课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 1  Introduction and Interpretive Tools

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Understand development of physical chemistry and the focuses of this subject；

2. Understand the basic tools required to analyze and interpret data sets from the clinic, laboratory, or literature.

3. Describe the differences between classic dosage forms and modern drug delivery systems.

2. 技能（能力）目标：

1. Cultivate the formulation design and development capabilities of powders and granules;

2. Master the preparation and quality evaluation skills of powders and granules.

2. 授课内容（依据教学大纲）及时间分配

1. Introduction (50分钟)

 Physical chemistry, physical pharmacy, pharmaceutical technology

2. Measurements, data, propagation of uncertainty (10分钟)

 Data analysis tools, dimensional analysis, significant figures, data types

3. Error and describing variability (10分钟)

 Determinate errors, indeterminate errors, precision and accuracy

4. Descriptive statistics (10分钟)

 Central tendency: mean, median, modes, variability: measures of dispersion

5. Visualizing results: graphic, methods, lines (20分钟)

Linear regression analysis  

3. 教学重点与难点

1. 教学重点

（1）The concept of physical chemistry and its research focus;

（2）The method to learn physical chemistry;

（3）Data analysis and graphic presentation of results.

2. 教学难点

（1）Understand the intrinsic characteristics of physical chemistry;

（2）How to demonstrate results through data analysis and graphic.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. After preparing a prescription calling for six capsules each containing three grains of aspirin, you remove the contents completely and weigh each. The weights are 2.85, 2.80, 3.02, 3.05, 2.95, and 3.15 grains. Compute the average weight of the contents of the capsules, the average deviation, and the standard deviation. One gram is equal to 15.432 grains (gr.).

2. The dosage of some drugs is expressed in “units.” Units are a measure of potency rather than quantity. For example, it has been found that each microgram of penicillinV is equivalent to 1.6 potency units. How many units are equivalent to 250 mg of penicillin V?

3. A milligram of d-alpha tocopherol is equivalent to 1.49 I.U. of vitamin E. A formula for vitamin E calls for 20 I.U. per capsule. How many kilograms of d-alpha tocopherol are required to make 200,000 capsules?

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 2  States of Matter

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Understand the nature of the intra- and intermolecular forces;

2. Understand the intermolecular forces and the states of matters;

3. Be able to perform calculations: ideal gas law, molecular weights, vapor pressure, boiling points, kinetic molecular theory, van der Waals real gases, the Clausius-Clapeyron equation, heats of fusion and melting points, phase rule equation;

4. Understand phase rule and use it for phase analysis.

2. 技能（能力）目标：

1. Cultivate the capabilities of powders and granules;

2. Master the calculation skills to obtain parameters such as vapor pressure, boiling points, molecular weights.

2. 授课内容（依据教学大纲）及时间分配

1. Bonding forces between molecules (10分钟)

2. The nature of the intra- and intermolecular forces   (10分钟)

3. The gaseous state (15分钟)

 Idea gas equation, PV=nRT    

4. The liquid state(15分钟)

 Clausius-Clapeyron equation: heat of vaporization   

5. Solids and the crystalline state (20分钟)

 Polymorphism, melting and heat of fusion

6. Phase equilibria and the phase rule (20分钟)

 The phase rule, F=C-P+2, phase diagram, single-component system, Two-component systems, solid dispersion, three-component systems, triangular diagram.

7. Summary (10分钟)

3. 教学重点与难点

1. 教学重点

（1）The concept of physical chemistry and its research focus;

（2）The method to learn physical chemistry;

（3）Data analysis and graphic presentation of results.

2. 教学难点

（1）Understand the intrinsic characteristics of physical chemistry;

（2）How to demonstrate results through data analysis and graphic presentation.

4. 教学方法选择

2. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. After preparing a prescription calling for six capsules each containing three grains of aspirin, you remove the contents completely and weigh each. The weights are 2.85, 2.80, 3.02, 3.05, 2.95, and 3.15 grains. Compute the average weight of the contents of the capsules, the average deviation, and the standard deviation. One gram is equal to 15.432 grains (gr.).

2. The dosage of some drugs is expressed in “units.” Units are a measure of potency rather than quantity. For example, it has been found that each microgram of penicillinV is equivalent to 1.6 potency units. How many units are equivalent to 250 mg of penicillin V?

3. A milligram of d-alpha tocopherol is equivalent to 1.49 I.U. of vitamin E. A formula for vitamin E calls for 20 I.U. per capsule. How many kilograms of d-alpha tocopherol are required to make 200,000 capsules?

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 3  Thermodynamics

授课时间

200分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Understand the theory of thermodynamics and its use for describing energy-related changes in reactions

2. Understand the first law of thermodynamics and its use;

3. Understand the second law of thermodynamics and its use;

4. Understand the third law of thermodynamics and its use;

5. Define and calculate free energy functions and apply them to pharmaceutically relevant issues.

6. Understand the basic principles of the impact of thermodynamics on pharmaceutically relevant applications.

7. Define the chemical potential and equilibrium processes

2. 技能（能力）目标：

1. Cultivate the capabilities of using thermodynamics law to analyze the relevant problems about physical chemistry;

2. Master the calculation skills to obtain parameters such as free energy functions, heat and entropy of a process.

2. 授课内容（依据教学大纲）及时间分配

1.  The first law of thermodynamics(40分钟)

 Internal energy (E), ΔE = Q + W, isothermal and adiabatic processes, work of expansion against a constant pressure, maximum work, changes of state at constant pressure.

