, then followed by introducing basic concepts

(2) Discuss the complicated knowledge points

(3) Solve problems together with students

2. 实验教学：（简要列出实验内容标题）

Not applicable.

五、更新或补充内容提要

六、复习思考题

(1) What are the basic characteristics of prokaryotic cells and eukaryotic cells?

(2) What the cellular makeup of microorganisms and their size range? and indicate how viruses differ from cellular microbes

(3) What is the generalized anatomy of bacterial cells?

(4) What is the structure and functions of cell walls? and what is the role of peptidoglycan?

(5) Review the major differences and similarities between prokaryotic and eukaryotic cells

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

中文版《微生物学与免疫学》，人民卫生出版社第8版

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Microbiology physiology and introduction to immunology

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To understand and grasp the microbial(bacterial) growth and metabolism

(2) To understand and grasp the principles of bacterial genetics

(3) To understand the basic functions and constitutes of immune system

2. 技能（能力）目标：结合实验课程目标

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Forms, Sources, and Functions of Essential Nutrients (8 min)

(2) Environmental Factors That Influence Microbes (10 min)

(3) Microbial Growth (3 min)

(4) The Basis of Population Growth: Binary Fission (5 min)

(5) Bacterial Cell Cycle (5 min)

(6) The Rate of Population Growth (3 min)

(7) Determinants of Population Growth (3 min)

(8) Introduction to Metabolism and Enzymes (8 min)

(9) Fermentation (5 min)

Lecture 2:

(10) The process of DNA replication in prokaryotic cells (12 min)

(11) Eukaryotic Transcription and Translation (3 min)

(12) Operon: A Model for Inducible Gene Regulation in Bacteria (10 min)

(13) Mutations, Categories of Mutations, Repair of Mutations (6 min)

(14) DNA Recombination in Bacteria (5 min)

(15) The Genetics of Animal Viruses (8 min)

(16) Genetic Engineering: Technical Aspects of Recombinant DNA and Gene Cloning (6 min)

Lecture 3

(17) Concept of immunology and immune system(6 min)

(18) Basic function of immune system(5 min)

(19) Constitutes of immune system(5 min)

(20) Concept of immune response, types and features of immune response(6 min)

(21) Applications of immunology(5 min)

(22) Organs and tissues in immune system(8 min)

(23) Cells and molecules in immune system(15 min)

三、教学重点与难点

1. 教学重点

(1) Bacterial population growth

(2) Bacterial DNA replication

(3) Basic concepts of immunology and immune system

2. 教学难点

(1) The process and enzymes involved in bacterial DNA replication

(2) The relationship of immune organs, cells and molecules of immune system

四、教学方法选择

1. 理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Examples and explanation of certain phenomenon involving the bacterial growth and metabolism

(2) Illustrations of bacterial growth, fermentation, nutrients and DNA replication

(3) Use cartoons to describe the functions and concepts of immune system

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Discuss the COVID-19 infection case to introduce the immunology concepts and functions

(2) Discuss the complicated knowledge points

(3) Solve problems together with students

2. 实验教学：（简要列出实验内容标题）

Not applicable.

五、更新或补充内容提要

六、复习思考题

(1) What is microbial growth? Explain the stages in the bacterial cell cycle and binary fission

(2) What is an operon? Describe the functions of regulators, promoters, and operators

(3) Compare conjugation, transformation, and transduction on the basis of general method, donor, and recipient

(4) What is the basic function of immune system?

(5) Can you list the important molecules which play function in immune responses? And can you differentiate them which are cell surface molecules and which of them are secreted proteins?

七、学习资源、课外自主学习参考

图文并茂的科学综述期刊：Nature Reviews Immunology

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Innate immunity

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1. 知识目标：

(1) To understand the principles of host defense and immune responses

(2) To understand the process and functions of innate immunity (inflammation, phagocytosis, interferons)

(3) To understand and grasp the function and mechanism of complement system

2. 技能（能力）目标：结合实验课程目标

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) The characteristics of basic host defenses (5 min)

(2) Introduction of three lines of host defense (5 min)

(3) First line of host defense: different barriers’ components, structure and functions (4 min)

(4) Introduction of innate and acquired immunity (6 min)

(5) The organs, tissues and cells’ in innate immune system (7 min)

(6) Leukocytes’ functions and mechanism in innate immunity (8 min)

Lecture 2:

(7) The Inflammatory Response and its features (4 min)

(8) The process and stages of Inflammation (10 min)

(9) Inflammatory Mediators, their functions and mechanisms (5 min)

(10) Phagocytosis: Phagocytes, Phases (8 min)

(11) Interferon: Types, roles and mechanisms (8 min)

Lecture 3

(12) Complement introduction: components, terms, and features (15 min)

(13) Complement activation pathways (10 min)

(14) Classic pathway(5 min)

(15) MB-lectin pathway(5 min)

(16) alternative pathways (10 min)

(17) Complement functions: Cytosis, Opsonization, Immune complex clearance, Inflammatory mediators, Involvement in acquired immune responses (20 min)

(18) Complement activation regulation (15 min)

三、教学重点与难点

1. 教学重点

(1) 3 activation pathways of complement system

(2) Functions of complement system

2. 教学难点

(1) The procedures of complement activation

(2) The regulation mechanisms of complement activation

四、教学方法选择

1. 理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Examples and explanation of certain inflammations

(2) Introduce the story how the complement system was found and investigated by scientist to heighten the curiosity and interest of students

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Draw the schematic diagram with students to better understand the cascade of complement activation

(2) Discuss the complicated knowledge points

(3) Solve problems together with students

2. 实验教学：（简要列出实验内容标题）

Not applicable.

五、更新或补充内容提要

六、复习思考题

(1) What is the difference between innate and acquired immunity? What are the general characteristics of each?

(2) How does the immune system distinguish self from foreign cells and particles?