2.  Thermochemistry(20分钟)

 Heat of formation, heat of reaction from bond energies, heat of neutralization

3. The second law of thermodynamics(60分钟)

 The efficiency of a heat engine, entropy, entropy and disorder

4.  The third law of thermodynamics（20分钟）

 Absolute entropies

5.  Free energy functions and applications （50分钟）

 Maximum net work, criteria of equilibrium and spontaneity, fugacity, open system, chemical potential, Clausius-Clapeyron equation, activity, standard free energy and the equilibrium constant

6. Summary （10分钟）

3. 教学重点与难点

3. 教学重点

（1）The concepts of law of three laws of thermodynamic;

（2）Describe different processes using first-law equations;

（3）The heat changes accompanying isothermal chemical reactions at constant pressure or volume.

（4）The Efficiency of a Heat engine

（5）Entropy and calculation of the entropy change in isothermal process or at constant pressure

（6）Helmholtz Energy and Gibbs Energy

4. 教学难点

（1）Understand the theory of thermodynamics and its use for describing energy-related changes in reactions;

（2）different calculations of thermodynamic parameters.

4. 教学方法选择

3. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. A weather balloon rises 2 miles into the upper atmosphere. Its volume at ground level is 2.50 liters at 1 atm pressure and 24 °C. What is its final volume if the atmospheric pressure is 8.77 × 10-3 atm and the temperature is -44.7 °C at the 2-mile position?

2. The vapor pressure of water at 25◦C is 23.8 mmHg. The average heat of vaporization between 25 °C and 40 °C is about 10,400 cal/mole. Using the Clausius-Clapeyron equation, calculate the vapor pressure at 40 °C. The experimentally determined value is 55.3 mmHg.

3. Isoflurane and halothane are nonflammable volatile liquids used for general anesthesia.

(a) What is the vapor pressure, p’, of isoflurane at room temperature, 25◦C? The heat of vaporization, ΔHV’, of isoflurane is 6782 cal/mole at its boiling point. The vapor pressure, p’, for isoflurane at its normal boiling point, 48.5◦C, is 1 atm according to the definition of the normal boiling point.

(b) What is the heat of vaporization, ΔHV’, of halothane within the temperature range 20 °Cto its boiling point, 50.2 °C? The vapor pressure, p’, of halothane at 20 °C is 243 mmHg. These two general anesthetics are slightly greater in vapor pressure than ether (ether, p = 217 torr at 20 °C). Of much greater importance, they are nonflammable, whereas ether is highly flammable.

(c) What other advantages does halothane have over ether as a general anesthetic? Consult a book on pharmacology.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 4  Determination of the Physical Properties of Molecules

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Understand the nature of intra- and intermolecular forces that are involved in stabilizing molecular and physical structures.

2. Understand the differences in the energetics of these forces and their relevance to different molecules.

3. Understand the differences in energies between the vibrational, translational, and rotational levels and define their meaning.

4. Understand the differences between atomic and molecular spectroscopic techniques and the information they provide.

2. 技能（能力）目标：

1. Cultivate the capabilities of using intrinsic structures of molecules to analyze their properties  relevant problems about physical chemistry;

2. Master the calculation skills to describe the properties of different molecules.

2. 授课内容（依据教学大纲）及时间分配

1. Molecular Structure, Energy, and Resulting Physical Properties (10分钟)

2. Additive and Constitutive Properties (10分钟)

3. Dielectric Constant and Induced Polarization (10分钟)

4. Permanent Dipole Moment of Polar Molecules (10分钟)

5. Electromagnetic Radiation (10分钟)

6. Atomic and Molecular Spectra (20分钟)

Ultraviolet and visible spectrophotometry, fluorescence and phosphorescence, infrared spectroscopy, electron paramagnetic and nuclear magnetic resonance spectroscopy, refractive index and molar refraction, optical rotation, optical rotatory dispersion, circular dichroism, electron and neutron scattering and emission spectroscopy.

3. 教学重点与难点

1. 教学重点

（1）The nature of intra- and intermolecular forces that are involved in stabilizing molecular and physical structures;

（2）The differences between atomic and molecular spectroscopic techniques and the information they provide;

（3）The differences in energies between the vibrational, translational, and rotational levels.

2. 教学难点

（1）The principles of different techniques for describing the properties of molecules;

（2）The equations involved in describing the parameters.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. The wavelength for the detection of lithium by its atomic emission spectrum is 670.8 nm. What is the energy of the photon of radiation that corresponds to this emission line for lithium?

2. A traditional convention to describe the absorbance through a 1-cm path length containing 1 gm of solute per 100 mL of solution was termed the E1%1cm value. The E1%1cm value for the ultraviolet absorbance of indomethacin at 318 nm is 182 per 100 mL g-1 cm-1. What is the molar absorptivity, ε, corresponding to this E1%1cm value? The molecular weight of indomethacin is 357.81 g/mole.

3. A blood serum sample is being analyzed for isoniazid by fluorescence induced with salicylaldehyde. The following relative fluorescence emission intensities are obtained for a blank sample with no drug, a standard of 0.80 μg/mL, and the serum sample: 1.2, 60.5, and 38.4, respectively. Assuming that the emission intensity is proportional to the isoniazid concentration, determine the isoniazid concentration in μg/mL in the serum

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 5  Nonelectrolytes

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Identify and describe the four colligative properties of nonelectrolytes in solution.

2. Understand the various types of pharmaceutical solutions.

3. Calculate molarity, normality, molality, mole fraction, and percentage expressions.

4. Calculate equivalent weights.

5. Define ideal and real solutions using Raoult’s and Henry’s laws.

6. Calculate vapor pressure lowering, boiling point elevation, freezing point lowering, and pressure for solutions of nonelectrolytes.

2. 技能（能力）目标：

1. Use Raoult’s law to calculate partial and total vapor pressure;

2. Use colligative properties to determine molecular weight.

2. 授课内容（依据教学大纲）及时间分配

1.  Physical properties of substances and solutions (10分钟)

 Colligative properties, additive properties, constitutive properties, type of solutions

2.  Concentration expressions (10分钟)

 Molarity and normality, molality, mole fraction, percentage expressions, conversion equations for concentration terms

3.  Equivalent weights (10分钟)

4.  Ideal and real solutions (30分钟)

 escaping tendency, Raoult’s law, real solutions, Henry’s law, distillation of binary mixtures

5.  Colligative properties (30分钟)

 Lowering of the vapor pressure, elevation of the boiling point, depression of the freezing point, osmotic pressure, measurement of osmotic pressure, van’t Hoff and Morse equations for osmotic pressure, thermodynamics of osmotic pressure and vapor pressure lowering

6.  Molecular weight determination (10分钟)

Choice of colligative properties

3. 教学重点与难点

1. 教学重点

（1）The four colligative properties of nonelectrolytes in solution;

（2）Raoult’s and Henry’s laws;

2. 教学难点

（1）Calculate vapor pressure lowering, boiling point elevation, freezing point lowering, and pressure for solutions of nonelectrolytes;

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. A solution of sucrose (molecular weight 342) is prepared by dissolving 0.5 g in 100 g of water. Compute (a) the weight percent, (b) the molal concentration, and (c) the mole fraction of sucrose and of water in the solution.

2. How many grams of Ca3(PO4)2 are required to prepare 170 mL of a 0.67 N solution? The molecular weight of Ca3(PO4)2 is 310.

3. (a) State Henry’s law and discuss its relationship to Raoult’s law. (b) How is Henry’s law used in the study of gases in solution?

4. The freezing point lowering of a solution containing 1.00 g of a new drug and 100 g of water is 0.573 °C at 25 °C.

(a) What is the molecular weight of the compound?

(b) What is the boiling point of the solution?

(c) What is the osmotic pressure of the solution?

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 6  Electrolyte Solutions

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Understand the important properties of solutions of electrolytes.

2. Understand and apply Faraday’s law and electrolytic conductance.

3. Calculate the conductance of solutions, the equivalent conductance, and the equivalent conductance of electrolytes.

4. Compare and contrast the colligative properties of electrolytic solutions and concentrated solutions of nonelectrolytes.

5. Apply the Arrhenius theory of electrolytic dissociation.

6. Understand the differences between osmolality and osmolarity

2. 技能（能力）目标：

1. Apply the theory of strong electrolytes; for example, calculate degree of dissociation, activity coefficients, and so on.

2. Calculate ionic strength;

3. Calculate osmotic coefficients, osmolality, and osmolarity.

2. 授课内容（依据教学大纲）及时间分配

1.  Properties of solutions of electrolytes (30分钟)

 Electrolysis, electrolytic conductance, measuring the conductance of solutions, equivalent conductance, equivalent conductance of strong and weak electrolytes, colligative properties of electrolytic solutions and concentrated solutions of nonelectrolytes

2.  Theory of electrolytic dissociation（20分钟）

 Drug and ionization, degree of dissociation

3.  Theory of strong electrolytes（20分钟）

 Activity and activity coefficients, activity of solvent, reference state, standard state, ionic strength, Debye-Hueckel theory

4.  Coefficients for expressing colligative properties （20分钟）

 The L value, osmotic coefficient, osmolality

5.  Summary（10分钟）

3. 教学重点与难点

1. 教学重点

（1）Faraday’s law and Conductance of electrolytes;

（2）Colligative properties of electrolytic solutions and concentrated solutions of nonelectrolytes.

2. 教学难点

（1）Arrhenius theory of electrolytic dissociation;

（2）Calculations: degree of dissociation, activity coefficients, ionic strength, osmolality, osmolarity.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. The equivalent conductance, C₀, of the sodium salt of a sulfonamide at infinite dilution was found by experiment to be 100.3 mho cm2/Eq. The C₀ for HCl is 426.16; for NaCl, it is 126.45. What is C0 for the free acid (the free sulfonamide)?

2. A 1.0 m solution of sucrose had an observed osmotic pressure of 24.8 atm at 0◦C. Calculate the van’t Hoff i factor for sucrose at this concentration.

3. The vapor pressure of pure water (23.8 torr) at 25^◦C is lowered when 100 g of the nonelectrolyte glucose is added to 1000 g of the water. The molecular weight of glucose is 180.16 g/mole. What are the activity and the activity coefficient of water at this temperature and concentration of glucose?

4. Compute the mean ionic activity coefficient of a 0.01 M aqueous solution of diphenylhydantoin sodium containing 0.01 M KCl at 25◦C. Use the limiting Debye–Huckel equation.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 7  Ionic Equilibria

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Describe the Br¨onsted–Lowry and Lewis electronic theories.