(3) What is the cascade in the 3 complement activation pathways?

(4) What are the basic functions of complement system?

(5) How the complement activation is regulated?

七、学习资源、课外自主学习参考

图文并茂的科学综述期刊：Nature Reviews Immunology

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Adaptive immunity: Antigen, MHC and Antibody

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1.知识目标：

(1) Know the similarities and differences between innate and adaptive immune system

(2) Grasp the definition of antigens, factors contributing to antigenicity, the different types of antigens and their respective function

(3) Know the structure and function of MHC molecules

(4) Understand the origin of diversity for MHC molecules and the biological significance for such diversity

(5) Know the endogenous and exogenous antigen presentation pathways and understand the different function the two antigen presentation pathways

(6) Know the structure of antibodies, main classes of antibodies and their characteristic structure and function

2.技能（能力）目标：

(1) Learn the basic immunology terms in English

(2) Improve the reading, listening, speaking and writing of scientific English

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Compare and contrast the innate and adaptive immune system (10 min)

(2) Definitions of antigen, antigenicity (10 min)

(3) The origin of antigens (5 min)  

(4) Factors affecting antigenicity and their applications in inducing immune response (13 min)

(5) The structure and function of different types of antigens (12 min)

Lecture 2:

(6) Structure and function of MHC Class I and Class II molecules (15 min)

(7) Expression pattern of MHC molecules (10 min)

(8) The origin of diversity of MHC molecules (15 min)

(9) Antigen presenting cells (10 min)

Lecture 3

 (10) The endogenous pathway of antigen processing and presentation (10 min)

(11) The exogenous pathway of antigen processing and presentation (10 min)

(12) The structure of antibodies (15 min)

(13) The structure, function, distribution and relative abundance of the five major classes of antibodies (15 min)

三、教学重点与难点

1．教学重点

(1) Innate and adaptive immune system

(2) MHC class I and class II molecules

(3) Five main classes of antibodies

2.教学难点

(1) The differences between innate and adaptive immune system

(2) The different types of antigens and their respective function

(3) Structural and functional difference between MHC class I and class II molecules

(4) Endogenous and exogenous antigen presentation pathways

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) PowerPoint slides for content display

(2) Video clip about adaptive immune system

(3) Video clip about antibody structure

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) On-screen multiple-choices quiz at the end of each section during the class

(2) Discussion about the roles of MHC molecules the potential outcome during a virus pandemic

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of Antigen, MHC and Antibody

六、复习思考题

(1) Outline the overall phases in a specific immune response

(2) Summarize the general features of adaptive/acquired immunity. How is adaptive immunity different from innate immunity?

(3) Define antigen and immunogen

(4) What are the main categories of antigens based on their chemistry and function?

(5) How do shape, size and complexity contribute to antigenicity?

(6) What is major histocompatibility complex? Explain how it participates in immune reactions

(7) Why do we need different pathways for antigen presentation?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

《医学免疫学》

Basic Immunology: Functions and Disorders of the Immune System

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

T cell development, activation and differentiation

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1.知识目标：

(1) Know the basic steps involved in the T cell development

(2) Understand the positive selection and negative selection steps in the T cell development and grasp the significance of having both

(3) Know the signals required for T cell activation and the molecules involved

(4) Know the main subsets of T cells and their respective function

2.技能（能力）目标：

(1) Learn the basic immunology terms in English

(2) Improve the reading, listening, speaking and writing of scientific English

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Overview of tissues and organs required for T cell development (10 min)

(2) Early thymocyte development (10 min)

(3) The origin of T cell receptor diversity (30 min)

Lecture 2:

(4) Overview of T cell development (double negative stages, double positive stage, single positive stage) (12min)

(5) Positive selection and its significance (12min)

(6) Negative selection and its significance (12min)

(7) The structure of T cell receptor (TCR) (10min)

(8) Lineage commitment: αβT cells and γδT cells (4min)

Lecture 3

(9) T cell activation signal 1: TCR-MHC-peptide signaling (20min)

(10) T cell activation signal 2: Co-stimulatory signal (20min)

(11) The classification and respective function of the T cell subsets (10min)

三、教学重点与难点

1．教学重点

(1) VDJ recombination

(2) T cell development

(3) T cell activation

2.教学难点

(1) The mechanism of V(D)J recombination

(2) Positive selection and negative selection in T cell development

(3) The three signals required for T cell activation

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) PowerPoint slides for content display

(2) TV show “Cells at work!” to demonstrate positive and negative selection process

(3) Video clip about T cell activation

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) On-screen multiple-choices quiz at the end of each section during the class

(2) Discussion about the significance of having both positive and negative selection

(3) Discussion about the involvement of immune synapse in T cell activation

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of T cell development and activation

六、复习思考题

(1) How is the diversity generated in the T cell receptors? Describe the major events in the origin of diversity of the immune system and features of the clonal selection theory.

(2) Why don’t we delete all cells that are positively selected?

(3) Why must the body develop tolerance to self?

(4) Describe the cooperative interactions between antigen-presenting cells and T cells. Why do we need such complicated and delicate systems?

(5) Explain how the different types of T cells are activated.

(6) What are the differences between the primary functions of helper T cells and cytotoxic T cells?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

《医学免疫学》

Basic Immunology: Functions and Disorders of the Immune System

Immunology, Kuby, 8^th Edition

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

B cell development

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Know the process of B cell development

(2) Know the differences of various types of B cells

2.技能（能力）目标：

(1) Know the process of B cell activation

(2) Understand the differences between B cell development and T cell development

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

1. The site of Hematopoiesis

(1) The Site of B-Cell Generation Changes during Gestation (20 min)

(2) Hematopoiesis in the Fetal Liver Differs from That in the Adult Bone Marrow (30 min)

Lecture 2:

2. B-Cell Development in the Bone Marrow  

(3) The stages of hematopoiesis are defined by cell surface markers, transcription-factor expression, and immunoglobulin gene rearrangements (20 min)

(4) The earliest steps in lymphocyte differentiation culminate in the generation of a common lymphoid progenitor (10 min)

(5) The later steps of B-cell development result in commitment to the B-cell phenotype (10 min)

(6) Immature B cells in the bone marrow are exquisitely sensitive to tolerance induction (5 min)

(7) B cells exported from the bone marrow are still functionally immature (5 min)

Lecture 3:

3. The Development of B-1 and Marginal-Zone B Cells, comparison of B- and T-Cell Development

(8) B-1 B cells are derived from a separate developmental lineage (10 min)

(9) Marginal-zone cells share phenotypic and functional characteristics with B-1 B cells and arise at the T2 stage (10 min)

(10) T-Dependent B-Cell Responses (10 min)

(11) T-Independent B-Cell Responses (10 min)

(12) Negative Regulation of B Cells (10 min)

三、教学重点与难点

1．教学重点

(1) The process of B cell development

(2) The classification of B cells and their characteristics

(3) The activation of B cells

2.教学难点

(1)  The process of VDJ rearrangement in B cell development

(2) The maturation of B cells

(3) The activation of B cells

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustration of B cell development

(2) Illustration of VDJ rearrangement in B cell development

(3) Illustration of B cell activation

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Why B cells are so diverse?

(2) What is negative selection in B cell development?

(3) What is positive selection in B cell development?

(4) What are the factors needed for B cell activation?

2.实验课教学

No applicable

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amounts of materials in each section

六、复习思考题

Review Contents about B cell development process

(1) Following expression of the pre-B-cell receptor on the progenitor B-cell surface, the B cell undergoes a few rounds of cell division. What purpose does this round of division serve in the development of the B-cell repertoire?

(2) Describe the phenotypic and functional differences between T1 and T2 immature B cells

(3) Name one distinguishing feature of TI-1 and TI-2 antigens

(4) Describe three mechanisms by which antigen can enter the lymph node and make contact with the B-cell receptor

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Immunology, Kuby, 8^th Edition

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Cytokines and cell mediated cytotoxicity

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Know cytokine and chemokines

2.技能（能力）目标：

(1) Know antibody-mediated effector functions

(2) Know cell-mediated effector functions

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Receptors and Signaling: Cytokines and Chemokines (10 min)

(2) General Properties of Cytokines and Chemokines (10 min)

(3) Six Families of Cytokines and Associated Receptor Molecules (10 min)

(4) Cytokine Antagonists (10 min)

(5) Cytokine-Related Diseases (5 min)

(6) Cytokine-Based Therapies (5 min)

Lecture 2:

(7) Antibody-Mediated Effector Functions (20 min)

(8) Antibodies mediate the clearance and destruction of pathogen in a variety of ways (10 min)

(9) Antibody isotypes mediate different effector functions (10 min)

(10) Fc receptors mediate many effector functions of antibodies (10 min)

Lecture 3:

(11) Cell-Mediated Effector Responses (10 min)

(12) Cytotoxic T lymphocytes recognize and kill infected or tumor cells via T-cell receptor activation (10 min)

(13) Natural killer cells recognize and kill infected cells and tumor cells by their absence of MHC class I (5 min)

(14) NKT cells bridge the innate and adaptive immune systems (5 min)

(15) Co-culturing T cells with foreign cells stimulates the mixed-lymphocyte reaction (5min)

(16) CTL activity can be demonstrated by cell-mediated lympholysis (5 min)

(17) The graft-versus-host reaction is an in vivo indication of cell-mediated cytotoxicity (10 min)

三、教学重点与难点

1.教学重点

(1) Cytokine and chemokines

(2) Interaction between cytokines and chemokines

(3) Antibody-mediated effector functions

(4) Cell-mediated effector functions

2.教学难点

(1) Antibody-mediated effector functions

(2) Cytotoxic T lymphocytes recognize and kill infected or tumor cells via T-cell receptor activation

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustration of antibody-mediated immune responses

(2) Illustration of cell-mediated immune responses

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) How T cells kill target cells?

(2) How NK cells kill target cells?

2.实验课教学

No applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key concept and adjust the amounts of materials in each section

六、复习思考题

(1) Distinguish between a hormone, a cytokine, a chemokine, and a growth factor. What functional attributes do they share, and what properties can be used to discriminate among them?

(2) How might receipt of a cytokine signal result in the alteration of the location of a lymphocyte?

(3) Describe how dimerization and phosphorylation of intracellular signaling molecules contribute to activation of cells by Type 1 cytokines

(4) NK cells do not express TCR molecules, yet they bind to class I MHC molecules on potential target cells. Explain how NK cells lacking TCRs can specifically recognize infected cells

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Immunology, Kuby, 8^th Edition

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Disorder in immunity（Chapter 16）

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1.知识目标：

(1) Know the basic characteristics of central nervous system (CNS) resident cell types

(2) Know the main features of glial cells including astrocyte and microglia

(3) Know relationship between glial cells and neurons in CNS

2.技能（能力）目标：

(1) Understand the contribution of glial cell-mediated neuroinflammation to neurological diseases

二、授课内容（依据教学大纲）及时间分配

Lecture 1: Immunology and Neurodegenerative Disorders (50 min)

(1) Neurological system and cells: astrocyte, microglia, oligodendrocyte and neuron

(2) Neuroinflammation: functions of non-neuronal cells (glial cells) in CNS and their contribution to disease pathogenesis

(3) Neuroinflammation in Alzheimer Disease, Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Lecture 2: Immunology and cancer (50 min)

(4) The mechanism of tumorigenesis

(5) Compromised immune responses in cancer

(6) Describe the novel clinical applications of the immuno-therapy in the treatment of cancer

Lecture 3: Autoimmune Disease (50 min)