2. Identify and define the four classifications of solvents.

3. Understand the concepts of acid–base equilibria and the ionization of weak acids and weak bases.

4. Understand the concepts of pH, pK, and pOH and the relationship between hydrogen ion concentration and pH.

5. Define strong acid and strong base.

6. Define and calculate acidity constants

2. 技能（能力）目标：

1. Calculate dissociation constants Ka and Kb and understand the relationship between Ka and Kb.

2. Calculate pH

2. 授课内容（依据教学大纲）及时间分配

1.  Broensted-Lowry theory and Lewis electronic theory（10分钟）

2.  Acid-base equilibria（20分钟）

 Ionization of weak acids, ionization of weak bases, ionization of water, ionization of polyprotic electrolytes, ampholytes

3.  Species concentration as a function of pH （15分钟）

4.  Calculation of pH（40分钟）

 Proton balance equations, conjugated acid-base pairs, solutions containing only a weak acid, solutions containing only a weak base, solution containing a single conjugate acid-base pair, two conjugate acid-base pair, solutions containing only a diprotic acid, solutions containing only an ampholyte, solutions containing only a diacidic base, two independent acid-base pairs, solutions containing two weak acids, solutions containing a salt of a weak acid and a weak base, solutions containing a weak acid and a weak base

5.  Acidity constants（5分钟）

 Effect of ionic strength

6.  Summary（10分钟）

3. 教学重点与难点

1. 教学重点

（1）Broensted-Lowry and Lewis electronic theories;

（2）Acid-base equilibria and ionization.

2. 教学难点

（1）pH calculation of various systems.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. If 100 mL of 0.005 M sulfathiazole is mixed with 57 mL of 0.003 M sodium hydroxide, what is the pH of the mixture? What is the pOH of the solution? Sulfathiazole reacts in part withNaOHto give sodium sulfathiazole. Hint: Use the Henderson–Hasselbalch equation. The pKa of sulfathiazole is 7.12.

2. Calculate the pH of a solution containing 0.1 M acetic acid and 0.1 M formic acid.

3. (a) What is thePBEfor a solution of ammonium chloride?

(b) What is the PBE for a solution containing equimolecular amounts of Na2HPO4 and ammonium chloride?

4. The pH of a 1:500 aqueous solution of ephedrine was determined with a pH meter and was found to be 10.70. Calculate the pKb for ephedrine.

5. Calculate α, the degree of dissociation of 0.01 M physostigmine, disregarding the secondary ionization. α is the concentration of the ionized form, [physostigmine+] = [OH−]/Cb, where Cb is the concentration of the compound.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 8  Buffered and Isotonic Solutions

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Understand the common ion effect.

2. Understand the relationship between pH, pKa, and ionization for weak acids and weak bases.

3. Understand the relationship between activity coefficients and the buffer equation.

4. Discuss the factors influencing the pH of buffer solutions.

5. Understand the concept and be able to calculate buffer capacity.

6. Describe the influence of concentration on buffer capacity.

7. Discuss the relationship between buffer capacity and pH on tissue irritation.

8. Describe the relationship between pH and solubility.

9. Describe the concept of tonicity and its importance in pharmaceutical systems.

2. 技能（能力）目标：

1. Apply the buffer equation, also known as the Henderson–Hasselbalch equation, for a weak acid or base and its salt.

2. Calculate solution tonicity and tonicity adjustments.

2. 授课内容（依据教学大纲）及时间分配

1.  The buffer equation (20分钟)

 Common ion effect, buffer equation for a weak acid and its salt, activity coefficients and the buffer equation, some factors influencing the pH of buffer solutions, drugs as buffers, pH indicators

2.  Buffer capacity (10分钟)

 Approximate calculation of buffer capacity, maximum buffer capacity, the influence of concentration on buffer capacity

3.  Buffers in pharmaceutical and biological systems (20分钟)

 In vivo biologic buffer systems, urine, pharmaceutical buffers, procedures for preparing pharmaceutical buffer solutions, pH on tissue irritation, stability versus optimum therapeutic response, pH and solubility

4.  Buffered isotonic solutions (20分钟)

 Measurement of tonicity, calculating tonicity using Liso values

5.  Methods of adjusting tonicity and pH (20分钟)

 Cryoscopic method, sodium chloride equivalent method, White-Vincent method, the Sprowls method

6.  Summary (10分钟)

3. 教学重点与难点

1. 教学重点

（1）Broensted-Lowry and Lewis electronic theories;

（2）Acid-base equilibria and ionization.

2. 教学难点

（1）pH calculation of various systems.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. If 100 mL of 0.005 M sulfathiazole is mixed with 57 mL of 0.003 M sodium hydroxide, what is the pH of the mixture? What is the pOH of the solution? Sulfathiazole reacts in part withNaOHto give sodium sulfathiazole. Hint: Use the Henderson–Hasselbalch equation. The pKa of sulfathiazole is 7.12.

2. Calculate the pH of a solution containing 0.1 M acetic acid and 0.1 M formic acid.

3. (a) What is thePBEfor a solution of ammonium chloride?

(b) What is the PBE for a solution containing equimolecular amounts of Na2HPO4 and ammonium chloride?