(7) Examples of autoimmune disease: systemic lupus erythematosus, Type I diabetes, Multiple sclerosis and others

(8) Explain the origins of autoimmunity and describe which persons are most often targeted by it

(9) Review the pathology of autoimmune diseases and the adverse medical effects they have

三、教学重点与难点

1.教学重点

(1) The source of microglia

(2) Steady-state and alternatively activated microglial cell phenotypes

(3) Activation of glial cells in the pathogenesis of neurodegenerative diseases

 (4) Overreaction and immunodeficiency in immunological diseases

2.教学难点

(1) Relationship of microglia to myeloid-lineage cells

(2) Relationship between glial cells and neurons

(3) Characteristic of different types of immunological diseases

四、教学方法选择

1.理论课堂教学

A.多媒体教学：

(1) Illustration of morphology of glial cells and neurons in CNS

 (2) Illustration of functions of glial cells and neurons

(3) Illustration of the relationship between glial cells and neurons

(4) Illustration of overreaction and immunodeficiency in immunological disorders

B.互动教学：

(1) What are the differences between neuron and glial cells?

(2) Why neuroinflammation contributes to neurological diseases?

(3) Why we say that microglia is a type of immunological cells?

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the pathology of autoimmune diseases and the adverse medical effects they have

六、复习思考题

(1) What is the general feature of the neuronal and non-neuronal cells?  

(2) What are the structure and functions of glial cells?

(3) What happens to the immune system during tumorigenesis?

(4) What is the characteristics of cancer, and explain the mechanism?

(5) Describe the problem that occurs during DNA replication at the ends of chromosomes. How are telomeres related to this problem?

(6) What are the three excision-repair systems found in eukaryotes, and which one is responsible for correcting thymine-thymine dimers that form as a result of UV light damage to DNA?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

(1) Immunology，Kuby等编著，第八版，2018年出版，W. H. Freeman and Company

(2) Immune System Disorders: Pathophysiology of Immune System, Diseases, Disorders & Function, Case Studies with Answers, Erin, Dr. Denney等编著, 2020年出版

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Disorder in immunity（Review and Midterm Exam）

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

 (1) Know the basic knowledge of immunology

(2) Know the basic knowledge of bacteria

(3) Know the disorder in immunity

2.技能（能力）目标：

(1) Understand all the key points in previous class

二、授课内容（依据教学大纲）及时间分配

Lecture 1: Review the key points in previous class (50 min)

(1) Introduction to microbiology, Microbiology physiology and introduction to immunology,  

(2) Antigen, antibody and MHC, T cell and B cell development, Immune effector mechanism: cytokine, cell mediated cytotoxicity, Disorder in immunity  

Lecture 2 and 3:

In class quiz about 100 min

三、教学重点与难点

1.教学重点

(1) General classification of microorganisms

(2) Cell structures of different microbes

(3) To understand and grasp the principles of bacterial genetics

(4) To understand the principles of host defense and immune responses

(5) Know the basic steps involved in the T cell and B cell development

2.教学难点

(1) The similarity and difference of the cell structures and organelles functions of prokaryotic cells and eukaryotic cells

(2) Basic concepts of immunology and immune system

(3) The regulation mechanisms of complement activation

(4) The signals required for T cell and B cell activation

四、教学方法选择

1.理论课堂教学

A.多媒体教学：

(1) Examples and explanation of certain inflammations

(2) Illustration of functions of glial cells and neurons

(3) Illustration of T cell and B cell development

(4) Illustration of overreaction and immunodeficiency in immunological disorders

B.互动教学：

(1) Summarize the general features of adaptive/acquired immunity. How is adaptive immunity different from innate immunity?

(2) What is the cascade in the 3 complement activation pathways?

(3) The organs, tissues and cells in innate immune system

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the all the key points in previous studies.

六、复习思考题

What is the relationship between microbiology and immunity?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

(1) Immunology，Kuby等编著，第八版，2018年出版，W. H. Freeman and Company

(2) Immune System Disorders: Pathophysiology of Immune System, Diseases, Disorders & Function, Case Studies with Answers, Erin, Dr. Denney等编著, 2020年出版

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Diagnosis, kill and prevention (non-immune) (Chapter 11, 12, 17)

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1.知识目标：

 (1) Know the general procedures for identifying pathogens

(2) Understand the methods of diagnosing infections

 (3) Understand the protocol and the key steps of Western blot and immunoprecipitation experiments

2.技能（能力）目标：

(1) Know the general procedures for identifying pathogens

二、授课内容（依据教学大纲）及时间分配

Lecture 1: Physical and Chemical Agents for Microbial Control (50 min)

(1) Qualities of chemical agents used in health care: target microbes, level of germicidal activity, toxicity and others

(2) Physical methods of control: heat, radiation, filtration and others

Lecture 2: Drugs, Microbes, Host: The Elements of Chemotherapy (50 min)

(3) Actions of selected antiviral drugs: overview, effects and examples

(4) Treatment of 2019-nCoV: combination of traditional medicine and antiviral drugs?

(5) The mysterious source of 2019-nCoV: bats and pangolins? where and when?

Lecture 3: Procedures for Identifying Pathogens and Diagnosing Infections (50 min)

(6) Overview of clinical microbiology: phenotypic, genotypic, immunologic and laboratory methods

(7) Introduction of the purposes of diagnosis

(8) Immunoassays: Western blot, radioimmunoassay and enzyme-linked immunosorbent assay (ELISA)

三、教学重点与难点

1.教学重点

(1) Similarities and differences between Western blot and immunofluorescent staining

 (2) Procedures and applications of immunoprecipitation

(3) Laboratory diagnosis of HIV Infection

2.教学难点

(1) The IgG heavy and light chain issues in immunoprecipitation

(2) Comparison between different immunologic methods and assays

(3) The most popular methods of diagnosis of HIV Infection

四、教学方法选择

1.理论课堂教学

A.多媒体教学：

(1) Illustration of Western blot

(2) Illustration of immunofluorescent staining

(3) Illustration of immunoprecipitation

(4) Illustration of diagnosis of HIV Infection

B.互动教学：

(1) What is genetic central dogma?

(2) What are the applications of different immunologic methods and assays?

(3) What type of specimen can be collected for further analysis?

(4) Why it is not hard to detect HIV and how to make it?

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

六、复习思考题

(1) Give several examples of antiviral drugs and describe their adverse drug reactions?

(2) What are the symptoms of COVID-19 and how to make the diagnosis?

(3) What is your opinion of the potential furin cleavage site inside 2019-nCoV?

(4) Describe the principles of Western blot?

(5) Give an example of the use of ELISA?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

(1) Microbiology: An Introduction，Gerard J. Tortora等编著，第十三版，2019年出版，Pearson

(2) Wastewater Microbiology. Gabriel Bitton等编著,第四版，2010年出版

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Detailed subclass microorganism study: Bacteria I (Chapter 4 and 18)

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1.知识目标：

(1) Know the basic characteristics of bacteria in terms of morphology, cell structure, nutrition, and reproduction

(2) Know bacterial external structure: Appendages (Flagella, Pili, Fimbriae)

(3) Know bacterial internal structure, contents of the cell cytoplasm

(4) Know the key features of gram-positive and negative cocci

2.技能（能力）目标：

(1) Know the basic characteristics of bacteria in terms of morphology, cell structure, nutrition, and reproduction

二、授课内容（依据教学大纲）及时间分配

Lecture 1: basic characteristics of bacteria in terms of morphology, cell structure, nutrition, and reproduction (50min)

(1) General Characteristics of Microorganisms and Their applications

(2) Human Use of Microorganisms  

(3) Evolution of Microorganisms

(4) Reproduction of bacteria  

Lecture 2: Classifications of bacteria (50min)

(5) Morphology, Gram stain, Growth requirements, biochemical reactions.

(6) Seroptype, antibiotic resistance patterns, rRNA sequence analysis

Lecture 3: Additional clinically important tests and practical classification of Bacteria (50min)

(7) Coagulase test

(8) Hemolysis test

(9) Lancefield serotyping

(10) Lactose Fermentation

(11) Practical Classification of Bacteria

三、教学重点与难点

1.教学重点

(1) Reproduction of bacteria

(2) Mechanism of gram stain

(3) How does hemolysis test work.

(4) Representatives in each class of bacteria depending on gram staining and morphology.

2.教学难点

(1) Differences between sexual and non-sexual reproduction

(2) Clinical important tests for bacteria

(3) Differences between Streptococcus and Staphylococcus

四、教学方法选择

1.理论课堂教学

A.多媒体教学：

(1) Illustration of morphology and cell structures of bacteria

(2) Illustration of reproductive types of bacteria

B.互动教学：

(1) What is the difference between bacteria cells, virus and mammalian cells?

(2) Why do bacteria need sexual reproduction?

(3) Why the gram-positive cells are stained purple in gram stain?

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

六、复习思考题

(1) What is the general anatomy of bacterial cells?

(2) What are the drugs commonly used to treat streptococcal infection?

(3) What are the symptoms of gonorrhea in males, females and newborns?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

(1) Microbiology: An Introduction，Gerard J. Tortora等编著，第十三版，2019年出版，Pearson

(2) Wastewater Microbiology. Gabriel Bitton等编著,第四版，2010年出版

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Detailed subclass microorganism study: Bacteria II (Chapter 19)

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Emphasize the basic characteristics of bacteria in terms of morphology, cell structure, nutrition, and reproduction

(2) Know bacterial internal structure, contents of the cell cytoplasm

(3) Know the key features of gram-positive and negative cocci

2.技能（能力）目标：

(1) Know the most important representative cocci in different species in these groups

二、授课内容（依据教学大纲）及时间分配

Lecture 1: The Gram-Positive Cocci of Medical Importance-Staphylococci (50min)

(1) Differentiate the bacteria to four major categories based upon morphology and gram stain

(2) General Characteristics of the Staphylococci

(3) Most important human pathogens of Staphylococci (Staphylococcus aureus)

(4) Physiological Characteristics of Staphylococcus aureus

(5) Virulence factors of Staphylococcus aureus

(6) Coagulase Test to differentiate different species of Staphylococcus

(7) Staphylococcal Disease (Localized cutaneous infections, Systemic infections, toxigenic disease)

(8) How to defense against, identify and treat Staphylococcal infections

(9) Some important stains in Staphylococcus that are antibiotic resistant (MRSA, VRSA)

Lecture 2: The Gram-Positive of Medical Importance-Streptococci (50min)

(10) General Characteristics of the Streptococci

(11) Classification of the Streptococc (Group A, B, C…)

(12) Lancefield Classification and Hemolysis test

(13) Group A Streptococci, beta-hemolysis-S. pyogenes

(14) Virulence factors of S. pyogenes

(15) Clinical diseases caused by S. pyogenes

(16) Identification, treatment and prevention of S. pyogenes

Lecture 3: The Gram-negative Cocci of Medical Importance-The Family Neisseriaceae (50min)

(17) General Characteristics of the Neisseriaceae

(18) Representative: Gonococcus (cause of gonorrhea)

三、教学重点与难点

1.教学重点

(1) Identification of Staphylococcus in samples

(2) Types of Staphylococcus Disease

(3) Differences between Streptococcus and Staphylococcus

(4) Pathogenesis of Staphylococcus

(5) Key features of gram-positive and negative cocci

2.教学难点

(1) Differences between sexual and non-sexual reproduction

(2) Differences between true versus opportunistic pathogen

(3) Clinical important tests for bacteria

(4) Differences between Streptococcus and Staphylococcus

四、教学方法选择

1.理论课堂教学

A.多媒体教学：

(1) Illustration of representative cocci in each Genus

(2) Illustration of microscopic morphology of pathogenic bacteria

B.互动教学：

(1) Why the gram-positive cells are stained purple in gram stain?