4. The pH of a 1:500 aqueous solution of ephedrine was determined with a pH meter and was found to be 10.70. Calculate the pKb for ephedrine.

5. Calculate α, the degree of dissociation of 0.01 M physostigmine, disregarding the secondary ionization. α is the concentration of the ionized form, [physostigmine+] = [OH−]/Cb, where Cb is the concentration of the compound.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》

Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 9 Solubility and Distribution Phenomena

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Define saturated solution, solubility, and unsaturated solution.

2. Define complete and partial miscibility.

3. Define thermodynamic, kinetic, and intrinsic solubility.

2. 技能（能力）目标：

1. Describe and give examples of polar, nonpolar, and semipolar solvents.

2. Understand the factors controlling the solubility of weak electrolytes.

3. Describe the influence of solvents and surfactants on solubility.

4. Measure thermodynamic solubility.

5. Describe what a distribution coefficient and partition coefficient are and their importance in pharmaceutical systems.

2. 授课内容（依据教学大纲）及时间分配

Introduction（10分钟）

Saturated solution, solubility, and unsaturated solution（10分钟）

Complete and partial miscibility （10分钟）

Thermodynamic, kinetic, and intrinsic solubility（10分钟）

Polar, nonpolar, and semipolar solvents（10分钟）

The factors controlling the solubility of weak electrolytes（15分钟）

The influence of solvents and surfactants on solubility（15分钟）

Distribution coefficient and partition coefficient and their importance in pharmaceutical systems（20分钟）

3. 教学重点与难点

3. 教学重点

（1）Thermodynamic, kinetic, and intrinsic solubility.

（2）The factors controlling the solubility of weak electrolytes.

（3）The influence of solvents and surfactants on solubility.

4. 教学难点

（1）Polar, nonpolar, and semi-polar solvents.

（2）Distribution coefficient and partition coefficient and their importance in pharmaceutical systems.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

Explain the definitions of saturated solution, solubility, and unsaturated solution.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Do calculations （案例、实例计算） about (1) The factors controlling the solubility of weak electrolytes; (2) The influence of solvents and surfactants on solubility; and (3) Distribution coefficient and partition coefficient and their importance in pharmaceutical systems.

5. 更新或补充内容提要

见PPT多媒体课件

6. 复习思考题

见PPT多媒体课件

Textbook, PRACTICE PROBLEMS FOR STUDENT USE

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

见PPT多媒体课件

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》

Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019药学全英文班

授课章节

Chapter 10 Complexation and Protein binding

授课时间

200分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Define the three classes of complexes.

2. Describe chelates, their physical properties, and what differentiates them from organic molecular complexes.

3. Describe the types of forces that hold together organic molecular complexes and give examples.

4. Describe the forces involved in polymer-drug complexes used for drug delivery and situations where reversible or irreversible complexes may be advantageous.

2. 技能（能力）目标：

1. Identify pharmaceutically examples of the three classes of complexes.

2. Discuss the uses and give examples of cyclodextrins in pharmaceutical applications.

3. Determine the stoichiometric ratio and stability constant for complex formation.

4. Describe the methods of analysis of complexes and their strengths and weaknesses.

5. Discuss the ways that protein binding can influence drug action.

6. Describe the equilibrium dialysis and ultrafiltration methods for determining protein binding.

7. Understand the factors affecting complexation and protein binding.

8. Understand the thermodynamic basis for the stability of complexes.

2. 授课内容（依据教学大纲）及时间分配

Introduction（10分钟）

The three classes of complexes（10分钟）

Chelates, their physical properties, and what differentiates them from organic molecular complexes （10分钟）

The types of forces that hold together organic molecular complexes and examples（5分钟）

The forces involved in polymer-drug complexes for drug delivery（10分钟）

The uses of cyclodextrins in pharmaceutical applications（15分钟）

Determination of the stoichiometric ratio and stability constant for complexes（60分钟）

The methods of analysis of complexes and their strengths（30分钟）

The ways that protein binding can influence drug action（10分钟）

Dialysis and ultrafiltration for determining protein binding（20分钟）

The factors affecting complexation and protein binding（10分钟）

The thermodynamic basis for the stability of complexes（10分钟）

3. 教学重点与难点

1. 教学重点

（1）The three classes of complexes.

（2）Chelates and their physical properties.

（3）Determine the stoichiometric ratio and stability constant for complex formation.

（4）The methods of analysis of complexes and their strengths and weaknesses.

（5）The ways that protein binding can influence drug action.

（6）The equilibrium dialysis and ultrafiltration methods for determining protein binding.

2. 教学难点

（1）The types of forces that hold together organic molecular complexes and examples.

（2）The forces involved in polymer-drug complexes used for drug delivery and situations where reversible or irreversible complexes may be advantageous.

（3）The uses and give examples of cyclodextrins in pharmaceutical applications.

（4）The factors affecting complexation and protein binding.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

Use example in PPT to explain the three classes of complexes, chelates and their physical properties.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Do calculations （案例、实例计算）to determine the stoichiometric ratio and stability constant for complex formation.

5. 更新或补充内容提要

见PPT多媒体课件

6. 复习思考题

见PPT多媒体课件

Textbook, PRACTICE PROBLEMS FOR STUDENT USE

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

见PPT多媒体课件

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》

Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 11 Diffusion

授课时间

200分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Define diffusion.

2. Understand the processes of dialysis, osmosis, and ultrafiltration.

3. Define and understand Fick's laws of diffusion and their application.

4. Relate permeability to a rate constant and to resistance.

5. Describe the various driving forces for diffusion, drug absorption, and elimination.

6. Describe multilayer diffusion and calculate component permeabilities.

2. 技能（能力）目标：

1. Describe examples of diffusion in the pharmaceutical sciences and the practice of pharmacy.

2. Describe the mechanisms of transport in pharmaceutical systems and identify which ones are diffusion based.

3. Calculate diffusion coefficient, permeability, and lag time.

4. Understand the concepts of steady state, sink conditions, membrane, and diffusion control.

5. Calculate drug release from a homogeneous solid.

2. 授课内容（依据教学大纲）及时间分配

Introduction（10分钟）

Diffusion and relevant examples in the pharmaceutical sciences and the practice of pharmacy（20分钟）

The processes of dialysis, osmosis, and ultrafiltration （10分钟）

Fick's laws of diffusion and their application（30分钟）

Diffusion coefficient, permeability, and lag time （20分钟）

Permeability relevance to a rate constant and to resistance（10分钟）

Various driving forces for diffusion, drug absorption, and elimination（10分钟）

Multilayer diffusion and calculate component permeabilities（20分钟）

Steady state, sink conditions, membrane, and diffusion control（30分钟）

Drug release from a homogeneous solid（40分钟）

3. 教学重点与难点

1. 教学重点

（1）Diffusion and relevant examples in the pharmaceutical sciences and the practice of pharmacy.

（2）The processes of dialysis, osmosis, and ultrafiltration.

（3）Permeability relevance to a rate constant and to resistance.

（4）Various driving forces for diffusion, drug absorption, and elimination.

2. 教学难点

（1）Fick's laws of diffusion and their application.

（2）Diffusion coefficient, permeability, and lag time.

（3）Multilayer diffusion and calculate component permeabilities.

（4）Steady state, sink conditions, membrane, and diffusion control.

（5）Drug release from a homogeneous solid.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

Use example in PPT to explain diffusion

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Do calculations （案例、实例计算）to determine (multilayer) diffusion coefficient, permeability and drug release

5. 更新或补充内容提要

见PPT多媒体课件

6. 复习思考题

见PPT多媒体课件

Textbook, PRACTICE PROBLEMS FOR STUDENT USE

7. 学习资源、课外自主学习参考

见PPT多媒体课件

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

见PPT多媒体课件

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》

Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019药学全英文班

授课章节

Chapter 14 Chemical Kinetics and Stability

授课时间

200分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Define reaction rate, reaction order, and molecularity.

2. Understand Michaelis-Menten (nonlinear) kinetic behavior and linearization techniques.

3. Interpret pH–rate profiles and kinetic data.

4. Understand the basis for transition-state theory and its application to chemical kinetics.

5. Describe the influence of temperature, ionic strength, solvent, pH, and dielectric constant on reaction rates.

6. Describe the factors that influence solid-state chemical kinetics.

7. Understand stability-testing protocols and regulatory requirements.

2. 技能（能力）目标：

1. Calculate half-life and shelf life of pharmaceutical products and drugs.

2. Calculate the increase in rate constant as a function of temperature (Q10).

3. Understand and apply apparent zero-order kinetics to the practice of pharmacy.

4. Identify and describe methods for the stabilization of pharmaceutical agents.

2. 授课内容（依据教学大纲）及时间分配

Introduction（10分钟）

Reaction rate, reaction order, and molecularity（30分钟）

Apply apparent zero-order kinetics to the practice of pharmacy （10分钟）

Half-life and shelf life of pharmaceutical products and drugs（30分钟）

Michaelis-Menten kinetic behavior and linearization techniques（10分钟）

pH–rate profiles and kinetic data（10分钟）

Transition-state theory and its application to chemical kinetics（20分钟）

The influence of temperature, ionic strength, solvent, pH, and dielectric constant on reaction rates （20分钟）

The increase in rate constant as a function of temperature （20分钟）

The factors that influence solid-state chemical kinetics （20分钟）

Methods for the stabilization of pharmaceutical agents（10分钟）

Stability-testing protocols and regulatory requirements（10分钟）

3. 教学重点与难点

1. 教学重点

（1）Reaction rate, reaction order, and molecularity.

（2）Apply apparent zero-order kinetics to the practice of pharmacy.

（3）Half-life and shelf life of pharmaceutical products and drugs.

（4）The increase in rate constant as a function of temperature (Q10).

（5）Methods for the stabilization of pharmaceutical agents.

2. 教学难点

（1）Michaelis-Menten kinetic behavior and linearization techniques.

（2）pH–rate profiles and kinetic data.

（3）Transition-state theory and its application to chemical kinetics.

（4）The influence of temperature, ionic strength, solvent, pH, and dielectric constant on reaction rates.

（5）The factors that influence solid-state chemical kinetics.

（6）Stability-testing protocols and regulatory requirements.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

Use example in PPT to explain reaction order and introduce the relationship between chemical reaction and half-life and shelf life of pharmaceutical products and drugs.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Do calculations （案例、实例计算）to determine half-life and shelf life of pharmaceutical products and drugs.