(2) What kind of bacterial infection have you seen in your everyday life?

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

六、复习思考题

(1) What are the drugs commonly used to treat streptococcal infection

(2) What are the symptoms of gonorrhea in males, females and newborns?

(3) What kind(s) of test could be employed to identify Staphylococcus in samples?

(4) What kind(s) of test could be employed to identify Steptococcus in samples?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

(1) Microbiology: An Introduction，Gerard J. Tortora等编著，第十三版，2019年出版，Pearson

(2) Wastewater Microbiology. Gabriel Bitton等编著,第四版，2010年出版

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Detailed subclass microorganism study: Bacteria III (Chapter 20-21)

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1.知识目标：

(1) Know the general characteristics of spores

(2) Know the basic classification of gram-positive bacilli

(3) Know the Genus Bacillus and Clostridium are spore-forming bacilli

(4) Understand the treatment and prevention of Anthrax

(5) Know the representative of Gram-positive regular non-spore-forming Bacilli

(6) Understand the multiplication cycle of Listeria

(7) Know the representative of Gram-positive irregular non-spore-forming Bacilli

(8) Know how to differentiate gram-positive Bacilli

(9) Know the medically important gram -negative Bacilli

2.技能（能力）目标：

(1) Know the most important representative Bacilli in different species in these groups

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

Medically Important Gram-Positive Bacilli (25 min)

(1) Three general groups (spore-forming, regular non-spore-forming, irregular non-spore-forming)

(2) The meaning of endospore (different from the fungal spores)

(3) Representatives of spore - forming bacilli (Genus Bacillus, Genus Clostridium)

(4) Bacillus anthracis (cause of authrax) and treatment of Anthrax

(5) Bacillus cereus (cause of food posining)

Gram-Positive Spore - Forming Bacilli 25 min

(6) Characteristics of Genus Clostridium (Anaerobic, Saprobic, catalase-negative)

(7) Genus Clostridium and disease (Wound and tissue infections: myonecrosis, antibiotic-associated colitis, and tetanus, food intoxication)

Lecture 2:

Gram-Positive Regular Non-Spore-Forming Bacilli (15 min)

(8) Representatives of Gram-Positive Regular Non-Spore-Forming Bacilli

(9) Listeria monocytogenes is an emerging food-borne pathogen

(10) Multiplication cycle of Listeria

(11) Genus Erysipelothrix and erysipeloid. The prevention and treatment of erysipeloid

Gram-Positive Irregular Non-Spore-Forming Bacilli (15 min)

(12) Classification (Non-acid-Fast Bacilli, Acid-Fast Bacilli and Filamentous Bacilli)

(13) Corynebacterium diphtheria

(14) Mycobacteria (Mycobacterium tuberculosis and Mycobacterium leprae)

(15) Actinomycetes: Filamentous Bacilli

(16) Scheme for differentiating gram-positive Bacilli

Actinomycetes: Filamentous Bacilli of Medical Importance (15 min)

(17) Medically Important Gram-Negative Bacilli

(18) True pathogens and Opportunists

(19) Aerobic Gram-negative Nonenteric Bacilli

(20) Characteritics of Pseudomonas (Opportunists)

(21) Pseudomonas: The Pseudomonads and Pseudomonas aeruginosa

Lecture 3: Related Gram-Negative Aerobic Rods (15 min)

(22) Brucella: Zoonotic Pathogen (Cause Brucellosis)

(23) Two species of Brucella (B.abortus and B.suis)

(24) Diagnosis and treatment of Brucella

(25) Bordetella pertussis (whooping cough)

(26) Tree major stages of whooping cough

(27) Treatment and Prevention of Bordetella pertussis (Vaccine: DTaP)

Family Enterobacteriaceae (15 min)

(28) Enteric pathogens (the most frequent cause of diarrheal illnesses)

(29) Characteristics of Enterobacteriaceae

Coliform Organisms and noncoliform Enterics (15 min)

(30) Escherichia. Coli (The most prevalent Enteric Bacillus)

(31) Salmonella (True enteric pathogen)

三、教学重点与难点

1.教学重点

(1) Differences between spore-forming and non-forming Bacilli

(2) Methods for detection, prevention and treatment of diphtheria

(3) Opportunistic infections of pseudomonas

2.教学难点

(1) Differences between spore-forming and non-forming Bacilli

(2) The basis of serological tests and what is their main use for enterics

(3) Effects of listeriosis in healthy adults, pregnant women, fetuses, and neonates

四、教学方法选择

1.理论课堂教学

A.多媒体教学：

(1) Illustration of general characteristics of spores

(2) Illustration of basic classification of gram-positive bacilli

(3) Illustration of the multiplication cycle of Listeria

(4) Illustration of how to differentiate gram-positive Bacilli

(5) Illustration of basic categories of Bacteria

B.互动教学：

(1) What are the differences between True pathogens and Opportunists?

(2) What are the essential components for DTaP vaccine?

(3) Why does Listeria use multiplication cycle?

(4) What kinds of bacteria could form endospores, what the use of endospores for bacteria?

(5) Recall the epidemiology of pertussis

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

六、复习思考题

(1) Adequate cooking is the usual way to prevent food poisoning. Why doesn’t it work for Clostridium perfringens and Bacillus food poisoning?

(2) Why do erysipeloids commonly appear on the hands, as opposed to other body parts?

(3) Why are Bacillus infections commonly associated with exposure to soil and dust?

(4) What are True pathogens and Opportunists?

(5) Which bacteria in the Family Enterobacteriaceae are true enteric pathogens and which ones are opportunists?