5. 更新或补充内容提要

见PPT多媒体课件

6. 复习思考题

见PPT多媒体课件

Textbook, PRACTICE PROBLEMS FOR STUDENT USE

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

见PPT多媒体课件

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》

Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 15 Interfacial Phenomena

授课时间

200分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Differentiate among different types of interfaces and describe relevant examples in the pharmaceutical sciences.

2. Understand the terms surface tension and interfacial tension and their application in pharmaceutical sciences.

3. Calculate surface and interface tensions, surface free energy, its changes, work of cohesion and adhesion, and spreading coefficient for different types of interfaces.

4. Recognize the electric properties of interfaces and the effects of electrolytes.

2. 技能（能力）目标：

1. Appreciate the different methods of surface and interface tension measurements.

2. Understand the mechanisms of adsorption on liquid and solid interfaces.

3. Classify surface-active agents and appreciate their applications in pharmacy.

4. Differentiate between different types of monolayers and recognize basic methods for their characterization.

2. 授课内容（依据教学大纲）及时间分配

Introduction（10分钟）

Different types of interfaces and relevant examples in the pharmaceutical sciences （30分钟）

Surface tension and interfacial tension and their application in pharmaceutical sciences （20分钟）

Different methods of surface and interface tension measurements（20分钟）

Calculations of surface and interface tensions, surface free energy and its changes, work of cohesion and adhesion, and spreading coefficient for different types of interfaces （40分钟）

The mechanisms of adsorption on liquid and solid interfaces（20分钟）

Classification of surface-active agents and their applications in pharmacy（30分钟）

Different types of monolayers and basic methods for their characterization（20分钟）

Electric properties of interfaces and the effects of electrolytes （10分钟）

3. 教学重点与难点

1. 教学重点

（1）Different types of interfaces and relevant examples in the pharmaceutical sciences.

（2）Surface tension and interfacial tension and their application in pharmaceutical sciences.

（3）Calculations of surface and interface tensions, surface free energy and its changes, work of cohesion and adhesion, and spreading coefficient for different types of interfaces.

（4）The electric properties of interfaces and the effects of electrolytes.

2. 教学难点

（1）Different methods of surface and interface tension measurements.

（2）The mechanisms of adsorption on liquid and solid interfaces.

（3）Classification of surface-active agents and their applications in pharmacy.

（4）Different types of monolayers and basic methods for their characterization.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

Use example in PPT to explain interfacial phenomena and the application in Pharmaceutics.

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

Do calculations （案例、实例计算）to determine surface and interface tensions, surface free energy and its changes, work of cohesion and adhesion, and spreading coefficient for different types of interfaces.

5. 更新或补充内容提要

见PPT多媒体课件

6. 复习思考题

见PPT多媒体课件

Textbook, PRACTICE PROBLEMS FOR STUDENT USE

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

见PPT多媒体课件

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 16 Colloidal dispersions

授课时间

200分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Understand the concept and classification of dispersed systems.

2. Be familiar with types of colloidal systems.

3. Describe optical properties of colloids, Faraday-Tyndal effect, Electronic Microscope, Light Scattering & MW.

4. Understand the factors affecting solubilization.

5. Understand kinetic properties of colloids

6. Be familiar with electronic properties of colloids.

2. 技能（能力）目标：

1. Master classification of dispersed systems, types of colloidal systems;

2. Master the optical, kinetic and electronic properties of colloids.

2. 授课内容（依据教学大纲）及时间分配

1. The concept and classification of dispersed systems. (15分钟)

2. Types of colloidal systems (20分钟)

3. Optical properties of colloids, Faraday-Tyndal effect, electronic microscope, light scattering & MW (65分钟)

4. The factors affecting solubilization（25分钟）

5. Kinetic properties of colloids（25分钟）

6. Electronic properties of colloids （45分钟）

7. Summary （5分钟）

3. 教学重点与难点

1. 教学重点

1. The concept and classification of dispersed systems.;

2. Different types of colloidal systems;

3. Optical properties of colloids, Faraday-Tyndal effect, Electronic Microscope, Light Scattering & MW.

4. The factors affecting solubilization;

5. Kinetic properties of colloids;

6. Electronic properties of colloids.

2. 教学难点

（1）Understand optical properties of colloids, Faraday-Tyndal effect, Electronic Microscope, Light Scattering & MW;

（2）Be familiar withkinetic properties of colloids.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

C. 视频动画教学

较重要的概念和知识采用动画视频的形式向学生直观展示。

5. 更新或补充内容提要

无

6. 复习思考题

1. What is Faraday-Tyndal effect? Why this happened?

2. Describe kinetic properties of colloids.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

Chapter 19  Rheology

授课时间

100分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Define rheology, provide examples of fluid pharmaceutical products exhibiting various rheologic behaviors

2. Define and understand: shear rate, shear stress, Newton's and non-Newtonian flow, viscosity, kinematic viscosity, pseudoplasticity, dilatancy, thixotropy, viscoelasticity.

3. Appreciate the fundamentals of the practical determination of rheologic properties and describe four types of viscometers.

2. 技能（能力）目标：

1. Recognize and identify specific rheologic behaviors with their corresponding rheograms.

2. Understand and calculate the effects of temperature on viscosity and recognize similarities between viscous flow and diffusion relative to temperature.