(6) Who is most at risk for contracting plague and why?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

(1) Microbiology: An Introduction，Gerard J. Tortora等编著，第十三版，2019年出版，Pearson

(2) Wastewater Microbiology. Gabriel Bitton等编著,第四版，2010年出版

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Fungi

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1．知识目标：

(1) Know the basic characteristics of fungi in terms of morphology, cell structure, nutrition, and reproduction

(2) Know the main features of fungal classification and representative examples of each group

(3) Know pathogenesis, diagnosis and control of fungal pathogens

(4) Understand the importance of fungi in ecology, agriculture, medicine, and basic science

2.技能（能力）目标：

(1) Learn basic English terms in microbiology

(2) Improve the skills in listening and speaking of English in microbiology

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Kingdom of fungi (5 min)

(2) Morphology of microscopic fungi (8 min)

(3) Structure of fungal cell (5 min)  

(4) Fungal nutrition of fungi (2 min)

(5) Reproductive strategies of fungi (5 min)

(6) Spore formation of fungi (10 min)

(7) Fungi classification (15 min)

Lecture 2:

(8) Fungi as infectious agents to human (15 min)

(9) True/Primary fungal pathogens (20 min)

(10) Fungal pathogens with intermediate virulence (15 min)

Lecture 3

(11) Opportunistic fungal pathogens (30 min)

(12) Fungal allergies and intoxications (5 min)

(13) Fungi as infectious agents to plants (2 min)

(14) The beneficial side of fungi (5 min)

(15) Budding yeast (Sacchromyces cerevisiae) is a great eukaryotic model (8 min)

三、教学重点与难点

1．教学重点

(1) Characteristics of yeasts and of molds

(2) Types of fungal spores and their functions

(3) The main features of fungal classification and representative examples

(4) Pathogenesis of fungal pathogens

(5) Common diagnostic methods and treatment for mycotic infections

2.教学难点

(1) Differences between sexual and non-sexual spores

(2) Differences between true versus opportunistic fungal pathogens

(3) Characteristic of different types of mycoses

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustration of morphology and cell structures of yeast and mold

(2) Illustration of reproductive cycle of different fungi

(3) Illustration of representative fungi in each phylum

(4) Illustration of microscopic morphology of pathogenic fungi

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) What is the difference between fungal cells, plants cells and mammalian cells?

(2) Why do fungi need sexual reproduction?

(3) Why cell wall synthesis and ergosterol synthesis are good targets for antifungal drugs?

(4) What kind of fungal infection have you seen in your everyday life?

2.实验课教学

Not applicable

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of fungi properties and fungi infections

六、复习思考题

(1) What are the differences between yeasts and molds?

(2) Why dimorphic fungi are easier to infect human?

(3) Explain general features of fungal classification, give examples of the four fungal phyla, and describe their structure and significance.

(4) How do primary pathogenic fungi differ from opportunistic fungi?

(5) Give examples of how fungi are beneficial?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

《医学微生物学》

Brock Biology of Microorganisms

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Viruses

授课时间

300分钟

一、教学目标：含知识目标、技能（能力）目标

1.知识目标：

(1) Know the general characteristics of viruses

(2) Understand the progression and scope of viral infection

(3) Explain how viral structure is related to viral classification

(4) Understand the treatment and prevention of viral infection

2.技能（能力）目标：

(1) Learn basic English terms in microbiology

(2) Improve the skills in listening and speaking of English in microbiology

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Structure of viruses (30 min)

(2) Virus classification (5 min)

(3) The life cycle of an animal virus (15 min)  

Lecture 2:

(4) Replication and transcription strategies in viruses (25 min)

(5) Damages to the host cell caused by viruses (5 min)

(6) Viral cultivation (5 min)

(7) Viral persistence and latency (5 min)

(8) Vidal oncogenicity (5 min)

(9) Viral diagnosis and treatment (5 min)

Lecture 3

(10) Enveloped double-stranded DNA viruses (30 min)

(11) Nonenveloped double-stranded DNA viruses (15 min)

(12) Nonenveloped single-stranded DNA viruses (5 min)

Lecture 4

(13) Enveloped segmented single-stranded RNA viruses (35 min)

(14) Enveloped nonsegmented single-stranded RNA viruses (15 min)

Lecture 5

(14) Enveloped nonsegmented single-stranded RNA viruses (20 min)

(15) Enveloped single-stranded RNA viruses encoding reverse transcriptase（30 min）

Lecture 6

(16) Nonenveloped single-stranded RNA viruses (25 min)

(17) Nonenveloped double-stranded RNA viruses (10 min)

(18) Bacteriophages (10 min)

(19) Prions (5 min)

三、教学重点与难点

1．教学重点

(1) Differences between DNA viruses and RNA viruses

(2) Baltimore classification of viruses based on viral genome replication and transcription

(3) Important pathogenic viruses: herpesvirus, HBV, HCV, influenza virus, coronavirus, rabies virus, Ebola virus, HIV2

2.教学难点

(1) Latency and recurrence of HSV; relationship between varicella and zoster

(2) Antigenic drift and shift of influenza viruses

(3) Comparison between different hepatitis viruses

(4) Timeline in HIV infection, asymptomatic HIV disease, and AIDS; HIV treatment

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) Illustration of structures of different viruses

(2) Illustration of life cycle of virus

(3) Illustration of classification of viruses

(4) Illustration of systems caused by different viruses

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) Can viruses be defined as cells?

(2) What are the essential components for virus replication?

(3) What kind of virus infection have you ever got?

(4) Why it is harder to develop vaccine for RNA viruses?

(5) Why RNA viruses are more prone to develop mutations?

(6) Why it is even harder to develop vaccine for HIV?

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of virus properties and virus infections

六、复习思考题

(1) Differentiate among lytic infection, latent infection, chronic infection, and transformation.