2. 授课内容（依据教学大纲）及时间分配

1.  Newtonian systems (20分钟)

 Newton’s law of flow, viscosity  

2.  Non-newtonian systems（20分钟）

 Plastic flow, pseudoplastic flow, dilatant flow

3.  Thixotropy（10分钟）

 Measurement, bulges and spurs, negative thixotropy, thixotropy in formulation

4.  Determination of rheologic properties（20分钟）

 Choice of viscometer, capillary viscometer, falling-sphere viscometer, cup-and-bob viscometer, cone-and-plate viscometer

5.  Viscoelasticity（10分钟）

 Measurement, Voigt model

6.  Psychorheology（10分钟）

7.  Summary（10分钟）

3. 教学重点与难点

1. 教学重点

（1）The concept of rheology, shear rate;

（2）Newton's and non-Newtonian flow;

（3）Viscosity and viscoelasticity;

（4）Thixotropy and its application in pharmaceutical formulations.

2. 教学难点

（1）Appreciate the fundamentals of the practical determination of rheologic properties and describe four types of viscometers.

4. 教学方法选择

1. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. A sample of petrolatum was analyzed in a Stormer viscometer at 25◦C. To obtain the coefficient of thixotropic breakdown, M, two upcurves were run, the upper curve having a top rate of shear of v₁= 543 rpm and the lower curve having a value of v₂= 325 rpm. The values of the constants were KV = 40.5 and K_f= 15.9. The driving weights in grams, w₁ and w₂, for the two shear rates, v₁ and v₂, respectively, were found from the flow curves to be w₁= 269 g and w₂=225 g. The yield value intercepts for the two curves were w_f1=124 g and w_f2=96 g. Compute the plastic viscosities, yield values, and the coefficient of thixotropic breakdown, M.

2. Explain how one would set up a sensory testing panel and carry out a psychorheologic study to correlate the properties of commercial hand lotions in relation to client acceptance.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012

课程名称

Physical Chemistry

所属学科

药学

教材名称

《Martin's Physical Pharmacy and Pharmaceutical Sciences》第6版, Patrick J. Sinko主编，Lippincott Williams & Wilkins出版社

授课年级

2019级药学全英文班

授课章节

 Chapter 20  Pharmaceutical

Polymers

授课时间

200分钟

1. 教学目标：含知识目标、技能（能力）目标

1. 知识目标：

1. Basic concepts of polymers, definitions, descriptive terms.

2. Understand the principles of polymer synthesis.

3. Distinguish the basic principles of homogeneous and dispersion polymerizations.

4. The thermal, physical, mechanical properties of polymers.

5. The glass transition temperature (Tg) and factors affecting the Tg.

6. Understand how polymer MW affects its properties.

7. Know the polymers and roles used in the pharmaceutics.

2. 技能（能力）目标：

1. Explain why polymers are used in drug delivery applications.

2. Be able to select the right polymers for formulation development.

2. 授课内容（依据教学大纲）及时间分配

1.  About polymers (10分钟)

 Monomer, oligomer, macromolecules

2.  Polymer synthesis and polymerization methods (10分钟)

 Copolymers and polymer blends, addition polymerization

3.  Polymer structure (10分钟)

 Interpenetrating polymer network, topology and isomerism

4.  Thermoplastic and thermoset polymers (10分钟)

5.  Polymer properties and characterization (20分钟)

 Crystalline and amorphous polymers, thermal transitions, glass transition temperature, mechanical properties, viscoelastic properties, molecular weight

6.  Variety of polymers (20分钟)

 Rubbers, plastics, fibers, adhesives

7.  Polymers as rheology modifiers (10分钟)

8.  Hydrogels (10分钟)

9.  Polymers for pharmaceutical applications (30分钟)

10.  Cellulose-based polymers, hydrocolloids (20分钟)

11.  Polymers in drug delivery (40分钟)

12.  Summary (10分钟)

3. 教学重点与难点

1. 教学重点

（1）The thermal, physical, mechanical properties of polymers;

（2）Different types of polymers and their applications in pharmaceutical formulations;

（3）Tg and factors affecting the Tg;

（4）The principles of polymer synthesis.

2. 教学难点

（1）how polymer molecular weight affects its properties.

（2）How to choose the right polymers for drug development.

4. 教学方法选择

2. 理论课堂教学

A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势）

采用示意图、图片等介绍课程内容，尤其通过举例说明对难以理解的概念进行类比阐述；对一些公式进行推导演示。

B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题）

课堂讲解、学生提问与课后习题相结合

5. 更新或补充内容提要

无

6. 复习思考题

1. Will the intrinsic viscosity of polyethylene oxide increase, decrease, or remain unaffected as the temperature of its aqueous solution is increased? Hint: Express your answer in terms of hydration.

2. Which statement is true for the elastic properties of polymers?

(a) Alowmodulus polymer is stiffer than a high modulus polymer.

(b) A high modulus polymer is tougher than a low modulus polymer.

(c) Stiffness is the ratio of strain to stress.

(d) Toughness is the area under stress and strain curve; energy to break.

7. 学习资源、课外自主学习参考

(可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等)

1. 李三鸣主编,《物理化学》(第8版), 人民卫生出版社, 2016

2. 李三鸣主编,《物理化学学习指导》(第三版), 人民卫生出版社，2014

3. 印永嘉等主编,《物理化学简明教程》(第四版),高等教育出版社, 2007

4. Peter Atkins & Julio Paula, Physical Chemistry, 北京，高等教育出版社，影印版，2006

5. 彭笑刚著，《物理化学讲义》, 高等教育出版社, 2012