(2) What accounts for the affinity of viruses for certain hosts or tissues?

(3) What are the primary problems in treating viral infections with drugs?  

(4) What viruses are oncogenic?

(5) Why annual vaccination is considered the best way to avoid infection of influenza?

(6) What are retroviruses, and how are they different from other viruses?

(7) What are the primary target cells and pathologic effects of HIV over time?

(8) How prions are different from viruses?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

《医学微生物学》

Brock Biology of Microorganisms

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Environmental and applied microbiology

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

1.知识目标：

(1) Know the different levels of an ecosystem

(2) Know the main microorganisms involved in the carbon, nitrogen and phosphorous cycle in the environment

(3) Know the use of microorganisms in waste treatment

(4) Know the application of microorganisms in food production

(5) Know the measures to minimize food poisoning and food spoilage

2.技能（能力）目标：

(1) Learn the basic immunology terms in English

(2) Improve the reading, listening, speaking and writing of scientific English

二、授课内容（依据教学大纲）及时间分配

Lecture 1:

(1) Introduction to ecology (15min)

(2) Natural recycling of bioelements (15min)

(3) Lithosphere (terrestrial microbiology) (10min)

(4) Hydrosphere (hydrologic cycle and aquatic ecosystems) (10min)

Lecture 2:

(5) Primary, secondary and tertiary stages of sewage treatment (10min)

(6) Types of microbes involved (10min)

(7) Microbial fermentations in food products (20min)

(8) Major forms of bacteria food poisoning (10min)

Lecture 3

(9) Measure for preventing food poisoning and spoilage (15min)

(10) Common products in industrial microbiology (20min)

(11) Bioreactors and scale-up production (15min)

三、教学重点与难点

1.教学重点

(1) The different levels of an ecosystem

(2) The application of microorganisms in food production

(3) The measures to minimize food poisoning and food spoilage

2.教学难点

(1) The name of microbes involved in carbon, nitrogen and phosphorous cycle

(2) The name of representative microbes involved in the food production

(3) The measures to minimize food poisoning

四、教学方法选择

1.理论课堂教学

A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

(1) PowerPoint slides for content display

(2) Video clips about sludge treatment

(3) Video clips about bread, beer and dairy product production

B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

(1) On-screen multiple-choices quiz at the end of each section during the class

(2) Discussion about the good and bad sides of microorganisms involved in food production and storage

(3) Discussion about the measures to minimize food spoilage and food poisoning

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

Emphasize the key components of ecosystem and the application of microbes

六、复习思考题

(1) Characterize the organization of the biosphere, from the highest to the lowest levels.

(2) What is the difference between the concepts of habitat and niche?

(3) What are the primary microbe participants in the carbon, nitrogen and phosphorous cycles?  

(4) How is water decontaminated by microbes and made safe to drink? What are the three stages of sewage treatment?

(5) What is activated sludge?

(6) What does an anaerobic digester do?

(7) How are microbiological involved in bread, alcoholic beverage and dairy products production?

(8) What are the main types of food poisoning? Provide examples of each. What are the measures to prevent food poisoning and spoilage?

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

《医学微生物学》

Brock Biology of Microorganisms

课程名称

Microbiology and immunology（英文）

所属学科

药学

教材名称

Foundations in Microbiology 10th Edition

Kuby Immunology 7th Edition

授课年级

药学全英班

二年级

授课章节

Informative Essay Writing

授课时间

150分钟

一、教学目标：含知识目标、技能（能力）目标

Test the information extraction and essay writing skills of students

二、授课内容（依据教学大纲）及时间分配

In Class Informative Essay Writing (150 min)

Topics to choose from:

1. A patient is under a certain drug treatment, if we want to compare some immune molecules production levels/cellular location (细胞上的定位) by the CD4 and CD8 T cells in peripheral blood of the patient after drug treatment, what immunologic detection methods will you use for this purpose? Given the molecules to be tested: a. Interferon-alpha (protein levels); b. complement receptor 1 (protein levels and cellular location).  

Please design and describe the whole procedure of this detetion. (The details of the experiments are not necessary, focus on the methods of each step.)

2. Why do we need different types of immune cells? Please use CD8+ and CD4+ T cells as examples to illustrate how these two types of T cells collaborate to defend our body. "

3. How cytotoxic T cells kill target cells?

4. (1) What are the general features of the glial cells and neurons?  

(2) Please describe the principle, procedure and applications of Immunoprecipitation?

(3) Please describe the main steps in the allergic response.

5. Talk about differences between Streptococcus and Staphylococcus, and how to differentiate them from a sample.

6. (1) Please draw a schematic diagram to indicate the structure of coronavirus COVID-19. On this diagram, please label the main components including the genetic materials, matrix proteins (if any), capsid, envelope (if any), spike proteins  

(2) Please briefly describe the functions of the key viral proteins (such as matrix proteins, spikes proteins).  

(3) Then describe the detailed life cycle of COVID-19.

Content and Format:

考试形式：开卷，可上网查阅（会查重）

上交形式：电子版，发送至邮箱1019932719@qq.com，文件命名为“姓名+学号”

字数要求：＞300字

语言要求：英文

格式要求：题目加粗 四号 Time New Roman；正文 小四 Time New Roman；正文1.5倍行间距；可配图（使用网上下载的图片需标明引用出处）

三、教学重点与难点

四、教学方法选择

 Online searching

 Essay writing

五、更新或补充内容提要

 No appliable

六、复习思考题

No appliable

七、学习资源、课外自主学习参考

No appliable

1.理论课堂教学

Not applicable

2.实验课教学

Not applicable.

五、更新或补充内容提要

课后总结：按照实际进度对知识点分详略进行讲解

六、复习思考题

Review chapters 17

七、学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

Pharmaceutical Analysis, David G. Watson, 2012

Pharmaceutical Analysis for Small Molecules